AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MARCH 12, 2001


                                                      REGISTRATION NO. 333-53386

--------------------------------------------------------------------------------
--------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                            ------------------------


                               AMENDMENT NO. 1 TO


                                    FORM S-4

                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933

                         ------------------------------

                           BIOTRANSPLANT INCORPORATED
             (Exact name of registrant as specified in its charter)


                                                                          
               DELAWARE                                  2834                                 04-3119555
 (State or other jurisdiction of            (Primary Standard Industrial                  (I.R.S. Employer
   incorporation or organization)           Classification Code Number)                Identification Number)


     BUILDING 75, 3RD AVENUE, CHARLESTOWN NAVY YARD, CHARLESTOWN, MA 02129
                                 (617) 241-5200

         (Address, including zip code, and telephone number, including
            area code, of registrant's principal executive offices)

                             ELLIOT LEBOWITZ, PH.D.
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                           BIOTRANSPLANT INCORPORATED
                            BUILDING 75, 3RD AVENUE
                             CHARLESTOWN NAVY YARD
                        CHARLESTOWN, MASSACHUSETTS 02129
                                 (617) 241-5200

 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)

                         ------------------------------

                                   COPIES TO:


                                                    
            STEVEN D. SINGER, ESQ.                                 WILLIAM T. WHELAN, ESQ.
             JAMES R. BURKE, ESQ.                      MINTZ, LEVIN, COHN, FERRIS, GLOVSKY AND POPEO,
               HALE AND DORR LLP                                            P.C.
                60 State Street                                     One Financial Center
          Boston, Massachusetts 02109                            Boston, Massachusetts 02111
           Telephone: (617) 526-6000                              Telephone: (617) 542-6000
           Telecopy: (617) 526-5000                               Telecopy: (617) 542-2241


                         ------------------------------

    APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as
practicable after this Registration Statement becomes effective and certain
other conditions under the Merger Agreement are met or waived.

    If the securities being registered on this form are being offered in
connection with the formation of a holding company and there is compliance with
General Instruction G, check the following box. / /

    If this form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and
list the Securities Act registration statement number of the earlier effective
registration statement for the same offering. / / ______


    If this form is a post-effective amendment filed pursuant to Rule 462(d)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. / / ______


                         ------------------------------

    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.

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                           [LOGO]                                                [LOGO]



                  MERGER PROPOSED--YOUR VOTE IS VERY IMPORTANT
                        SPECIAL MEETINGS OF STOCKHOLDERS
                         TO BE HELD ON           , 2001


To the Stockholders of BioTransplant and Eligix:

    The boards of directors of BioTransplant Incorporated and Eligix, Inc. have
unanimously approved a merger agreement that will result in Eligix becoming a
wholly-owned subsidiary of BioTransplant.

    If the merger is completed:

    - BioTransplant stockholders will continue to own their existing shares of
      BioTransplant common stock; and


    - An aggregate of up to 6,600,000 shares of BioTransplant common stock will
      be issued in connection with the merger. Of these 6,600,000 shares, Eligix
      security holders will be entitled to receive an aggregate of up to
      5,610,000 shares of BioTransplant common stock, either in the merger or
      upon exercise or conversion of Eligix options, warrants and notes assumed
      by BioTransplant in the merger, and members of Eligix' management will
      receive an aggregate of 990,000 shares of BioTransplant common stock
      pursuant to the Eligix management equity incentive plan.


    Immediately after the merger, Eligix security holders and management members
will own approximately 32.1% of the fully-diluted BioTransplant common stock,
assuming the exercise or conversion of all outstanding Eligix options, warrants
and notes assumed by BioTransplant in the merger. BioTransplant common stock is
quoted on the Nasdaq National Market under the symbol "BTRN."


    The merger cannot be completed unless Eligix' stockholders approve the
merger agreement and the merger and BioTransplant stockholders approve the
issuance of BioTransplant common stock as provided for in the merger agreement.
We have scheduled special meetings on               , 2001 for Eligix
stockholders to vote on the merger agreement and BioTransplant stockholders to
vote on the related issuance of shares of BioTransplant common stock. Whether or
not you plan to attend a special meeting, please take the time to vote by
completing and mailing the enclosed proxy card to us. YOUR VOTE IS VERY
IMPORTANT.



    This document provides you with detailed information about the proposed
merger. We encourage you to read this entire document carefully. IN PARTICULAR,
PLEASE SEE THE SECTION ENTITLED "RISK FACTORS" ON PAGE 14 OF THIS DOCUMENT FOR A
DISCUSSION OF RISKS ASSOCIATED WITH THE MERGER.



                                    
       Elliot Lebowitz, Ph.D.                     Walter C. Ogier
PRESIDENT AND CHIEF EXECUTIVE OFFICER  PRESIDENT AND CHIEF EXECUTIVE OFFICER
     BioTransplant Incorporated                    Eligix, Inc.


    NEITHER THE UNITED STATES SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE
SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THE BIOTRANSPLANT COMMON
STOCK TO BE ISSUED IN THE MERGER OR DETERMINED IF THIS JOINT PROXY
STATEMENT/PROSPECTUS IS ACCURATE OR ADEQUATE. ANY REPRESENTATION TO THE CONTRARY
IS A CRIMINAL OFFENSE.

              Joint Proxy Statement/Prospectus dated       , 2001
             First mailed to stockholders on or about       , 2001

                           BIOTRANSPLANT INCORPORATED
                            BUILDING 75, 3RD AVENUE
                             CHARLESTOWN NAVY YARD
                        CHARLESTOWN, MASSACHUSETTS 02129

                            ------------------------

                   NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                        TO BE HELD ON             , 2001

                            ------------------------

To the Stockholders of BioTransplant:

    We will hold a special meeting of the stockholders of BioTransplant on
            , 2001, at 10:00 a.m., local time, at Hale and Dorr LLP, 60 State
Street, Boston, Massachusetts, for the following purposes:


    1.  To consider and vote upon a proposal to approve the issuance of up to
5,610,000 shares of BioTransplant common stock to security holders of
Eligix, Inc., either in the merger or upon exercise or conversion of Eligix
options, warrants and notes assumed by BioTransplant in the merger, and 990,000
shares of BioTransplant common stock to members of Eligix management as
contemplated by the agreement and plan of merger, dated as of December 8, 2000,
among BioTransplant, BT/EL Acquisition Co., a wholly-owned subsidiary of
BioTransplant, and Eligix. Under the terms of the merger agreement, BT/EL
Acquisition Co. will be merged with and into Eligix, with Eligix being the
surviving corporation. Following the merger, Eligix will become a wholly-owned
subsidiary of BioTransplant; and



    2.  To transact any other business as may properly come before the
BioTransplant special meeting or any adjournment or postponement of the
BioTransplant special meeting, including without limitation, potential
adjournments or postponements of the BioTransplant special meeting for the
purpose of soliciting additional proxies in order to approve the proposed
issuance of BioTransplant common stock in connection with the merger.


    Only holders of record of shares of BioTransplant common stock at the close
of business on             , 2001, the record date for the BioTransplant special
meeting, are entitled to notice of, and to vote at, the BioTransplant special
meeting and any adjournments or postponements of it.

    After careful consideration, your board of directors has unanimously
approved the merger and the merger agreement and recommends that you vote FOR
approval of the proposed issuance of up to 5,610,000 shares of BioTransplant
common stock to the security holders of Eligix and 990,000 shares of
BioTransplant common stock to members of the management of Eligix in connection
with the merger.

    We have described the merger, merger agreement and the transactions
associated with it, including the stock issuance, in more detail in the
accompanying joint proxy statement/prospectus, which you should read in its
entirety before voting. A copy of the merger agreement is attached as Annex A to
the accompanying joint proxy statement/prospectus.


    We cannot complete the merger unless the issuance of the shares in
connection with the merger agreement is approved by a majority of the votes
represented by the shares of BioTransplant common stock cast on the proposal to
issue the shares, whether in person or by proxy.


    All holders of BioTransplant common stock are cordially invited to attend
the BioTransplant special meeting in person. HOWEVER, TO ENSURE YOUR
REPRESENTATION AT THE BIOTRANSPLANT SPECIAL MEETING, WHETHER OR NOT YOU PLAN TO
ATTEND THE MEETING, YOU ARE URGED TO COMPLETE, SIGN AND RETURN THE ENCLOSED
PROXY CARD AS PROMPTLY AS POSSIBLE IN THE ENCLOSED POSTAGE-PREPAID ENVELOPE. You
may revoke your proxy in the manner described in the accompanying joint proxy
statement/prospectus at any time before it is voted at the BioTransplant special
meeting. Executed proxies with no instructions indicated thereon will be voted
"FOR" approval of the issuance of up to 5,610,000 shares of BioTransplant common
stock to the security holders of Eligix and 990,000 shares of BioTransplant
common stock to members of the management of Eligix in connection with the
merger.


                                                      
                                                         By Order of the Board of Directors,

Charlestown, Massachusetts                               Steven D. Singer
            , 2001                                       SECRETARY


    THE BOARD OF DIRECTORS OF BIOTRANSPLANT RECOMMENDS THAT STOCKHOLDERS VOTE
"FOR" THE PROPOSED ISSUANCE OF BIOTRANSPLANT COMMON STOCK IN CONNECTION WITH THE
MERGER.

    YOUR VOTE IS IMPORTANT. WHETHER OR NOT YOU PLAN TO ATTEND THE BIOTRANSPLANT
MEETING, PLEASE COMPLETE, SIGN, DATE AND RETURN THE ENCLOSED PROXY CARD AS
PROMPTLY AS POSSIBLE IN THE ENCLOSED POSTAGE-PREPAID ENVELOPE.

                                  ELIGIX, INC.
                               200 BOSTON AVENUE
                          MEDFORD, MASSACHUSETTS 02155

                            ------------------------

                   NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                        TO BE HELD ON             , 2001

                            ------------------------

To the Stockholders of Eligix:

    A special meeting of stockholders of Eligix will be held on             ,
2001, at 10:00 a.m., local time, at the offices of Mintz, Levin, Cohn, Ferris,
Glovsky and Popeo, P.C., One Financial Center, Boston, Massachusetts, for the
following purposes:

    1.  To consider and vote upon a proposal to approve and adopt the agreement
and plan of merger, dated as of December 8, 2000, by and among BioTransplant
Incorporated, BT/EL Acquisition Co., a wholly-owned subsidiary of BioTransplant,
and Eligix, and the merger, as described in the attached joint proxy
statement/prospectus;

    2.  To amend Eligix' certificate of incorporation to change the manner in
which proceeds are to be distributed upon any liquidation, distribution or
winding up of Eligix, as described in the attached joint proxy
statement/prospectus; and


    3.  To transact any other business as may properly come before the meeting
or any adjournment or postponement thereof.


    Holders of record of Eligix common stock and of Eligix preferred stock at
the close of business on             , 2001 will be entitled to vote at the
Eligix meeting or any adjournment or postponement thereof. A list of
stockholders entitled to vote will be kept at Eligix, Inc., 200 Boston Avenue,
Medford, Massachusetts 02155, for ten days before the meeting.

    After careful consideration, your board of directors has unanimously
approved the merger agreement, the merger and the amendment to Eligix'
certificate of incorporation and recommends that you vote FOR each of these
proposals.

    UNDER DELAWARE LAW, STOCKHOLDERS OF ELIGIX HAVE RIGHTS OF APPRAISAL IN
CONNECTION WITH THE MERGER AS DESCRIBED IN THE ACCOMPANYING JOINT PROXY
STATEMENT/PROSPECTUS.

    Information regarding the merger, the merger agreement, Eligix,
BioTransplant and related matters is contained in the accompanying joint proxy
statement/prospectus and the annexes thereto, which are incorporated by
reference herein and form a part of this notice.

    PLEASE DO NOT SEND ANY CERTIFICATES FOR YOUR STOCK AT THIS TIME.

    Your vote is important. Whether or not you plan to attend the Eligix
meeting, please complete, sign, date and return your proxy in the enclosed
envelope promptly.


                                                       
                                                          By Order of the Board of Directors,

Medford, Massachusetts                                    Robert Momsen
            , 2001                                        SECRETARY


                               TABLE OF CONTENTS



                                                           
QUESTIONS AND ANSWERS ABOUT THE SPECIAL MEETINGS AND THE
  MERGER....................................................      1
SUMMARY.....................................................      3
  Selected Historical Consolidated Financial Information of
    BioTransplant...........................................     10
  Selected Historical Financial Information of Eligix.......     11
  Summary Unaudited Pro Forma Condensed Combined
    Information.............................................     12
  Comparative Per Share Data................................     13
RISK FACTORS................................................     14
  Cautionary Statement Concerning Forward-Looking
    Statements..............................................     23
MARKET PRICE AND DIVIDEND INFORMATION.......................     25
  Market Price Information..................................     25
  Dividend Information......................................     26
THE BIOTRANSPLANT SPECIAL MEETING...........................     27
  General...................................................     27
  Date, Time and Place......................................     27
  Purpose of the Special Meeting............................     27
  BioTransplant Board of Directors' Recommendation..........     27
  Record Date...............................................     27
  Vote Required; Vote at the Special Meeting................     27
  Proxies...................................................     28
  Revocability of Proxies...................................     28
  Solicitation of Proxies...................................     28
THE ELIGIX SPECIAL MEETING..................................     29
  General...................................................     29
  Date, Time and Place......................................     29
  Purpose of the Special Meeting............................     29
  Eligix Board of Directors' Recommendation.................     29
  Record Date...............................................     29
  Vote Required; Vote at the Special Meeting................     30
  Voting Agreements.........................................     30
  Proxies...................................................     30
  Revocability of Proxies...................................     31
  Solicitation of Proxies...................................     31
  Appraisal Rights..........................................     31
THE MERGER..................................................     32
  Background of the Merger..................................     32
  Recommendation of the Board of Directors of BioTransplant;
    BioTransplant's Reasons for the Merger..................     34
  Recommendation of the Board of Directors of Eligix;
    Eligix' Reasons for the Merger..........................     36
  Opinion of BioTransplant's Financial Advisor..............     38
  Interests of Executive Officers and Directors of Eligix in
    the Merger..............................................     42
  Stock Options, Warrants and Convertible Notes.............     46
  Accounting Treatment of the Merger........................     47
  Form of Merger............................................     47
  Merger Consideration......................................     47
  Effective Time of the Merger..............................     48
  Material United States Federal Income Tax
    Considerations..........................................     48
  Nasdaq National Market Quotation..........................     51
  Right of Stockholders to Appraisals.......................     51
  Appraisal Rights Procedures...............................     51



                                       i



                                                           
  Resale of BioTransplant Common Stock Issued in Connection
    with the Merger.........................................     54
THE MERGER AGREEMENT........................................     55
  The Merger................................................     55
  Consideration.............................................     55
  Conversion of Shares......................................     55
  Escrow....................................................     56
  Treatment of Eligix Stock Options.........................     57
  Treatment of Eligix Warrants..............................     57
  Treatment of Eligix Convertible Notes.....................     57
  Exchange of Stock Certificates............................     57
  Representations and Warranties............................     58
  Covenants.................................................     59
  Expenses..................................................     62
  Related Matters After the Merger..........................     62
  Indemnification of BioTransplant by Eligix Stockholders
    and Eligix Management Members...........................     62
  Conditions to Obligations to Effect Merger................     63
  Termination; Breakup Fees.................................     66
  Amendment and Waiver......................................     66
OTHER AGREEMENTS............................................     67
  Voting and Transfer Restriction Agreements................     67
  Lock-Up Agreements........................................     68
  Escrow Agreement..........................................     68
  Affiliate Agreements......................................     69
  Employment Offer Letters..................................     69
  Invention, Non-Disclosure and Non-Competition
    Agreements..............................................     70
INFORMATION CONCERNING BIOTRANSPLANT........................     72
  Business..................................................     72
  Management's Discussion and Analysis of Financial
    Condition and Results of Operations.....................     89
  Management................................................     93
  Executive Compensation....................................     97
  Severance Agreements with Executive Officers..............     99
  Compensation of Directors.................................    100
  Certain Transactions......................................    100
INFORMATION CONCERNING ELIGIX...............................    101
  Business..................................................    101
  Management's Discussion and Analysis of Financial
    Condition and Results of Operations.....................    102
UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL
  INFORMATION...............................................    105
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL HOLDERS AND
  MANAGEMENT OF BIOTRANSPLANT...............................    114
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL HOLDERS AND
  MANAGEMENT OF ELIGIX......................................    117
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL HOLDERS AND
  MANAGEMENT OF BIOTRANSPLANT FOLLOWING THE MERGER..........    121
DESCRIPTION OF BIOTRANSPLANT CAPITAL STOCK..................    123
  General...................................................    123
  BioTransplant Common Stock................................    123
  BioTransplant Preferred Stock.............................    123
  Delaware Law and Bylaw Provisions.........................    123
COMPARISON OF STOCKHOLDER RIGHTS............................    124
  General...................................................    124
  Capitalization............................................    124



                                       ii



                                                           
  Voting Rights.............................................    124
  Number and Classification of Directors....................    125
  Removal of Directors......................................    125
  Filling Vacancies on the Board of Directors...............    125
  Charter Amendments........................................    125
  Amendments to Bylaws......................................    126
  Action by Written Consent.................................    126
  Notice of Stockholder Actions.............................    126
  Right to Call Special Meeting of Stockholders.............    127
  Limitation of Personal Liability of Directors.............    128
  Dividends.................................................    128
  Conversion................................................    129
  Liquidation...............................................    130
  Rights in an Acquisition Event............................    130
  Appraisal Rights..........................................    131
APPROVAL OF AMENDMENT TO ELIGIX' AMENDED AND RESTATED
  CERTIFICATE OF INCORPORATION..............................    132
STOCKHOLDER PROPOSALS.......................................    132
LEGAL MATTERS...............................................    133
EXPERTS.....................................................    133
WHERE YOU CAN FIND MORE INFORMATION.........................    134
INDEX TO FINANCIAL STATEMENTS...............................    F-1




                     
ANNEXES

A.                      Agreement and Plan of Merger
B.                      Amendment to the Amended and Restated Certificate of
                        Incorporation of Eligix, Inc.
C.                      Opinion of Lazard Freres & Co. LLC
D.                      Section 262 of the Delaware General Corporation Law


                                      iii

        QUESTIONS AND ANSWERS ABOUT THE SPECIAL MEETINGS AND THE MERGER

Q.  WHY ARE BIOTRANSPLANT AND ELIGIX PROPOSING TO MERGE?

A. BioTransplant and Eligix are proposing to merge for a number of reasons,
    including the following:


       - we believe that there is a significant strategic fit between Eligix'
         products under development and BioTransplant's proposed AlloMune family
         of products that will position BioTransplant as an industry leader in
         using the transplantation of cells, tissues and organs as a means to
         regulate the human immune system in cancer and other diseases;


       - Eligix has a broad portfolio of products under development that
         diversifies BioTransplant's risk and adds additional sources of
         potential revenue;

       - the two companies have complementary technologies, expertise and
         collaborative relationships that will significantly strengthen
         BioTransplant's research and development capabilities; and


       - the two companies have complementary management teams that will
         strengthen the commercial infrastructure of the combined company.


Q.  WHAT IF THE MERGER IS NOT COMPLETED?


A. It is possible the merger will not be completed. This might happen if, for
    example, Eligix stockholders do not adopt the merger agreement or the
    BioTransplant stockholders do not approve the issuance of the common stock
    in connection with the merger. Should that occur, neither BioTransplant nor
    Eligix is under any obligation to make or consider any alternative proposal
    regarding the purchase of stock held by Eligix stockholders.


Q.  WHAT DO ELIGIX STOCKHOLDERS NEED TO DO NOW?

A. After carefully reading and considering the information contained in this
    joint proxy statement/prospectus, please complete, sign and date your proxy
    and return it in the enclosed return envelope as soon as possible, so that
    your shares of Eligix stock may be represented and voted at the Eligix
    special meeting of stockholders. If you sign and send in your proxy and do
    not indicate how you want to vote, we will count your proxy as a vote for
    the proposal to approve the merger agreement and the merger and the proposal
    to amend the Eligix certificate of incorporation.

Q.  WHAT DO BIOTRANSPLANT STOCKHOLDERS NEED TO DO NOW?

A. After carefully reading and considering the information contained in this
    joint proxy statement/prospectus, please complete, sign and date your proxy
    and return it in the enclosed return envelope as soon as possible, so that
    your shares of BioTransplant stock may be represented and voted at the
    BioTransplant special meeting of stockholders. If you sign and send in your
    proxy and do not indicate how you want to vote, we will count your proxy as
    a vote for the proposal to issue shares of BioTransplant common stock in
    connection with the merger.


Q.  IF MY SHARES ARE HELD IN THE NAME OF A BROKERAGE HOUSE, CUSTODIAN, NOMINEE
    OR OTHER FIDUCIARY, WILL THE STOCKHOLDER OF RECORD VOTE MY SHARES FOR ME?



A. The stockholder of record will vote your shares only if you provide
    instructions on how to vote. You should follow the directions provided by
    the stockholder of record regarding how to instruct the holder to vote your
    shares. If you do not instruct the stockholder of record, your shares will
    not be voted.


                                       1

Q.  CAN I CHANGE MY VOTE AFTER I HAVE MAILED MY SIGNED PROXY?


A. Yes. You can change your vote at any time before your proxy is voted at the
    special meeting. If you hold your shares in your own name, you can do this
    in one of three ways. First, you can send a written notice stating that you
    would like to revoke your proxy. Second, you can complete and submit a new
    proxy. If you choose either of these two methods, you must submit your
    notice of revocation of your new proxy to the address set forth in the
    answer to the last question below. Third, you can attend the special meeting
    and vote in person. However, attending the meeting without voting in person
    at the meeting will not revoke your proxy. If you beneficially own shares
    that are held in the record name of your broker or other nominee, you should
    follow the directions provided by the stockholder of record regarding how to
    change your vote.


Q.  SHOULD ELIGIX STOCKHOLDERS SEND IN THEIR STOCK CERTIFICATES NOW?

A. No. After the merger is completed, Eligix stockholders will receive
    instructions for exchanging Eligix stock certificates. Please do not send in
    your stock certificates with your proxy.

Q.  WHEN AND WHERE ARE THE SPECIAL MEETINGS?


                                                                  
A.  For BioTransplant:                                                  For Eligix:
                        , 2001                                          , 2001
                                10:00 a.m. local time                           10:00 a.m. local time
                                Hale and Dorr LLP                               Mintz, Levin, Cohn, Ferris,
                                60 State Street                                 Glovsky and Popeo, P.C.
                                Boston, Massachusetts 02109                     One Financial Center
                                                                                Boston, Massachusetts 02111


Q.  WHEN DO YOU EXPECT THE MERGER TO BE COMPLETED?


A. We expect to complete the merger in             2001.


Q.  WHO CAN HELP ANSWER MY QUESTIONS?


A. If you have any questions about the merger or if you need additional copies
    of this joint proxy statement/prospectus or the enclosed proxy, you should
    contact:



                                            
For BioTransplant Stockholders:                For Eligix Stockholders:

    BioTransplant Incorporated                 Eligix, Inc.
    Building 75, 3rdAvenue                         200 Boston Avenue
    Charlestown Navy Yard                          Medford, MA 02155
    Charlestown, MA 02129                          Attention: James R. Fitzgerald, Jr.
    Attention: Richard V. Capasso                  Telephone: (781) 870-4624
    Telephone: (617) 241-5200


                                       2

                                    SUMMARY


    We believe this summary highlights the material aspects of the transaction.
However, to understand the merger fully and for a more complete description of
the legal terms of the merger, you should read carefully this entire document
and the documents to which we have referred you. See "Where You Can Find More
Information" on page 134. We have included page references parenthetically to
direct you to a more complete description of the topics in this summary.



                                 THE COMPANIES
                             (SEE PAGES 72 AND 101)


BIOTRANSPLANT INCORPORATED
BUILDING 75, 3RD AVENUE
CHARLESTOWN NAVY YARD
CHARLESTOWN, MASSACHUSETTS 02129
(617) 241-5200

    BioTransplant is a biotechnology company that develops pharmaceutical
products and systems to enable the body's immune system to better tolerate the
transplantation of foreign cells, tissues and organs.

    BioTransplant was organized as a Delaware corporation in 1990.
BioTransplant's world wide web site address is www.biotransplant.com. The
information in our web site is not incorporated by reference into this joint
proxy statement/ prospectus. Our web site address is included in this document
as an inactive textual reference only.

ELIGIX, INC.
200 BOSTON AVENUE
MEDFORD, MASSACHUSETTS 02155
(781) 393-8500

    Eligix is a biomedical company engaged in the research and development of
cellular therapies to enhance human immune response to cancers, autoimmune
disorders and solid organ transplants and to reduce the risk of infection and
hypersensitivity reactions in blood transfusions.

    Eligix was organized as a Delaware corporation in 1996. Eligix' world wide
web site address is www.eligix.com. The information in this web site is not
incorporated by reference into this joint proxy statement/prospectus. This web
site address is included in this document as an inactive textual reference only.


                                   THE MERGER
                                 (SEE PAGE 32)


    Through the merger, Eligix will become a wholly-owned subsidiary of
BioTransplant. In connection with the merger, BioTransplant will issue an
aggregate of up to 6,600,000 shares of its common stock. Of these 6,600,000
shares of BioTransplant common stock:



    - Eligix security holders will receive an aggregate of up to 5,610,000
      shares of BioTransplant common stock in exchange for their Eligix
      securities, either in the merger or upon exercise or conversion of Eligix
      options, warrants or notes assumed by BioTransplant in the merger; and



    - members of Eligix' management team will receive an aggregate of 990,000
      shares of BioTransplant common stock under the Eligix management equity
      incentive plan.


    The merger agreement is attached to this joint proxy statement/prospectus as
Annex A. We encourage you to read the merger agreement as it is the legal
document that governs the merger.


                                 VOTES REQUIRED
                             (SEE PAGES 27 AND 30)


BIOTRANSPLANT


    Under the applicable rules of the Nasdaq National Market, approval of the
proposed issuance of BioTransplant common stock in connection with the merger
requires the vote of a majority of the votes represented by the shares of
BioTransplant common stock cast on the proposal, whether in person or by proxy,
because the number of shares of BioTransplant common stock to be issued in the
merger will exceed 20% of the outstanding shares of BioTransplant common stock
prior to the merger.


    As of             , 2001, the record date for the special meeting of
BioTransplant stockholders, BioTransplant's directors, executive

                                       3

officers and affiliates owned approximately   % of the outstanding shares of
BioTransplant common stock.

ELIGIX

    Approval of the merger agreement and the merger requires the vote of:

    - a majority of the votes represented by the outstanding shares of Eligix
      common stock and preferred stock, voting together as a single class; and

    - two-thirds of the votes represented by the outstanding shares of the
      Eligix preferred stock, voting together as a single class.

    Approval of the amendment to the certificate of incorporation requires the
vote of:

    - a majority of the votes represented by the outstanding shares of Eligix
      common stock and preferred stock, voting together as a single class;

    - two-thirds of the votes represented by the outstanding shares of the
      Eligix preferred stock, voting together as a single class; and


    - a majority of the votes represented by the outstanding shares of Eligix
      Series A preferred stock and Series B preferred stock, voting together as
      a single class.



                        RECOMMENDATIONS TO STOCKHOLDERS
                             (SEE PAGES 34 AND 36)


TO BIOTRANSPLANT STOCKHOLDERS:

    The BioTransplant board of directors voted unanimously to approve the merger
agreement and the merger and the proposed issuance of BioTransplant common stock
in connection with the merger. The BioTransplant board believes that the merger
is in your best interests and recommends that you vote FOR the proposed issuance
of BioTransplant common stock in connection with the merger.

TO ELIGIX STOCKHOLDERS:

    The Eligix board of directors voted unanimously to approve the merger
agreement, the merger and the transactions contemplated thereby. The Eligix
board believes that the merger and the amendment to the certificate of
incorporation are advisable and in your best interests and recommends that you
vote FOR the proposal to approve the merger agreement and the merger and the
amendment to the certificate of incorporation.


                     WHAT HOLDERS OF ELIGIX SECURITIES WILL
                             RECEIVE IN THE MERGER
                                 (SEE PAGE 55)



    Eligix security holders will receive an aggregate of up to 5,610,000 shares
of BioTransplant common stock in connection with the merger. The distribution of
the 5,610,000 shares among the different classes of Eligix capital stock will
depend on which, if any, holders of Eligix preferred stock elect to convert
their shares into Eligix common stock rather than receive their liquidation
preferences. Assuming the holders of Eligix preferred stock elect to receive
their liquidation preferences, Eligix stockholders will receive:


    - 0.1152 of a share of BioTransplant common stock for each share of Eligix
      Series A preferred stock that they own;

    - 0.1296 of a share of BioTransplant common stock for each share of Eligix
      Series B preferred stock that they own;

    - 0.3889 of a share of BioTransplant common stock for each share of Eligix
      Series C-1 preferred stock that they own;

    - 0.1152 of a share of BioTransplant common stock for each share of Eligix
      Series C-2 preferred stock that they own;

    - 0.1296 of a share of BioTransplant common stock for each share of Eligix
      Series C-3 preferred stock that they own; and


    - 0.0913 of a share of BioTransplant common stock for each share of Eligix
      common stock that they own.



    To the extent that holders of Eligix preferred stock elect to convert their
shares into Eligix common stock, rather than receive their liquidation
preferences, the number of shares of BioTransplant common stock exchangeable for
each share of Eligix common stock will be between 0.0913 of a BioTransplant
share


                                       4


assuming no conversion of Eligix preferred stock and 0.1540 of a BioTransplant
share assuming full conversion of Eligix preferred stock.


    BioTransplant will not issue fractional shares of BioTransplant common stock
in connection with the merger. Instead, Eligix stockholders will receive cash
for any fractional share of BioTransplant common stock owed to them.

    Options, warrants or notes that are exercisable or convertible into shares
of Eligix capital stock will be assumed by BioTransplant and will be exercisable
or convertible for BioTransplant common stock. As discussed above, the number of
shares issuable upon exercise or conversion of these options, warrants or notes,
and the exercise or conversion price per share, will be adjusted using the same
conversion ratio applied to determine the number of shares of BioTransplant
stock to be issued per share of Eligix capital stock in the merger.

    Eligix has agreed to use its reasonable best efforts to cause the exercise
of all outstanding warrants and the conversion of all outstanding notes prior to
the closing of the merger.


                          WHAT ELIGIX MANAGEMENT WILL
                             RECEIVE IN THE MERGER
                                 (SEE PAGE 42)



    If the merger is completed, members of Eligix' management team will receive
an aggregate of 990,000 shares of BioTransplant common stock under the Eligix
management equity incentive plan. The shares issuable to the members of Eligix'
management vest over a 365-day period following the closing of the merger, with:



    - 33 1/3% of the shares vesting 90 days after the closing of the merger;



    - an additional 33 1/3% vesting 180 days after the closing of the merger;



    - an additional 23 1/3% vesting 270 days after the closing of the merger;
      and



    - the final 10% vesting 365 days after the closing of the merger.



    If, within the first 365 days after the merger, BioTransplant terminates an
Eligix management member other than for cause or a management member terminates
employment with BioTransplant with good reason, that management member's shares
will vest in full immediately upon termination. Otherwise, BioTransplant will
have the right to repurchase a terminated management member's unvested shares
for $.01 per share.



                           OWNERSHIP OF BIOTRANSPLANT
                              FOLLOWING THE MERGER
                                 (SEE PAGE 121)


    Eligix security holders and management members will receive an aggregate of
up to 6,600,000 shares of BioTransplant common stock in the merger, or
approximately 32.1% of the fully-diluted shares of BioTransplant common stock
following the merger, assuming the exercise or conversion of all Eligix stock
options, warrants and convertible notes.


                     CONDITIONS TO COMPLETION OF THE MERGER
                                 (SEE PAGE 63)


    The completion of the merger depends upon meeting a number of conditions,
including the following:

    - the approval of the stockholders of BioTransplant and Eligix;

    - that the holders of no more than 10% of the outstanding voting stock of
      Eligix exercise appraisal rights under the Delaware General Corporation
      Law;

    - the filing with the Nasdaq National Market with respect to the listing of
      the shares of BioTransplant common stock issued in connection with the
      merger;

    - the receipt of legal opinions regarding corporate matters and the material
      tax consequences of the merger;

    - that the holders of at least 95% of the shares of capital stock of Eligix,
      including outstanding options to purchase shares of Eligix capital stock,
      will have signed lock-up agreements, subject to limited exceptions;

    - the adoption by the Eligix stockholders of the proposed amendment to the
      Eligix certificate of incorporation;

                                       5

    - the execution and delivery of the escrow agreement;

    - the termination of existing Eligix stockholder agreements, investor rights
      agreements, voting agreements and registration rights agreements;

    - the extension by BioTransplant of offers of employment to the members of
      Eligix management; and

    - other customary contractual conditions specified in the merger agreement.


    The conditions to the merger may be waived by the company entitled to assert
the condition. If either BioTransplant or Eligix chooses to waive a material
condition to the completion of the merger, including the receipt of legal
opinions regarding material tax consequences, we will amend this joint proxy
statement/prospectus and resolicit your vote.



    ESCROW FOR INDEMNIFICATION OF BIOTRANSPLANT AND MILESTONE ESCROW SHARES
                             (SEE PAGES 62 AND 68)


    Eligix stockholders and members of Eligix management receiving shares in
connection with the Eligix management equity incentive plan will not immediately
receive all of the BioTransplant shares issuable in the merger. Twenty percent
of their shares will automatically be placed in escrow. If the merger agreement
is approved and the merger occurs, all stockholders of Eligix who have not
perfected appraisal rights under the Delaware General Corporation Law, by
receipt of BioTransplant common stock in the merger, will be deemed to have
agreed to the terms of the escrow agreement referred to in the merger agreement.

    One half of the shares that are placed in escrow, referred to as the
indemnification escrow shares, will be used to indemnify BioTransplant against
damages due to:

    - a misrepresentation, breach of warranty or failure to perform any covenant
      or agreement of Eligix contained in the merger agreement;

    - failure by an Eligix stockholder to have good, valid and marketable title
      to his, her or its Eligix stock; and

    - any written demand by an Eligix stockholder for a judicial determination
      of the fair value of his, her or its dissenting shares under Section 262
      of the Delaware General Corporation Law, with specified exceptions, with
      respect to dissenting shares in excess of 5% and less than or equal to 10%
      of the outstanding shares of Eligix capital stock.


    This obligation to indemnify BioTransplant is limited to the indemnification
escrow shares. The indemnification obligations will end 15 months after closing.
At that time, if BioTransplant does not have any unresolved claims for the
property remaining in this escrow, the indemnification escrow shares will be
released to the former Eligix stockholders and management members.


    The other one half of the shares placed in escrow, referred to as the
milestone escrow shares, will only be distributed if Eligix achieves CE mark
approval for its TCell-HDM product by December 31, 2001. CE mark approval
indicates compliance with European standards for safety and allows certified
products to be marketed and sold in Europe.


    Two representatives will be authorized to represent the Eligix stockholders
and management members in all matters relating to the escrow. Robert Momsen and
Pieter Schiller have been selected by the Eligix board to act as the
representatives of the Eligix stockholders. Approval by the Eligix stockholders
of the merger will constitute approval of the selection of these
representatives.


                           NO SOLICITATION BY ELIGIX
                                 (SEE PAGE 61)


    Eligix has agreed that it will not initiate or engage in any discussion
regarding a business combination of Eligix with any other party. Eligix has
further agreed to cause each of its officers, directors, employees,
representatives and agents not to do any of these things.


                      TERMINATION OF THE MERGER AGREEMENT
                                 (SEE PAGE 66)


    BioTransplant and Eligix can mutually agree to terminate the merger
agreement, and either

                                       6

BioTransplant or Eligix can terminate the merger agreement if any of the
following occurs:

    - the other party commits a material breach of any representation, warranty
      or covenant under the merger agreement;

    - the approval of the stockholders of BioTransplant or Eligix is not
      obtained; or

    - the merger is not completed by April 30, 2001 by reason of the failure of
      any condition precedent to that party's closing of the merger unless the
      failure results primarily from a breach of any of that party's
      representations, warranties or covenants contained in the merger
      agreement.


                                  BREAK-UP FEE
                                 (SEE PAGE 66)



    If either BioTransplant or Eligix terminates the merger agreement, all
obligations of the parties under the merger agreement terminate and there will
be no liability, except that if the merger agreement is terminated by either
party as a result of the other party's failure to perform or comply in all
material respects with the agreements and covenants under the merger agreement,
the non-terminating party will pay the terminating party $2,000,000.



                          OPINION OF FINANCIAL ADVISOR
                                 (SEE PAGE 38)



    In deciding to approve the merger, BioTransplant's board of directors
received an opinion, dated December 8, 2000, from its financial advisor, Lazard
Freres & Co. LLC, that the total consideration to be paid in the merger was fair
from a financial point of view to BioTransplant. The full text of the opinion is
attached as Annex C to this joint proxy statement/prospectus and should be read
carefully in its entirety. THE OPINION OF LAZARD DOES NOT CONSTITUTE A
RECOMMENDATION TO ANY STOCKHOLDER AS TO HOW THE STOCKHOLDER SHOULD VOTE WITH
RESPECT TO MATTERS RELATING TO THE MERGER.



     INTERESTS OF EXECUTIVE OFFICERS AND DIRECTORS OF ELIGIX IN THE MERGER
                                 (SEE PAGE 42)


    In considering the recommendation of the Eligix board, you should be aware
of the interests that executive officers and directors of Eligix have in the
merger. These include:



    - the issuance of an aggregate of 990,000 shares of BioTransplant common
      stock in satisfaction of the obligations to Eligix management under the
      Eligix management equity incentive plan;



    - acceleration of vesting of James R. Fitzgerald's and Walter C. Ogier's
      options to purchase stock;


    - employment offers being extended to members of Eligix management;


    - continued mortgage assistance for Walter C. Ogier;


    - indemnification of Eligix directors and officers for actions taken prior
      to the merger; and

    - Eligix officers and directors becoming officers and/or directors of
      BioTransplant.

    In discussing the fairness of the merger to stockholders of Eligix, Eligix'
board of directors took into account these interests. These interests are
different from and in addition to their interests as stockholders and the
interests of Eligix stockholders generally.

    As of             , 2001, the record date for the special meeting of Eligix
stockholders, directors and executive officers of Eligix and their affiliates as
a group owned approximately    % of the outstanding shares of Eligix capital
stock.


                                  ELIGIX LOAN
                                 (SEE PAGE 103)



    Eligix will borrow up to $2.0 million from BioTransplant to fund operations
through the anticipated closing date of the merger. The loan is evidenced by a
promissory note, which bears interest at the prime rate. The loan will be
forgiven concurrently with the closing of the merger, provided that if the
merger does not


                                       7

close on or before June 30, 2001, then the note will become immediately due and
payable in full.


                              ACCOUNTING TREATMENT
                                 (SEE PAGE 47)


    We expect the merger to be accounted for using purchase accounting, with
BioTransplant being deemed to have acquired Eligix.


            MATERIAL UNITED STATES FEDERAL INCOME TAX CONSIDERATIONS
                                 (SEE PAGE 48)


    We have structured the merger so that, in general, no gain or loss will be
recognized by Eligix stockholders for U.S. federal income tax purposes on the
exchange of shares of Eligix stock for shares of BioTransplant common stock.
Eligix stockholders, however, will recognize gain for U.S. federal income tax
purposes on any cash received in lieu of fractional shares. BioTransplant and
Eligix must receive legal opinions to this effect as a condition to the closing
of the merger.

    Tax matters are very complicated, and the tax consequences of the merger to
Eligix stockholders will depend on the facts of each stockholder's own
situation. Each Eligix stockholder should consult his, her or its tax advisor
for a full understanding of the tax consequences of the merger to the
stockholder.

                              REGULATORY APPROVALS

    The merger is not subject to the filing and waiting period requirements of
the Hart-Scott-Rodino Antitrust Improvements Act of 1976.


                               VOTING AGREEMENTS
                                 (SEE PAGE 67)



    The directors, officers and holders of five percent or more of the
outstanding voting power of Eligix common stock and preferred stock, who
collectively beneficially own approximately 66.4% of the outstanding voting
power of Eligix capital stock, 67.3% of the outstanding voting power of the
Eligix preferred stock and 67.3% of the outstanding voting power of the Eligix
Series A preferred stock and Series B preferred stock, have already agreed under
voting agreements to vote in favor of the merger agreement and the merger and
the amendment to the Eligix certificate of incorporation. The shares of Eligix
capital stock that are subject to voting agreements constitute the voting power
required to approve the merger agreement, the merger and the amendment to the
Eligix certificate of incorporation.



                    ELIGIX STOCKHOLDERS' RIGHT OF APPRAISAL
                                 (SEE PAGE 51)



    Under Delaware law, Eligix stockholders who do not vote in favor of the
merger and who comply with notice requirements and other procedures will have
the right to receive the "fair value" of their shares in cash rather than the
shares of BioTransplant common stock specified in the merger agreement. "Fair
value" will be determined by a Delaware court and may be more than, the same as,
or less than the value of the consideration to be paid to other Eligix
stockholders. Merely voting against the merger will not protect your rights to
an appraisal. Failure to follow all the steps required by Delaware law will
result in the loss of your rights to appraisal. The Delaware law requirements
for exercising appraisal rights are described in further detail on pages 51 to
54. In addition to reading "Appraisal Rights Procedures," see Annex D, which
contains a copy of the Delaware statute governing appraisal rights.



     HOW THE RIGHTS OF AN ELIGIX STOCKHOLDER WILL DIFFER AS A BIOTRANSPLANT
                                  STOCKHOLDER
                                 (SEE PAGE 124)


    The rights of Eligix stockholders after the merger will be governed by
BioTransplant's certificate of incorporation and bylaws. Those rights differ
from rights of Eligix stockholders under Eligix' charter and bylaws.


                              RISKS OF THE MERGER
                                 (SEE PAGE 14)



    In considering whether to approve the merger agreement and/or issuance of
shares in connection with the merger, you should consider the risks of the
merger, including the risk of fluctuations in the market price of BioTransplant
common stock, risks associated with the merger and integrating the companies'
businesses and


                                       8


the fact that the directors and officers of BioTransplant and Eligix may have
interests in the merger that are different from, or in addition to, yours. We
urge you to read carefully the factors described in "Risk Factors" on pages 14
to 23 before voting.



                        BIOTRANSPLANT PRICE INFORMATION
                                 (SEE PAGE 25)


    Shares of BioTransplant common stock are listed on the Nasdaq National
Market. On December 8, 2000, the last full trading day prior to the public
announcement of the proposed merger, BioTransplant common stock closed at $8.375
per share. On             , 2001, BioTransplant common stock closed at $    per
share.


    We are unable to provide information with respect to the market prices of
the Eligix stock because there is no established trading market for shares of
Eligix stock.


                                   TRADEMARKS


    BioTransplant-TM-, ImmunoCognance-TM-, AlloMune-TM- and BTI-322-TM- are
BioTransplant's trademarks. BCell-HDM-TM-, TCell-HDM-TM-, PanT-HDM-TM-,
BrCa-HDM-TM-, Neu/RBC-HDM-TM-, AcT-IV-TM-, Leuko-HDM-TM-, ReacT-HDM-TM-,
AcTCell-HDM-TM- and HDM-TM- are trademarks of Eligix. This joint proxy
statement/prospectus also contains trademarks and trade names of others.


                                       9

    SELECTED HISTORICAL CONSOLIDATED FINANCIAL INFORMATION OF BIOTRANSPLANT


    The annual financial information set forth below has been derived from the
audited consolidated financial statements of BioTransplant. The information
should be read in connection with, and is qualified in its entirety by reference
to, BioTransplant's financial statements and the notes included elsewhere in
this joint proxy statement/prospectus.





                                                                            YEARS ENDED DECEMBER 31,
                                                              ----------------------------------------------------
                                                                1996       1997       1998       1999       2000
                                                              --------   --------   --------   --------   --------
                                                                     (IN THOUSANDS, EXCEPT PER SHARE DATA)
                                                                                           
CONSOLIDATED STATEMENT OF OPERATIONS DATA:
Revenues:
  License fees..............................................  $ 2,000    $ 5,000    $ 1,000    $ 3,500    $     --
  Research and development..................................    5,750      7,125      5,688      5,189       4,563
                                                              -------    -------    -------    -------    --------
            Total revenues..................................    7,750     12,125      6,668      8,689       4,563
                                                              -------    -------    -------    -------    --------
Expenses:
  Research and development..................................   12,268     13,988     14,730     15,680      14,974
  General and administrative................................    2,680      2,963      2,477      2,446       2,543
                                                              -------    -------    -------    -------    --------
            Total expenses..................................   14,948     16,951     17,207     18,126      17,517
Operating loss..............................................   (7,198)    (4,826)   (10,579)    (9,437)    (12,954)
Interest income.............................................    1,296      1,731      1,318        782       1,335
Interest expense............................................     (135)       (58)       (10)       (18)        (60)
                                                              -------    -------    -------    -------    --------
Net loss....................................................  $(6,037)   $(3,153)   $(9,211)   $(8,673)   $(11,679)
                                                              =======    =======    =======    =======    ========
Basic and diluted net loss per common share.................  $ (1.08)   $ (.037)   $ (1.07)   $ (1.01)   $  (1.01)
Basic and diluted weighted average common shares
  outstanding...............................................    5,582      8,569      8,579      8,598      11,547

CONSOLIDATED BALANCE SHEET DATA (AT PERIOD END):
Cash and cash equivalents...................................  $ 6,564    $ 9,784    $13,168    $17,649    $ 11,481
Short-term investments......................................   13,001     19,863      6,843      3,718       3,391
Working capital.............................................   17,788     24,111     15,499     14,629      13,315
Long-term investments.......................................   10,311      1,015         --         --         105
Total assets................................................   32,316     32,939     22,683     23,419      17,158
Stockholders' equity (deficit)..............................   29,262     26,154     16,958     15,645      14,422



                                       10

              SELECTED HISTORICAL FINANCIAL INFORMATION OF ELIGIX


    The annual financial information set forth below has been derived from the
audited financial statements of Eligix, except for net loss per basic and
diluted common share and basic and diluted weighted average common shares
outstanding. The information should be read in connection with, and is qualified
in its entirety by reference to, Eligix' financial statements and notes included
elsewhere in this joint proxy statement/prospectus. Eligix was incorporated on
December 27, 1996. Accordingly, financial information prior to 1997 is
immaterial.



    Diluted weighted average shares is the same as basic weighted average shares
since shares issuable upon the exercise or conversion of stock options, warrants
and convertible preferred stock are not included in the calculation as those
shares are antidilutive.





                                                                YEARS ENDED DECEMBER 31,
                                                       ------------------------------------------
                                                         1997       1998        1999       2000
                                                       --------   ---------   --------   --------
                                                         (IN THOUSANDS, EXCEPT PER SHARE DATA)
                                                                             
STATEMENT OF OPERATIONS DATA:
General, administrative and marketing expenses.......  $ 1,091    $   1,649   $  2,162   $  3,683
Research and development expenses....................    1,922        3,925      8,257      8,097
Loss from operations.................................   (3,013)      (5,574)   (10,419)   (11,780)
Interest income......................................      138          220        306        150
Interest expense.....................................       (1)         (44)      (222)    (1,342)
Net loss.............................................   (2,876)      (5,398)   (10,335)   (12,972)
Net loss per basic and diluted common share..........  $    --    $ (775.75)  $(149.21)  $ (83.05)
Basic and diluted weighted average common shares
  outstanding........................................       --            7         69        156

BALANCE SHEET DATA (AT PERIOD END):
Cash and cash equivalents............................  $ 2,004    $  12,879   $  3,269   $    712
Working capital......................................    1,549       11,446      1,530     (9,571)
Total assets.........................................    2,257       14,674      6,761      3,707
Long term debt and convertible preferred stock.......    4,624       21,072     23,455     22,598
Stockholders' deficit................................   (2,883)      (8,272)   (18,596)   (29,298)



                                       11

           SUMMARY UNAUDITED PRO FORMA CONDENSED COMBINED INFORMATION


    The following table summarizes unaudited pro forma condensed combined
information of BioTransplant, presented elsewhere in this joint proxy
statement/prospectus, reflecting the completion of the merger with Eligix and
assuming the merger had been effective for the periods indicated. BioTransplant
will account for this transaction using the purchase method of accounting.
Additionally, this information reflects the conversion of all outstanding shares
of Eligix preferred stock into BioTransplant common stock, which will take place
upon the closing of the merger.


    The summary unaudited pro forma condensed combined information is not
necessarily indicative of the results of operations or financial position that
would have been reported if the merger actually occurred on the dates indicated,
nor is the information necessarily indicative of the future operating results or
financial position of the combined company.

    The summary unaudited pro forma condensed combined information is derived
from the unaudited pro forma condensed combined information and related notes
included elsewhere in this joint proxy statement/prospectus, which you should
read in their entirety.




                                                                 YEAR ENDED
                                                              DECEMBER 31, 2000
                                                              -----------------
                                                               (IN THOUSANDS,
                                                              EXCEPT PER SHARE
                                                                    DATA)
                                                           
PRO FORMA CONDENSED COMBINED STATEMENT OF OPERATIONS DATA:
Total revenues..............................................      $  4,563
Total expenses..............................................        41,005
Net loss....................................................       (35,727)
Net loss per basic and diluted common share.................         (2.28)

PRO FORMA CONDENSED COMBINED BALANCE SHEET DATA (AT PERIOD
  END):
Cash and cash equivalents...................................      $  8,493
Working capital.............................................         7,591
Total assets................................................        42,361
Stockholders' equity........................................        35,502



                                       12

                           COMPARATIVE PER SHARE DATA

    The following table summarizes certain unaudited historical per share data
for BioTransplant and Eligix and the combined per share data on an unaudited pro
forma basis after giving effect to the merger using the purchase method of
accounting. You should read the information below along with the historical
financial data and the unaudited pro forma condensed combined financial data
included elsewhere in this joint proxy statement/prospectus. Neither
BioTransplant nor Eligix has ever declared any cash dividends.

    We have used the following calculations in deriving the per share data:

    - Book value is computed by dividing total stockholders' equity by the
      number of common shares outstanding, which excludes convertible preferred
      stock and convertible notes.

    - BioTransplant pro forma combined book value per share is computed by
      dividing pro forma stockholders' equity by the pro forma number of shares
      of BioTransplant common stock which would have been outstanding had the
      merger been consummated as of each balance sheet date.


    - Eligix equivalent pro forma combined amounts are calculated by multiplying
      the BioTransplant pro forma combined per share amounts and book value by
      the common stock exchange ratio of 0.0913.





                                                                AT AND FOR THE YEAR
                                                              ENDED DECEMBER 31, 2000
                                                              -----------------------
                                                           
HISTORICAL--BIOTRANSPLANT:
Net loss per basic and diluted share........................          $  (1.01)
Book value per share........................................              1.22

HISTORICAL--ELIGIX:
Net loss per basic and diluted share........................            (79.46)
Book value per share........................................            (74.02)

PRO FORMA COMBINED--PER BIOTRANSPLANT SHARE:
Net loss per basic and diluted share........................             (2.28)
Book value per share........................................              2.63

EQUIVALENT PRO FORMA COMBINED--PER ELIGIX SHARE:
Net loss per basic and diluted share........................             (7.25)
Book value per share........................................             (6.76)



                                       13

                                  RISK FACTORS


    You should carefully consider the following risk factors relating to the
merger before you decide whether to vote to approve and adopt the merger
agreement and the proposed issuance of BioTransplant common stock in connection
with the merger. You should also consider the other information in this joint
proxy statement/prospectus and the additional information in BioTransplant's
other reports on file with the Securities and Exchange Commission. See "Where
You Can Find More Information" on page 134.


                          RISKS RELATING TO THE MERGER

    ELIGIX STOCKHOLDERS AND MANAGEMENT MEMBERS MAY FORFEIT UP TO TWENTY PERCENT
OF THE BIOTRANSPLANT SHARES ISSUED IN CONNECTION WITH THE MERGER.


    Eligix stockholders and management members risk forfeiture of up to 20% of
the shares of BioTransplant common stock issued in connection with the merger,
or an aggregate of up to 1,320,000 shares, assuming the exercise or conversion
of all outstanding Eligix options, notes and warrants immediately prior to the
merger. In connection with the merger, these shares will be placed into an
escrow account. One half of the shares held in escrow, the indemnification
escrow shares, will be available to BioTransplant to satisfy the indemnification
obligations of the Eligix stockholders and management members. Eligix
stockholders and members of management may not receive any of the
indemnification escrow shares in the escrow account since those shares may be
required to indemnify BioTransplant under the terms of the merger agreement.


    The other one half of the shares of BioTransplant common stock held in
escrow, the milestone escrow shares, will only be distributed to Eligix
stockholders and management members if Eligix receives CE mark approval of the
TCell-HDM product on or before December 31, 2001. If Eligix does not receive
this approval by December 31, 2001, Eligix stockholders and management members
will not receive any of the milestone escrow shares.


    If Eligix stockholders and members of management do not receive any of the
indemnification escrow shares or the milestone escrow shares, then, assuming
that the holders of Eligix preferred stock elect to convert their shares into
common stock rather than receive their liquidation preferences:



    - the aggregate number of shares of BioTransplant common stock issued to
      Eligix security holders and management members in the merger, assuming
      full exercise or conversion of options, notes and warrants, will be
      5,280,000 shares, rather than 6,600,000 shares; and



    - Eligix security holders will receive only 80% of the shares of
      BioTransplant common stock that they would otherwise have been entitled to
      receive.



    For a detailed discussion of the terms of the escrow agreement, please see
Exhibit A to the merger agreement, which is attached as Annex A to this joint
proxy statement/prospectus.


    BECAUSE THE NUMBER OF SHARES ELIGIX SECURITY HOLDERS AND MANAGEMENT MEMBERS
WILL RECEIVE IN THE MERGER IS FIXED, THE VALUE OF THE CONSIDERATION TO BE
RECEIVED BY ELIGIX SECURITY HOLDERS AND MANAGEMENT MEMBERS COULD DECREASE.


    The number of shares Eligix security holders and management members will
receive in connection with the merger will be fixed even if the BioTransplant
stock price changes. All outstanding Eligix securities will be converted into an
aggregate of up to 5,610,000 shares of BioTransplant common stock issuable in
the merger or upon exercise or conversion of options, warrants and notes assumed
by BioTransplant in the merger. In addition, BioTransplant will issue 990,000
shares of its common stock to Eligix' management members under the Eligix
management equity incentive plan. The number of shares issued will not be
adjusted in the event of changes in the price of BioTransplant common stock. In
addition, Eligix may not terminate the merger agreement solely because of a
change in the stock


                                       14


price of BioTransplant. Consequently, if the market price of the BioTransplant
common stock decreases, the value of the consideration that Eligix security
holders will receive in connection with the merger will decrease.


    WE MAY FACE CHALLENGES IN INTEGRATING ELIGIX INTO BIOTRANSPLANT AND, AS A
RESULT, MAY NOT REALIZE THE EXPECTED BENEFITS OF THE ANTICIPATED MERGER.

    The merger involves the integration of two different companies that have
previously operated independently. Integrating Eligix' operations, technologies
and personnel with those of BioTransplant will be a complex process. We may not
be able to complete the integration rapidly. After the integration, the combined
company may not achieve the expected benefits of the merger. The diversion of
the attention of our management and any difficulties encountered in the process
of combining our companies could lead to unanticipated liabilities and costs and
cause the disruption of, or a loss of momentum in, the business activities of
the combined company. Further, the process of combining our companies could
negatively affect employee morale and the ability of the combined company to
retain some of its key employees after the merger. As a consequence, we may not
successfully integrate Eligix or profitably manage the combined company. In
addition, following the transaction, the combined company may not achieve
revenues, net income or loss levels, efficiencies or synergies that justify the
merger, and the merger may not result in increased earnings for the combined
company in any future period.


    ELIGIX SECURITY HOLDERS AND MANAGEMENT MEMBERS RISK A LOSS IN VALUE OF THE
BIOTRANSPLANT COMMON STOCK ISSUED IN CONNECTION WITH THE MERGER BEFORE THOSE
SHARES CAN BE SOLD.



    The shares of BioTransplant common stock issuable in connection with the
merger, including the shares issuable to Eligix management members and shares
issuable upon exercise or conversion of options, warrants and notes assumed by
BioTransplant, are subject to a lock-up period. None of these shares may be sold
for 90 days following the effective time of the merger and a portion of the
shares may not be sold for an additional 275 days. There is a risk that the
value of the BioTransplant shares issued in connection with the merger will
decline before those shares are released from the lock-up.



    THE LOSS OF KEY ELIGIX OR BIOTRANSPLANT PERSONNEL COULD MAKE IT DIFFICULT TO
COMPLETE EXISTING PROJECTS AND UNDERTAKE NEW PROJECTS.



    The success of the combined company depends on our ability to identify, hire
and retain our employees, and a significant component of the value of the merger
is in the know-how and experience of the Eligix and BioTransplant employees that
we expect to employ following the merger. None of the employees of Eligix or
BioTransplant will be bound by a long-term agreement with the combined company
or be covered by key-man life insurance after the merger. If key Eligix or
BioTransplant employees were to leave after the merger, we may be unable to
integrate Eligix' delivery systems into our product offerings, complete existing
Eligix projects or undertake new projects.



    Under the terms of Eligix' stock incentive plan, the vesting of stock
options to purchase an aggregate of approximately 864,999 shares of Eligix stock
held by Eligix employees automatically accelerates as a result of the merger. In
addition, options to purchase an aggregate of 2,749,100 shares of Eligix common
stock issued on May 25, 2000, which were exercisable in full on the date of
issuance but subject to a right of repurchase by Eligix, will no longer be
subject to the repurchase right in the event of a merger. These options have
substantial value to the Eligix employees. Because a substantial number of
options will vest in full and be immediately exercisable after the merger,
Eligix employees will not be incentivized through these stock options to remain
employed after the merger as a condition to the continued vesting of their
options. Consequently, we face the risk that Eligix employees will leave
following the merger. In addition, BioTransplant employees had vested options as
of February 28, 2001 to purchase an aggregate of approximately 923,000 shares of
BioTransplant common stock and, thus, may not be incentivized through stock
options to remain employed following the merger.


                                       15


    BIOTRANSPLANT MAY INCUR SIGNIFICANT SEVERANCE-RELATED COSTS AFTER THE MERGER
IF ELIGIX MANAGEMENT MEMBERS LEAVE FOR GOOD REASON OR BIOTRANSPLANT TERMINATES
THEM WITHOUT CAUSE.



    Each of the twelve management members of Eligix will be entitled to receive
severance-related payments if he or she leaves for good reason or is terminated
without cause after the merger. Consequently, BioTransplant may incur
significant severance-related costs, including:



    - cash severance payments of up to an aggregate of approximately $1,173,000
      if all twelve Eligix management members leave; and



    - the acceleration in full of the vesting of the 990,000 shares of
      BioTransplant common stock to be issued under the Eligix management equity
      incentive plan, which shares had a value of $5,445,000 based on the
      closing price of BioTransplant's common stock on February 28, 2001.


    RISKS RELATING TO THE COMBINED COMPANY'S FINANCIAL RESULTS AND NEED FOR
                                   FINANCING

    WE WILL REQUIRE SUBSTANTIAL ADDITIONAL FINANCING IN THE NEAR TERM, WHICH MAY
BE DIFFICULT TO OBTAIN AND MAY DILUTE YOUR OWNERSHIP INTEREST IN US.


    We anticipate that our existing funds will only be sufficient to fund our
operating and capital requirements through the middle of 2001. We expect to use
rather than generate funds from operations for the foreseeable future. In
particular, we will require substantial funds to conduct research and
development, including preclinical testing and clinical trials of our AlloMune
System and high density microparticle, or HDM, products, and to manufacture and
market any products that are approved for commercial sale. If we cannot raise
more funds, we could be required to reduce our capital expenditures, scale back
our research and product developments, reduce our workforce and/or license to
others products or technologies we would otherwise seek to commercialize
ourselves.



    We may seek additional funding through collaborative arrangements, borrowing
money and by the sale of additional equity securities. Any sales of additional
equity securities are likely to result in further dilution to our then existing
stockholders. Further, if we issue additional equity securities, the new equity
securities may have rights, preferences or privileges senior to those of
existing holders of our common stock. We may also borrow money from conventional
lenders, possibly at high interest rates, which will increase the risk of your
holdings. Despite our efforts, additional funding may not be available to us at
all or only on terms that are unacceptable to us. We also could be required to
seek funds through arrangements with collaborative partners or others that may
require us to relinquish rights to some of our technologies, product candidates
or products which we would otherwise pursue on our own.


    Even if we are able to raise additional funds in a timely manner, our future
capital requirements will vary depending on many factors, including the
following:

    - continued progress in our research and development programs, as well as
      the magnitude of these programs;

    - the resources required to successfully complete our clinical trials;

    - the time and costs involved in obtaining regulatory approvals;

    - the cost of manufacturing and commercialization activities;

    - the cost of any additional facilities requirements;

    - the timing, receipt and amount of milestone and other payments from
      collaborative partners;

    - the timing, receipt and amount of sales and royalties from our potential
      products in the market; and

                                       16

    - the costs involved in preparing, filing, prosecuting, maintaining and
      enforcing patent claims and other patent-related costs, including
      litigation costs and the costs of obtaining any required licenses to
      technologies.

    BIOTRANSPLANT AND ELIGIX HAVE INCURRED SUBSTANTIAL LOSSES, EXPECT TO
CONTINUE TO INCUR ADDITIONAL LOSSES AND WILL NOT BE SUCCESSFUL UNTIL THE
COMBINED COMPANY REVERSES THIS TREND.

    BioTransplant and Eligix have incurred losses in each year since their
respective dates of organization. The combined company expects to incur
operating losses for the foreseeable future.


    To date, we have not successfully commercialized and sold the types of
products we are currently developing. The products that we are developing will
require additional research and development, extensive preclinical studies and
clinical trials and regulatory approval before they can be sold commercially. In
particular, we may need to successfully develop several new technologies in
order to complete development of our AlloMune System and our high density
microparticle products. If we do not successfully develop and commercialize any
products, we will never become profitable.



    To date, BioTransplant has generated substantially all of its revenues from
payments from its collaborative partners. In 2000, BioTransplant generated
$4,563,475, or 100% of its total revenue, from its collaboration with Novartis,
which was terminated in October 2000 in connection with the formation of our
joint venture with Novartis. BioTransplant has not received any revenues from
the sale of products. To date, Eligix has not generated any material revenue.
BioTransplant anticipates that it may be a number of years, if ever, before the
combined company will receive significant revenues from product sales or
royalties.



  RISKS RELATED TO THE BUSINESS, INDUSTRY AND STRATEGY OF THE COMBINED COMPANY



    THERE ARE UNCERTAINTIES AS TO THE EFFECTIVENESS OF OUR TECHNOLOGICAL
APPROACHES AND, AS A RESULT, WE MAY NOT BE ABLE TO SUCCESSFULLY DEVELOP AND
COMMERCIALIZE ANY PRODUCTS.



    Our future success depends on the successful development of our
ImmunoCognance technology. The MEDI-507 antibody product under development and
the prototype AlloMune System have been tested in relatively few patients and we
may not be able to demonstrate the clinical benefits of these products in a
larger patient population. Furthermore, the technology that we have exclusively
licensed to our joint venture with Novartis Pharma AG is based upon the
transplantation of organs from swine into humans. To our knowledge,
transplantation of swine organs has never been tested in humans. As a
consequence, we are not sure whether any of our or our collaborators' potential
products will be effective in treating any of the disorders we have targeted. In
addition, these products may prove to have undesirable or unintended side
effects, toxicities or other characteristics that may prevent or limit their
commercial use. If our technological approach is not successful or accepted,
then neither we nor our collaborators will be able to develop or commercialize
these products.


                                       17


    WE ARE DEPENDENT ON MEDIMMUNE AND NOVARTIS TO DEVELOP, MANUFACTURE AND SELL
TECHNOLOGIES EXCLUSIVELY LICENSED BY US, AND IF THESE PARTIES ARE NOT
SUCCESSFUL, THEN WE WILL NOT ACHIEVE SIGNIFICANT REVENUES BASED ON THESE
TECHNOLOGIES.



    We have a collaborative agreement with MedImmune under which we have
provided MedImmune with the exclusive worldwide right to develop and
commercialize products derived from the BTI-322 and MEDI-507 antibodies. In
addition, our joint venture, Immerge BioTherapeutics, has exclusively licensed
to Novartis the right to develop and commercialize any products derived from
Immerge's research program in xenotransplantation, which refers to the
transplantation of cells, tissues and organs from one species to another. Under
each of these collaborative agreements, we have the right to receive royalties
on product sales. Our ability to achieve royalty revenue under these
arrangements is heavily dependent on the efforts and activities of MedImmune and
Novartis. Our arrangements with MedImmune and, through our joint venture, with
Novartis allow them significant discretion in determining the efforts and
resources that they will apply to the development and commercialization of
products based upon our technologies. Accordingly, we are unable to control
whether or not products based upon our technologies will be scientifically or
commercially successful.



    The risks that we face in connection with our agreements with MedImmune and
Novartis include the following:



    - These agreements are subject to termination without cause and on short
      notice under specified circumstances. If either MedImmune or Novartis
      terminates its collaboration with us, or the joint venture, in the case of
      Novartis, it may be difficult for us to attract a new partner to develop
      and commercialize products based on our technologies and may adversely
      affect the perception of us in the business and financial communities.



    - If MedImmune or Novartis were to breach or terminate its agreement with
      us, or the joint venture, in the case of Novartis, reduce its funding or
      otherwise fail to conduct the collaboration successfully, we could be
      required to devote additional internal resources to the program that is
      the subject of the collaboration, scale back or terminate the program or
      seek an alternative partner.



    - MedImmune and Novartis may pursue higher priority programs or change the
      focus of their research and/or development programs, which could affect
      either party's commitment to us.



    - After a product has been approved for marketing, any reductions in
      marketing or sales efforts or a discontinuation of marketing or sales of
      that product by MedImmune or Novartis would reduce our revenues, which
      will be based on a percentage of net sales.



    THE MARKET MAY NOT BE RECEPTIVE TO OUR PRODUCTS UPON THEIR INTRODUCTION,
WHICH WILL PREVENT US FROM BEING PROFITABLE.


    The commercial success of our products when and if they are approved for
marketing will depend upon their acceptance by the medical community and
third-party payors as clinically useful, cost effective and safe. All of the
products that we are developing are based upon new technologies or therapeutic
approaches. As a result, it may be more difficult for us to convince the medical
community and third-party payors to accept and use our products.

    Other factors that we believe will materially affect market acceptance of
our products include:

    - the timing of our receipt of marketing approvals and the countries in
      which approvals are obtained;

    - the safety, efficacy and ease of administration of our products;

    - the success of our physician education programs; and

                                       18

    - the availability of government and third-party payor reimbursement of our
      products.

    THE PROGRESS OF THE XENOTRANSPLANTATION RESEARCH PROGRAM OF OUR JOINT
VENTURE COULD BE DELAYED BY DISRUPTIONS IN ITS SUPPLY OF MINIATURE SWINE.


    Our joint venture's xenotransplantation research program is based upon the
transplantation of tissues and organs from swine into humans. Charles River
Laboratories has been supplying miniature swine for our research programs since
our inception in 1991 and is currently the only supplier of the miniature swine
organs that the joint venture uses in its research. Although the miniature swine
from which the joint venture with Novartis will receive organs are located at
several different facilities, a disease epidemic or other catastrophe could
destroy all or a portion of the miniature swine herd, which would interrupt or
significantly delay the joint venture's research. In addition, if Charles River
Laboratories terminates or breaches its agreement with the joint venture, it may
not have the resources or capabilities to maintain the miniature swine herds
itself which would cause the joint venture to delay or curtail its research
efforts with respect to the xenotransplantation program.


    XENOTRANSPLANTATION INVOLVES RISKS WHICH HAVE RESULTED IN ADDITIONAL FDA
OVERSIGHT AND WHICH IN THE FUTURE MAY RESULT IN ADDITIONAL REGULATION.


    Xenotransplantation poses a risk that viruses or other animal pathogens may
be unintentionally transmitted to a human patient. The United States Food and
Drug Administration will require testing to determine whether infectious agents,
including specific viruses referred to as porcine endogenous retroviruses, also
known as PERV, are present in patients who have received cells, tissues or
organs from miniature swine. While porcine endogenous retroviruses have not been
shown to cause any disease in pigs, it is not known what effect, if any, these
retroviruses may have on humans.



    Other companies are currently conducting clinical trials involving the
transplantation of pig cells into humans. The FDA requires lifelong monitoring
of these transplant recipients. If porcine endogenous retroviruses or any other
virus or infectious agent is detected in tests or samples from these transplant
recipients, the FDA may require Novartis to halt its clinical trials and perform
additional tests to assess the risk of infection to potential patients. This
could result in delays in the successful development and commercialization of
any xenotransplantation products.



    The FDA has proposed, but not yet established, definitive regulatory
guidelines for xenotransplantation. We and Novartis may not be able to comply
with any final guidelines the FDA may issue.


               RISKS RELATING TO CLINICAL AND REGULATORY MATTERS

    IF OUR CLINICAL TRIALS ARE NOT SUCCESSFUL OR ARE NOT COMPLETED ON A TIMELY
BASIS, WE WILL NOT BE ABLE TO DEVELOP AND COMMERCIALIZE ANY RELATED PRODUCTS
AND, THEREFORE, WE WILL NOT ACHIEVE PROFITABILITY.

    To obtain regulatory approvals for the commercial sale of our future
products, we and our collaborative partners will need to complete extensive
clinical trials in humans to demonstrate the safety and efficacy of the
products. BioTransplant and Eligix have both had limited experience in
conducting clinical trials.

    Prior to commencing new clinical trials, we must submit investigational new
drug and/or investigational device exemption applications to the FDA. Even if we
receive authorization from the FDA to commence clinical trials, we or our
collaborative partners may not be able to successfully complete these trials
within an acceptable timeframe, if at all. How quickly we and our collaborative
partners complete clinical trials is dependent in part upon the rate of
enrollment of patients. Patient enrollment is a function of many factors,
including the size of the patient population, the proximity of patients to
clinical sites, the eligibility criteria for the study and the existence of
competitive clinical trials. In particular, the patient population for some of
our potential products is small. If we experience

                                       19

delays in patient enrollment, we may incur additional costs and delay our
research and development programs.

    Furthermore, we, our collaborative partners or the FDA may suspend our
clinical trials at any time on various grounds, including a finding that the
patients in the trials are being exposed to unacceptable health risks. Finally,
our clinical trials, if completed, may not show the potential product to be safe
or effective, thereby preventing regulatory approval.


    WE ARE DEPENDENT ON OUR COLLABORATIVE PARTNERS TO CONDUCT CLINICAL TRIALS ON
SOME OF OUR PRODUCTS AND, THEREFORE, WE ARE NOT IN CONTROL OF THE TIMING OF
THESE CLINICAL TRIALS.



    We are dependent upon MedImmune to conduct clinical trials with respect to
MEDI-507 and will be dependent upon Novartis to conduct clinical trials for the
development of xenotransplantation products, if any, that arise out of our joint
venture's research program. We may become dependent upon other third parties to
conduct future clinical trials of our AlloMune System and HDM products. As a
result, we will have less control over these clinical trials than if we were
conducting the trials directly. Consequently, these trials may not begin or be
completed on a schedule that is acceptable to us.



    THE APPROVAL PROCESS IS COSTLY AND LENGTHY AND WE MAY NOT OBTAIN AND
MAINTAIN THE REGULATORY APPROVALS REQUIRED TO SUCCESSFULLY MARKET AND SELL OUR
PRODUCTS.



    We must obtain regulatory approval for our ongoing development activities
and before marketing or selling any of our products. We may not receive
regulatory approvals to conduct clinical trials of our products or to
manufacture or market our products. In particular, the combined company may not
receive approval from the FDA or any other regulatory authority to market its
TCell-HDM and BCell-HDM products, its most advanced product candidates. In
addition, regulatory agencies may not grant such approvals on a timely basis or
may revoke previously granted approvals or impose fines, suspensions, product
recalls and other sanctions if we fail to comply with applicable regulatory
requirements.



    The process of obtaining FDA and other required regulatory approvals is
expensive and typically takes a number of years, depending on the complexity and
novelty of the product. Any delay in obtaining or failure to obtain required
clearance or approval of a product by the appropriate regulatory authorities,
would materially adversely affect our ability to generate revenues from the
affected product. BioTransplant and Eligix both have limited experience in
filing and prosecuting the applications required to gain regulatory approval.


    There is limited regulatory precedent for the approval of products based
upon the technologies that we are employing to develop products. The AlloMune
System and the HDM products are based on new technologies and/or new therapeutic
approaches that have not been extensively tested in humans. Accordingly, the
regulatory requirements governing these types of products may be more rigorous
than for conventional products. In addition, the FDA has not yet established
final or comprehensive guidelines for xenotransplantation. As a result, we may
experience a longer regulatory process in connection with any products that we
or our collaborators seek to develop based on these new technologies and/or new
therapeutic approaches.

    We also are subject to numerous foreign regulatory requirements governing
the design and conduct of the clinical trials and the manufacturing and
marketing of our future products. The approval procedure varies among countries.
The time required to obtain foreign approvals often differs from that required
to obtain FDA approvals. Moreover, approval by the FDA does not ensure approval
by regulatory authorities in other countries.

                                       20


    All of these regulatory risks also are applicable to development,
manufacturing and marketing undertaken by our key collaborators, MedImmune and
Novartis, and any other future collaborators who may seek to develop, market and
sell products based upon our technologies.


                    RISKS RELATING TO INTELLECTUAL PROPERTY

    WE MAY NOT BE ABLE TO OBTAIN PATENT PROTECTION FOR OUR DISCOVERIES AND WE
MAY INFRINGE PATENT RIGHTS OF THIRD PARTIES.

    Our success depends in significant part on our ability to:

    - obtain patents;

    - protect trade secrets;

    - operate without infringing upon the proprietary rights of others; and

    - prevent others from infringing on our proprietary rights.


    The validity and permissible scope of claims covered in patents relating to
our technology involve important unresolved legal principles. Furthermore, there
is substantial uncertainty as to whether human clinical data will be required
for issuance of patents for human therapeutics. If human clinical data are
required, our ability to obtain patent protection could be delayed or otherwise
adversely affected.


    Patents may not issue from any patent applications that we own or license.
If patents do issue, the claims allowed may not be sufficiently broad to protect
our technology. In addition, issued patents that we own or license may be
challenged, invalidated or circumvented. Our patents also may not afford us
protection against competitors with similar technology. Because patent
applications in the United States are maintained in secrecy until patents issue,
third parties may have filed or maintained patent applications for technology
used by us or covered by our pending patent applications without our being aware
of these applications.


    We may not hold proprietary rights to all of the patents related to our
proposed products or services. In some cases, these patents may be owned or
controlled by third parties. As a result, we or our collaborative partners may
be required to obtain licenses under third-party patents to market our proposed
products or services. If licenses are not available on acceptable terms, we or
our collaborative partners will not be able to market these products or
services.



    WE MAY BE SUED BY THIRD PARTIES THAT CLAIM THAT OUR PRODUCTS UNDER
DEVELOPMENT INFRINGE ON THEIR INTELLECTUAL PROPERTY RIGHTS, PARTICULARLY BECAUSE
THERE IS SUBSTANTIAL UNCERTAINTY ABOUT THE VALIDITY AND BREADTH OF
BIOTECHNOLOGY-RELATED PATENTS.



    We may be exposed to future litigation by third parties based on claims that
our products under development infringe the intellectual property rights of
others. The risk is exacerbated by the fact that the validity and breadth of
claims covered in biotechnology-related patents of the type we seek to obtain
and maintain involve complex legal and factual questions for which important
legal principles are unresolved. Any litigation or claims against us, whether or
not valid, could result in substantial costs, could place a significant strain
on our financial resources and could harm our reputation. In addition,
intellectual property litigation or claims could force us to do one or more of
the following:



    - cease developing or selling products that incorporate the challenged
      intellectual property, which would adversely affect our ability to
      generate revenue;



    - obtain a license from the holder of the infringed intellectual property
      right, which license may not be available to us on reasonable terms, if at
      all; and


                                       21


    - redesign our products under development or being sold, which would be
      costly and time-consuming.



    IF WE LOSE IMPORTANT LICENSE RIGHTS, WE MAY BE UNABLE TO SUCCESSFULLY
DEVELOP AND COMMERCIALIZE OUR PRODUCTS AND ACHIEVE PROFITABILITY.



    We are a party to technology in-licenses with the Catholic University of
Louvain and the Alberta Research Council, which are described on page 83 of this
joint proxy statement/prospectus. We expect to enter into additional licenses in
the future. These in-licenses relate to important technologies that may be
necessary for the development and commercialization of our products. These
licenses impose various commercialization, sublicensing, royalty, insurance and
other obligations on us. If we fail to comply with these requirements, the
licensors will have the right to terminate these licenses, which could affect
our ability to exploit important technologies that are required for successful
development of our products.


          RISKS RELATING TO PRODUCT MANUFACTURING, MARKETING AND SALES


    BIOTRANSPLANT AND ELIGIX HAVE NO SALES AND MARKETING EXPERIENCE AND MAY
DEPEND SIGNIFICANTLY ON THIRD PARTIES WHO MAY NOT SUCCESSFULLY COMMERCIALIZE OUR
PRODUCTS.



    We have no sales, marketing and distribution experience. We plan to rely
significantly on sales, marketing and distribution arrangements with third
parties, including our collaborative partners. For example, we have granted
MedImmune exclusive marketing rights to the MEDI-507 product under development
and have granted Novartis exclusive worldwide rights to develop and market
products based upon our xenotransplantation technologies. We may have to enter
into additional marketing arrangements in the future and we may not be able to
enter into these additional arrangements on terms which are favorable to us, if
at all. In addition, we may have limited or no control over the sales, marketing
and distribution activities of these third parties. Our future revenues will be
materially dependent upon the success of the efforts of these third parties.



    We may seek to market some of our products independently, including our high
density microparticle products, which are our nearest-term products under
development. If we determine to perform sales, marketing and distribution
functions ourselves, we could face a number of additional risks, including:


    - we may not be able to attract and build a significant marketing staff or
      sales force;

    - the cost of establishing a marketing staff or sales force may not be
      justifiable in light of the revenues generated by any particular product;
      and

    - our direct sales and marketing efforts may not be successful.

    THE COMBINED COMPANY HAS LIMITED MANUFACTURING CAPABILITIES AND WILL DEPEND
ON THIRD-PARTY MANUFACTURERS WHO MAY NOT SUCCESSFULLY MANUFACTURE OUR PRODUCTS.

    The combined company has limited manufacturing experience. To continue to
develop products, apply for regulatory approvals and, ultimately, commercialize
any products, we will need to develop, contract for or otherwise arrange for the
necessary manufacturing capabilities.


    Although Eligix has a commercial scale manufacturing facility, Eligix relies
on four third-party manufacturers for the equipment and disposable components of
its system. Eligix may also be reliant upon third parties for supply of some
antibodies.



    BioTransplant currently relies upon MedImmune to produce material for
preclinical and clinical testing purposes and the combined company expects to
continue to do so in the future. In addition, if the combined company receives
the necessary regulatory approvals for its products, it also expects to rely
upon third parties, including its collaborative partners, to produce materials
required for the


                                       22


commercial production. There are a limited number of manufacturers capable of
manufacturing these products for the combined company that are able to comply
with the FDA's regulations for good manufacturing practices. If the combined
company is unable to manufacture its own products or arrange for third-party
manufacturing of its products, or unable to do so on commercially reasonable
terms, the combined company may not be able to complete development of or market
its products.



    To the extent that the combined company enters into manufacturing
arrangements with third parties, it will be dependent upon these third parties
to perform their obligations in a timely manner. If third-party manufacturers
with whom the combined company contracts fail to perform their obligations, the
combined company may be adversely affected in a number of ways, including:


    - it may not be able to initiate or continue clinical trials of products
      that are under development;

    - it may be delayed in submitting applications for regulatory approvals for
      its products; and

    - ultimately, it may not be able to meet commercial demands for its
      products.


                       RISKS RELATING TO OUR COMMON STOCK


    OUR STOCK PRICE IS HIGHLY VOLATILE, WHICH COULD CAUSE YOU TO LOSE PART OR
ALL OF YOUR INVESTMENT.


    The market price of our common stock is highly volatile. For example, during
the past three years, our stock price fluctuated from a low sale price of $1.00
in the quarter ended December 31, 1998 to a high sale price of $23.00 in the
quarter ended March 31, 2000. For a summary of the high and low sale prices for
our common stock, see "Market Price and Dividend Information" on page 25. Prices
for our common stock will be determined in the market place and may be
influenced by many factors, including variations in our financial results and
investors' perceptions of us, as well as their perceptions of general economic,
industry and market conditions. Broad market fluctuations may adversely affect
the market price of our common stock and may cause a rapid and substantial
decline in the value of your investment in our common stock.



           CAUTIONARY STATEMENT CONCERNING FORWARD-LOOKING STATEMENTS


    BioTransplant and Eligix believe this document contains "forward-looking
statements" within the meaning of the Private Securities Litigation Reform Act
of 1995. These statements are subject to risks and uncertainties and are based
on the beliefs and assumptions of the management of BioTransplant and Eligix,
based on information currently available to each company's management. When we
use words such as "believes," "expects," "anticipates," "intends," "plans,"
"estimates," "should," "likely" or similar expressions, we are making
forward-looking statements. Forward-looking statements include the information
concerning possible or assumed future results of operations of BioTransplant set
forth under:

    - "Summary";

    - "Risk Factors";

    - "The Merger--Background of the Merger," "--Recommendation of the Board of
      Directors of BioTransplant; BioTransplant's Reasons for the Merger,"
      "--Recommendation of the Board of Directors of Eligix; Eligix' Reasons for
      the Merger" and "--Opinion of BioTransplant's Financial Advisor";

    - "Information Concerning BioTransplant";

    - "Information Concerning Eligix"; and

    - "Unaudited Pro Forma Condensed Combined Financial Information."

                                       23


    Forward-looking statements are not guarantees of performance. They involve
risks, uncertainties and assumptions. The future results and stockholder values
of BioTransplant or Eligix may differ materially from those expressed in the
forward-looking statements. Many of the factors that will determine these
results and values are beyond our ability to control or predict. Stockholders
are cautioned not to put undue reliance on any forward-looking statements. For
those statements, BioTransplant claims the protection of the safe harbor for
forward-looking statements contained in the Private Securities Litigation Reform
Act of 1995.



    For a discussion of some of the factors that may cause actual results to
differ materially from those suggested by the forward-looking statements, please
read carefully the information under "Risk Factors." This list of factors that
may affect future performance and the accuracy of forward-looking statements is
illustrative, but by no means exhaustive. Accordingly, all forward-looking
statements should be evaluated with the understanding of their inherent
uncertainty. We expressly disclaim any obligation to update or alter our
forward-looking statements, whether as a result of new information, future
events or otherwise.


                                       24

                     MARKET PRICE AND DIVIDEND INFORMATION

MARKET PRICE INFORMATION

    BioTransplant common stock has traded on the Nasdaq National Market under
the symbol "BTRN" since May 8, 1996.

    The table below sets forth, for the periods indicated, the reported high and
low sale prices of BioTransplant common stock on the Nasdaq National Market.
Because there is no established trading market for shares of Eligix stock,
information with respect to the market prices of Eligix stock has been omitted.




                                                                BIOTRANSPLANT
                                                                COMMON STOCK
                                                             -------------------
                                                               HIGH       LOW
                                                             --------   --------
                                                                  
CALENDAR 1998
Quarter ended March 31, 1998...............................  $ 6.13      $4.00
Quarter ended June 30, 1998................................    4.25       3.13
Quarter ended September 30, 1998...........................    3.75       1.50
Quarter ended December 31, 1998............................    3.00       1.00

CALENDAR 1999
Quarter ended March 31, 1999...............................  $ 2.69      $1.88
Quarter ended June 30, 1999................................    4.93       1.94
Quarter ended September 30, 1999...........................    7.50       4.50
Quarter ended December 31, 1999............................    9.28       5.00

CALENDAR 2000
Quarter ended March 31, 2000...............................  $23.00      $6.25
Quarter ended June 30, 2000................................   10.56       4.68
Quarter ended September 30, 2000...........................   18.31       8.38
Quarter ended December 31, 2000............................   18.50       6.19

CALENDAR 2001
Quarter ending March 31, 2001 (through March 9, 2001)......  $ 9.22      $4.63



    On December 8, 2000, the last full trading day prior to the public
announcement of the proposed merger, the last reported sale price of
BioTransplant common stock on the Nasdaq National Market was $8.375 per share.

    On           , 2001, the most recent practicable date prior to the printing
of this joint proxy statement/prospectus, BioTransplant had approximately
      stockholders of record and the last reported sale price of BioTransplant
common stock on the Nasdaq National Market was $      per share.

    Because the market price of BioTransplant common stock may fluctuate, the
market price per share of the shares of BioTransplant common stock that holders
of Eligix stock will receive in the merger may increase or decrease prior to the
merger.

    WE URGE ELIGIX STOCKHOLDERS TO OBTAIN A CURRENT MARKET QUOTATION FOR
BIOTRANSPLANT COMMON STOCK.

    We cannot assure you as to what the market price will be at the effective
time of the merger. The number of shares to be issued by BioTransplant in the
merger is fixed. Accordingly, the market value of the shares of BioTransplant
common stock that holders of Eligix securities will receive may vary
significantly from the prices shown above.

                                       25

DIVIDEND INFORMATION

    BioTransplant has never declared or paid any dividends on its common stock.
BioTransplant does not expect to pay cash dividends in the foreseeable future.
In addition, BioTransplant is party to a loan agreement that prohibits
BioTransplant from paying dividends without the written consent of the lending
institution. See "Information Concerning BioTransplant--Management's Discussion
and Analysis of Financial Condition and Results of Operations" and note 3 to the
consolidated financial statements of BioTransplant.

    Eligix has never paid any cash dividends on the Eligix common stock, and if
the merger is not consummated, it anticipates that it will continue to retain
any earnings for the foreseeable future for use in the operation of its
business.

                                       26

                       THE BIOTRANSPLANT SPECIAL MEETING

GENERAL

    This joint proxy statement/prospectus is being furnished to stockholders of
BioTransplant as part of the solicitation of proxies by the BioTransplant board
of directors for use at a special meeting of stockholders of BioTransplant. The
BioTransplant board will use the proxies at the special meeting to be held on
and at the date, time and place set forth below.

DATE, TIME AND PLACE

    We will hold the special meeting at the offices of Hale and Dorr LLP, 60
State Street, Boston, Massachusetts 02109, at 10:00 a.m. local time on
            , 2001.

PURPOSE OF THE SPECIAL MEETING

    At the special meeting, we are asking holders of BioTransplant common stock
to approve the issuance of an aggregate of up to 5,610,000 shares of
BioTransplant common stock to Eligix security holders, either in the merger or
upon exercise or conversion of Eligix options, warrants and notes assumed by
BioTransplant in the merger, and 990,000 shares of BioTransplant common stock to
members of Eligix management, in connection with the agreement and plan of
merger, dated as of December 8, 2000, among BioTransplant, BT/EL Acquisition
Co., a wholly owned subsidiary of BioTransplant, and Eligix.

BIOTRANSPLANT BOARD OF DIRECTORS' RECOMMENDATION

    The BioTransplant board of directors, after careful consideration, has
unanimously approved the merger agreement and the merger and recommends a vote
FOR the proposed issuance of BioTransplant common stock in connection with the
merger.

RECORD DATE

    Only holders of record of BioTransplant common stock at the close of
business on             , 2001 are entitled to notice of and to vote at the
BioTransplant special meeting. On the record date there were       outstanding
shares of BioTransplant common stock held by       stockholders of record. Each
share is entitled to one vote. The representation, in person or by properly
executed proxy, of the holders of a majority of all of the shares of common
stock entitled to vote at the BioTransplant special meeting is necessary to
constitute a quorum at the BioTransplant special meeting.


VOTE REQUIRED; VOTE AT THE SPECIAL MEETING



    Under applicable rules of the Nasdaq National Market, the proposed issuance
of BioTransplant common stock in connection with the merger will require the
affirmative vote of the holders of a majority of the votes represented by the
shares of BioTransplant common stock cast on the proposal to issue the shares,
whether in person or by proxy, because the number of shares of BioTransplant
common stock to be issued in the merger will exceed 20% of the outstanding
shares of BioTransplant common stock prior to the merger.



    Shares of BioTransplant common stock represented in person or by proxy will
be counted for the purposes of determining whether a quorum is present at the
BioTransplant special meeting. Shares which abstain from voting as to the
proposal, and shares held on behalf of the beneficial owner in the name of a
broker or nominee who indicates on his or her proxy that he or she does not have
discretionary authority to vote these shares on the proposal, will be treated as
shares that are present and entitled to vote at the BioTransplant special
meeting for purposes of determining whether a quorum exists. Abstentions and
broker non-votes are not considered to be votes cast with respect to a
particular matter and will thus have no effect on the proposal to issue shares
of BioTransplant common stock in connection with the merger.


    As of the record date for the BioTransplant special meeting, directors and
executive officers of BioTransplant and their affiliates held approximately   %
of the outstanding shares of BioTransplant common stock.

                                       27

PROXIES


    All shares of BioTransplant common stock which are entitled to vote and are
represented at the BioTransplant special meeting by properly executed proxies
received prior to or at such meeting, and not revoked, will be voted at the
meeting based on, and consistent with, the instructions indicated on such
proxies. Except for the case of broker non-votes, if no instructions are
indicated, properly executed proxies will be voted for approval of the proposed
issuance of BioTransplant common stock in connection with the merger.



    The BioTransplant board does not know of any matters other than those
described in the notice of the BioTransplant special meeting that are to come
before the meeting. If any other matters are properly presented at the
BioTransplant special meeting for consideration, including, among other things,
consideration of a motion to adjourn or postpone the meeting to another time
and/or place, including, without limitation, for the purposes of soliciting
additional proxies or allowing additional time for the satisfaction of
conditions to the merger, the persons named in the enclosed form of proxy and
acting under that authority generally will have discretion to vote on these
other matters using their best judgment. Despite this discretionary voting
authority, proxies voting against a specific proposal may not be used by the
persons named in the proxies to vote for adjournment or postponement of the
meeting for the purpose of giving management additional time to solicit votes to
approve that specific proposal.


REVOCABILITY OF PROXIES


    Any proxy given in response to this solicitation may be revoked by the
person giving it at any time before it is voted. Proxies may be revoked by:


    - filing with the Secretary of BioTransplant, at or before the taking of the
      vote at the BioTransplant special meeting, a written notice of revocation
      bearing a later date than the proxy; or

    - duly executing a later-dated proxy relating to the same shares and
      delivering it to the Secretary of BioTransplant before the taking of the
      vote at the BioTransplant special meeting; or


    - attending the BioTransplant special meeting and voting in person, although
      attendance alone at the BioTransplant special meeting will not constitute
      a revocation of a proxy.



    Any written notice of revocation or subsequent proxy should be sent to
BioTransplant, Building 75, 3rd Avenue, Charlestown, MA 02109, Attention:
Corporate Secretary, or hand delivered to the Secretary of BioTransplant at or
before the taking of the vote at the BioTransplant special meeting. Stockholders
that have instructed a broker to vote their shares must follow directions
received from the broker in order to change their vote or to vote at the
BioTransplant special meeting.


SOLICITATION OF PROXIES


    All expenses of BioTransplant's solicitation of proxies for the
BioTransplant special meeting will be paid by BioTransplant. In addition to
solicitation by use of the mails, proxies may be solicited from BioTransplant
stockholders by directors, officers and employees of BioTransplant in person or
by telephone, facsimile or other means of communication. These directors,
officers and employees will not be additionally compensated, but may be
reimbursed for reasonable out-of-pocket expenses in connection with soliciting
proxies. BioTransplant has retained W.F. Doring & Co., a proxy solicitation
firm, for assistance in connection with the solicitation of proxies for the
BioTransplant special meeting at a cost of approximately $5,000 plus
reimbursement of reasonable out-of-pocket expenses. Arrangements will also be
made with brokerage houses, custodians, nominees and fiduciaries for forwarding
of proxy solicitation materials to beneficial owners of shares held of record by
the brokerage houses, custodians, nominees and fiduciaries, and BioTransplant
will reimburse these brokerage houses, custodians, nominees and fiduciaries for
their reasonable expenses incurred in connection with the distribution of proxy
solicitation materials.


                                       28

                           THE ELIGIX SPECIAL MEETING

GENERAL

    This joint proxy statement/prospectus is being furnished to stockholders of
Eligix as part of the solicitation of proxies by the Eligix board of directors
for use at a special meeting of stockholders of Eligix. The Eligix board will
use the proxies at the special meeting to be held on and at the date, time and
place set forth below.

DATE, TIME AND PLACE

    We will hold the special meeting at the offices of Mintz, Levin, Cohn,
Ferris, Glovsky and Popeo, P.C., One Financial Center, Boston, Massachusetts
02111, at 10:00 a.m., local time, on             , 2001.

PURPOSE OF THE SPECIAL MEETING

    At the special meeting, we are asking Eligix stockholders to approve and
adopt the agreement and plan of merger dated as of December 8, 2000 among
BioTransplant, BT/EL Acquisition Co., a wholly-owned subsidiary of
BioTransplant, and Eligix, and the merger.

    We are also asking Eligix stockholders to approve an amendment to the
certificate of incorporation of Eligix that changes the manner in which proceeds
are to be distributed upon any liquidation, distribution or winding up of
Eligix.

ELIGIX BOARD OF DIRECTORS' RECOMMENDATION

    The Eligix board of directors, after careful consideration, has unanimously
approved the merger agreement and the merger and has declared the merger
agreement advisable and in the best interests of Eligix and its stockholders. In
addition, the Eligix board of directors has unanimously approved the amendment
to the certificate of incorporation and has declared the amendment advisable and
in the best interests of Eligix and its stockholders. The Eligix board of
directors recommends a vote FOR approval and the adoption of the merger
agreement and the merger and the amendment of the Eligix certificate of
incorporation.

RECORD DATE

    Only holders of record of Eligix common stock and preferred stock at the
close of business on             , 2001 are entitled to notice of and to vote at
the Eligix special meeting. On the record date there were:

    -       outstanding shares of Eligix common stock;

    -       outstanding shares of Eligix Series A preferred stock;

    -       outstanding shares of Eligix Series B preferred stock;

    -       outstanding shares of Eligix Series C-1 preferred stock;

    -       outstanding shares of Eligix Series C-2 preferred stock; and

    -       outstanding shares of Eligix Series C-3 preferred stock.

                                       29

    Each share of Eligix common stock and preferred stock will be entitled to
one vote. The representation, in person or by properly executed proxy, of the
holders of a majority of all of the shares of common stock and preferred stock
entitled to vote at the Eligix special meeting is necessary to constitute a
quorum at the Eligix special meeting.

VOTE REQUIRED; VOTE AT THE SPECIAL MEETING

    The approval and adoption of the merger agreement and the merger will
require the affirmative vote of the holders of a majority of the votes
represented by the shares of Eligix common stock and preferred stock outstanding
on the Eligix record date, voting together as a single class, and two-thirds of
the votes represented by the shares of Eligix preferred stock outstanding on the
Eligix record date, voting together as a single class.

    The approval and adoption of the amendment to the Eligix certificate of
incorporation will require the affirmative vote of:

    - the holders of a majority of the votes represented by the shares of Eligix
      common stock and preferred stock outstanding on the Eligix record date,
      voting together as a single class;

    - two-thirds of the votes represented by the shares of Eligix preferred
      stock outstanding on the Eligix record date, voting together as a single
      class; and

    - a majority of the votes represented by the shares of Eligix Series A
      preferred stock and Series B preferred stock outstanding on the Eligix
      record date, voting together as a single class.

    Shares of Eligix common stock and preferred stock represented in person or
by proxy will be counted for the purposes of determining whether a quorum is
present at the Eligix special meeting. All shares with respect to which holders
abstain from voting as to a proposal will be treated as shares that are present
and entitled to vote at the Eligix special meeting for purposes of determining
whether a quorum exists, but abstentions will have the same effect as votes
against the proposals being brought before the special meeting.

VOTING AGREEMENTS


    Fourteen stockholders, each either a director, officer or 5% stockholder of
Eligix, have executed a voting and transfer restriction agreement with
BioTransplant whereby they have agreed to vote an aggregate of 14,900,679 shares
of Eligix capital stock, representing approximately 66.4% of the capital stock
entitled to vote at the Eligix special meeting, 67.3% of the preferred stock
entitled to vote at the Eligix special meeting and 67.3% of the Series A
preferred stock and Series B preferred stock entitled to vote at the special
meeting, in favor of the approval and adoption of the merger agreement and the
merger and of the amendment to the certificate of incorporation. The shares of
Eligix capital stock that are subject to voting agreements constitute the voting
power required to approve the merger agreement, the merger and the amendment to
the Eligix certificate of incorporation. See "Other Agreements--Voting and
Transfer Restriction Agreements."


PROXIES


    All shares of Eligix common stock and preferred stock that are entitled to
vote and are represented at the Eligix special meeting by properly executed
proxies received prior to or at such meeting, and not revoked, will be voted at
the Eligix special meeting as the instructions on the executed proxies indicate.
If no instructions are indicated on a proxy, the proxy will be voted for each
proposal.



    The Eligix board of directors does not know of any matters other than those
described in the notice of the Eligix special meeting that are to come before
the meeting. If any other matters are


                                       30


properly presented at the Eligix special meeting for consideration, including,
among other things, consideration of a motion to adjourn or postpone the meeting
to another time and/or place, including, without limitation, for the purposes of
soliciting additional proxies or allowing additional time for the satisfaction
of conditions to the merger, the persons named in the enclosed form of proxy and
acting under that authority generally will have discretion to vote on these
other matters using their best judgment. Despite this discretionary voting
authority, proxies voting against a specific proposal may not be used by the
persons named in the proxies to vote for adjournment or postponement of the
meeting for the purpose of giving management additional time to solicit votes to
approve that specific proposal.


REVOCABILITY OF PROXIES

    Any proxy given in connection with this solicitation may be revoked by the
person giving it at any time before it is voted. Proxies may be revoked by:

    - filing with the Secretary of Eligix, at or before the taking of the vote
      at the Eligix special meeting, a written notice of revocation bearing a
      later date than the proxy; or

    - duly executing a later-dated proxy relating to the same shares and
      delivering it to the Secretary of Eligix before the taking of the vote at
      the Eligix special meeting; or


    - attending the Eligix special meeting and voting in person, although
      attendance alone at the Eligix special meeting will not constitute a
      revocation of a proxy.


    Any written notice of revocation or subsequent proxy should be sent to
Eligix, 200 Boston Avenue, Medford, MA 02155, Attention: Corporate Secretary, or
hand delivered to the Secretary of Eligix at or before the taking of the vote at
the Eligix special meeting.

SOLICITATION OF PROXIES


    All expenses of Eligix' solicitation of proxies for the Eligix special
meeting will be paid by Eligix and BioTransplant. In addition to solicitation by
use of the mails, proxies may be solicited from Eligix stockholders by
directors, officers and employees of Eligix in person or by telephone, facsimile
or other means of communication. These directors, officers and employees will
not be additionally compensated, but may be reimbursed for reasonable
out-of-pocket expenses in connection with the solicitation of proxies.


APPRAISAL RIGHTS

    If you do not wish to accept BioTransplant common stock in the merger, you
have the right under Delaware law to have the fair value of your shares
determined by the Delaware Court of Chancery. This right to appraisal is subject
to a number of restrictions and technical requirements. Generally, in order to
exercise your appraisal rights you must:

    - send a written demand to Eligix for appraisal in compliance with Delaware
      law before the vote on the merger;

    - not vote in favor of the merger; and

    - continuously hold your Eligix capital stock, from the date you make the
      demand for appraisal through the closing of the merger.


    Merely voting against the merger will not protect your rights to an
appraisal. Annex D to this joint proxy statement/prospectus contains a copy of
the Delaware statute governing appraisal rights. If you do not follow all the
steps required by Delaware law, you will lose your rights to appraisal. See "The
Merger--Right of Stockholders to Appraisals" and "--Appraisal Rights Procedures"
on page 51 and "Comparison of Stockholder Rights" on page 124.


                                       31

                                   THE MERGER

    The following summarizes the material terms of the merger and the merger
agreement. We urge stockholders to read carefully the merger agreement and the
fairness opinion of Lazard Freres & Co. LLC which are attached as Annexes A and
C, respectively, to this joint proxy statement/prospectus.

BACKGROUND OF THE MERGER


    BioTransplant is regularly involved in the review of private and public
companies with which it may form strategic partnerships to further its
objectives in the cancer and transplantation therapy markets. In early 1999,
representatives of Eligix and BioTransplant held discussions primarily focused
on a range of partnering possibilities with respect to the transplantation
technologies being developed by each party. Elliot Lebowitz, President and Chief
Executive Officer of BioTransplant, proposed that Eligix supply its high density
microparticle, or HDM, technology for use in BioTransplant's AlloMune System.
Following a discussion with members of Eligix' board of directors, Walter C.
Ogier, President and Chief Executive Officer of Eligix, informed Dr. Lebowitz
that Eligix was not interested in BioTransplant's proposal because members of
Eligix' board of directors determined that Eligix and BioTransplant would be
unable to identify a financial structure that would be acceptable to both
parties. Dr. Lebowitz and Mr. Ogier decided to discontinue further discussions
at that time.



    Throughout 1999 and early 2000, BioTransplant engaged in discussions with a
number of biopharmaceutical and medical device companies concerning a potential
business combination or other partnering transaction. On April 17, 2000,
BioTransplant formally engaged Lazard as its financial advisor in connection
with potential corporate transactions, including mergers, acquisitions and
financings. Thereafter, Lazard began to advise BioTransplant with respect to a
potential merger with Eligix.



    On May 4, 2000, Eligix retained Pacific Growth Equities as its financial
advisor to provide advisory services in connection with the potential
acquisition of Eligix by a third party. Eligix recognized that it would need to
access significant additional capital to pursue its clinical and European
marketing strategies. Eligix determined that the financial options for an
early-stage biomedical company are limited and that it would be difficult to
obtain capital independently. Accordingly, Eligix determined that finding a
merger partner or an acquirer was the best option to accomplish its goals.
Eligix and its financial advisor had preliminary discussions with approximately
two dozen companies, of which approximately six displayed an interest in merging
with or acquiring Eligix and one submitted a proposal that was less advantageous
than that submitted by BioTransplant.


    On June 2, 2000, Dr. Lebowitz and Mr. Ogier met to discuss the potential
benefits of a merger.

    During June 2000, George Milstein of Pacific Growth Equities, financial
advisor to Eligix, contacted Dr. Lebowitz concerning the potential business
combination between BioTransplant and Eligix.

    On June 13, 2000, Dr. Lebowitz provided non-confidential information
concerning Eligix to the BioTransplant board of directors and notified the board
that Eligix was a private company with interesting technology and was a
potential acquisition candidate.

    On June 13, 2000, BioTransplant and Eligix entered into a confidentiality
agreement.

    On June 21, 2000, Dr. Lebowitz, Mr. Ogier, the management teams from
BioTransplant and Eligix, and representatives of Lazard and Pacific Growth
Equities met to present and review respective business plans and discuss
potential strategic synergies of a business combination.

    During late June through August 2000, Dr. Lebowitz and Mr. Ogier engaged in
a series of exploratory, non-binding discussions relating to the structure and
pricing of the potential acquisition and informally briefed their respective
boards at that time.

                                       32

    On July 7, 2000, Dr. Lebowitz provided the BioTransplant board of directors
with information concerning the advantages of merging with Eligix.

    On July 11, 2000, Mr. Ogier provided the Eligix board of directors with
information concerning the advantages of merging with BioTransplant.

    In late July 2000, BioTransplant delivered a due diligence request list to
Eligix and in mid-August 2000, Eligix delivered a due diligence request list to
BioTransplant.

    On August 7, 2000, Dr. Lebowitz transmitted to Mr. Ogier a non-binding
proposal outlining the potential benefits of the business combination and the
economic and other key terms of the acquisition. Mr. Ogier circulated the
proposal to the Eligix board.

    On August 16, 2000, August 23, 2000, September 15, 2000, September 27, 2000,
November 8, 2000 and November 21, 2000, the Eligix board of directors met, in
person or by telephonic conference call, to discuss the proposed business
combination. At each meeting, the board reviewed with management information
regarding the strategic fit of the two companies and the proposed structure and
terms of the merger. The board also considered at each meeting the potential
risks related to the proposal.

    On September 8, 2000, Dr. Lebowitz transmitted to Mr. Ogier a non-binding
proposal outlining the potential benefits of the business combination and the
economic and other key terms of the acquisition.

    On September 19, 2000, Mr. Ogier sent a letter to Dr. Lebowitz in response
to the September 8, 2000 proposal in which Mr. Ogier requested a clarification
of some of the terms of the proposed structure of the business combination.

    On September 25, 2000, Dr. Lebowitz sent a letter to Mr. Ogier to clarify
the terms of the September 8, 2000 proposal.

    On September 26, 2000, Dr. Lebowitz, Richard Capasso, Vice President of
Finance of BioTransplant, and representatives from Lazard met with and made a
presentation to the Eligix board of directors.

    During late September and early October 2000, members of senior management
of BioTransplant and Eligix, with the assistance of legal counsel and
representatives of Lazard and Pacific Growth Equities, continued to negotiate
the structure and terms of a merger.

    Throughout September, October and November 2000, the management of each of
BioTransplant and Eligix and their respective legal, financial and accounting
advisors, conducted a detailed due diligence review of the other party's
business, financial condition and operations.

    On October 10, 2000, Hale and Dorr LLP, outside counsel to BioTransplant,
delivered to Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., outside
counsel to Eligix, a draft of a proposed agreement and plan of merger and
related documents.

    During the period from October 16, 2000 through October 30, 2000,
BioTransplant's management team and legal, financial and accounting advisors met
by telephonic conference call to review and summarize the progress of their due
diligence.

    During the period between October 13, 2000 through October 30, 2000, Eligix'
management team and legal, financial and accounting advisors met by telephonic
conference call to review and summarize the progress of their due diligence.

    On October 18, 2000, Eligix and BioTransplant entered into a reciprocal
exclusivity agreement.


    On October 18, 2000, BioTransplant transmitted to Eligix a proposal focusing
on specific elements of the proposed business combination, including the
composition of the board of directors of the


                                       33


combined company, the nature and scope of the lock-up agreement and
reimbursement for costs incurred in connection with the merger.


    On October 24, 2000, November 6, 2000, November 14, 2000 and November 20,
2000, the BioTransplant board of directors met by telephonic conference call to
discuss the proposed business combination. At each meeting, the board reviewed
with management information regarding the valuation of Eligix, the strategic fit
of the two companies and the proposed structure and terms of the merger. The
board also considered at each meeting the potential risks related to the
proposal and the due diligence information reported to it by Dr. Lebowitz.

    During the period from October through December 8, 2000, senior management
of BioTransplant and Eligix, together with their legal, financial and accounting
advisors engaged in a series of discussions to negotiate the terms of the
definitive agreement and plan of merger.


    On December 8, 2000, at a special meeting of the BioTransplant board of
directors, management reported on the status of the merger discussions with
Eligix and the BioTransplant board of directors discussed various issues
relating to the proposed business combination. At the meeting, representatives
of Lazard reviewed its financial analysis with respect to the possible
combination of BioTransplant and Eligix, and then delivered the oral opinion of
Lazard, later confirmed in writing, that the total consideration to be paid in
the merger was fair to BioTransplant, from a financial point of view.
Additionally, Hale and Dorr LLP made a presentation regarding the significant
terms of the merger agreement and the voting agreement to be entered into by
affiliates of Eligix and reviewed with the board its fiduciary duties in
connection with the proposed transaction. Following the presentations and
further discussion, the execution of the agreement and plan of merger and
related matters were approved by the BioTransplant board.


    On December 8, 2000, the Eligix board of directors met by telephonic
conference call to review the final merger agreement. After reviewing the terms
of the agreement and discussing the benefits of and risks of the merger and the
board's fiduciary duties with its legal and financial advisors, the Eligix board
of directors approved the agreement and plan of merger and related matters.

    On December 8, 2000, following final approval by the BioTransplant board and
the Eligix board, the merger agreement was executed by both companies and a
significant majority of the stockholders of Eligix delivered voting agreements.

    On December 11, 2000, prior to the commencement of trading on the Nasdaq
National Market, BioTransplant and Eligix issued a joint press release
announcing the merger.

RECOMMENDATION OF THE BOARD OF DIRECTORS OF BIOTRANSPLANT; BIOTRANSPLANT'S
  REASONS FOR THE MERGER

    THE BIOTRANSPLANT BOARD OF DIRECTORS HAS UNANIMOUSLY APPROVED THE MERGER AND
MERGER AGREEMENT AND THE TRANSACTIONS CONTEMPLATED THEREBY AND BELIEVES THAT THE
TERMS OF THE MERGER ARE FAIR TO, AND IN THE BEST INTERESTS OF, BIOTRANSPLANT AND
ITS STOCKHOLDERS. THE BIOTRANSPLANT BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR"
THE PROPOSED ISSUANCE OF BIOTRANSPLANT COMMON STOCK IN CONNECTION WITH THE
MERGER.


    In reaching its decision to approve the merger agreement, the BioTransplant
board of directors consulted with its management team and legal, financial,
accounting and other advisors and independently considered the proposed merger
agreement and the transaction contemplated by the merger agreement. We have
summarized below the material factors considered by BioTransplant's board of
directors:



    - Eligix is focused on the development of proprietary cellular
      transplantation and immune therapy technologies for the treatment of
      cancer, which is an area of strategic importance for BioTransplant. The
      board of directors of BioTransplant believes that the acquisition of
      Eligix will


                                       34


      broaden BioTransplant's strategic direction in the development of
      proprietary technologies for the treatment of cancer, hematologic and
      autoimmune disorders, as well as for organ transplantation.


    - Eligix' high density microparticle cell separation devices under
      development are expected to provide a key component of BioTransplant's
      AlloMune System, enabling BioTransplant to offer, along with the MEDI-507
      antibody, a comprehensive approach to increase the safety and efficiency
      of transplantations for cancer and other diseases.


    - BioTransplant has a significant number of products that are in early
      stages of clinical development. Eligix brings a portfolio of complementary
      early- and late-stage products under development, including one and
      possibly two products that are expected to enter Phase III clinical trials
      in 2001. Eligix has significant pre-clinical development programs for
      applications of its high density microparticles, from which one or more
      products may start clinical development over the next 24 months.


    - BioTransplant's board of directors believes that Eligix' capabilities in
      the areas of manufacturing, marketing and sales will provide the
      opportunity to more rapidly advance the BioTransplant product pipeline
      toward commercialization.


    - Eligix has one product which has received CE mark approval and one product
      for which Eligix is preparing a submission for CE mark approval. Eligix
      expects that both of these products will be on the market in Europe in
      2001. BioTransplant's strategy of accelerating the date on which it
      recognizes product revenue will be achieved if the combined company
      successfully sells these products in Europe.


    - Eligix has collaborations with notable academic collaborators, including
      Harvard University's Dana Farber Cancer Institute and Johns Hopkins
      University, which BioTransplant's board of directors believes will enable
      BioTransplant to engage in a broader spectrum of activities than it would
      engage in alone, thereby strengthening its research and development
      platform.

    - Eligix and BioTransplant have complementary management teams, both of
      which have extensive experience in immunology and transplantation, which
      BioTransplant's board of directors believes will significantly strengthen
      BioTransplant's infrastructure.

    - The board of directors of BioTransplant has determined that, compared to
      continuing to operate alone, the merger with Eligix will have better
      potential to improve BioTransplant's long-term operating and financial
      results and make BioTransplant a more competitive enterprise, which
      BioTransplant's board of directors expects will benefit its stockholders.

    - The BioTransplant board considered the terms of the merger agreement,
      including the termination fee to be paid by Eligix in the event of the
      termination of the merger agreement for specified reasons.

    - The opinion of Lazard that, as of December 8, 2000, and based upon and
      subject to the matters described in its opinion, the total consideration
      to be paid in the merger is fair to BioTransplant from a financial point
      of view.

    The board of directors of BioTransplant also considered factors which
weighed against the merger, including:

    - The potential adverse effect that the public announcement of the merger
      would have on the market price of BioTransplant common stock for example,
      as a result of the dilutive effect of the shares of BioTransplant common
      stock issued in the merger.

                                       35

    - The fixed nature of the exchange ratio and the resulting risk that, should
      there be a significant increase in the market value of BioTransplant's
      common stock, the value of the consideration to be received by Eligix
      stockholders would be increased.

    - The risk that Eligix' products would not be successfully developed and
      marketed in the projected timetable, if at all, and the risk that other
      benefits of the merger or financing needs would not be fully achieved.

    - The risk that Eligix' products would not have the expected compatibility
      as a component of BioTransplant's AlloMune System.

    - The difficulty in successfully integrating separate operations of
      BioTransplant and Eligix.

    - The risk that the merger would not be consummated following the public
      announcement thereof.

    - The termination fee to be paid by BioTransplant in the event of the
      termination of the merger agreement for specified reasons.

    In view of the wide variety of factors considered in connection with its
evaluation of the merger and the complexity of these matters, the BioTransplant
board did not find it useful to and did not attempt to quantify, rank or
otherwise assign relative weights to these factors. In addition, the
BioTransplant board did not undertake to make any specific determination as to
whether any particular factor, or any aspect of any particular factor, was
favorable or unfavorable to the BioTransplant board's ultimate determination,
but rather the BioTransplant board conducted an overall analysis of the factors
described above, including thorough discussions with and questioning of
BioTransplant's management and legal, financial and accounting advisors. In
considering the factors described above, individual members of the BioTransplant
board may have given different weight to different factors.

RECOMMENDATION OF THE BOARD OF DIRECTORS OF ELIGIX; ELIGIX' REASONS FOR THE
  MERGER

    THE ELIGIX BOARD OF DIRECTORS HAS UNANIMOUSLY APPROVED THE MERGER AND MERGER
AGREEMENT AND THE TRANSACTIONS CONTEMPLATED THEREBY AND BELIEVES THAT THE TERMS
OF THE MERGER ARE FAIR TO, AND IN THE BEST INTERESTS OF, ELIGIX AND ITS
STOCKHOLDERS. THE ELIGIX BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" APPROVAL OF
THE MERGER AGREEMENT AND THE MERGER.

    In the course of reaching its decision to adopt the merger agreement, the
Eligix board consulted with Eligix' management, as well as its legal, financial,
accounting and other advisors, and considered the following material factors:


    - The risks and potential rewards associated with, as an alternative to the
      merger, continuing to execute Eligix' strategic plan as an independent
      entity. These risks include, among others, the risks associated with
      remaining independent amidst industry-wide consolidation, risks relating
      to Eligix' ability to obtain the additional cash required to fund its
      operating and capital requirements as a stand-alone company, and the
      rewards include, among others, the ability of existing Eligix stockholders
      to partake in the potential future growth and profitability of
      BioTransplant.


    - The possibility, as alternatives to the merger, of seeking to be acquired
      by another company, seeking to engage in one or more joint ventures or
      seeking to engage in a combination with a company other than BioTransplant
      and the Eligix board's conclusion that a transaction with BioTransplant is
      more feasible, and is expected to yield greater benefits, than the likely
      alternatives. The Eligix board concluded that a combination with
      BioTransplant was more feasible than the other alternatives it reviewed
      for reasons including the fact that BioTransplant was interested in
      pursuing a transaction with Eligix, and Eligix' view that the transaction
      could be acceptably completed from a timing and regulatory standpoint, and
      would yield greater benefits than the alternatives given BioTransplant's
      financial strength, and the ability of a

                                       36

      combined company to fund a greater number of long-term growth projects and
      to compete effectively.

    - The value of the consideration provided for in the merger agreement based
      on the then-current market price and historical trading price of
      BioTransplant shares over the past year and relative to the stock price
      premiums paid in mergers of comparable size that the premium offered in
      the merger was within the range of premiums paid in comparable
      transactions, and that Eligix' stockholders would hold approximately 32.1%
      of the fully-diluted stock of the combined company after the merger.


    - The prospects of Eligix to compete effectively in the future, the
      prospects of BioTransplant based on Eligix' analysis of information
      pertaining to BioTransplant, and Eligix management's view, based on its
      due diligence, of BioTransplant's prospects to compete effectively in the
      future.


    - The ability to complete the merger as a tax-free reorganization for U.S.
      federal income tax purposes.


    - The terms and conditions of the merger agreement, which permit Eligix
      generally to conduct its business in the ordinary course during the period
      prior to the consummation of the merger. See "The Merger
      Agreement--Covenants--Conduct of Business Prior to the Merger."



    - That two or three members of the Eligix board would become directors of
      BioTransplant, as described under "The Merger Agreement--Covenants--Board
      of Directors of BioTransplant."



    - That while the merger is likely to be completed, there are risks
      associated with obtaining necessary approvals, and as a result of some of
      the conditions to the completion of the merger, it is possible that the
      merger may not be completed. See "The Merger Agreement--Conditions to
      Obligations to Effect Merger."


    - The interests that certain executive officers and directors of Eligix may
      have with respect to the merger in addition to their interests as
      stockholders of Eligix generally. See "--Interests of Executive Officers
      and Directors of Eligix in the Merger."

    - The merger will enable Eligix stockholders to participate in, and benefit
      from the future growth potential of, an integrated company with a greater
      depth of technologies, marketing opportunities and financial and operating
      resources which should enhance the ability to bring technology to market.

    - The public market for BioTransplant common stock will offer Eligix
      stockholders liquidity while avoiding the risk and investment in time and
      expense of an initial public offering.

    - The availability of stock options for the publicly traded BioTransplant
      stock, which Eligix expects will enable the combined companies to attract
      and retain high caliber employees and consultants to continue the
      development of technology.

    - After the merger, the combined companies will be able to pursue further
      potential acquisitions to strengthen their technology offerings using the
      publicly traded BioTransplant common stock as all or part of the
      consideration.

    In view of the wide variety of factors considered in connection with its
evaluation of the merger and the complexity of these matters, the Eligix board
did not find it useful to and did not attempt to quantify, rank or otherwise
assign relative weights to these factors. In addition, the Eligix board did not
undertake to make any specific determination as to whether any particular
factor, or any aspect of any particular factor, was favorable or unfavorable to
the Eligix board's ultimate determination, but rather the Eligix board conducted
an overall analysis of the factors described above, including thorough
discussions with and questioning of Eligix' management and legal, financial and
accounting advisors. In

                                       37

considering the factors described above, individual members of the Eligix board
may have given different weight to different factors.

OPINION OF BIOTRANSPLANT'S FINANCIAL ADVISOR


    At a meeting of the BioTransplant board of directors held on December 8,
2000, at which the BioTransplant board of directors considered the merger and
approved the merger agreement and the merger, Lazard rendered its oral opinion,
which was subsequently confirmed in writing, that, as of December 8, 2000 and
based upon and subject to the matters reviewed with the BioTransplant board of
directors, the total consideration to be paid in the merger was fair from a
financial point of view to BioTransplant.



    The full text of the Lazard opinion is attached hereto as Annex C and is
incorporated herein by reference. The description of the Lazard opinion set
forth herein is qualified in its entirety by reference to the full text of the
Lazard opinion set forth in Annex C. BioTransplant stockholders are urged to
read the Lazard opinion in its entirety for a description of the procedures
followed, assumptions made, matters considered and qualifications and
limitations on the review undertaken by Lazard in connection therewith. The
Lazard opinion is necessarily based upon the economic, monetary, market and
other conditions as they were in effect on, and the information made available
as of, the date of the Lazard opinion. The Lazard opinion is directed to the
BioTransplant board of directors and addresses only the fairness from a
financial point of view to BioTransplant of the total consideration to be paid
in the merger. It does not address the merits of the underlying decision by
BioTransplant to engage in the merger and does not constitute a recommendation
to any BioTransplant stockholder as to how the stockholder should vote on any
matter relating to the merger at any meeting of BioTransplant stockholders held
for the purpose of considering the merger.


    In the course of performing its review and analyses for rendering its
opinion, Lazard:

    - reviewed the financial terms and conditions contained in the merger
      agreement and the form of escrow agreement appended thereto;

    - analyzed certain historical business and financial information relating to
      BioTransplant and Eligix;

    - reviewed various financial forecasts and other data provided to Lazard by
      BioTransplant and Eligix relating to their respective businesses;

    - held discussions with members of the senior management of BioTransplant
      and Eligix with respect to the businesses and prospects of BioTransplant
      and Eligix, respectively, the strategic objectives of each and possible
      benefits which might be realized following the merger;

    - reviewed public information with respect to certain other companies in
      lines of business Lazard believed to be generally comparable to the
      businesses of BioTransplant and Eligix;


    - reviewed the financial terms of a number of other business combinations
      involving companies in lines of business Lazard believed to be generally
      comparable to those of BioTransplant and Eligix;


    - reviewed the historical stock prices and trading volumes of BioTransplant
      common stock; and

    - conducted such other financial studies, analyses and investigations as
      Lazard deemed appropriate.

    Lazard relied upon the accuracy and completeness of the financial and other
information provided by BioTransplant and Eligix and reviewed by Lazard for
purposes of the Lazard opinion. Lazard did not assume any responsibility for any
independent verification of such information or any independent valuation or
appraisal of any of the assets or liabilities of BioTransplant or Eligix, or
concerning the

                                       38

solvency or fair value of either BioTransplant or Eligix. With respect to
financial forecasts, Lazard assumed that they had been reasonably prepared on
bases reflecting the best currently available estimates and judgments of the
managements of BioTransplant and Eligix as to the future financial performance
of BioTransplant and Eligix, respectively. Lazard assumed no responsibility for
and expressed no view as to such forecasts or the assumptions on which they were
based.

    In rendering its opinion, Lazard assumed that the merger would be completed
on the terms described in the merger agreement, without any waiver of any
material terms or conditions by BioTransplant, and that obtaining the necessary
regulatory approvals, if any, for the merger would not have an adverse effect on
BioTransplant. Lazard further assumed that the merger would be accounted for as
a purchase under United States generally accepted accounting principles and that
the merger would qualify as a tax free reorganization for United States federal
income tax purposes.

    In connection with rendering the Lazard opinion, Lazard performed a variety
of financial analyses. The preparation of a fairness opinion involves various
determinations as to the most appropriate and relevant methods of financial
analysis and the application of these methods to the particular circumstances
and, therefore, such an opinion is not readily susceptible to a partial analysis
or summary description. Accordingly, notwithstanding the separate analyses
summarized below, Lazard believes that its analyses must be considered as a
whole and that selecting portions of the analyses or factors considered by it,
without considering all such factors or analyses, or attempting to ascribe
relative weights to some or all such analyses and factors could create an
incomplete view of the evaluation process underlying the Lazard opinion.

    In performing its analyses, Lazard made numerous assumptions with respect to
industry performance, general business and economic conditions and other
matters, many of which are beyond the control of BioTransplant. The analyses
performed by Lazard are not necessarily indicative of actual values or actual
future results, which may be significantly more or less favorable than suggested
by such analyses. Lazard did not assign any specific weight to any of the
analyses described below and did not draw any specific conclusions from or with
regard to any one method of analysis. With respect to the analysis of comparable
companies and the analysis of selected precedent transactions summarized below,
no public company utilized as a comparison is identical to BioTransplant or
Eligix and no transaction is identical to the merger. Accordingly, an analysis
of publicly traded comparable companies and comparable business combinations is
not mathematical; rather, it involves complex considerations and judgments
concerning the differences in financial and operating characteristics of the
companies and other factors that could affect the public trading values or
announced merger transaction values, as the case may be, of BioTransplant or
Eligix and the companies to which they were compared. The analyses do not
purport to be appraisals or to reflect the prices at which any securities may
trade at the present time or at any time in the future. In addition, as
described above, the Lazard opinion was just one of many factors taken into
consideration by the BioTransplant board of directors. Consequently, Lazard's
analyses should not be viewed as determinative of the decision of the
BioTransplant board of directors or the BioTransplant management with respect to
the fairness of the total consideration set forth in the merger agreement.

    The following is a summary of the material financial and comparative
analyses performed by Lazard in connection with providing to, and reviewing
with, the BioTransplant board of directors its oral opinion, subsequently
confirmed in writing, at the meeting of the BioTransplant board of directors on
December 8, 2000.


    ELIGIX SENSITIVITIES.  The BioTransplant management prepared three cases of
sensitivities, reflecting the BioTransplant management's best current estimates
and judgments as to the outcome of clinical trials of various products under
development by Eligix, to the projections provided by Eligix: (1) low case,
(2) mid case and (3) high case. Lazard based its analyses on both the low case
and mid case projections. Lazard did not base its analyses on the high case
projection because it viewed the low case


                                       39


and mid case projections as better reflecting the potential future financial
performance of Eligix based on numerous assumptions with respect to industry
performance, general business and economic conditions and other matters.



    COMPARABLE PUBLICLY TRADED COMPANIES ANALYSIS.  Lazard performed a
comparable public companies analysis to assist the BioTransplant board of
directors in valuing Eligix based on various financial multiples of selected
comparable public companies in the biotechnology industry. In performing this
analysis, Lazard reviewed financial information relating to Eligix from the low
case and mid case scenarios and compared such information to corresponding
financial information, ratios and public market multiples for four other
biotechnology companies Lazard deemed to be comparable, based on similarities in
product development and market capitalization, to Eligix. The companies included
in this analysis were:


       - BioTransplant Incorporated

       - Immune Response Corporation

       - IntraBiotics Pharmaceuticals, Inc.

       - ViroLogic, Inc.

    Using publicly available information, Lazard calculated the following
multiples for the aforementioned comparable companies:



                                                    LOW        MEAN      MEDIAN      HIGH
                                                  --------   --------   --------   --------
                                                                       
Enterprise value as a multiple of:
2000E revenues..................................    4.15x     10.71x     13.12x     14.87x
2001E revenues..................................    3.58       6.91       3.68      13.48
2002E revenues..................................    1.62       9.50       6.18      24.02
2003E revenues..................................    0.97       3.14       2.25       7.08
2004E revenues..................................    0.63       1.75       1.25       3.86
2005E revenues..................................    1.17       1.39       1.39       1.61



    Using the multiples calculated in the comparable companies analysis, based
on the mid case scenario and 2003E and 2004E revenue multiples, Lazard derived a
range of implied equity values of $80 million to $131 million and $68 million to
$120 million, respectively, for Eligix. Based on the low case scenario and 2003E
and 2004E revenue multiples, Lazard derived a range of implied equity values of
$46 million to $75 million and $53 million to $94 million, respectively, for
Eligix. Lazard noted that the implied offer price of $59 million in the merger
was below or within the range of implied equity values of Eligix derived from
the comparable publicly traded company analysis.



    SELECTED PRECEDENT TRANSACTIONS ANALYSIS.  Lazard performed a selected
precedent transactions analysis to assist the BioTransplant board of directors
in valuing Eligix based on transaction values expressed as multiples of various
financial measures in selected transactions. Using publicly available
information, Lazard reviewed and analyzed financial and operating data relating
to the following selected transactions, which involved companies with products
in late stage clinical development or products that recently received marketing
approval, in the biotechnology industry:


    - Chiron Corporation/PathoGenesis Corporation

    - Elan Corporation/Liposome Company, Inc.

    - Genzyme Corporation/Biomatrix, Inc.

    - King Pharmaceuticals, Inc./Medco Research

    - MedImmune, Inc./US Bioscience

    - Celltech plc/Chiroscience Group plc

    - Gilead Sciences, Inc./NeXstar Pharmaceuticals, Inc.

    - Warner-Lambert Company/Agouron Pharmaceuticals, Inc.

                                       40

    Lazard compared, among other things, the transaction value of the selected
precedent transaction as a multiple of revenues:



                                                     LOW        MEAN      MEDIAN      HIGH
                                                   --------   --------   --------   --------
                                                                        
Transaction value as a multiple of:
LTM revenues.....................................    3.78x      8.38x      8.21x     14.04x
FY+1 revenues....................................    3.71       6.45       7.12       8.80
FY+2 revenues....................................    3.42       5.64       6.24       7.55
FY+3 revenues....................................    2.74       3.77       3.76       5.09



    Based on the mid case scenario and 2002E and 2003E revenue multiples, the
range of multiples from precedent transactions produces a range of implied
equity values of $185 million to $247 million and $152 million to $202 million,
respectively, for Eligix. Based on the low case scenario and 2002E and 2003E
revenue multiples, the range of multiples from precedent transactions produces a
range of implied equity values of $98 million to $130 million and $87 million to
$116 million, respectively, for Eligix. Lazard noted that the implied offer
price of $59 million in the merger was below the range of implied equity values
of Eligix derived from the selected precedent transactions analysis.


    DISCOUNTED CASH FLOW ANALYSIS.  Lazard performed a probability-adjusted
discounted cash flow analysis to assist the BioTransplant board of directors in
valuing Eligix based on the present value of expected future cash flows of
Eligix. The discounted cash flow analysis was based upon perpetual growth rates
of 0.0%, 2.5% and 5.0% and a range of discount rates from 11% to 13%. The range
of discount rates is derived from a weighted average cost of capital analysis
from comparable publicly traded companies.


    Using this analysis, Lazard derived a range of implied equity values of
$116 million to $176 million for Eligix based on the mid case scenario and
$81 million to $141 million for Eligix based on the low case scenario. Lazard
noted that the implied offer price of $59 million in the merger was below the
range of implied equity values of Eligix derived from the discounted cash flow
analysis.


    CONTRIBUTION ANALYSIS.  Lazard performed a contribution analysis to assist
the BioTransplant board of directors in valuing Eligix based on the relative
contribution of each company to the combined pro forma entity. Lazard calculated
the relative contribution by both BioTransplant and Eligix to the combined
company with respect to implied discounted cash flow equity values and projected
financial data including revenues, earnings before interest, taxes, depreciation
and amortization (EBITDA) and earnings before interest and taxes (EBIT), and
compared these results to the pro forma equity ownership of 66% by BioTransplant
and 34% by Eligix of the combined company.

                                       41

    The following table illustrates the relative contribution of both
BioTransplant and Eligix to the combined company:



                                         MID CASE SCENARIO          LOW CASE SCENARIO
                                      ------------------------   ------------------------
                                      BIOTRANSPLANT    ELIGIX    BIOTRANSPLANT    ELIGIX
                                      -------------   --------   -------------   --------
                                                                     
Revenue:
2001E...............................       27%          73%           42%          58%
2002E...............................        5%          95%            9%          91%
2003E...............................        4%          96%            6%          94%
2004E...............................       15%          85%           19%          81%
2005E...............................       13%          87%           15%          85%

EBITDA:.............................
2001E...............................        NM           NM            NM           NM
2002E...............................        NM           NM            NM           NM
2003E...............................        NM           NM            NM           NM
2004E...............................       41%          59%            NM           NM
2005E...............................       22%          78%           44%          56%

EBIT:
2001E...............................        NM           NM            NM           NM
2002E...............................        NM           NM            NM           NM
2003E...............................        NM           NM            NM           NM
2004E...............................       40%          60%            NM           NM
2005E...............................       20%          80%           43%          57%

DCF Equity Values...................       61%          39%           69%          31%



    Lazard noted that the percentage contribution of Eligix to the combined
company was, based on the measures outlined in the contribution analysis,
comparable to or greater than its pro forma equity ownership of the combined
company.


    Lazard is an internationally recognized investment banking firm and is
continually engaged in the valuation of businesses and their securities in
connection with mergers and acquisitions, negotiated underwritings, secondary
distributions of listed and unlisted securities, private placements, leveraged
buyouts, and valuations for estate, corporate and other purposes. Lazard was
selected to act as financial advisor to the BioTransplant board of directors
because of its expertise and its reputation in investment banking and mergers
and acquisitions combined with its strong presence in the healthcare industry.

    In connection with Lazard's services as financial advisor to BioTransplant,
including its delivery of the opinion summarized above, BioTransplant has agreed
to pay Lazard a fee of approximately $1.0 million, a substantial portion of
which is contingent upon the completion of the merger. BioTransplant has also
agreed to reimburse Lazard for all reasonable expenses incurred in connection
with the engagement. In addition, BioTransplant agreed to indemnify Lazard
against certain liabilities, including liabilities under the federal securities
law, relating to or arising out of the engagement. In the ordinary course of its
business, Lazard and its affiliates may actively trade in the securities of
BioTransplant for its own account and for the account of its customers and,
accordingly, may at any time hold a long or short position.

INTERESTS OF EXECUTIVE OFFICERS AND DIRECTORS OF ELIGIX IN THE MERGER

    In considering the recommendation of the Eligix board of directors in favor
of the merger agreement and the merger, Eligix stockholders should be aware of
the interests that certain directors and executive officers of Eligix have in
the merger that are different from, or in addition to the

                                       42

interests of the stockholders of Eligix generally. These interests are different
from and in addition to their interests as stockholders. These interests relate
to or arise from, among other things:

    - the issuance of 990,000 shares of BioTransplant common stock, in the
      aggregate, to specified officers of Eligix, referred to as management
      members, in fulfillment of Eligix' management equity incentive payment
      obligation;


    - accelerated vesting of James R. Fitzgerald's and Walter C. Ogier's stock
      options upon consummation of the merger;


    - employment offers being extended to Eligix management members;


    - the continued payment of mortgage assistance to Walter C. Ogier;


    - the continued indemnification of Eligix directors and officers for actions
      taken prior to the merger; and

    - the election of Walter C. Ogier, Susan Racher and Arnold Oronsky as
      members of the BioTransplant board of directors upon the completion of the
      merger.

    Except as described below, those persons have, to the knowledge of
BioTransplant and Eligix, no material interest in the merger apart from those of
stockholders generally. The Eligix board of directors was aware of, and
considered the interests of, their directors and executive officers when it
approved the merger agreement and the merger.


    ELIGIX MANAGEMENT EQUITY INCENTIVE PLAN.  On May 25, 2000, the board of
directors of Eligix adopted a management equity incentive plan. The board
subsequently amended and restated the plan on December 8, 2000. The amended plan
provides that 12 individuals, each a member of the Eligix management team, will
receive an aggregate of 15% of the total consideration received by Eligix in the
event of a merger or similar business transaction. Accordingly, BioTransplant
will issue an aggregate of 990,000 shares of BioTransplant common stock as
follows:





                                                                                   NUMBER OF
                                                                                 BIOTRANSPLANT
NAME                                           ELIGIX TITLE                         SHARES
----                                           ------------                      -------------
                                                                           
Walter C. Ogier...........  President and Chief Executive Officer                   162,295
James R. Fitzgerald,        Senior Vice President, Finance and Operations and
  Jr......................  Chief Financial Officer                                  97,377
David N. Cook, Ph.D.......  Senior Vice President, Research and Development          97,377
Tara Clark................  Vice President, Marketing                                97,377
James A. Embree...........  Vice President, Manufacturing                            97,377
Judith Snow...............  Vice President, Quality Assurance                        97,377
Non-executive managers
  (six individuals).......                                                          340,820




    The shares of BioTransplant common stock issued under the management equity
incentive plan will vest as follows:


    - 33 1/3% will vest 90 days after the closing of the merger;

    - another 33 1/3% will vest 180 days after the closing of the merger;

    - another 23 1/3% will vest 270 days after the closing of the merger; and

    - the final 10% will vest 365 days after the closing of the merger.


    The merger agreement requires that BioTransplant file a registration
statement on Form S-8 within 75 days of the closing of the merger in order to
register the 990,000 shares of BioTransplant common


                                       43


stock issuable to the Eligix management members. Ten percent of the management
equity incentive shares will be placed in escrow to secure any indemnification
claims by BioTransplant, and ten percent of the management equity incentive
shares will be placed in escrow to secure the achievement of the CE mark
milestone by Eligix.


    If a member of Eligix management is offered employment and BioTransplant
terminates the employment for cause, or the employee terminates employment
without good reason, BioTransplant will have the option to repurchase any of
that person's unvested shares of BioTransplant common stock at a price of $.01
per share. It is a condition to the closing of the merger that BioTransplant
offer employment to all Eligix management members. Please see "Other
Agreements--Employment Offer Letters" below for a discussion of the employment
terms.

    However:

    - if an Eligix management member is not offered employment with
      BioTransplant, that person's shares of BioTransplant common stock will
      vest upon the closing of the merger; and

    - if an Eligix management member becomes an employee of BioTransplant but
      BioTransplant terminates his or her employment without cause or the
      employee terminates his or her employment for good reason, that person's
      shares of BioTransplant common stock will vest immediately upon
      termination.


    In addition, the shares of BioTransplant common stock issued under the
management equity incentive plan will immediately vest in the event that:


    - BioTransplant merges into another corporation;

    - more than 50% of BioTransplant's voting power is transferred in one
      transaction or a series of related transactions;

    - BioTransplant sells, leases or otherwise disposes of all or substantially
      all of its assets; or

    - BioTransplant sells or transfers all or substantially all of the assets
      held by Eligix prior to the merger.


    ELIGIX STOCK OPTIONS.  Options to purchase an aggregate of approximately
864,999 shares of Eligix common stock granted to directors and executive
officers of Eligix will accelerate upon the completion of the merger. In
addition, options to purchase an aggregate of 2,749,100 shares of Eligix common
stock issued on May 25, 2000, which were exercisable in full on the date of
issuance but are subject to a right of repurchase by Eligix, will no longer be
subject to the repurchase right in the event of a


                                       44


merger. The following table shows options held by directors and executive
officers of Eligix as of February 28, 2001 and assumes the merger occurs on
April 30, 2001:





                                                                                    NUMBER OF
                                                                                    SHARES OF
                                                                                      ELIGIX
                                                                                      COMMON
                                                                                      STOCK
                                               NUMBER OF                            SUBJECT TO
                                               SHARES OF                              OPTION                     ELIGIX
                                                ELIGIX                               THAT ARE                 OPTION SHARES
                                                COMMON                                VESTED                   ACCELERATED
                             DATE OF             STOCK                                AS OF                       UPON
                              OPTION          SUBJECT TO          EXERCISE         FEBRUARY 28,               CONSUMMATION
OFFICER OR DIRECTOR           GRANT             OPTIONS            PRICE               2001                     OF MERGER
-------------------          --------   -----------------------   --------   ------------------------   -------------------------
                                                                                         
Walter C. Ogier............  10/17/97                  600,000     $0.15                     390,000                      210,000
                              5/25/00                  600,000     $0.01                           0*                     600,000
James R. Fitzgerald, Jr....    2/9/00                  450,000     $0.15                      97,500                      450,000
                              9/27/00                  450,000     $0.01                      97,500                      450,000
David N. Cook, Ph.D........   12/1/99                  300,000     $0.15                      80,000                            0
                               2/9/00                    4,500     $0.15                       4,500                            0
                              5/25/00                  304,500     $0.01                           0*                     304,500
Tara Clark.................   9/30/99                  175,000     $0.15                      49,583                            0
                               2/9/00                    3,500     $0.15                       3,500                            0
                              5/25/00                  178,500     $0.01                           0*                     178,500
James A. Embree............   3/27/98                  125,000     $0.15                      77,083                            0
                              7/14/99                   50,000     $0.15                      15,833                            0
                               2/9/00                   16,000     $0.15                      16,000                            0
                              5/25/00                  291,000     $0.01                           0*                     291,000
Judith Snow................  10/22/98                  175,000     $0.15                      81,667                            0
                              7/14/99                   50,000     $0.15                      15,833                            0
                               2/9/00                   15,000     $0.15                      15,000                            0
                              5/25/00                  240,000     $0.01                           0*                     240,000
Laura Coulter-Jones........        --                       --        --                          --                           --
Robert Momsen..............        --                       --        --                          --                           --
Arnold L. Oronsky, Ph.D....        --                       --        --                          --                           --
Susan Racher...............        --                       --        --                          --                           --
Pieter Schiller............        --                       --        --                          --                           --



------------------------

*   These options are immediately exercisable. However, the shares issuable upon
    exercise vest over a five-year period with any unvested shares being subject
    to repurchase by Eligix. The shares fully vest and the repurchase right
    terminates upon consummation of the merger.

    EMPLOYMENT OFFER LETTERS.  As a condition to the closing of the merger,
BioTransplant must offer employment to all members of the management team.
BioTransplant is offering the six executive officers of Eligix the following
positions:




NAME                            PROPOSED TITLE
----                            --------------
                             
Walter C. Ogier...............  President and Chief Operating Officer
James R. Fitzgerald, Jr.......  Executive Vice President, Finance and Administration
David N. Cook, Ph.D...........  Senior Vice President, Development
Tara Clark....................  Vice President, Marketing
James A. Embree...............  Vice President, Manufacturing
Judith Snow...................  Vice President, Quality Assurance



                                       45

    BioTransplant has agreed that each of these officers will be eligible for an
annual cash bonus and will be able to participate in BioTransplant's annual
merit-based stock option plan. Please see "Other Agreements--Employment Offer
Letters" below for a detailed description of the offers.


    MORTGAGE ASSISTANCE.  BioTransplant has agreed that upon the completion of
the merger it will provide mortgage assistance, under the same terms and
conditions as provided by Eligix, to Walter Ogier. Mr. Ogier will receive
monthly mortgage assistance payments through March 31, 2002 of $584.00 per
month.


    INDEMNIFICATION OF DIRECTORS AND OFFICERS.  The merger agreement provides
that for six years after the completion of the merger, BioTransplant will not
alter or impair any exculpatory or indemnification provision now existing in the
Eligix certificate of incorporation or bylaws. In addition, the merger agreement
provides that BioTransplant will indemnify each present and former director and
officer for all liabilities pertaining to matters existing or occurring at or
prior to the completion of the merger to the fullest extent permitted by
Delaware law.

STOCK OPTIONS, WARRANTS AND CONVERTIBLE NOTES


    Under the merger agreement, at the effective time of the merger,
BioTransplant will assume the Eligix 1997 equity incentive plan and all stock
options granted under the plan. Each stock option outstanding under the plan at
the effective time will be converted into a stock option to acquire
BioTransplant common stock on the same terms and conditions as applied to the
Eligix stock option. The number of shares of BioTransplant common stock to be
issued in respect of a BioTransplant option will be equal to the number of
shares of Eligix common stock that would be issued in respect of that option
multiplied by the common stock conversion ratio, rounded down to the nearest
whole share. The exercise price per share of BioTransplant common stock for any
Eligix option will be equal to the exercise price per share of Eligix common
stock for that option divided by the common stock conversion ratio, rounded down
to the nearest whole cent. Assuming the holders of Eligix preferred stock elect
to receive their liquidation preferences, the common stock conversion ratio will
be 0.0913. To the extent that holders of Eligix preferred stock elect to convert
their shares into Eligix common stock, rather than receive their liquidation
preferences, the common stock conversion ratio will be between 0.0913 and
0.1540. As of December 31, 2000, 8,000,000 shares of Eligix common stock were
reserved for issuance upon the exercise of outstanding Eligix stock options
granted under the plan.


    Under the merger agreement, Eligix agrees to use its reasonable best efforts
to cause the exercise of any outstanding Eligix warrants prior to the effective
time of the merger. To the extent there are outstanding Eligix warrants at the
effective time, BioTransplant will assume the warrants as follows:

    - each Eligix common stock warrant will be deemed to constitute a warrant to
      acquire, on the same terms as were applicable under the Eligix common
      stock warrant at the effective time, as modified by the merger agreement,
      the number of shares of BioTransplant common stock as is equal to the
      number of Eligix common shares subject to the unexercised portion of the
      warrant multiplied by the common stock conversion ratio, and the exercise
      price per share of BioTransplant common stock will be equal to the
      exercise price per share of Eligix common stock for that warrant divided
      by the common stock conversion ratio; and

    - each Eligix Series B preferred stock warrant will be deemed to constitute
      a warrant to acquire, on the same terms as were applicable under the
      Eligix Series B preferred stock warrant at the effective time, as modified
      by the merger agreement, the number of shares of BioTransplant common
      stock as is equal to the number of shares of BioTransplant common stock as
      is equal to the number of Series B preferred shares subject to the
      unexercised portion of the warrant multiplied by 0.1296, and the exercise
      price per share of BioTransplant common stock will be equal to the
      exercise price per share of Eligix Series B preferred stock for that
      warrant divided by 0.1296.

                                       46

    Under the merger agreement, Eligix agrees to use its reasonable best efforts
to cause the conversion of any outstanding Eligix convertible notes, together
with accrued interest thereon, into Eligix Series C-1 preferred stock prior to
the effective time of the merger. To the extent there are outstanding Eligix
convertible notes at the effective time, BioTransplant will deem each
outstanding convertible note that is convertible into Eligix Series C-1
preferred stock, together with accrued interest thereon, to be convertible into
the number of shares of BioTransplant common stock as is equal to the number of
Eligix Series C-1 preferred shares into which the Eligix Series C-1 note is
convertible immediately prior to the effective time of the merger multiplied by
0.3889. The maturity date, payment, subordination, subrogation and other terms
of any assumed notes will otherwise remain unchanged.


ACCOUNTING TREATMENT OF THE MERGER



    Consistent with generally accepted accounting principles, the merger will be
accounted for under the "purchase" method of accounting. BioTransplant expects a
significant portion of the purchase price to be allocated to goodwill and
identifiable intangible assets. The merger is expected to result in a charge
against earnings for in-process research and development.


FORM OF MERGER


    Subject to the terms and conditions of the merger agreement and consistent
with Delaware law, at the effective time of the merger, BT/EL Acquisition Co., a
wholly owned subsidiary of BioTransplant, will merge with and into Eligix.
Eligix will be the surviving corporation of the merger and a wholly owned
subsidiary of BioTransplant, and will continue under the name "Eligix, Inc."


MERGER CONSIDERATION


    BioTransplant will issue an aggregate of up to 5,610,000 shares of its
common stock to Eligix security holders in connection with the merger. At the
effective time of the merger, the portion of the 5,610,000 shares of
BioTransplant common stock allocated to any particular Eligix stockholder will
depend on whether the holders of shares of Eligix preferred stock elect to
receive their liquidation preference or convert their shares of preferred stock
into common stock. If the holders of Eligix preferred stock elect to receive
their liquidation preferences and the remaining merger shares are allocated
proportionately to holders of Eligix common stock:


    - each holder of Eligix preferred stock will be entitled to receive, subject
      to adjustment to account for any stock splits, as a liquidation
      preference:

     - 0.1152 of a share of BioTransplant common stock for each share of
       Series A preferred stock;

     - 0.1296 of a share of BioTransplant common stock for each share of
       Series B preferred stock;

     - 0.3889 of a share of BioTransplant common stock for each share of
       Series C-1 preferred stock;

     - 0.1152 of a share of BioTransplant common stock for each share of
       Series C-2 preferred stock; and


     - 0.1296 of a share of BioTransplant common stock for each share of
       Series C-3 preferred stock that the stockholder owns; and



    - each holder of Eligix common stock will be entitled to receive, subject to
      adjustment to account for any stock splits, 0.0913 of a share of
      BioTransplant common stock for each share of Eligix common stock that the
      stockholder owns.



    To the extent that holders of Eligix preferred stock elect to convert their
shares into Eligix common stock, rather than receive their liquidation
preferences, the number of shares of BioTransplant common stock exchangeable for
each share of Eligix common stock will be between 0.0913 of a share


                                       47


of BioTransplant common stock assuming no conversion of Eligix preferred stock
into Eligix common stock and 0.1540 of a share of BioTransplant common stock
assuming full conversion of Eligix preferred stock into Eligix common stock.



    Stockholders will receive cash for any fractional share that they would
otherwise receive in the merger. As of the effective time of the merger, all
shares of Eligix stock will no longer be outstanding, will automatically be
cancelled and will cease to exist. At that time, each holder of a certificate
representing shares of Eligix stock, other than shares as to which appraisal
rights have been properly exercised, will cease to have any rights as a
stockholder except the right to receive BioTransplant common stock, the right to
any dividends or other distributions under the merger agreement and the right to
receive cash for any fractional share of BioTransplant common stock.


    The merger consideration was determined through arm's-length discussions
between BioTransplant and Eligix.

EFFECTIVE TIME OF THE MERGER


    The merger will become effective upon the filing of a certificate of merger
with the Secretary of State of the State of Delaware, or at a later time as
stated in the certificate of merger or agreed upon by BioTransplant and Eligix.
The filing of the certificate of merger will occur at the time of closing of the
merger.


MATERIAL UNITED STATES FEDERAL INCOME TAX CONSIDERATIONS

    GENERALLY.  The following discussion is a general summary of the material
United States federal income tax consequences of the merger. The discussion is
based on and subject to the Internal Revenue Code, Treasury Regulations under
the Internal Revenue Code, existing administrative interpretations and court
decisions as of the date of this joint proxy statement prospectus, all of which
are subject to change, possibly with retroactive effect, and all of which are
subject to differing interpretation. The discussion does not address the effects
of the merger under any state, local or foreign tax laws.

    The discussion does not purport to deal with all aspects of federal income
taxation that may affect particular stockholders in light of their individual
circumstances, and it does not address any tax consequences for stockholders
subject to special treatment under the federal income tax law, including
insurance companies, tax-exempt organizations, financial institutions,
broker-dealers, foreign individuals or entities, stockholders who hold their
stock as part of a hedge, appreciated financial position, straddle or conversion
transaction, stockholders who do not hold their stock as capital assets and
stockholders who have acquired their stock upon the exercise of employee stock
options or otherwise as compensation, including the shares of BioTransplant
issued to the management members. In addition, the discussion below does not
consider the effect of any applicable state, local or foreign laws.

    EACH ELIGIX STOCKHOLDER IS URGED TO CONSULT HIS, HER OR ITS TAX ADVISOR WITH
RESPECT TO THE SPECIFIC TAX CONSEQUENCES OF THE MERGER TO HIM, HER OR IT,
INCLUDING THE EFFECT OF UNITED STATES FEDERAL, STATE AND LOCAL, AND FOREIGN AND
OTHER TAX RULES, AND THE EFFECT OF POSSIBLE CHANGES IN TAX LAWS.

    BioTransplant has received an opinion dated the date hereof from, its
counsel, Hale and Dorr LLP, a copy of which is filed as Exhibit 8.1 to the
registration statement of which this joint proxy statement/ prospectus is a
part, to the effect that, based upon and subject to the facts, representations,
covenants and assumptions set forth therein, the merger constitutes a
reorganization with the meaning of Section 368(a) of the Code. Eligix has
received an opinion dated the date hereof from its counsel, Mintz, Levin, Cohn,
Ferris, Glovsky and Popeo, P.C., a copy of which is filed as Exhibit 8.2 to the
registration statement of which this joint proxy statement/prospectus is a part,
to the effect that, based upon and subject to the facts, representations,
covenants and assumptions set forth therein, the merger

                                       48

constitutes a reorganization with the meaning of Section 368(a) of the Code. The
above opinions are based on facts existing at the date hereof and the date of
the closing of the merger. In addition, it is a condition to the obligation of
BioTransplant to effect the merger that BioTransplant receive an opinion dated
the date of closing of the merger from Hale and Dorr LLP, and it is a condition
to the obligation of Eligix to effect the merger that Eligix receive an opinion
dated the date of the closing of the merger from Mintz, Levin, Cohn, Ferris,
Glovsky and Popeo, P.C., in each case to the effect that the merger constitutes
a reorganization within the meaning of Section 368(a) of the Internal Revenue
Code for federal income tax purposes. The opinions issued at the closing will be
based on facts existing at the date thereof.

    As a result of the merger qualifying as a reorganization there are the
following tax consequences:

    TAX CONSEQUENCES TO BIOTRANSPLANT, BT/EL ACQUISITION CO. AND ELIGIX.  For
federal income tax purposes, no gain or loss will be recognized by
BioTransplant, BT/EL Acquisition Co. or Eligix solely as a result of the merger.

    TAX CONSEQUENCES TO ELIGIX STOCKHOLDERS.  For federal income tax purposes:


(1) no gain or loss will be recognized by the stockholders of Eligix upon the
    exchange of their shares of Eligix stock for shares of BioTransplant common
    stock issued in connection with the merger, except with respect to cash, if
    any, received in lieu of fractional shares of BioTransplant common stock;



(2) the aggregate tax basis of the shares of BioTransplant common stock received
    in exchange for shares of Eligix stock issued in connection with the merger
    (including a fractional share of BioTransplant common stock for which cash
    is received) will be the same as the aggregate tax basis of the shares of
    Eligix stock surrendered in the merger;



(3) the holding period for shares of BioTransplant common stock received in
    exchange for shares of Eligix stock will include the period during which the
    Eligix stockholder held the shares of Eligix stock; and



(4) a stockholder of Eligix who receives cash in lieu of a fractional share of
    BioTransplant common stock will recognize gain or loss equal to the
    difference, if any, between the stockholder's basis in the fractional share
    (determined under clause (2) above) and the amount of cash received.



    The above description does not apply to stockholders who exercise appraisal
rights. A holder of Eligix stock who exercises appraisal rights with respect to
the merger and receives cash in exchange for shares of Eligix stock will
generally recognize capital gain or loss measured by the difference between the
amount of cash received and the stockholder's basis in those shares, provided
that the payment is not treated as a dividend under Section 302 of the Code or
otherwise. A sale of shares based on an exercise of appraisal rights generally
will not be treated as a dividend if the stockholder exercising appraisal rights
owns no shares of BioTransplant immediately after the merger, after giving
effect to the constructive ownership rules of the Code. The capital gain or loss
will be long-term capital gain or loss if the holder's holding period in the
shares is more than one year. Any payment in respect of an exercise of appraisal
rights may be subject to backup withholding where required by the Code.


    The opinions described above will neither bind the Internal Revenue Service
nor preclude the Internal Revenue Service from adopting positions contrary to
those expressed above, and no assurance can be given that contrary positions
will not be asserted successfully by the Internal Revenue Service or adopted by
a court if the issues are litigated. Neither BioTransplant nor Eligix intends to
obtain a ruling from the Internal Revenue Service with respect to the tax
consequences of the merger.


    If the IRS were to successfully challenge the "reorganization" status of the
merger, each Eligix stockholder would recognize taxable gain or loss with
respect to the Eligix stock surrendered, measured by the difference between
(1) the fair market value, as of the time of the merger, of the BioTransplant


                                       49


common stock received in the merger and (2) the stockholder's tax basis in the
Eligix stock surrendered therefor in the merger. In this event, a stockholder's
aggregate basis in the BioTransplant common stock so received would equal its
fair market value as of the time of the merger and the holding period for this
BioTransplant stock would begin the day after the merger.



    TAXATION OF ESCROWED SHARES.  Under the merger agreement, each Eligix
stockholder (other than a stockholder validly asserting appraisal rights) will
receive outright, upon surrender of its shares of Eligix stock, shares of
BioTransplant common stock equal to 80% of the whole number of shares of
BioTransplant common stock into which the shares of Eligix stock surrendered by
the stockholder are to be converted. The remaining 20% of the whole number of
shares of BioTransplant common stock into which the Eligix stock are to be
converted will be placed in escrow as security for indemnification obligations
incurred by the Eligix stockholders and payment of the milestone escrow shares,
as required by the merger agreement. Each Eligix stockholder will be credited
with the number of shares placed in escrow on its behalf. See "The Merger
Agreement--Indemnification of BioTransplant by Eligix Stockholders and Eligix
Management Members."


    Each Eligix stockholder will allocate its basis in its shares of Eligix
stock among all of the shares of BioTransplant common stock received by the
stockholder as a result of the merger, including both shares of BioTransplant
common stock received outright and shares of BioTransplant common stock placed
in escrow on the stockholder's behalf.

    No gain or loss will be recognized by an Eligix stockholder upon the
distribution of escrowed shares to the stockholder upon termination of the
escrow or upon the distribution of escrowed shares to BioTransplant in
satisfaction of indemnification claims or as a result of a failure to meet the
milestone.

    Each Eligix stockholder will be subject to United States federal income tax
on all amounts earned on property held by the escrow representatives and
credited to that stockholder. Any dividends paid on the escrowed BioTransplant
common stock will be distributed currently to the Eligix stockholders, subject
to limited exceptions.


    In the event that some or all of the escrow shares are distributed to
BioTransplant in satisfaction of an indemnification claim or as a result of a
failure to meet the milestone, the stockholder's tax basis in the escrow shares
returned to BioTransplant will be allocated among and added to the stockholder's
tax basis in the stockholder's remaining shares of BioTransplant common stock.



    REPORTING REQUIREMENTS.  Eligix stockholders will be required to attach a
statement to their tax returns for the year of the merger that contains the
information listed in Treasury Regulation Section 1.368-3(b). This statement
must include the holder's tax basis in the holder's Eligix stock and a
description of the BioTransplant common stock received therefor. ELIGIX
STOCKHOLDERS ARE URGED TO CONSULT THEIR TAX ADVISORS WITH RESPECT TO ANY TAX
REPORTING REQUIREMENTS.


                                       50


    WE INTEND THIS DISCUSSION TO PROVIDE ONLY A SUMMARY OF THE MATERIAL FEDERAL
INCOME TAX CONSEQUENCES OF THE MERGER. WE DO NOT INTEND THAT IT BE A COMPLETE
ANALYSIS OR DESCRIPTION OF ALL POTENTIAL FEDERAL INCOME TAX CONSEQUENCES OF THE
MERGER. WE DO NOT ADDRESS ALL CATEGORIES OF STOCKHOLDERS, AND WE DO NOT ADDRESS
STATE, LOCAL OR FOREIGN TAX CONSEQUENCES. IN ADDITION, AS NOTED ABOVE, WE DO NOT
ADDRESS TAX CONSEQUENCES THAT MAY VARY WITH, OR ARE CONTINGENT UPON, INDIVIDUAL
CIRCUMSTANCES. WE STRONGLY URGE YOU TO CONSULT YOUR TAX ADVISOR TO DETERMINE
YOUR PARTICULAR UNITED STATES FEDERAL, STATE, LOCAL OR FOREIGN INCOME OR OTHER
TAX CONSEQUENCES RESULTING FROM THE MERGER, IN LIGHT OF YOUR INDIVIDUAL
CIRCUMSTANCES.


NASDAQ NATIONAL MARKET QUOTATION

    It is a condition to the closing of the merger that BioTransplant file a
notification form for listing of additional shares with the Nasdaq National
Market.

RIGHT OF STOCKHOLDERS TO APPRAISALS

    Under the Delaware General Corporation Law, any holder of Eligix capital
stock who does not wish to accept the merger consideration in respect of his,
her or its shares of common stock has the right to dissent from the merger and
to seek an appraisal of, and to be paid the fair cash value (exclusive of any
element of value arising from the accomplishment or expectation of the merger)
for, his, her or its shares of stock, judicially determined, and paid to the
stockholder in cash, together with a fair rate of interest, if any, provided
that the stockholder fully complies with the provisions of Section 262 of the
Delaware General Corporation Law.

    Making sure that you actually perfect your appraisal rights can be
complicated. The procedural rules are specific and must be followed precisely.
Failure to comply with the procedure may cause a termination or waiver of your
appraisal rights. The following information is intended as a brief summary of
the material provisions of the statutory procedures you must follow in order to
perfect your appraisal right. Please review Section 262 for the complete
procedure. Eligix will not give you any notice other than as described in this
joint proxy statement/prospectus and as required by the Delaware General
Corporation Law. A copy of Section 262 is attached as Annex D to this joint
proxy statement/ prospectus.

    The holders of BioTransplant common stock do not have any appraisal rights
in connection with the transactions contemplated by the merger agreement.

APPRAISAL RIGHTS PROCEDURES

    If you are an Eligix stockholder and you wish to exercise your appraisal
rights, you must satisfy the provisions of Section 262 of the Delaware General
Corporation Law. Section 262 requires the following:

        YOU MUST MAKE A WRITTEN DEMAND FOR APPRAISAL.  You must deliver a
    written demand for appraisal to Eligix before the vote on the merger
    agreement is taken at the special meeting. This written demand for appraisal
    must be separate from your proxy. A vote against the merger agreement alone
    will not constitute demand for appraisal.

        YOU MUST REFRAIN FROM VOTING FOR APPROVAL OF THE MERGER.  You must not
    vote for approval of the merger agreement. If you vote, by proxy or in
    person, in favor of the merger agreement, this will terminate your right to
    appraisal. You can also terminate your right to appraisal if you return a
    signed proxy and (1) fail to vote against approval of the merger or
    (2) fail to note that you are abstaining from voting. Your appraisal rights
    will be terminated even if you previously filed a written demand for
    appraisal.

                                       51

        YOU MUST CONTINUOUSLY HOLD YOUR ELIGIX SHARES.  You must continuously
    hold your shares of Eligix capital stock, from the date you make the demand
    for appraisal through the closing of the merger. If you are the record
    holder of Eligix capital stock on the date the written demand for appraisal
    is made but thereafter transfer the shares prior to the merger, you will
    lose any right to appraisal in respect of those shares. You should read the
    paragraphs below for more details on making a demand for appraisal.


    A written demand for appraisal of Eligix stock is only effective if it is
signed by, or for, the stockholder of record who owns the Eligix shares at the
time the demand is made. The demand must be signed as the stockholder's name
appears on the Eligix common stock certificates(s). If you are the beneficial
owner of Eligix capital stock, but not the stockholder of record, you must have
the stockholder of record sign a demand for appraisal.


    If you own Eligix capital stock in a fiduciary capacity, such as a trustee,
guardian or custodian, you must disclose the fact that you are signing the
demand for appraisal in that capacity.

    If you own Eligix capital stock with more than one person, such as in a
joint tenancy or tenancy in common, all the owners must sign, or have signed for
them, the demand for appraisal. An authorized agent, which could include one or
more of the joint owners, may sign the demand for appraisal for a stockholder of
record; however, the agent must expressly disclose who the stockholder of record
is and that the agent is signing the demand as that stockholder's agent.


    If you are a record owner, such as a broker, who holds Eligix capital stock
as a nominee for others, you may exercise a right of appraisal with respect to
the shares held for one or more beneficial owners, while not exercising the
appraisal right for other beneficial owners. In this case, you should specify in
the written demand the number of shares as to which you wish to demand
appraisal. If you do not expressly specify the number of shares, we will assume
that your written demand covers all the shares of Eligix capital stock that are
in your name.


    If you are an Eligix stockholder who elects to exercise appraisal rights,
you should mail or deliver a written demand to:

                                  Eligix, Inc.
                                200 Boston Ave.
                               Medford, MA 02155
                      Attention: Robert Momsen, Secretary

    It is important that Eligix receive all written demands before the vote
concerning the merger agreement is taken at the special meeting. As explained
above, this written demand should be signed by, or on behalf of, the stockholder
of record. The written demand for appraisal should specify the stockholder's
name and mailing address, the number of shares of stock owned, and that the
stockholder is thereby demanding appraisal of that stockholder's shares.

    If you fail to comply with any of these conditions and the merger becomes
effective, you will only be entitled to receive the merger consideration
provided in the merger agreement.

    WRITTEN NOTICE.  Within ten days after the closing of the merger, Eligix
must give written notice that the merger has become effective to each
stockholder who has fully complied with the conditions of Section 262.

    PETITION WITH THE CHANCERY COURT.  Within 120 days after the merger, either
the surviving corporation or any stockholder who has complied with the
conditions of Section 262, may file a petition in the Delaware Court of
Chancery. This petition should request that the chancery court determine the
value of the shares of stock held by all the stockholders who are entitled to
appraisal rights. A dissenting stockholder must serve a copy of the petition on
the surviving corporation. If no petition is filed by either the surviving
corporation or any stockholder within the 120-day period, the rights of all

                                       52

dissenting stockholders will cease. Stockholders seeking appraisal rights should
not assume that the surviving corporation will file a petition with respect to
the fair value of their shares. Because the surviving corporation has no
obligation and no present intention to file this petition, if you do not file
this petition within 120 days after the closing, you will lose your rights of
appraisal.

    WITHDRAWAL OF DEMAND.  If you change your mind and decide you no longer want
appraisal rights, you may withdraw your demand for appraisal rights at any time
within 60 days after the closing of the merger. You may also withdraw your
demand for appraisal rights after the 60-day period, but only with the written
consent of the surviving corporation. If you effectively withdraw your demand
for appraisal rights, you will receive the merger consideration provided in the
merger agreement.

    REQUEST FOR APPRAISAL RIGHTS STATEMENT.  If you have complied with the
conditions of Section 262, you are entitled to receive a statement from the
surviving corporation. This statement will set forth the number of shares that
have demanded appraisal rights, and the number of stockholders who own those
shares. In order to receive this statement, you must send a written request to
the surviving corporation within 120 days after the merger. After the merger,
the surviving corporation has ten days after receiving a request to mail you the
statement.

    CHANCERY COURT PROCEDURES.  If you properly file a petition for appraisal in
the Delaware Court of Chancery and deliver a copy to Eligix, Eligix will then
have 20 days to provide the chancery court with a list of the names and
addresses of all stockholders who have demanded appraisal rights and have not
reached an agreement with Eligix as to the value of their shares. The chancery
court will then send notice to all the stockholders who have demanded appraisal
rights. If the chancery court thinks it is appropriate, the chancery court has
the power to conduct a hearing to determine whether the stockholders have fully
complied with Section 262 of the Delaware General Corporation Law and whether
they are entitled to appraisal rights under that section. The chancery court may
also require you to submit your stock certificates to the Registry in Chancery
so that it can note on the certificates that an appraisal proceeding is pending.
If you do not follow the chancery court's directions, you may be dismissed from
the proceeding.

    APPRAISAL OF SHARES.  After the chancery court determines which stockholders
are entitled to appraisal rights, the chancery court will appraise the shares of
stock. To determine the fair value of the shares, the chancery court will
consider all relevant factors except for any appreciation or depreciation due to
the anticipation or accomplishment of the merger. After the chancery court
determines the fair value of the shares, it will direct the surviving
corporation to pay that value to the stockholders who are entitled to appraisal
rights. The chancery court can also direct the surviving corporation to pay
interest, simple or compound, on that value if the chancery court determines
that interest is appropriate. In order to receive payment for your shares, you
must then surrender your stock certificates to the surviving corporation.

    The chancery court could determine that the fair value of shares of stock is
more than, the same as, or less than the merger consideration. In other words,
if you demand appraisal rights, you could receive less consideration than you
would under the merger agreement. You should also be aware that an opinion of an
investment banking firm that the merger is fair is not an opinion that the
merger consideration is the same as the fair value under Section 262.

    COSTS AND EXPENSES OF APPRAISAL PROCEEDING.  The costs of the appraisal
proceeding may be assessed against the surviving corporation and the
stockholders participating in the appraisal proceeding, as the chancery court
deems equitable under the circumstances. You may request that the chancery court
determine the amount of interest, if any, the surviving corporation should pay
on the value of stock owned by stockholders entitled to the payment of interest.
You may also request that the chancery court allocate the expenses of the
appraisal action incurred by any stockholder pro rata against the value of all
the shares entitled to appraisal.

                                       53

    LOSS OF STOCKHOLDER'S RIGHTS.  If you demand appraisal rights, after the
closing of the merger you will not be entitled:

    - to vote the shares of stock for which you have demanded appraisal rights
      for any purpose;

    - to receive payment of dividends or any other distribution with respect to
      the shares of stock for which you have demanded appraisal, except for
      dividends or distributions, if any, that are payable to holders of record
      as of a record date prior to the effective time of the merger; or

    - to receive the payment of the consideration provided for in the merger
      agreement (unless you properly withdraw your demand for appraisal).

    If no petition for an appraisal is filed within 120 days after the closing
of the merger, your right to an appraisal will cease. You may withdraw your
demand for appraisal and accept the merger consideration by delivering to the
surviving corporation a written withdrawal of your demand, except that (1) any
attempt to withdraw made more than 60 days after the closing of the merger will
require the written approval of the surviving corporation, and (2) an appraisal
proceeding in the chancery court cannot be dismissed unless the chancery court
approves.

    IF YOU FAIL TO COMPLY STRICTLY WITH THE PROCEDURES DESCRIBED ABOVE, YOU WILL
LOSE YOUR APPRAISAL RIGHTS. CONSEQUENTLY, IF YOU WISH TO EXERCISE YOUR APPRAISAL
RIGHTS, WE STRONGLY URGE YOU TO CONSULT A LEGAL ADVISOR BEFORE ATTEMPTING TO
EXERCISE YOUR APPRAISAL RIGHTS.

RESALE OF BIOTRANSPLANT COMMON STOCK ISSUED IN CONNECTION WITH THE MERGER


    The shares of BioTransplant common stock issuable to stockholders of Eligix
upon consummation of the merger have been registered under the Securities Act of
1933. These BioTransplant shares will be freely tradeable without restriction by
those stockholders who are not deemed to be "affiliates" of BioTransplant or
Eligix, as that term is defined under the Securities Act.



    Shares of BioTransplant common stock received by those stockholders of
Eligix who are deemed to be affiliates of Eligix may be resold without
registration under the Securities Act only as permitted by Rule 145 under the
Securities Act or as otherwise permitted under the Securities Act. Each person
deemed to be an affiliate of Eligix will enter into an affiliate agreement with
BioTransplant in which he or she agrees not to offer, sell, pledge, transfer or
otherwise dispose of any shares of BioTransplant common stock distributed to
them in connection with the merger, except in compliance with Rule 145 under the
Securities Act, or in a transaction that is otherwise exempt from the
registration requirements of the Securities Act and provided an opinion of
counsel, satisfactory to BioTransplant, has been provided to BioTransplant to
the effect that registration of the shares is not required under the Securities
Act in connection with the proposed transaction, or in an offering that is
registered under the Securities Act.


    In addition, a number of stockholders of Eligix have signed or will sign
lock-up agreements and/or voting and transfer restriction agreements that
contractually limit their ability to sell shares of BioTransplant common stock.
Please see "Other Agreements" below for a description of these agreements.

    This joint proxy statement/prospectus does not cover any resales of
BioTransplant common stock received by persons who are deemed to be affiliates
of Eligix.

                                       54

                              THE MERGER AGREEMENT

    The following description summarizes the material provisions of the merger
agreement. We urge stockholders to read the merger agreement carefully, which is
attached as Annex A to this joint proxy statement/prospectus.

THE MERGER

    Following the adoption of the merger agreement by the stockholders of
Eligix, the approval of the issuance of shares of BioTransplant common stock as
contemplated by the merger agreement by the stockholders of BioTransplant and
the satisfaction or waiver of the other conditions to the merger, a wholly-owned
subsidiary of BioTransplant, BT/EL Acquisition Co., will be merged with and into
Eligix. Eligix will survive the merger as a wholly-owned subsidiary of
BioTransplant. If all conditions to the merger are satisfied or waived, the
merger will become effective at the time of the filing by the surviving
corporation of a duly executed certificate of merger with the Secretary of State
of the State of Delaware.

CONSIDERATION

    In connection with the merger, BioTransplant will issue an aggregate of up
to 6,600,000 shares of common stock. Of these 6,600,000 shares:

    - an aggregate of up to 5,610,000 shares will be issued in exchange for all
      of the shares of Eligix capital stock outstanding immediately prior to the
      effective time of the merger and upon exercise or conversion of Eligix
      options, warrants and notes outstanding immediately prior to the effective
      time of the merger; and


    - an aggregate of 990,000 shares will be issued to Eligix management members
      under the Eligix management equity incentive plan.


CONVERSION OF SHARES


    TREATMENT OF ELIGIX PREFERRED STOCK.  Holders of Eligix preferred stock
immediately prior to the merger may elect either to receive the liquidation
preference applicable to the series of preferred stock held by the preferred
stockholder or to convert their shares of preferred stock into Eligix common
stock and receive BioTransplant common stock at the common stock conversion
ratio described below.



    The merger agreement requires that the merger shares first be allocated to
holders of Eligix preferred stock to satisfy the liquidation preference of that
stock. The remaining merger shares are allocated proportionately to holders of
Eligix common stock interests, giving effect to the amount of common stock that
would have been issued upon the exercise or conversion of all Eligix stock
options, warrants and notes outstanding immediately prior to the completion of
the merger.



    The holders of Eligix preferred stock are entitled to the following
liquidation preferences:





SERIES                                                     LIQUIDATION PREFERENCE
------                                                     ----------------------
                                                        
Series A.................................................         $1.3333
Series B.................................................         $1.5000
Series C-1...............................................         $4.5000
Series C-2...............................................         $1.3333
Series C-3...............................................         $1.5000




    To calculate the number of shares of BioTransplant common stock that will
satisfy each series' liquidation preference, we divided the applicable
liquidation preference by $11.5714, which is the average of the closing prices
for a share of BioTransplant common stock on the Nasdaq National


                                       55


Market for the 30 trading days immediately preceding December 5, 2000, which is
three calendar days prior to the date of the merger agreement. Then we
multiplied the conversion ratio by the number of outstanding shares of the
applicable series of preferred stock.



    As of February 28, 2001, the number of shares of Eligix Series A, Series B,
Series C-1, Series C-2 and Series C-3 preferred stock outstanding, assuming the
exercise or conversion, as of the closing date of the merger, of all warrants or
notes exercisable for or convertible into shares of preferred stock, the
conversion ratio and the number of shares of BioTransplant common stock to be
received in satisfaction of the liquidation preferences were as follows:





                                                    NUMBER OF                             NUMBER OF
SERIES                                            ELIGIX SHARES   CONVERSION RATIO   BIOTRANSPLANT SHARES
------                                            -------------   ----------------   --------------------
                                                                            
Series A........................................   10,911,332          0.1152              1,256,985
Series B........................................   11,246,005          0.1296              1,457,482
Series C-1......................................    5,348,900          0.3889              2,080,187
Series C-2......................................            0          0.1152                      0
Series C-3......................................            0          0.1296                      0
                                                                                           ---------
    Total BioTransplant Shares Issuable in
    Satisfaction of Series A, B, C-1, C-2 and
    C-3 Liquidation Preferences.................                                           4,794,654
                                                                                           =========




    TREATMENT OF ELIGIX COMMON STOCK.  Assuming all of the preferred
stockholders elect to receive their liquidation preferences, rather than convert
their shares into Eligix common stock prior to the merger, each issued and
outstanding share of Eligix common stock, other than shares held in the treasury
of Eligix, shares held by BioTransplant or BT/EL Acquisition Co. or dissenting
shares, will be converted into the right to receive 0.0913 shares of
BioTransplant. In any event, the common stock conversion ratio will be equal to
a fraction:


    - the numerator of which is 6,600,000, the total consideration, minus the
      sum of:

     - 990,000, the management incentive shares, and

     - the number of shares of BioTransplant common stock issued to holders of
       Eligix preferred stock in fulfillment of liquidation preferences,
       including shares of BioTransplant common stock issuable to the holders of
       Eligix preferred warrants and preferred convertible notes; and

    - the denominator of which is the total number of issued and outstanding
      shares of Eligix common stock at the effective time of the merger,
      including all shares of Eligix common stock issued or issuable upon
      exercise of any outstanding Eligix common stock options and warrants,
      whether vested or unvested.


    If any preferred stockholders elect to convert their shares of Eligix
preferred stock into Eligix common stock prior to the merger, the common stock
conversion ratio will be between 0.0913 and 0.1540, depending on how many
preferred stockholders, if any, convert their shares into Eligix common stock.


    All shares of Eligix common stock, when converted, will no longer be
outstanding and will automatically be canceled and retired and will cease to
exist.

ESCROW

    Twenty percent of all shares received by Eligix stockholders and management
members in the merger will be placed in escrow. One half of the escrowed shares
will consist of the shares to cover indemnification obligations and the other
one half will consist of the milestone escrow shares. By approving the merger,
the Eligix stockholders will authorize the creation of the escrow and the

                                       56

appointment of Robert Momsen and Pieter Schiller as their indemnification
representatives with respect to indemnification matters. The management members
will be bound by the terms of the escrow agreement by becoming signatories to
the agreement.

TREATMENT OF ELIGIX STOCK OPTIONS


    At the effective time of the merger, each unexpired and unexercised
outstanding option to purchase shares of Eligix common stock, whether vested or
unvested, previously granted by Eligix under its stock option plan will be
assumed by BioTransplant and converted into options to purchase shares of
BioTransplant common stock. The number of shares of BioTransplant common stock
subject to the assumed Eligix stock options will be adjusted based on the
conversion ratio described above. Any fractional shares of BioTransplant common
stock resulting from this adjustment will be rounded down to the nearest share.
The exercise price per share of BioTransplant common stock under the Eligix
stock options will equal the exercise price per share of the Eligix common stock
under the original stock options divided by the conversion ratio. The exercise
prices will be rounded up to the next highest whole cent.


TREATMENT OF ELIGIX WARRANTS


    Under the merger agreement, Eligix agrees to use its reasonable best efforts
to cause the exercise of any outstanding Eligix warrants prior to the effective
time of the merger. To the extent there are outstanding Eligix warrants at the
effective time of the merger, BioTransplant will assume all unexpired and
unexercised outstanding warrants to purchase Eligix capital stock and convert
the warrants into warrants to purchase BioTransplant common stock. The number of
shares of, and the exercise price for, the BioTransplant common stock subject to
the assumed Eligix warrants will be adjusted based on the conversion ratios
described above.


TREATMENT OF ELIGIX CONVERTIBLE NOTES

    Under the merger agreement, Eligix agrees to use its reasonable best efforts
to cause the conversion of any outstanding Eligix convertible notes, together
with accrued interest thereon, into Eligix Series C-1 preferred stock prior to
the effective time of the merger. To the extent there are outstanding Eligix
convertible notes at the effective time of the merger, BioTransplant will deem
each outstanding convertible note that is convertible into Eligix C-1 preferred
stock, together with accrued interest thereon, to be convertible into the number
of shares of BioTransplant common stock as is equal to the number of Eligix
Series C-1 preferred shares into which the Eligix Series C-1 note is convertible
immediately prior to the effective time of the merger multiplied by 0.3889. The
maturity date, payment, subordination, subrogation and other terms of any
assumed note will otherwise remain unchanged.

EXCHANGE OF STOCK CERTIFICATES

    SURRENDER OF SHARES OF ELIGIX COMMON STOCK AND ELIGIX PREFERRED STOCK.  From
and after the effective time of the merger, each holder of a certificate which
represented, prior to the effective time, shares of Eligix capital stock will
have the right to surrender each certificate to BioTransplant and receive
certificates representing the number of shares of BioTransplant common stock,
other than the shares placed in the escrow, cash in lieu of any fractional
shares of BioTransplant common stock and any dividends or distributions to which
they are entitled. The surrendered certificates will be cancelled. ELIGIX
STOCKHOLDERS SHOULD NOT SEND IN THEIR CERTIFICATES UNTIL THEY RECEIVE ADDITIONAL
INFORMATION FROM EITHER BIOTRANSPLANT OR ELIGIX.


    FRACTIONAL SHARES.  BioTransplant will not issue any fractional shares of
BioTransplant common stock in the merger. Instead, each holder of shares of
Eligix common stock or Eligix preferred stock


                                       57


exchanged in connection with the merger who would otherwise have been entitled
to receive a fraction of a share of BioTransplant common stock will be entitled
to receive cash, without interest, in an amount equal to the product of that
stockholder's fractional part of BioTransplant common stock multiplied by
$11.5714, which is the average of the closing prices for a share of
BioTransplant common stock on the Nasdaq National Market for the 30 trading days
immediately preceding December 5, 2000, which is three calendar days prior to
the date of the merger agreement.


    NO FURTHER REGISTRATION OR TRANSFER OF ELIGIX COMMON STOCK AND ELIGIX
PREFERRED STOCK.  At the effective time of the merger, the stock transfer books
of Eligix will be closed and there will be no further transfers of shares of
Eligix common stock or Eligix preferred stock on the records of Eligix. After
the effective time of the merger, the holders of Eligix stock certificates will
cease to have any rights with respect to such shares of Eligix common stock and
Eligix preferred stock except as otherwise provided for in the merger agreement
or by applicable law.

    DISSENTING SHARES.  Dissenting Eligix shares will not be converted into or
represent the right to receive BioTransplant common stock. If the holder of the
dissenting shares forfeits his, her or its right to appraisal under the Delaware
General Corporation Law or has properly withdrawn his, her or its right to
appraisal:

    - these shares will no longer be dissenting shares and will be converted
      into and represent the right to receive shares of BioTransplant common
      stock in connection with the merger; and

    - BioTransplant will deliver to the holder of these shares a certificate
      representing eighty percent of the shares issued to the stockholder in
      connection with the merger, and will deliver to the escrow agent a
      certificate representing the remaining twenty percent of the shares of
      BioTransplant common stock issued to the stockholder in connection with
      the merger. Please see "The Merger--Right of Stockholders to Appraisals"
      and --"Appraisal Rights Procedures."


    LOST CERTIFICATES.  If any Eligix certificates are lost, stolen or
destroyed, an Eligix stockholder must provide an appropriate affidavit of that
fact. BioTransplant may require the owner of the lost, stolen or destroyed
Eligix certificates to deliver a bond as indemnity against any claim that may be
made against BioTransplant with respect to the Eligix certificates alleged to
have been lost, stolen or destroyed.


REPRESENTATIONS AND WARRANTIES

    In the merger agreement, BioTransplant, Eligix and BT/EL Acquisition Co.
have made a number of representations and warranties about their business,
financial condition, structure and other facts pertinent to the merger. These
relate to:

    - their organization, existence, good standing, corporate power and similar
      corporate matters;

    - their capitalization;

    - their authorization, execution, delivery and performance and the
      enforceability of the merger agreement and related matters;

    - the absence of conflicts, violations and defaults under their corporate
      charters and bylaws and other agreements and documents;

    - required governmental and third-party consents;

    - their financial statements;


    - the absence of changes, as specified in the merger agreement, in their
      businesses since September 30, 2000;


    - tax matters;

                                       58

    - preclinical and clinical testing;

    - intellectual property;

    - their contracts;

    - litigation;

    - their employees;

    - their employee benefit plans;

    - environmental matters;

    - legal compliance;

    - brokers' fees;

    - their books and records; and

    - the accuracy of information provided to the other party.

    Eligix has also represented and warranted as to:

    - its subsidiaries;

    - the absence of undisclosed liabilities;

    - its assets;

    - its properties and leases;

    - powers of attorney;

    - its insurance policies;

    - its licenses and permits; and

    - business relationships with affiliates.

    BioTransplant has also represented and warranted as to the interim
operations of BT/EL Acquisition Co. and the accuracy and completeness of
documents and reports filed by BioTransplant with the SEC.


COVENANTS


    Each of BioTransplant and Eligix has agreed to use its reasonable best
efforts to take all actions and to do all things necessary, proper or advisable
to consummate the transactions contemplated by the merger agreement.

    CONDUCT OF BUSINESS PRIOR TO THE MERGER.  Each of BioTransplant and Eligix
has agreed to use its reasonable best efforts to carry on its business in the
ordinary course in substantially the same manner as previously conducted, except
as contemplated by the merger agreement. Specifically, Eligix has agreed not to,
without the prior written consent of BioTransplant:


    - issue, sell or redeem any shares of capital stock or other securities,
      except upon the conversion or exercise of convertible securities, options
      or warrants;


    - effect a stock split or declare or make any dividends or other
      distributions on its shares of capital stock;

    - create, incur or assume indebtedness, guarantee the obligations of any
      other person or entity or make any loans or investments in any other
      person or entity;

                                       59

    - enter into, adopt or amend the management equity incentive plan, any
      employee benefit plan or employment or severance arrangement or increase
      the compensation or fringe benefits of, or materially modify the
      employment terms of, its directors, officers or employees generally, or
      pay any benefit not required by any existing employee benefit plan;

    - acquire, sell, lease, encumber or otherwise dispose of any assets or
      property with a value of greater than $25,000 per transaction and $100,000
      in the aggregate, other than purchases and sales in the ordinary course of
      business;

    - mortgage or pledge any of its property or assets or subject any assets to
      a security interest;

    - discharge or satisfy any security interest or pay any obligation or
      liability other than in the ordinary course of business;

    - amend its charter or bylaws;

    - change its accounting methods, principles or practices in any material
      respect, except as required by GAAP;

    - enter into, amend, terminate, take or omit to take any action that would
      constitute a violation or default under, or waive any rights under, any
      material contract or agreement;

    - make or commit to any capital expenditure in excess of $25,000 per item or
      $100,000 in the aggregate;

    - institute or settle any legal proceeding;

    - take or fail to take any action with the knowledge that the action or
      failure to take action would result in any of the representations or
      warranties in the merger agreement becoming untrue or any of the
      conditions of the merger set forth in the merger agreement not being
      satisfied;

    - make or change any material tax election; or

    - agree in writing or otherwise to take any of the actions listed above.

    In addition, BioTransplant has agreed not to, without the prior written
consent of Eligix:

    - amend its charter or bylaws;

    - change its accounting methods, principles or practices in any material
      respects, except as required by GAAP;

    - take or fail to take any action with the knowledge that the action or
      failure to take action would result in any of its representations and
      warranties set forth in the merger agreement becoming untrue or any of the
      conditions set forth in the merger agreement not being satisfied;

    - enter into a term sheet or letter of intent to acquire, acquire or agree
      to acquire, by any manner, any business or any corporation, partnership,
      association or other business organization or division thereof, or
      otherwise acquire or agree to acquire any assets, for a value that
      requires approval of BioTransplant's stockholders or that exceeds either
      $5,000,000 in cash or 10% of BioTransplant's outstanding capital stock;


    - with some exceptions, including the granting of options under an equity
      incentive plan, issue or sell shares of capital stock, or any securities
      exercisable for or convertible into shares of capital stock, at a
      purchase, exercise or conversion price which is, as determined by the
      board of BioTransplant:


     - less than the fair market value of the securities at the time the
       obligation to issue or sell the securities arises; and

                                       60

     - not commercially reasonable given the nature of the transaction involved;
       or

    - agree in writing or otherwise to take any of the actions listed above.

    GOVERNMENTAL AND THIRD-PARTY APPROVALS.  Eligix and BioTransplant have
agreed to use their respective best efforts to obtain all approvals,
authorizations and consents of all third parties and governmental entities which
are necessary to be obtained by them to consummate the merger.

    ELIGIX IS RESTRICTED FROM TRYING TO SELL TO ANOTHER PARTY.  Except for
specified exceptions, Eligix has agreed that it will not, directly or
indirectly:

    - initiate, solicit, encourage or otherwise facilitate any inquiry,
      proposal, offer or discussion with any person or entity, other than
      BioTransplant, concerning any merger, reorganization, consolidation, sale,
      license or distribution of material assets, liquidation, dissolution,
      share exchange, recapitalization or other similar business transaction
      involving Eligix or a division of Eligix;

    - provide any non-public information concerning the business, properties or
      assets of Eligix, or a division of Eligix, to any person or entity, other
      than BioTransplant;


    - engage in discussions or negotiations with any person or entity other than
      BioTransplant concerning any merger, reorganization, consolidation, sale,
      license or distribution of material assets, liquidation, dissolution,
      share exchange, recapitalization or similar business transaction involving
      Eligix or a division of Eligix; or



    - execute an agreement with respect to, or otherwise enter into, any merger,
      reorganization, consolidation, sale, license or distribution of material
      assets, liquidation, dissolution, share exchange, recapitalization or
      similar business transaction involving Eligix or a division of Eligix
      without the consent of BioTransplant.


    Eligix has further agreed to cause each of its officers, directors,
employees, representatives and agents not to do any of the things described
above. Eligix has agreed that it will immediately notify BioTransplant in detail
about inquiries, discussions or negotiations of the nature described above.

    DIRECTOR AND OFFICER INDEMNIFICATION.  BioTransplant has agreed that, to the
extent allowed by applicable law, all rights to indemnification existing on the
date of the merger agreement in favor of the present officers and directors of
Eligix prior to the merger as provided in Eligix' certificate of incorporation
or bylaws shall continue in full force and effect for a period of six years
following the merger.

    The merger agreement provides that from and after the effective time of the
merger, BioTransplant will, and will cause the surviving corporation to,
indemnify and hold harmless each present and former director and officer of
Eligix against any costs, expenses, judgments, fines, losses, claims, damages,
liabilities or amounts paid in settlement incurred in connection with any
actions taken in their capacities as directors and/or officers of Eligix, to the
fullest extent permitted by Delaware law.


    LOCK-UP AND AFFILIATE AGREEMENTS.  Eligix has agreed to use its reasonable
best efforts to deliver or caused to be delivered to BioTransplant as soon as
practicable and, in any case, prior to the effective time of the merger, lock-up
agreements executed by specified Eligix stockholders and optionholders. The
lock-up agreement restricts the stockholder's or optionholder's ability to sell
shares of BioTransplant common stock for a period of one year, beginning when
the merger becomes effective.


    Eligix has also agreed to use its reasonable best efforts to deliver or
cause to be delivered to BioTransplant as soon as practicable and, in any case,
prior to the mailing of this joint proxy statement/ prospectus, an affiliate
agreement executed by each affiliate of Eligix who has not previously executed a
voting and transfer restriction agreement.

                                       61

    LISTING OF MERGER SHARES.  BioTransplant has agreed that, prior to the
effective time of the merger, it will file a Nasdaq National Market Notification
for listing of Additional Shares with Nasdaq with respect to the 6,600,000
shares of BioTransplant common stock being issued to Eligix security holders and
management members in connection with the merger.


    BOARD OF DIRECTORS OF BIOTRANSPLANT.  The BioTransplant board of directors
has agreed to use its best efforts to cause the BioTransplant board, immediately
after the merger becomes effective, to include two members designated by Eligix.
The BioTransplant board also agrees to continue to nominate the two members
designated by Eligix, except to the extent that the designee dies, resigns,
refuses to stand for re-election or is otherwise removed from office consistent
with the provisions of BioTransplant's certificate of incorporation and bylaws.
In the event that an open position of the BioTransplant board is otherwise to be
filled prior to the effective time of the merger, BioTransplant will seek the
concurrence of Eligix in the appointment of a third person as well, which
concurrence will not be unreasonably withheld. It is currently anticipated that
the BioTransplant board will elect Walter C. Ogier, Eligix' President and Chief
Executive Officer, Susan Racher and Arnold L. Oronsky, Ph.D., all Eligix
directors, as BioTransplant directors.



    DELIVERY OF TAX NOTICES.  Eligix has agreed, if requested by BioTransplant
on or before the closing of the merger, to deliver to BioTransplant and the
Internal Revenue Service notices that the Eligix shares are not "U.S. real
property interests" under the Treasury Regulations of Sections 897 and 1445 of
the Internal Revenue Code or the Eligix stockholders will deliver to
BioTransplant certifications that they are not foreign persons based on the
Treasury Regulations under Section 1445 of the Internal Revenue Code. If Eligix
fails to deliver these notices or the Eligix stockholders fail to deliver these
certificates, BioTransplant has the right to withhold from the amount payable
(including any BioTransplant common stock) to the Eligix stockholders all
amounts required under Section 1445 of the Internal Revenue Code.


EXPENSES

    Each of BioTransplant and Eligix will bear its own costs and expenses,
including legal fees and expenses, incurred in connection with the merger.
However, if the merger is completed, Eligix will not incur more than an
aggregate of $375,000 in legal and accounting fees and expenses in connection
with the merger.

RELATED MATTERS AFTER THE MERGER

    At the time of the merger, BT/EL Acquisition Co. will be merged into Eligix,
and Eligix will become the surviving corporation in the merger and a
wholly-owned subsidiary of BioTransplant. Each share of BT/EL Acquisition Co.
common stock issued and outstanding immediately prior to the merger will be
converted into and exchanged for one validly issued, fully paid and
nonassessable share of common stock of the surviving corporation. The
certificate of incorporation of BT/EL Acquisition Co., as in effect immediately
prior to the time of the merger, will become the certificate of incorporation of
the surviving corporation, except that the name will be changed to
"Eligix, Inc." and the name of the incorporator shall be deleted. The bylaws of
BT/EL Acquisition Co. will become the bylaws of the surviving corporation,
except that the name will be changed to "Eligix, Inc."

INDEMNIFICATION OF BIOTRANSPLANT BY ELIGIX STOCKHOLDERS AND ELIGIX MANAGEMENT
MEMBERS


    The merger agreement provides that the holders of Eligix stock who receive
BioTransplant common stock in the merger and the Eligix management members who
receive BioTransplant common stock under the management equity incentive plan
will indemnify BioTransplant for any and all


                                       62


damages, subject to the limitations described below, that BioTransplant may
suffer as a result of any of the following:


    - a misrepresentation, breach of warranty or failure to perform any covenant
      or agreement of Eligix contained in the merger agreement;

    - any failure by any Eligix stockholder to have good, valid and marketable
      title to the outstanding shares of Eligix stock issued in the name of the
      Eligix stockholder, free and clear of all security interests; or


    - with respect to dissenting shares in excess of five percent and less than
      or equal to ten percent of the outstanding shares of Eligix stock as of
      the effective time, any written demand by an Eligix stockholder for a
      judicial determination of the fair value of his, her or its dissenting
      shares under Section 262 of the Delaware General Corporation Law, whether
      or not the stockholder withdraws his or her demand for appraisal prior to
      the effective time of the merger.


    The representations and warranties contained in the merger agreement
continue in effect for 15 months following the closing.

    To secure the indemnification obligations of the Eligix stockholders and
members of management, ten percent of the BioTransplant common stock that would
otherwise be payable to them in connection with the merger will be held in
escrow. Pursuant to the merger agreement, Robert Momsen and Pieter Schiller have
been designated as the representatives of the indemnifying holders with respect
to indemnification matters.

    The total liability of the indemnifying holders for their indemnification
obligations shall not exceed the fair market value of the indemnification escrow
shares held in escrow, and the indemnifying holders shall not be liable until
the aggregate claim for damages exceeds $500,000, at which time the indemnifying
holders shall be liable for amounts in excess of $500,000.

    No Eligix stockholder or member of management shall have a right of
contribution against Eligix or the surviving corporation with respect to any
breach by Eligix of any representation, warranty, covenant or agreement.

    Except with respect to claims based on fraud, after the closing of the
merger, the indemnification rights of BioTransplant are BioTransplant's
exclusive remedy with respect to claims resulting from or relating to any
misrepresentation, breach of warranty or failure to perform any covenant or
agreement contained in the merger agreement.

CONDITIONS TO OBLIGATIONS TO EFFECT MERGER

    The respective obligations of BioTransplant and Eligix to effect the merger
are subject to the satisfaction or waiver of the following conditions: (1) the
merger and merger agreement must have been approved by the stockholders of
Eligix, (2) the authorization of the issuance of shares of BioTransplant common
stock in connection with the merger must have been approved by the stockholders
of BioTransplant and (3) the registration statement on Form S-4 must have been
declared effective by the Securities and Exchange Commission and there must be
no stop order in effect suspending the effectiveness of the registration
statement or any proceedings pending that seek a stop order.

    In addition, the obligations of BioTransplant and BT/EL Acquisition Co. to
effect the merger are subject to the satisfaction or waiver of the following
conditions:

    - the holders of no more than 10% of the outstanding voting stock of Eligix
      have exercised appraisal rights;

                                       63


    - Eligix must have obtained all waivers, permits, consents, approvals or
      other authorizations, and effected the registrations, filings and notices,
      required by Eligix to effect the merger;


    - the representations and warranties of Eligix in the merger agreement must
      be true and correct as of the date of the merger agreement and at the
      effective time, except to the extent that the representation is
      specifically made as of a particular date or as of the date of the merger
      agreement, in which case the representation or warranty must be true and
      correct as of that date;

    - Eligix shall have performed or complied with in all material respects all
      agreements and covenants required to be performed or complied with under
      the merger agreement at or prior to the effective time of the merger;

    - no action, suit or proceeding shall be pending or threatened where an
      unfavorable judgment, order, decree, stipulation or injunction would
      prevent or cause the rescission of the merger or have a material adverse
      effect on Eligix, and no judgment, order, decree, stipulation or
      injunction of this type shall be in effect;

    - Eligix shall have delivered to BioTransplant a certificate making
      representations as required by the merger agreement;

    - BioTransplant must have received a letter from PricewaterhouseCoopers LLP,
      independent auditors of Eligix, containing statements and information of
      the type ordinarily included in accountants' "comfort letters";


    - BioTransplant shall have received an opinion from counsel to Eligix with
      respect to corporate matters as set forth in the merger agreement;


    - BioTransplant shall have received copies of resignations, effective as of
      the time the merger becomes effective, of each director and officer of
      Eligix;

    - BioTransplant shall have received an opinion from its counsel to the
      effect the merger is a reorganization for federal income tax purposes
      under Section 368(a) of the Internal Revenue Code;


    - with specified exceptions, as set forth in the merger agreement, the
      holders of at least 95% of the total number of outstanding shares of
      Eligix capital stock on a fully diluted basis will have signed a lock-up
      agreement or voting and transfer restriction agreement, as applicable, by
      the closing of the merger;


    - BioTransplant shall have received the other certificates and instruments
      that it reasonably requests in connection with the closing of the merger;

    - BioTransplant shall have received originally-executed voting and transfer
      restriction agreements from Eligix stockholders as required by the merger
      agreement;

    - the escrow representatives, the management members and the escrow agent
      must have entered into the escrow agreement;


    - there shall have been no material adverse change in the business,
      properties, operations, condition, assets or liabilities of Eligix and no
      event or events shall have occurred that could reasonably be expected to
      have a material adverse effect on Eligix, with specified exceptions, as
      set forth in the merger agreement, and BioTransplant shall have received a
      certificate signed on behalf of Eligix as required by the merger
      agreement;


    - each of the stockholder agreements, investor rights agreements and voting
      agreements entered into prior to the date of the merger agreement by the
      holders of Eligix stock, registration rights agreements entered into prior
      to the date of the merger agreement by Eligix and other similar

                                       64

      agreements, including agreements with holders of Eligix warrants and
      holders of Eligix notes, shall have been terminated by Eligix and each of
      the other parties to the agreements;

    - the Eligix board of directors shall have recommended to the stockholders
      of Eligix, and the stockholders shall have approved, an amendment to the
      Eligix amended and restated certificate of incorporation as required by
      the merger agreement and Eligix shall have taken all necessary or
      appropriate action to cause this amendment to the certificate of
      incorporation to be, and the certificate of incorporation, as so amended
      shall be, in full force and effect; and

    - the management members of Eligix shall have entered into employment offer
      letters and invention, non-disclosure and non-competition agreements as
      required by the merger agreement.

    In addition, the obligation of Eligix to effect the merger is subject to the
satisfaction of the following conditions:

    - BioTransplant shall have filed a notice with the Nasdaq National Market
      with respect to the listing of the shares of BioTransplant common stock
      issued in connection with the merger;

    - BioTransplant shall have obtained all of the waivers, permits, consents or
      authorizations, and effected all of the registrations, filings and
      notices, which are required by BioTransplant to effect the merger;

    - the representations and warranties of BioTransplant and BT/EL Acquisition
      Co. in the merger agreement must be true and correct as of the date of the
      merger agreement and at the effective time, except to the extent that the
      inaccuracy of any representation is specifically made as of a particular
      date or as of the date of the merger agreement, in which case the
      representation or warranty must be true and correct as of that date;

    - each of BioTransplant and BT/EL Acquisition Co. must have performed or
      complied with, in all material respects, all agreements and covenants
      required to be performed or complied with by it under the merger agreement
      at or prior to the effective time of the merger;

    - no action, suit or proceeding shall be pending or threatened where an
      unfavorable judgment, order, decree, stipulation or injunction would
      prevent or cause the rescission of the merger or have a material adverse
      effect on BioTransplant, and no judgment, order, decree, stipulation or
      injunction of this type shall be in effect;

    - BioTransplant shall have delivered to Eligix a certificate making
      representations as required by the merger agreement;

    - Eligix must have received a letter from Arthur Andersen LLP,
      BioTransplant's independent auditors, containing statements and
      information of the type ordinarily included in accountants' "comfort
      letters";


    - Eligix must have received an opinion from counsel to BioTransplant with
      respect to corporate matters as set forth in the merger agreement;


    - Eligix shall have received an opinion from its counsel in a form
      satisfactory to Eligix to the effect the merger is a reorganization for
      federal income tax purposes under Section 368(a) of the Internal Revenue
      Code;

    - Eligix shall have received the other certificates and instruments that it
      reasonably requests in connection with the closing of the merger;

    - BioTransplant, the escrow representatives, the Eligix management members
      and the escrow agent shall have executed the escrow agreement;

                                       65

    - BioTransplant shall have entered into employment offer letters and
      invention, non-disclosure and non-competition agreements with the Eligix
      management members as required by the merger agreement; and

    - there shall have been no material adverse change in the business,
      properties, condition, assets or liabilities of BioTransplant and no event
      or events shall have occurred that could reasonably be expected to have a
      material adverse effect on BioTransplant, with certain exceptions, and
      Eligix shall have received a certificate signed on behalf of BioTransplant
      as required by the merger agreement.

TERMINATION; BREAKUP FEES

    The merger agreement may be terminated at any time prior to the closing of
the merger as follows:

    - BioTransplant and Eligix may terminate the merger agreement by mutual
      written consent;


    - BioTransplant or Eligix may terminate the merger agreement if the other
      party is in breach of any representation, warranty or covenant contained
      in the merger agreement, which breach causes the other party to be unable
      to "bring down" the representations, warranties and covenants at closing,
      and the breach is not remedied within 20 days of delivery of written
      notice;


    - BioTransplant or Eligix may terminate the merger agreement by giving
      written notice to the other parties at any time after the Eligix
      stockholders have voted on, and failed to approve, the merger agreement or
      the BioTransplant stockholders have voted on, and failed to approve, the
      issuance of the BioTransplant shares in connection with the merger; or

    - BioTransplant or Eligix may terminate the merger agreement by giving
      written notice to the other party if the closing has not occurred on or
      before April 30, 2001 by reason of the failure of any condition precedent
      to the terminating party's closing of the merger, unless the failure
      results primarily from a breach by the terminating party of any
      representation, warranty or covenant contained in the merger agreement.


    If either BioTransplant or Eligix terminates the merger agreement for any of
the reasons stated above, all obligations of the parties under the merger
agreement shall terminate and there will be no liability, except that if the
merger agreement is terminated by either party as a result of the other party's
failure to perform or comply in all material respects with the agreements and
covenants under the merger agreement, the non-terminating party will pay the
terminating party $2.0 million in cash.


AMENDMENT AND WAIVER


    Generally, the boards of directors of BioTransplant and Eligix may amend the
merger agreement at any time prior to the effective time. However, after the
stockholders of Eligix approve the merger and/or the BioTransplant stockholders
approve the issuance of the shares, any amendment will be restricted by the
Delaware General Corporation Law, and no amendment shall be made that by law
requires further approval by the Eligix and/or BioTransplant stockholders
without the necessary approval. Amendments must be in writing and signed by all
parties and waivers must be in writing and signed by the waiving party.


                                       66

                                OTHER AGREEMENTS

VOTING AND TRANSFER RESTRICTION AGREEMENTS


    Contemporaneously with the execution of the merger agreement, BioTransplant
entered into voting and transfer restriction agreements with officers, directors
and 5% holders of Eligix owning approximately 66.4% of the combined voting power
of the outstanding capital stock of Eligix, 67.3% of the voting power of the
outstanding preferred stock of Eligix and 67.3% of the voting power of the
outstanding Series A preferred stock and Series B preferred stock of Eligix.
Under the voting and transfer restriction agreements, each signing stockholder
has agreed to vote, and has executed an irrevocable proxy to vote, all shares of
Eligix common and preferred stock in the following manner:


    - in favor of adoption of the merger agreement, the merger, or any matter
      that reasonably could be expected to facilitate the merger, including the
      proposed certificate of amendment to the Eligix certificate of
      incorporation;

    - in opposition to any matter inconsistent with the merger; and

    - not in favor of any competing acquisition for all or a majority of the
      outstanding capital stock or assets of Eligix.

    The stockholders who have signed the voting and transfer restriction
agreements further agree not to solicit, encourage or recommend that other
Eligix stockholders:

    - vote their shares in a manner contrary to the merger;

    - not vote their Eligix shares at all;


    - tender, exchange or otherwise dispose of their shares in connection with
      an offer to buy all or a majority of the outstanding capital stock or
      assets of Eligix from an entity other than BioTransplant; or


    - attempt to exercise any appraisal rights or other similar rights a
      stockholder may have.


    During the term of the voting and transfer restriction agreement, each
signing stockholder has agreed not to sell, transfer, pledge or otherwise
dispose of, or reduce an interest in or risk relating to, any of the shares of
Eligix stock that he or she owns unless the transfer is pursuant to the terms of
the merger agreement or the transferee of the shares agrees to be bound by the
voting and transfer restriction agreement. Each signing stockholder has also
agreed, with respect to the BioTransplant common stock owned as a result of the
transactions contemplated by the merger agreement, not to sell, transfer, pledge
or otherwise dispose of, or reduce an ownership interest in the shares as set
forth below:


    - for a period of 90 days following the effective time of the merger, any of
      its, his or her shares;

    - for the period beginning on the 91st day following the effective time and
      ending 180 days after the effective time, 66 2/3% of its, his or her
      shares;

    - for the period beginning on the 181st day following the effective time and
      ending on the 270th day following the effective time, 33 1/3% of its, his
      or her shares; and

    - for the period beginning on the 271st day following the effective time and
      ending on the 365th day after the effective time, 10% of its, his or her
      shares.


    If BioTransplant enters into a registered public offering of its stock at
any time during the one-year period following the effective time, the signing
stockholders agree, upon the request of BioTransplant and the managing
underwriter, not to sell, transfer, pledge or otherwise dispose of any of its,
his or her shares received in connection with the merger for a period of up to
90 days following the effective date of the registration statement. This 90-day
restriction will not apply if the officers and directors of BioTransplant are
not bound by the same terms.


                                       67


    The signing stockholder further agrees not to offer, sell, transfer, pledge
or otherwise dispose of shares owned by him or her as a result of the
transactions contemplated by the merger agreement unless (1) done in a manner
consistent with the provisions of Rule 145 of the Securities Act of 1933,
(2) by means of a registration statement covering the proposed sale or transfer,
or (3) the selling stockholder furnishes an opinion of counsel stating
registration of the shares under the Securities Act of 1933 is not required for
their sale or transfer.


LOCK-UP AGREEMENTS


    As a condition to the closing of the merger, the holders of at least 95% of
the total number of outstanding shares of Eligix capital stock at the effective
time, on a fully-diluted basis, subject to specified exceptions, must enter into
lock-up agreements or voting and transfer restriction agreements with
BioTransplant. Under the lock-up agreements, the signing stockholders agree,
with respect to the shares of BioTransplant common stock owned as a result of
the transactions contemplated by the merger agreement, not to sell, transfer,
pledge or otherwise dispose of, or reduce an interest in or risk relating to the
shares as set forth below:


    - for a period of 90 days following the effective time of the merger, any of
      its, his or her shares;

    - for the period beginning on the 91st day following the effective time and
      ending 180 days after the effective time, 66 2/3% of its, his or her
      shares;

    - for the period beginning on the 181st day following the effective time and
      ending on the 270th day following the effective time, 33 1/3% of its, his
      or her shares; and

    - for the period beginning on the 271st day following the effective time and
      ending on the 365th day after the effective time, 10% of its, his or her
      shares.


    If BioTransplant enters into a registered public offering of its stock at
any time during the one-year period following the effective time, the signing
stockholders agree that, upon the request of BioTransplant and the managing
underwriter, not to sell, transfer, pledge or otherwise dispose of any of its,
his or her shares received in connection with the merger for a period of up to
90 days following the effective date of the registration statement. This 90-day
restriction will not apply if BioTransplant's officers and directors are not
bound by the same terms.


ESCROW AGREEMENT

    BioTransplant will deposit in escrow, with The American Stock Transfer and
Trust Company, as escrow agent, certificates representing 20% of the shares of
BioTransplant common stock issuable to the holders of Eligix stock and the
management members for the purpose of securing:


    - the indemnification obligations of the Eligix stockholders and the
      management members under the merger agreement (one half of the escrow
      shares); and


    - the payment of milestone escrow shares to the Eligix stockholders and
      management members subject to Eligix receiving the CE mark, which denotes
      conformity with European standards for safety, for the TCell-HDM product
      on or before December 31, 2001 (one half of the escrow shares).

    The escrow shares will be issued in the name of the escrow agent or its
nominee and may not be transferred or assigned while held in escrow, other than
by operation of law. BioTransplant will pay all of the fees of the escrow agent
for services performed under the escrow agreement.

    BioTransplant and the Eligix stockholders and management members whose
shares are held in escrow agree to jointly and severally indemnify the escrow
agent for carrying out any duties under the escrow agreement.


    In the event BioTransplant distributes any securities in respect to, or in
exchange for, the shares of BioTransplant common stock by way of a stock
dividend, stock split or otherwise, these securities shall


                                       68


be issued in the name of the escrow agent or its nominee and delivered to the
escrow agent who shall hold the shares in escrow. In the event BioTransplant
distributes cash dividends or property other than securities, in respect to the
shares held in escrow, the cash or property shall be promptly distributed by the
escrow agent to those for whom the BioTransplant shares are being held in
escrow.



    Under the escrow agreement, the escrow shares will be voted by the escrow
agent on behalf of the Eligix stockholders and management members consistent
with instructions received by the escrow agent from the escrow representatives.
In the absence of these instructions, the escrow agent will not vote the shares
held in escrow.



    The escrow agent shall distribute the BioTransplant shares held in escrow
(1) based on, and consistent with, a written instrument signed by BioTransplant
and the escrow representative or (2) based on, and consistent with, the written
directive of a court. In the event neither of the preceding occurs, the escrow
agent shall distribute fifty percent of the shares in escrow to the persons in
whose names the shares are registered upon the achievement of milestones
established in the escrow agreement and fifty percent to the persons in whose
names the shares are registered after the passage of 15 months following the
execution of the escrow agreement. If the milestone established in the merger
agreement is not satisfied, the escrow agent will deliver fifty percent of the
shares in escrow to BioTransplant. If BioTransplant asserts an indemnification
claim, some (but no more than the number of indemnification escrow shares) of
the shares held in escrow will remain in escrow and be distributed upon
resolution of the indemnification claim.


AFFILIATE AGREEMENTS


    To ensure compliance with the Securities Act of 1933, the directors,
executive officers and principal stockholders of Eligix have entered into
affiliate agreements with BioTransplant. Under the affiliate agreements, the
signing stockholders have agreed not to offer, sell, transfer, pledge or
otherwise dispose of, or reduce an interest in or risk relating to, shares owned
by it, him or her as a result of the transactions contemplated by the merger
agreement, unless: (1) done in a manner consistent with the provisions of
Rule 145 of the Securities Act of 1933, (2) by means of a registration statement
covering the proposed sale or transfer, or (3) the selling stockholder furnishes
an opinion of counsel stating registration of the shares under the Securities
Act of 1933 is not required for their sale or transfer.


EMPLOYMENT OFFER LETTERS


    Under the merger agreement, each of the twelve management members of Eligix
will receive an employment letter from BioTransplant offering that employee a
position at BioTransplant. Please see the form of employment offer letter, which
is Exhibit G to the merger agreement, which is attached as Annex A to this joint
proxy statement/prospectus. The letter states that the employee is eligible to
receive the following:


    - a salary paid on a semi-monthly basis;

    - an annual cash bonus;


    - stock distributions under the annual merit-based stock option program;


    - severance payments;

    - medical, dental, life and long-term disability insurance; and

    - three weeks paid vacation.

                                       69

    The terms of the offer letters for the six executive officers within Eligix
management are:




                                                                                        PROPOSED TITLE
                        CURRENT TITLE   PROPOSED BASE      TARGET         SEVERANCE           AT
NAME                      AT ELIGIX        SALARY       CASH BONUS %       PAYMENT       BIOTRANSPLANT
----                   ---------------  -------------   ------------   ---------------  ---------------
                                                                         
Walter C. Ogier         President and      $240,000          35%          1 year at      President and
                       Chief Executive                                   double base    Chief Operating
                           Officer                                         salary           Officer

James R. Fitzgerald,     Senior Vice        190,000          25         6 months base   Executive Vice
  Jr.                    President,                                        salary         President,
                         Finance and                                                      Finance and
                         Operations,                                                    Administration
                       Chief Financial
                           Officer

David N. Cook, Ph. D.    Senior Vice        187,500          25         6 months base     Senior Vice
                         President,                                        salary         President,
                        Research and                                                      Development
                         Development

Tara Clark             Vice President,      130,000          20         6 months base   Vice President,
                          Marketing                                        salary          Marketing

James A. Embree        Vice President,      157,504          20         6 months base   Vice President,
                        Manufacturing                                      salary        Manufacturing

Judith Snow            Vice President,      145,000          20         6 months base   Vice President,
                           Quality                                         salary           Quality
                          Assurance                                                        Assurance



    Employment with BioTransplant is contingent upon the employee signing an
Invention, Non-Disclosure and Non-Competition Agreement with BioTransplant.

INVENTION, NON-DISCLOSURE AND NON-COMPETITION AGREEMENTS


    BioTransplant requires all of its employees to enter into an invention,
non-disclosure and non-competition agreement upon commencement of employment.
Accordingly, all employees of Eligix hired by BioTransplant, including the
twelve management members of Eligix, must execute an invention, non-disclosure
and non-competition agreement upon the closing of the merger.



    Under the terms of this agreement, an employee agrees that all proprietary
information relating to BioTransplant's business that is of a confidential
nature is the exclusive property of BioTransplant and will not be disclosed to a
person or entity that is not employed by BioTransplant without BioTransplant's
prior written approval. Upon the request of BioTransplant or upon an employee's
termination, any proprietary information reduced to a tangible form, and any
copies thereof, will be delivered to BioTransplant by the employee. The
employee's obligation not to use or disclose and to return material extends to
information, material and tangible property of customers, suppliers and third
parties who have disclosed the same to BioTransplant.



    Under this agreement, the employee agrees to promptly disclose to
BioTransplant all inventions, improvements, discoveries, methods, developments,
software and works of authorship, collectively referred to as inventions,
created or reduced to practice during the term of employment at BioTransplant.
Further, the employee agrees to assign to BioTransplant all right, title and
interest in inventions, patents, patent applications, copyrights and copyright
applications. An employee is not required to assign his or her interest in an
invention if the invention is made during non-business


                                       70


hours, at a location other than BioTransplant and without BioTransplant's tools,
equipment or proprietary information.


    For the duration of his/her employment and the subsequent two years, the
employee agrees not to:

    - own any interest in, lend to, hold any position in, or perform any work on
      behalf of any entity, including on the employee's own behalf, that is
      competitive with products developed, designed, produced or sold by
      BioTransplant during his/her employment at BioTransplant;

    - divert, take away or attempt to take away clients, customers or accounts,
      potential or otherwise, of BioTransplant which were served or contacted
      while the employee was employed by BioTransplant; or

    - directly or indirectly recruit, solicit, or hire any employee of
      BioTransplant or cause, or attempt to cause, an employee of BioTransplant
      to terminate or otherwise cease his/her relationship with BioTransplant.


    The employee further agrees to represent that he/she is not bound by the
terms of any non-disclosure or non-compete agreement with another entity, other
than those disclosed in writing to BioTransplant. Additionally, any employee
signing the agreement agrees to represent that, in carrying out the terms and
duties of employment (1) he/she will not violate any agreements prohibiting the
disclosure of confidential information of another entity and (2) he/she will not
disclose or cause BioTransplant to use confidential information or material
belonging to any other entity or person.


                                       71

                      INFORMATION CONCERNING BIOTRANSPLANT

                                    BUSINESS

COMPANY OVERVIEW

    BioTransplant is developing pharmaceutical products and systems to enable
the body's immune system to better tolerate the transplantation of foreign
cells, tissues and organs. Our lead product, MEDI-507, is being developed in
collaboration with MedImmune, Inc. We are also independently developing other
proprietary technology, which we refer to as ImmunoCognance technology, which is
based upon mixing elements of a donor's immune system with that of a patient in
a manner that enables the patient to recognize the donor's tissues as if those
foreign tissues belonged to the patient. We believe that our ImmunoCognance
technology will have the following benefits when compared to current
technologies:

    - improve clinical outcomes in bone marrow transplantation for cancer and
      other diseases;

    - reduce or eliminate the need for long-term administration of potentially
      debilitating immunosuppressive drugs to a patient after a transplantation
      procedure;

    - minimize infections and health complications that may result from
      conventional therapies used in connection with the transplantation of
      foreign cells, tissues and organs;

    - reduce the cost of treating end-stage organ disease; and

    - increase the supply of cells, tissues and organs available for
      transplantation procedures.

    Based upon our ImmunoCognance technology, we are developing a portfolio of
products designed to improve therapies associated with organ and bone marrow
transplantation as well as to improve the treatment of cancer, autoimmune
diseases and blood disorders. Our AlloMune System for Cancer is currently in a
multi-center Phase I/II clinical trial for therapy-resistant lymphoma, and we
anticipate filing an investigational new drug application in 2001 for a Phase I
clinical trial in patients with advanced melanoma and kidney cell tumors. We
expect that Phase I clinical studies of our AlloMune System for Transplantation
for human kidney transplantation will begin in 2001.

    In September 2000, we and Novartis Pharma AG formed a new company, Immerge
BioTherapeutics AG, to conduct further research in the area of
xenotransplantation, which is the transplantation of cells, tissues and organs
from one species to another. We and Novartis contributed our respective
technology and intellectual property to Immerge. Novartis owns 67% of Immerge,
and we own 33%. See "--Collaborations and Agreements--Novartis/BioTransplant
Joint Venture."

    We are working with MedImmune in the development of MEDI-507. We have
exclusively licensed MEDI-507 to MedImmune as a stand-alone agent, and we are
entitled to royalties on the sale of the drug, as well as milestone payments for
the achievement of specific product-related milestones. MEDI-507 is currently in
Phase I/II clinical trials for the treatment of psoriasis, and we expect that
Phase II clinical trials for the treatment of psoriasis will begin in 2001.
MedImmune has completed Phase I/II trials for graft-versus-host disease, an
often fatal outcome of bone marrow transplantation procedures.

    In addition to our corporate collaboration with MedImmune and our joint
venture with Novartis, we are collaborating with a number of other
organizations, including the Massachusetts General Hospital, in the field of
cell, tissue and organ transplantation.


    We believe that we have built a strong patent portfolio relating to our
technology. As of February 28, 2001, we owned or had licensed 37 issued United
States patents and 39 allowed or pending United States patent applications, as
well as foreign counterparts for some of the patent applications.


                                       72

INDUSTRY OVERVIEW

    TRANSPLANTATION BIOLOGY

    The immune system is one of the major biological defense mechanisms
protecting an individual against disease and invasion by disease-carrying
agents, referred to as pathogens. In the context of transplantation, the immune
system can distinguish self from foreign, non-self, cells by recognizing
specific markers on cells called antigens. The immune system is capable of
producing a biological response to clear and destroy the cells carrying the
foreign, non-self antigens.

    When an individual receives a cell, tissue or organ transplant, the
recipient's immune system generally recognizes the transplanted tissue as
foreign and initiates an immune response, resulting in rejection of the foreign
cell, tissue or organ. This immune response results from the recognition by the
immune system of foreign antigens on the surface of the cells of the donor that
are different from those of the recipient. If, as in the case of identical
twins, the antigens of the donor and the recipient are identical, no rejection
response occurs. In all other cases, differences between antigens can provide
sufficient stimulus to cause an immune response and, consequently, rejection of
the cell, tissue or organ.

    Throughout an individual's life, the immune system reacts to foreign
antigens and develops white blood cells known as T cells that are capable of
recognizing and responding to specific foreign antigens. T cells learn to
distinguish self from non-self when they mature in a specialized organ called
the thymus. This maturation step induces tolerance to the individual's own
antigens. When mature antigen-specific T cells recognize antigens in
transplanted tissue, they become activated and initiate a cascade of events,
including the proliferation of T cells and another type of white blood cell,
known as B cells. Certain activated T cells can kill cells bearing foreign
antigens and B cells are capable of producing antigen-specific proteins called
antibodies. Antibodies can bind to foreign cells or proteins and lead to their
destruction or clearance from the body.

    There are two primary types of immune response to transplanted foreign
tissue--hyperacute and acute rejection. Hyperacute rejection occurs immediately
upon transplantation and results from the reactivity of pre-existing antibodies
with antigens presented by the donor tissue. In hyperacute rejection, the donor
cell, tissue or organ is destroyed within hours and no treatment is currently
available. Acute rejection occurs after transplantation of a cell, tissue or
organ when T cells recognize the antigens of the donor as foreign, become
activated and, over a period of days or weeks, initiate a rejection response
that may lead to the ultimate loss of the cell, tissue or organ. Approximately
50% of organ transplant patients will experience an acute rejection episode in
the first year after transplantation.


    The current approach to preventing acute rejection in transplant patients is
to administer a combination of immunosuppressive medications, which suppress the
ability of T cells to recognize and respond to antigens. These medications,
however, not only inhibit T cells from recognizing antigens of donor cells,
tissues or organs, but also block the patient's T cells from recognizing other
foreign antigens. As a result, the transplant recipient is vulnerable to viral,
bacterial and fungal infections. In addition, long-term use of these
immunosuppressive drugs can lead to cardiovascular disease, kidney and liver
damage, as well as an increased incidence of some types of cancer such as skin
and lip cancer and lymphomas. Most importantly, despite the administration of
various immunosuppressive medications, instances of rejection still occur
frequently and may necessitate increased doses of immunosuppressive drugs or
inclusion of other anti-rejection therapies, thus compounding unwanted side
effects and complications. If the rejection cannot be controlled, the rejected
cell, tissue or organ must be removed and another transplant will be required.


                                       73

    BONE MARROW TRANSPLANTATION

    Bone marrow contains cells, referred to as stem cells, which have the
ability to develop into the different kinds of blood cells in the human body.
When bone marrow containing these stem cells is collected from one individual
and transplanted into a recipient who has been conditioned with irradiation or
chemotherapy, the stem cells from the donor bone marrow take root, or engraft,
into the bone marrow of the recipient and replace some or all of the recipient's
blood cells. Because it is often easier to collect the stem cells from blood
rather than bone marrow, a donor can be treated with chemical agents that induce
the stem cells to migrate from the bone marrow into the blood. Thus, the same
effect can be achieved by transplanting either bone marrow or blood from
pretreated individuals. For simplicity, we use the term bone marrow
transplantation to refer to the transplantation of stem cells from either bone
marrow or blood.

    Bone marrow transplantation is used as a treatment for:

    - certain types of cancers, including:

           - kidney cell tumors,

           - breast tumors,

           - certain childhood cancers, such as Ewing's sarcoma, and

           - hematologic, or blood cell, cancers such as acute and chronic
             leukemia, lymphoma, and multiple myeloma;

    - certain congenital immune system deficiencies; and

    - bone marrow failure, referred to as aplastic anemia.

    Researchers are also investigating experimentally bone marrow
transplantation for:

    - the treatment of certain metabolic diseases, such as Hurler's syndrome;

    - genetic disorders, such as sickle cell anemia and thalassemia; and

    - severe autoimmune diseases, such as therapy-resistant psoriasis and
      rheumatoid arthritis.

    There are two types of bone marrow transplantation that are currently
performed: autologous bone marrow transplantation and allogeneic bone marrow
transplantation.

    AUTOLOGOUS BONE MARROW TRANSPLANTATION.  In autologous transplantation,
doctors treat the patient with high-dose chemotherapy to kill the tumor, and use
the patient's own bone marrow cells, harvested prior to administration of the
chemotherapy, to reconstitute the patient's bone marrow cells following the
chemotherapy treatment. In autologous transplantation, the goal of
administration of the bone marrow that had been harvested prior to the
chemotherapy is to overcome the damage to the patient's bone marrow that occurs
during the chemotherapy.

    ALLOGENEIC BONE MARROW TRANSPLANTATION.  In allogeneic transplantation, the
patient receives transplanted bone marrow cells harvested from a healthy donor.
In allogeneic transplantation for cancer, not only does the bone marrow
transplantation overcome the damage that the chemotherapy causes to the bone
marrow, but the transplanted donor immune cells also may be capable of
eradicating the patient's tumor. In allogeneic transplantation for metabolic
diseases and genetic disorders, the infusion of donor cells allows for the
recovery of healthy, metabolically normal donor cells to replace the recipient's
genetic defects. In autoimmune disease, the body's immune response becomes
abnormal in that it mistakenly recognizes its own cells or tissues as non-self.
For allogeneic transplantation for severe autoimmune disease, the goal is to
ablate, or destroy, the patient's malfunctioning immune system and replace it
with the donor immune system. We expect this treatment

                                       74

to result in the patient's reconstituted immune system ceasing to recognize its
own cells or tissues as non-self and tolerating them.

    In conventional autologous or allogeneic bone marrow transplantation,
patients first undergo a pre-transplant process called ablation in which their
diseased bone marrow is destroyed by either intense radiation or chemotherapy,
essentially wiping out their immune system. More recently, milder conditioning
regimens have been introduced to minimize the damage of the chemotherapy. The
use of milder, non-ablative preparatory regimens has expanded the group of
patients eligible for bone marrow transplantation.

    Differences in the antigens of donor and recipient significantly limit donor
availability for allogeneic bone marrow transplantation. Even when the donor and
the recipient are tissue-matched siblings, complications such as
graft-versus-host disease, poor immune function, and graft failure can occur
from minor antigen differences between donor and recipient as well as from the
side effects caused by the treatments used to overcome these differences.
Graft-versus-host disease is a potentially fatal complication of allogeneic
transplantation in which the donor cells, once transplanted in the patient,
recognize the patient as non-self, and attack the patient's normal tissues, such
as the skin, gastrointestinal track and liver. Moderately severe to
life-threatening acute graft-versus-host disease occurs in 10 to 50% of patients
given an allogeneic transplantation from a tissue-matched sibling donor. A
significantly higher incidence and severity of the disease is reported in
patients receiving transplants from partially matched family donors or unrelated
volunteers. The treatment for graft-versus-host disease includes steroids and
other immunosuppressive drugs. However, up to 50% of patients do not respond to
steroids and other currently-available immunosuppressants, and a significant
number of these patients will die as a result of the graft-versus-host disease.

    To minimize the possibility of graft-versus-host disease, typically only
patients who have closely genetically matched donors are considered suitable
candidates for allogeneic bone marrow transplantation. The likelihood of having
a perfectly matched donor is only approximately 1%, which is the approximate
rate of identical twin births in the United States. Statistically, the
likelihood of any sibling being a full tissue match is 25%, and there is
approximately an additional 5% likelihood of finding a full tissue matched
relative in the extended family. Thus, there is approximately a 30% chance of
finding a suitably matched donor in the family, where suitability is defined as
being an appropriate donor for a conventional transplant. Because of the
difficulty in locating a fully tissue matched bone marrow donor, many patients
are unable to undergo the bone marrow transplantation procedure.

    ORGAN TRANSPLANTATION


    During the last two decades organ transplantation has become an established
therapy for end-stage organ disease due in part to the significant progress that
has been made since the introduction of cyclosporine by Novartis in 1983. In
1999, over 30,000 organ transplants were performed in patients suffering from
end-stage kidney, liver, heart and lung disease in the United States and Western
Europe. We estimate that patients in the United States spend over $5.0 billion
annually on organ transplantation. However, rejection of the transplanted organ
by the recipient's immune system frequently limits the success of these
procedures. To prevent rejection of the transplanted organ, recipients must
maintain a lifelong regimen of immunosuppressive therapy. Care subsequent to the
transplant accounts for over half of the costs of organ transplantation. These
post-transplant healthcare costs include costs associated with lifelong
immunosuppressive therapy and hospitalizations due to complications resulting
from the chronic use of immunosuppressive drugs, infections and transplant
rejections. Other treatments for end-stage organ disease, such as kidney
dialysis, are even more expensive. While dialysis is an option for the treatment
of kidney failure, many non-kidney transplant patients die while waiting for
organs. Accordingly, we expect that improvements in transplantation technology
that reduce the wait for suitable organs and minimize infections and other
complications,


                                       75


including retransplantation and the toxicities associated with chronic use of
immunosuppressive drugs, will lower the overall cost of treating end-stage organ
disease.


    There is a critical shortage of organs worldwide and waiting lists have been
established for potential organ transplant recipients. Over 74,000 patients in
the United States suffering from end-stage organ disease were on waiting lists
for a lifesaving organ transplant in 2000, based on data provided by the United
Network for Organ Sharing. This number has more than quadrupled since 1988, and
the number of deaths on the waiting list has increased proportionately. If an
adequate supply of transplant organs were available and the complications of
transplantation minimized, we estimate that an additional 100,000 critically ill
patients annually could benefit from treating end-stage organ disease by using
organ transplantation to replace disease-damaged organs instead of using
artificial devices.

    While the number of cadaver donors has increased in the last ten years, the
demand for organs has increased even more rapidly. Efforts to ease this organ
shortage through public campaigns and advertisements designed to enlarge the
pool of potential organ donors have been only moderately successful. Increased
automotive safety has adversely affected the donation rate by reducing the
number of deaths resulting from automobile accidents. In addition, we believe
the decline in the quality of organs available for transplant may reduce organ
graft half-lives, thereby increasing the need for additional organs to be used
in repeated transplantation procedures. The potential donor pool has also been
limited by the risk that allotransplantation, which is the transplantation of
organs between different individuals of the same species, can spread infectious
disease. Advances have been made in the procedures used to obtain multiple
organs from a single donor and in organ preservation techniques, but a severe
shortage of organs still exists and the backlog of patients awaiting
transplantation continues to grow. The shortage of donor organs restricts the
number of transplant procedures performed and forces many patients to undergo
costly and less effective alternatives to transplantation. This delay renders
transplant candidates much sicker at the time of transplantation than they would
have been if the organ transplant had been possible sooner.

                                       76

PRODUCTS UNDER DEVELOPMENT

    The following table summarizes the status of our, and our collaborator's and
joint venture's, product research and development programs:




PRODUCT UNDER DEVELOPMENT              INDICATION               STATUS*          COLLABORATOR
-------------------------     ----------------------------  ---------------   ------------------
                                                                     
MEDI-507....................  Psoriasis                     Phase I/II        MedImmune
                              Graft-Versus-Host Disease     Phase I/II        MedImmune

ALLOMUNE SYSTEM FOR           Lymphoma                      Phase I/II        None
  CANCER....................
                              Kidney Cell Tumors            Investigational   None
                                                            new drug
                                                            application in
                                                            preparation
                              Melanoma                      Investigational   None
                                                            new drug
                                                            application in
                                                            preparation
                              Other cancers                 Preclinical       None

ALLOMUNE SYSTEM FOR           Kidney Transplantation        Phase I           None
  TRANSPLANTATION...........
                              Congenital Blood Disorders    Preclinical       None
                              Autoimmune Diseases           Preclinical       None
                              Metabolic Diseases            Preclinical       None

                              Animal to Human               Preclinical       Joint Venture with
                              Transplantation                                 Novartis
XENOTRANSPLANTATION.........



------------------------
*   Preclinical means that the product is being evaluated or optimized in animal
    models. Phase I means an investigational new drug application, or IND, has
    been filed with the United States Food and Drug Administration and that the
    product candidate is in clinical trials to evaluate safety. Phase I/II means
    that the product candidate is in clinical trials for safety and potential
    efficacy.

    MEDI-507


    MEDI-507 is a novel and proprietary humanized monoclonal antibody derived
from the BTI-322 monoclonal antibody. A monoclonal antibody is a single antibody
that reacts to a specific antigen and can trigger or block an immune response.
Drs. Herve Bazin and Dominique Latinne of the Experimental Immunology Unit of
the Catholic University of Louvain, Belgium, discovered the BTI-322 monoclonal
antibody, the rodent precursor of MEDI-507. In early 1993, we obtained exclusive
rights to develop and commercialize the BTI-322 monoclonal antibody. We modified
the BTI-322 monoclonal antibody to create MEDI-507, a molecule more similar to a
human antibody, and in 1995 we formed a collaboration with MedImmune to develop
and commercialize products derived from MEDI-507. We are also independently
developing MEDI-507 as an important component of our AlloMune System and have
sublicensed to our joint venture with Novartis our rights to develop MEDI-507 as
part of a xenotransplantation system.



    MedImmune is focusing its initial development efforts with MEDI-507 for the
treatment of psoriasis and graft-versus-host disease. In psoriasis, an
autoimmune response leads to chronic inflammation and hyperproliferating skin,
as well as other more serious consequences. Graft-versus-host disease is an
often fatal outcome of bone marrow transplantation where white blood cells from
the donor bone marrow attack the tissue of the recipient.


                                       77

    We believe that MEDI-507 could be used to reduce undesired immune system
activity by binding to CD2, which is a receptor found on T cells. T cells are
immune cells that act as the agents of the immune system and are responsible for
part of the body's primary immune response to foreign antigens. When these
immune cells come in contact with foreign tissue, they become activated and
proliferate. The immune cells then attack and destroy the targeted foreign
tissue, or in the case of autoimmune disease, mistakenly attack the body's own
tissue. The theory behind MEDI-507's development plan is tied to its ability to
bind to the T cell and block activation of these cells. We expect that through
this process, MEDI-507 can either turn off the T cells completely or selectively
eliminate them from the body, while allowing other immune cells to respond
normally to other antigens.

    Clinical studies conducted by us and by others have demonstrated that
MEDI-507 has the potential to be a safe and effective agent for the prevention
and treatment of graft-versus-host disease, as well as transplant rejection. For
example, during 1999, MedImmune concluded a multicenter Phase I/II trial of
MEDI-507 in patients with severe acute graft-versus-host disease who had failed
previous treatment with corticosteroids, the most commonly used initial
treatment in this patient population. Seventeen patients with moderate to severe
graft-versus-host disease were given four doses of MEDI-507. Over the 100-day
observation period, 71 percent of the patients experienced a reduction in grade
of graft-versus-host disease; over half of the patients resolved their disease
at some point during the follow up.


    MedImmune is currently conducting additional Phase I/II clinical trials to
evaluate MEDI-507 for the treatment of graft-versus-host disease. One study of
this type, which was completed in 2000, examined the effect of adding MEDI-507
to conventional steroid treatment at the onset of graft-versus-host disease. In
this study, 34 adult patients who developed severe acute graft-versus-host
disease following a stem cell transplant or bone marrow transplant were treated
with steroids in addition to either four doses of MEDI-507 or a placebo. The
results demonstrated that the addition of MEDI-507 to steroid treatment at the
onset of graft-versus-host disease was well tolerated. In another study,
MedImmune is using an open label trial to assess the ability of MEDI-507 to
treat graft-versus-host disease in pediatric stem cell transplant or bone marrow
transplant patients. Currently, there are no agents approved for the treatment
of graft-versus-host disease in children. MedImmune did not design these initial
clinical trials to allow retreatment of the patient with MEDI-507.


    We believe that MEDI-507 may also be effective in treating T cell mediated
diseases such as psoriasis, inflammatory bowel disease, multiple sclerosis and
rheumatoid arthritis. Presently, MedImmune has completed a Phase I clinical
trial evaluating MEDI-507 and is conducting two Phase I/II clinical trials for
the treatment of psoriasis as a proof-of-concept for its use in autoimmune
disease. The results of the Phase I study showed that MEDI-507 was well
tolerated by the patients. We expect MedImmune to conduct Phase II trials for
this indication in 2001.

    In 1998, MedImmune received orphan drug designation from the Office of
Orphan Products Development of the FDA for the use of MEDI-507 in the treatment
of graft-versus-host disease. Congress enacted the Orphan Drug Act to encourage
development of drugs for rare diseases and conditions affecting a small patient
population, generally less than 200,000 people. Orphan drug designation of a
product can potentially provide a company with seven years of market exclusivity
if the company is the first to receive FDA product marketing approval for the
orphan drug in the designated indication. Additionally, this designation
provides a company with tax credits of 50% for clinical research expenses and
the opportunity for clinical research grants.

    ALLOMUNE SYSTEMS

    We are designing our AlloMune Systems to re-educate a patient's immune
system so that it does not reject transplanted cells, tissues and organs. We are
currently evaluating the use of our AlloMune

                                       78

Systems in the treatment of blood cell cancers and to reduce the need for
lifelong immunosuppressive therapy in connection with human organ transplants.

    The AlloMune System is a proprietary system that we are developing to
incorporate multiple components. We are designing it to allow a milder procedure
for allogeneic bone marrow transplantation and to reduce or eliminate the need
for lifelong immunosuppressive therapy in human-to-human organ transplantation.
Because the AlloMune System is expected to be suitable for elderly and
relatively infirm patients, as well as patients without tissue-matched donors,
we expect that it will enable a significantly expanded pool of patients to be
considered for transplantation. We expect that the AlloMune System will expand
the pool of eligible transplantation recipients by reprogramming the immune
system to recognize donor and patient as self, thereby overcoming the
complications that result when the patient or the donor recognizes the other's
cells, tissues and organs as non-self. This reprogramming of the immune system
is expected to be created by establishing a state of mixed bone marrow chimerism
between the donor and the patient with the use of MEDI-507.

    Mixed bone marrow chimerism refers to bone marrow in which the cells of both
the donor and the patient co-exist. To achieve mixed bone marrow chimerism, the
doctor first blocks the patient's immune response to the new foreign antigens
from the donor by giving the patient injections of anti-T cell antibody, such as
MEDI-507, which depletes the patient's mature T cells. The doctor performs this
process prior to the transplantation of the donor bone marrow into the patient.
Concurrent with the administration of the anti-T cell antibody, the patient
receives doses of radiation or, in the case of cancer patients, chemotherapy, to
make space in the patient's bone marrow and allow the transplanted bone marrow
to "seed" the newly created space. The doctor then injects bone marrow cells
from the donor into the patient.

    We and others have conducted studies that demonstrate that the creation of
the mixed bone marrow chimerism will cause the patient to tolerate the donor
antigens and regard them as antigens of the patient. By regarding the donor's
antigens as self, the patient's immune system retains its ability to respond to
foreign pathogens without rejecting cells, tissues or organs transplanted from
the bone marrow donor. In addition, in the case of blood cell cancers, the
creation of mixed bone marrow chimerism allows the immune cells from the donor
to preferentially attack the cancer cells rather than the patient's own cells.


    ALLOMUNE SYSTEM FOR CANCER.  We are developing our AlloMune System to treat
several types of blood cancers, such as lymphomas, leukemias and myelomas, as
well as other malignancies such as kidney cell tumors, melanoma and other
cancers. We are designing our AlloMune System for Cancer to re-program a
patient's immune defenses so that the patient can benefit from potentially life
saving bone marrow transplantation. By using a combination of chemotherapy and
the AlloMune System, we are seeking to make bone marrow transplants more
successful by allowing the transplanted bone marrow to aggressively attack
cancer cells but not the patient's own immune defenses, and without the side
effects of graft-versus-host disease or the morbidity caused by destroying the
patient's own bone marrow, as is done in conventional bone marrow transplants.


    We are designing the AlloMune System for Cancer to employ a less-intensive,
non-ablative amount of chemotherapy, which we believe will increase the types of
disease conditions that can be treated, as well as patients' ability to tolerate
the treatment. We believe that doctors can administer this regimen safely to
patients who, because of their age or concomitant other medical problems, would
not have been suitable transplant candidates with ablative regimens.

    In 1999, our research collaborator, Massachusetts General Hospital,
performed a study under an investigational new drug application using a
prototype of the AlloMune System for Cancer with 21 patients having
therapy-resistant blood cancers, including lymphomas. Results of the study
demonstrated that treatment led to an overall positive response rate of 67% (38%
complete response, 29% partial response). In a recent extension of that study,
Massachusetts General Hospital

                                       79

demonstrated the feasibility of using this prototype AlloMune System for
transplantation using donors who were not fully tissue matched.

    In early 2000, we initiated a Phase I/II clinical trial of our AlloMune
System for Cancer to treat patients with therapy-resistant lymphoma under an
investigational new drug application. We expect to complete our Phase I/II
clinical trial in late 2001. We are planning to file an investigational new drug
application and begin studies in patients with solid tumors in 2001.

    ALLOMUNE SYSTEM FOR TRANSPLANTATION.  We are also developing the AlloMune
System for Transplantation to re-program the patient's immune system to accept a
transplanted donor organ without the need for life-long immunosuppressive
therapy. During 1999, we received clearance of an investigational new drug
application with the FDA to begin a Phase I clinical trial of the AlloMune
System for Transplantation in living-donor kidney transplantation. Recent
results from our cancer clinical studies have led us to make changes to the
protocol for this Phase I clinical trial.

    Our academic collaborators at the Massachusetts General Hospital have
initiated a hospital internal review board-approved Phase I/II
proof-of-principle evaluation of the prototype AlloMune System for
transplantation in humans. Physicians at Massachusetts General Hospital treated
the initial patient under the investigational new drug application for myeloma,
a blood cell cancer, and end-stage kidney disease using a prototype AlloMune
System approach. The patient received both a kidney transplant and a bone marrow
transplant more than two years ago. The patient has been free of
immunosuppressive drugs for nearly two years and has normal kidney function, no
evidence of graft-versus-host disease, and her myeloma is at nearly undetectable
levels.

    XENOTRANSPLANTATION

    Xenotransplantation refers to the transplantation of cells, tissues or
organs from one species to another. Xenotransplantation is intended to address
the problems arising from the limited supply of available human cells, tissues
and organs for transplantation by developing technologies to permit the
transplantation of cells, tissues and organs from other species, such as swine.
Since 1993, we have collaborated with Novartis to research and develop
xenotransplantation products.


    In September 2000, we entered into a joint venture with Novartis to continue
research on xenotransplantation products using the technology and intellectual
property that we and Novartis had previously developed, both independently and
in collaboration with one another. This joint venture began operations in
January 2001. The goal of the joint venture is to demonstrate the feasibility
and safety of swine to primate transplantation leading to clinical trials of
xenotransplantation for the treatment of end-stage organ failure in humans. We
expect that the joint venture will conduct this research in three general areas:


    - First, the joint venture will seek to demonstrate proof of concept for
      organ survival in primate model systems in collaboration with researchers
      at the Massachusetts General Hospital. These experiments will employ
      several technologies and procedures, including:

     - swine that carry human genes that inhibit hyperacute rejection, referred
       to as transgenic swine;

     - proprietary inbred miniature swine;

     - proprietary technology licensed from the Alberta Research Council, which
       removes natural antibodies from the recipient's blood prior to the
       transplant to reduce or eliminate hyperacute rejection;

     - immunosuppressive compounds; and

                                       80

     - the transplantation of pig thymus tissue to reprogram the recipient's
       immune system to recognize the donor tissue as self.

          Our objective is to extend the current survival times for swine organs
      transplanted into primates from approximately one month post-transplant to
      three to six months by destroying the pre-existing antibody-producing
      cells in combination with pig thymus tissue transplantation. We refer to
      this process as transplantation tolerance. Previous studies have
      demonstrated the ability of porcine, or pig, thymic tissue transplanted
      into a mouse to induce transplantation tolerance. In these studies,
      researchers documented permanent acceptance of pig skin transplants in
      mice with an otherwise normal immune system and specific T cell
      unresponsiveness to pig antigens in culture. Allogeneic large animal
      studies using inbred miniature swine have also demonstrated the ability of
      allogeneic pig thymic transplants to induce tolerance to kidney grafts
      from the donor of the thymic tissue in the absence of chronic
      immunosuppressive drug use.


    - Second, the joint venture will continue studies begun by us to examine the
      safety of porcine to human xenotransplantation. Others have demonstrated
      that a type of porcine viruses, referred to as porcine endogenous
      retroviruses, have the potential to infect human cells. We previously
      reported on the results of studies that documented the ability of one
      strain of miniature swine to be free of the porcine endogenous retrovirus
      types that have been shown to be capable of infecting human cells in
      culture.


    - Third, the joint venture will focus on adapting recent successes in
      porcine nuclear transfer technology in which a genetically modified
      miniature swine has been cloned with modifications that are believed to
      enhance the survival rates of porcine organs in primates.

    COLLABORATIONS AND AGREEMENTS

    As part of our strategy, we have established alliances with pharmaceutical
and other biotechnology companies, academic institutions, scientists and
government laboratories. Currently, our principal strategic alliances are the
following:

    MEDIMMUNE


    In October 1995, we formed a collaborative arrangement with MedImmune for
the development and commercialization of products to treat and prevent
rejection. The collaboration is based upon the development of products derived
from the BTI-322 monoclonal antibody, MEDI-507 and future generations of
products derived from these molecules. In connection with the collaboration, we
granted MedImmune an exclusive worldwide license to develop and commercialize
the BTI-322 monoclonal antibody and MEDI-507 and any products based on the
BTI-322 monoclonal antibody or MEDI-507, other than the use of the BTI-322
monoclonal antibody or MEDI-507 in kits or systems for xenotransplantation or
allotransplantation. MedImmune paid us a $2.0 million license fee at the time of
formation of the collaboration and agreed to fund and assume responsibility for
clinical testing and commercialization of any resulting products. MedImmune also
provided $2.0 million in non-refundable research support through December 31,
1997 and has agreed to make milestone payments which could total an additional
$11.0 million, all of which is repayable from royalties on the BTI-322
monoclonal antibody or MEDI-507. MedImmune has also agreed to pay royalties on
any sales of the BTI-322 monoclonal antibody or MEDI-507 and future generations
of products, if any. Royalties will depend, in part, upon the efforts of
MedImmune to perform clinical testing, obtain regulatory approvals and market
and sell the BTI-322 monoclonal antibody and MEDI-507. MedImmune controls the
amount and timing of the resources devoted to these activities.


                                       81

    DR. DAVID H. SACHS/THE MASSACHUSETTS GENERAL HOSPITAL


    In January 1991, we entered into a ten-year agreement with MGH, which was
extended for an additional five-year term in December 2000, under which we fund
a portion of the research of Dr. Sachs and other MGH personnel in the area of
transplantation of cells, tissues and organs. In exchange for our research
funding, MGH has granted us exclusive worldwide royalty-bearing rights to
technology and inventions developed in the course of research funded by us,
subject to a royalty to be paid to MGH and subject to customary retention rights
of the United States government. We also have a right of first refusal in
connection with any additional research proposals in the field of tissue and
organ transplantation to be submitted by Dr. Sachs and his colleagues, who are
funded by us, to other commercial sponsors.


    NOVARTIS/BIOTRANSPLANT JOINT VENTURE

    From 1993 through October 2000, we were party to two collaboration
agreements with Novartis to research, develop and commercialize
xenotransplantation products. During the collaboration, we received an aggregate
of $33.5 million in research funding and $16.5 million in license fees and
milestone payments from Novartis. In September 2000, we entered into an
arrangement with Novartis to combine our respective expertise in the field of
xenotransplantation into a newly-formed, independently-run Swiss company,
Immerge BioTherapeutics AG, and terminated our prior collaborations in
xenotransplantation.

    Novartis has committed to provide an aggregate of $30.0 million in research
funding over three years to the joint venture. Both we and Novartis have
exclusively licensed to the joint venture patent rights and technology in the
field of xenotransplantation. The joint venture has granted to Novartis an
exclusive, worldwide, royalty-bearing license to develop and commercialize any
xenotransplantation products resulting from its research. We will receive
royalties from the sale of xenotransplantation products by Novartis, if any.


    In December 2000, Immerge BioTherapeutics AG formed a wholly-owned Delaware
subsidiary, Immerge BioTherapeutics, Inc. The Delaware subsidiary expects to
enter into a contract research agreement with us, under which we will commit
approximately 20 full-time employees to perform research for the joint venture
and we will also agree to provide administrative services for the joint venture,
all at a rate to be negotiated.



    Novartis holds 67% of the shares of the joint venture and we hold the
remaining 33%. All income, gain, profit or loss of the joint venture will be
allocated to us and Novartis pro rata based on our respective equity ownership
of the joint venture in effect in the period in which these items accrue.
Initially, the board of directors of Immerge BioTherapeutics, Inc. will consist
of four directors: one selected by us, one selected by Novartis and two
additional directors, one each designated by us and Novartis, who are experts in
the field of xenotransplantation. Immerge BioTherapeutics AG has agreed not to
undertake, or permit its subsidiaries to undertake, specified fundamental
corporate actions without the consent of both shareholders. The joint venture
began operations in January 2001.


    CHARLES RIVER LABORATORIES


    According to the terms of a miniature swine transfer and maintenance
agreement with Charles River Laboratories, we and the joint venture will have
exclusive rights to use miniature swine that Charles River Laboratories is
developing for use in the allotransplantation and xenotransplantation programs,
respectively. The joint venture and BioTransplant will bear their proportionate
costs of maintaining the miniature swine herd. The agreement expires in 2003,
but the parties may agree to renew the agreement for an additional five-year
period.


                                       82


    STEM CELL SCIENCES LTD.



    According to the terms of a strategic alliance with Stem Cell Sciences Ltd.,
our joint venture with Novartis will have worldwide, exclusive rights, subject
to the payment of a royalty, to technology, products and processes for the
derivation and manipulation of porcine embryonic stem cells and nuclear transfer
technology developed during the research term and useful in xenotransplantation
in humans. We have made equity investments in Stem Cell Sciences that
represented 30% of the outstanding shares of that company. Stem Cell Sciences
has used substantially all of the consideration from our equity investment to
fund the research and development of nuclear transfer technology and, in
particular, the development of technology, products and processes useful for
xenotransplantation in humans. We made additional investments in Stem Cell
Sciences in 1996, 1997 and 1998 to maintain our 30% ownership position and to
support additional research through December 31, 1999. Stem Cell Sciences raised
additional equity during 2000, resulting in a dilution of our ownership to
approximately 25%.


    ALBERTA RESEARCH COUNCIL

    The Alberta Research Council has granted us a worldwide royalty-bearing
license for specified patents and patent applications covering technology
potentially useful for removal of natural antibodies against xenografts. We
expect to exclusively sublicense our rights under this agreement to our joint
venture with Novartis. The license is exclusive except for one patent
application directed to the removal of natural antibodies against xenografts,
which is co-owned by one of the inventors and was assigned to a competitor. The
Alberta Research Council has also granted a non-exclusive, worldwide, royalty-
bearing license to use any of its information, data, formulas or processing
information that pertain to the manufacture, development or use of any products
resulting from the licensed patents in the field of xenotransplantation.

    CATHOLIC UNIVERSITY OF LOUVAIN (BELGIUM)


    We are funding research by Drs. Herve Bazin and Dominique Latinne at the
Experimental Immunology Unit of the Catholic University of Louvain, Belgium, for
the development of monoclonal antibodies. We have exclusive, worldwide
royalty-bearing commercialization rights to discoveries, including the BTI-322
monoclonal antibody, made in laboratories under our sponsorship, subject to a
royalty.


MANUFACTURING AND SUPPLY


    We currently have no manufacturing facilities or staff for clinical or
commercial production of any products or systems under development. We plan to
rely initially on third parties to manufacture our product candidates for
research, preclinical testing, clinical trials and commercialization, if any,
with a long-term objective to develop internal manufacturing capability where
appropriate.


    MedImmune is manufacturing supplies of MEDI-507 required for preclinical
studies, clinical trials and commercial products using its own manufacturing
facilities. We have the option to continue to use MedImmune as a supplier or to
use an alternative manufacturer or supplier.

    Novartis has exclusive worldwide rights to manufacture xenotransplantation
products arising from the research program conducted by our joint venture with
Novartis.

SALES AND MARKETING

    Due to the early stage of our development efforts, we presently have no
marketing or sales personnel.

                                       83


    MedImmune has exclusive worldwide marketing rights to the BTI-322 monoclonal
antibody, MEDI-507 and future generations of these products, if any, other than
the use of the BTI-322 monoclonal antibody and MEDI-507 for kits or systems for
xenotransplantation and allotransplantation.



    We currently hold all marketing rights to the AlloMune System, although we
may seek a corporate partner to support the development and commercialization of
the AlloMune System. In the United States, we currently intend to market the
AlloMune System for solid organ transplantation and cancer related products and
systems to the approximately 250 transplant centers, which we believe will allow
significant market coverage with relatively few sales personnel. To implement
this marketing strategy, we intend to hire a limited number of sales and
marketing personnel. In foreign markets, we expect to use local pharmaceutical
companies to market our products and systems due to the complexities of foreign
regulations and medical practices.


    Novartis has exclusive worldwide rights to market and sell
xenotransplantation products arising from the research program conducted by our
joint venture with Novartis.

RESEARCH AND DEVELOPMENT


    Our total research and development expenses were $14.7 million,
$15.7 million and $15.0 million for 1998, 1999 and 2000, respectively.
Collaborative research and development revenues totaled $6.7 million,
$8.7 million and $4.6 million in 1998, 1999 and 2000, respectively.


PATENTS AND PROPRIETARY RIGHTS


    As of February 28, 2001, we owned or had been licensed 37 issued United
States patents and 39 allowed or pending United States patent applications, as
well as foreign counterparts for certain of the patent applications. These
patents and patent applications are directed to, among other things, MEDI-507,
our AlloMune Systems and our xenotransplantation technologies.


    Our policy is to aggressively prosecute and enforce our patents and
proprietary technology. We intend to continue to file United States and foreign
patent applications to protect technology, inventions and improvements that are
considered important to the development of our business. We also rely upon trade
secrets, know how, continuing technological innovation and licensing
opportunities to develop and maintain our competitive position.


    We are aware of granted patents that claim monoclonal antibodies that bind
to T cells. Johnson & Johnson, which manufactures and sells OKT3, a
T cell-binding monoclonal antibody, owns these patents. We believe that the
BTI-322 monoclonal antibody is distinguishable from other monoclonal antibodies
claimed in Johnson & Johnson's patents, and does not infringe these patents
either literally or under the doctrine of equivalents.


    We have reviewed issued patents which include claims relating to humanized
monoclonal antibodies. These patents are held by biotechnology companies and an
academic institution. We, together with MedImmune, have obtained a license for
MEDI-507 from Protein Design Laboratories Inc. under its humanized antibody
patents.


    We are also aware of a granted United States patent directed to the
production of transgenic animals by the use of a microinjection technique which
is licensed to a competitor. This patent could have an adverse impact on our, or
our licensees and collaborators, ability to produce transgenic animals by
microinjection. In addition, we are aware of a United States patent that is
directed to embryonic stem cells. This patent may have an adverse impact on our,
or our licensees' or collaborators', programs for producing transgenic swine by
the use of embryonic stem cells.


    Some of our know-how and technology is not patentable. To protect our
rights, we require all of our employees, consultants, advisors and collaborators
to enter into confidentiality agreements with us.

                                       84

COMPETITION


    We face intense competition from a wide range of pharmaceutical,
biopharmaceutical and medical device companies, as well as academic and research
institutions and government agencies. Our competitors include organizations that
are pursuing the same or similar technologies as those that constitute our
technology platform and organizations that are pursuing products that are
competitive with our potential products. For example, the development of
superior immunosuppressant therapeutics, mechanical organ systems and other
improvements in therapies for end-stage organ disease could adversely affect the
size of our available markets. We are aware that Chimeric Therapies, Inc. plans
to develop mixed bone marrow chimerism to include tolerance for allogeneic solid
organ and bone marrow transplants. In addition, we are aware of other companies
that are pursuing research and development of alternative products or
technologies addressing the same disease categories as our development programs.
In particular, there are several commercially available anti-rejection drugs
that may compete with the MEDI-507 product under development, including:



    - OKT3 (marketed by Ortho Biotech, Inc, a subsidiary of Johnson & Johnson);



    - ATGAM (marketed by Pharmacia Upjohn);



    - ThymoGlobulin-Registered Trademark- (marketed by SangStat Medical
      Corporation);



    - Zenapax-Registered Trademark- (marketed by Roche Laboratories); and



    - Simulect-Registered Trademark- (marketed by Novartis).



    To the extent that these therapeutics address the problems associated with
transplantation on which we have focused, they may represent significant
competition.



    Many of the organizations competing against us have financial and other
resources substantially greater than our own. In addition, many of our
competitors have significantly greater experience in testing pharmaceutical and
other therapeutic products and obtaining FDA and other regulatory approvals of
products for use in health care. Accordingly, our competitors may succeed more
rapidly than we will in obtaining FDA approval for products. If we commence
significant commercial sales of our products, we will also be competing with
respect to manufacturing efficiency and marketing capabilities, areas in which
we have limited or no experience.



    Principal competitive factors in our industry include:


    - efficacy;

    - safety;

    - reliability;

    - price;

    - availability of reimbursement; and


    - intellectual property position.



    We believe that the quality and breadth of our technology platform, the
skill of our employees, our intellectual property platform and our capabilities
for research and development are competitive strengths. However, many of our
competitors have significantly larger technology and intellectual property
platforms than we do and greater capabilities in research and development.


GOVERNMENT REGULATION

    The development and commercialization of our products will be subject to
regulation in the United States by numerous regulatory authorities including the
Federal Food and Drug Administration

                                       85

and Federal Trade Commission and by comparable regulatory authorities in foreign
countries. These regulatory authorities and other federal, state and local
entities will regulate, among other things, the preclinical and clinical
testing, safety, effectiveness, approval, clearance, manufacturing, labeling,
packaging, export, storage, recordkeeping, adverse event reporting, and
promotion and advertising of our products.


    We will require FDA approval or clearance of our products, including a
review of the manufacturing processes and facilities used to produce our
products, before we may market the products in the United States. Based upon
initial discussions with the FDA, we believe that the BTI-322 monoclonal
antibody and MEDI-507 will be classified as biological products by the FDA.
Biological products are subject to dual regulation. Their approval for
marketing, among other things, is regulated under the Public Health Service Act
through a biologics license application. However, biological products are also
drugs and must meet drug standards under the Federal Food, Drug and Cosmetics
Act. These federal drug standards include good manufacturing practices
regulations and regulations governing clinical trials.



    The manufacture of xenograft products for human transplantation can be
expected to raise issues concerning both the safety and effectiveness of the
products and compliance with and further development of standards for good
manufacturing practices of these products. The Public Health Service published
draft guidance in 1996 on infectious disease issues related to
xenotransplantation and in 1999 on the infectious disease implication of blood
donation from recipients of xenotransplants. In January 1998, PHS held a public
meeting on emerging policy issues, but final guidance and/or regulations do not
yet exist. We cannot predict the content of future policy or regulations
relating to xenotransplantation products, or the effect any future policy or
regulation may have on our, or our licensees' or collaborators', ability to
research, develop, manufacture and market xenotransplantation products.



    Development of a therapeutic product for human use under applicable laws and
regulations is a multi-step process. First, in vitro and/or animal testing must
be conducted in a manner consistent with good laboratory practices to establish
the potential safety and effectiveness of the experimental product in a given
disease. If a product is found to be reasonably safe and potentially effective
in preclinical trials, the next step in the process is human clinical trials. An
investigational new drug application containing, among other things, the
preclinical data, chemistry, manufacturing and control information, and an
investigative plan, must be submitted to the FDA and allowed to become effective
by the agency before clinical trials may begin. There can be no assurance that
submission of an investigational new drug application will result in the ability
to commence clinical trials. In addition, the FDA may place a clinical trial on
hold or terminate it if, among other reasons, it concludes that clinical
subjects are being exposed to an unacceptable health risk.


    Clinical trials typically involve three phases, although those phases can
overlap:

        PHASE I.  Phase I is conducted to evaluate the safety and
    pharmacokinetics of the experimental product in humans, and if possible, to
    gain early indications of effectiveness. Phase I studies may also evaluate
    various routes, dosages and schedules of product administration.

        PHASE II.  If acceptable product safety is demonstrated in Phase I,
    Phase II studies are initiated. In Phase II, clinical trials are conducted
    in groups of patients afflicted with a specific disease or condition for
    which the product is intended for use in order to further test safety, begin
    evaluating effectiveness, optimize dosage amounts and determine dose
    schedules and routes of administration.

        PHASE III.  If Phase II studies yield satisfactory results and no hold
    is placed on further studies by the FDA, Phase III studies begin. Phase III
    studies are usually randomized, double blind studies testing for product
    safety and effectiveness in an expanded patient population in order to

                                       86

    evaluate the overall risk/benefit relationship of the product and to provide
    an adequate basis for product labeling. These studies also may compare the
    safety and effectiveness of the product with currently available products.

    It is not possible to estimate the time in which Phase I, II and III studies
    will be completed with respect to a given product, if at all, and the time
    period may last as long as several years.


    Following completion of clinical investigations, the preclinical and
clinical data that have been accumulated, together with chemistry, manufacturing
and controls specifications and information, are submitted to the FDA in a
biologics license application. To approve a product regulated under a biologics
license application, the agency must determine, among other things, that the
product is safe, pure and potent, and that any facility in which it is
manufactured, processed, packed or held, meets standards designed to assure the
product's continued safety, purity and potency. There can be no assurance that
the FDA will approve a product in a timely manner, if at all. The approval
process can be very lengthy and depends, among other things, upon the time it
takes to review the submitted data, the FDA's comments on the application and
the time required for us to provide satisfactory answers or additional clinical
data if requested.



    If the FDA approves a biologics license application, we will need to
continue to be compliant with strict FDA requirements concerning good
manufacturing practices, enforced by periodic inspections and adverse event
reporting, as well as with any special requirements imposed as a part of the
biologics license application approval. Changes to approved biological products
that affect safety or effectiveness require approved supplemental applications,
as do changes in manufacturing that have a substantial potential to adversely
affect product safety or effectiveness. These supplemental applications may
require the submission of clinical or comparability data and must be approved
before the product may be marketed as modified.



    In addition, the nature of marketing claims that the FDA will permit us to
make in the labeling and advertising of our products will be limited to those
specified in an FDA clearance or approval, and claims exceeding those that are
cleared or approved will constitute a violation of the FDA's Food, Drug and
Cosmetics Act. Violations of the Food, Drug and Cosmetics Act or regulatory
requirements at any time during the product development process, approval
process or after approval may result in agency enforcement actions, including
recall, license suspension or revocation, seizure of products, fines,
injunctions and/or civil or criminal penalties. Any agency enforcement action
could have a material adverse effect on us.


    The advertising of our products will also be subject to regulation by the
Federal Trade Commission, under the FTC Act. The FTC Act prohibits unfair
methods of competition and unfair or deceptive acts in or affecting commerce.
Violations of the FTC Act, such as failure to have substantiation for product
claims, would subject us to a variety of enforcement actions, including
compulsory process, cease and desist orders and injunctions. FTC enforcement can
result in orders requiring, among other things, limits on advertising,
corrective advertising, consumer redress and recision of contracts. Violations
of FTC enforcement orders can result in substantial fines or other penalties.

    The Orphan Drug Act of 1983 generally provides incentives to manufacturers
to undertake development and marketing of products to treat relatively rare
diseases, those where fewer than 200,000 persons in the United States at the
time of application for orphan drug designation would be likely to receive the
treatment. A product that receives orphan drug designation by the FDA and is the
first product to receive FDA marketing approval for its indication is entitled
to a seven-year exclusive marketing period in the United States for that
indication. We intend to pursue this designation with respect to any of our
products intended for patient populations in the United States of less than
200,000. MEDI-507 has received orphan drug designation, both as a stand-alone
product, and as a

                                       87

component of our AlloMune System. In addition, orphan drug exclusivity can be
terminated for a number of reasons, including that the manufacturer cannot
provide an adequate supply of the drug.


    We also face several regulatory obstacles in the European Union. Although
there are minor orphan drug provisions in some European countries, there is, as
yet, no overall process equivalent to that followed in the United States. The
results of all preclinical, development/manufacturing and Phase I, II and III
clinical study data generated in Europe or the United States may also be
submitted to the European Medicines Evaluation Agency, the counterpart of the
FDA, for approval as a Marketing Approval Application, or MAA, which is the
equivalent of a biologics license application. Approval of the MAA permits
product marketing within all countries of the European Union. This MAA procedure
can take a year or more to complete. Approval procedures for marketing of
products in countries that are not European Union member states vary from
country to country and the time required for approval may be longer or shorter
than that required for FDA approval. In addition, for products exported from the
United States to any foreign country or territory, applicable FDA export
requirements must be met.


EMPLOYEES


    As of December 31, 2000, we had 62 full-time employees, 50 of whom were
engaged in research, development, clinical and quality assurance/quality control
activities. Of our full time employees, we expect that approximately 20 will
devote substantially all of their time to research for the joint venture with
Novartis under a research agreement with Immerge BioTherapeutics, Inc. None of
our employees are represented by a labor union or covered by a collective
bargaining agreement.


PROPERTIES

    We lease a facility which contains approximately 34,000 square feet of space
in Charlestown, Massachusetts. The lease has a 15-year term ending in 2009 with
an option to extend for an additional five years. We believe that our current
facilities will be sufficient to meet our needs for the foreseeable future.

LEGAL PROCEEDINGS

    We are currently not a party to any material legal proceedings.

                                       88

          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                   AND RESULTS OF OPERATIONS OF BIOTRANSPLANT

OVERVIEW

    Since commencement of operations in 1990, BioTransplant has been engaged
primarily in the research and development of pharmaceutical products and systems
to enable the body's immune system to better tolerate the transplantation of
foreign cells, tissues and organs. The major sources of BioTransplant's working
capital have been the proceeds from sales of equity securities, sponsored
research funding and license fees, capital lease financings and borrowings under
a term loan. BioTransplant has not generated any revenues from the sale of
products to date, and does not expect to receive any product revenues for
several years, if ever. BioTransplant will be required to conduct significant
additional research, development, testing and regulatory compliance activities
that, together with general and administrative expenses, are expected to result
in significant and increasing operating losses for at least the next several
years.


    From 1993 through October 2000, BioTransplant was a party to two
collaboration agreements with Novartis to research, develop and commercialize
xenotransplantation products. During the collaboration, BioTransplant received
an aggregate of $33.5 million in research funding and $16.5 million in license
fees and milestone payments from Novartis. In September 2000, BioTransplant
entered into an arrangement with Novartis to combine their respective expertise
in the field of xenotransplantation into a newly-formed, independently-run Swiss
company, Immerge BioTherapeutics AG, which began operations in January 2001, and
terminated their prior collaborations in xenotransplantation.


    Novartis has committed to provide an aggregate of $30.0 million in research
funding over three years to the joint venture. Both BioTransplant and Novartis
have exclusively licensed to the joint venture patent rights and technology in
the field of xenotransplantation. The joint venture has granted to Novartis an
exclusive, worldwide royalty-bearing license to develop and commercialize any
xenotransplantation products resulting from the joint venture's research.
BioTransplant will receive royalties from the sale of xenotransplantation
products by Novartis, if any.


    In December 2000, Immerge BioTherapeutics AG formed a wholly-owned Delaware
subsidiary, Immerge BioTherapeutics, Inc. BioTransplant expects to enter into a
contract research agreement with the Delaware subsidiary, under which
BioTransplant will commit approximately 20 full-time employees to perform
research and will agree to provide administrative services, all at a rate to be
agreed upon.



    Novartis holds 67% of the shares of the joint venture and BioTransplant
holds the remaining 33%. All income, gain, profit or loss of the joint venture
will be allocated to BioTransplant and Novartis pro rata based upon their
respective equity ownership of the joint venture in effect in the period in
which these items accrue. Initially, the board of directors of Immerge
BioTherapeutics, Inc. will consist of four directors: one selected by
BioTransplant, one selected by Novartis and two additional directors, one each
designated by BioTransplant and Novartis, who are experts in the field of
xenotransplantation. Immerge BioTherapeutics AG has agreed not to undertake, or
permit its subsidiaries to undertake, specified fundamental corporate actions
without the consent of both shareholders.



    In October 1995, BioTransplant and MedImmune entered into a collaborative
research agreement for the development of products to treat and prevent organ
rejection. MedImmune paid BioTransplant a $2.0 million license fee at the time
of execution of the agreement, and agreed to fund and assume responsibility for
clinical testing and commercialization of the BTI-322 monoclonal antibody and
other related products. MedImmune has provided $2.0 million of non-refundable
research support and has agreed to make milestone payments which could total up
to an additional $11.0 million. Any milestone payments which are received are
repayable from royalties on the BTI-322 monoclonal antibody and other related
products.


                                       89

RESULTS OF OPERATIONS


    YEARS ENDED DECEMBER 31, 2000 AND 1999



    Revenues decreased to $4.6 million in 2000 from $8.7 million in 1999. The
decrease in revenues was primarily due to $4.6 million in sponsored research
payments received under the Novartis agreement in 2000, compared to
$8.7 million in sponsored research payments, milestone payments and license
revenue received under the Novartis agreement during 1999.



    Research and development expenses decreased to $15.0 million in 2000 from
$15.7 million in 1999. This decrease was primarily due to decreased levels of
external research support.



    General and administrative expenses increased to $2.5 million in 2000 from
$2.4 million in 1999. This increase was primarily due to increases in
BioTransplant's general corporate expenditures in 2000 compared to 1999.



    Interest income increased to $1.3 million in 2000 from $782,000 in 1999. The
increase was due primarily to higher cash balances available for investment
purposes as well as rising interest rates.



    As a result of the above factors, BioTransplant generated a net loss in 2000
of $11.7 million, or $1.01 per share, compared to a net loss of $8.7 million, or
$1.01 per share, in 1999.


    YEARS ENDED DECEMBER 31, 1999 AND 1998


    Revenues increased to $8.7 million in 1999 from $6.7 million in 1998. The
increase in revenues was primarily due to $8.7 million in sponsored research,
milestone payments and license revenue from the Novartis agreements in 1999,
compared to $6.7 million in sponsored research and license revenue from Novartis
during 1998.


    Research and development expenses increased to $15.7 million in 1999 from
$14.7 million in 1998. This increase was primarily due to additional external
research support combined with increases in research and development staff and
associated increases in supplies and support services.

    General and administrative expenses decreased slightly to $2.4 million in
1999 from $2.5 million in 1998. This decrease was primarily due to decreased
outside professional services rendered in connection with market research and
business development.


    Interest income decreased to $0.8 million in 1999 compared to $1.3 million
in 1998. The decrease was due to lower average cash balances available for
investment during 1999.



    As a result of the above factors, BioTransplant incurred a net loss in 1999
of $8.7 million, or $1.01 per share, compared to a net loss of $9.2 million, or
$1.07 per share, in 1998.



QUARTERLY RESULTS OF OPERATIONS



    The following table sets forth unaudited selected operating results for each
of the eight fiscal quarters in the two years ended December 31, 2000. We
believe that the following selected quarterly information includes all
adjustments, consisting only of normal, recurring adjustments, that we consider
necessary to present this information fairly. You should read this financial
information in conjunction with the financial statements and related notes
appearing elsewhere in this joint proxy statement/ prospectus. Our results of
operations have fluctuated in the past and are likely to continue to fluctuate


                                       90


greatly from quarter to quarter in the future. Therefore, results of operations
for any previous periods are not necessarily indicative of results of operations
to be recorded in the future.





                                                                      QUARTER ENDED
                                -----------------------------------------------------------------------------------------
                                MARCH 31,   JUNE 30,   SEPT. 30,   DEC. 31,   MARCH 31,   JUNE 30,   SEPT. 30,   DEC. 31,
                                  1999        1999       1999        1999       2000        2000       2000        2000
                                ---------   --------   ---------   --------   ---------   --------   ---------   --------
                                                        (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)
                                                                                         
Revenue.......................   $ 1,239    $ 1,238     $ 3,735    $ 2,477     $ 1,488    $ 1,488     $ 1,476    $   106
Operating expenses............     4,355      4,379       4,497      4,896       4,302      4,251       4,310      4,654
Net loss......................    (2,892)    (2,968)       (602)    (2,213)     (2,499)    (2,408)     (2,501)    (4,271)
Basic and diluted net loss per
  common share................   $ (0.34)   $ (0.35)    $ (0.07)   $ (0.26)    $ (0.23)   $ (0.21)    $ (0.21)   $ (0.36)



LIQUIDITY AND CAPITAL RESOURCES


    Since its inception, BioTransplant's operations have been funded principally
through the net proceeds of an aggregate of $83.2 million from sales of equity
securities. BioTransplant has also received $50.0 million from research and
development and collaboration agreements with Novartis, $4.0 million from an
alliance agreement with MedImmune and $2.9 million in equipment financing. The
proceeds of the sales of equity securities, equipment financing and cash
generated from the corporate collaborations with Novartis and MedImmune have
been used to fund operating losses of approximately $68.8 million and the
investment of approximately $5.6 million in equipment and leasehold improvements
through December 31, 2000. During 1999, BioTransplant extended and increased its
term note with a bank from $500,000 to $1.0 million for certain equipment and
fixtures borrowing. There were $486,000 in borrowings outstanding under this
term note at December 31, 2000. BioTransplant had no significant commitments as
of December 31, 2000 for capital expenditures.


    On February 11, 2000, BioTransplant issued and sold to a group of investors
an aggregate of 1,215,000 shares of its common stock, at a purchase price of
$8.00 per share, for net proceeds of approximately $9.0 million.


    BioTransplant has entered into sponsored research and consulting agreements
with certain hospitals, academic institutions and consultants, requiring
periodic payments by BioTransplant. Aggregate minimum funding obligations under
these agreements, each of which includes cancellation provisions, total
approximately $4.9 million, which includes approximately $3.4 million in 2001.



    BioTransplant had cash, cash equivalents and short-term investments of
$14.9 million as of December 31, 2000 as compared to $21.4 million as of
December 31, 1999.



    Assuming the merger is consummated, BioTransplant anticipates that its
existing cash, cash equivalents and short-term investments will be sufficient to
fund its operating and capital requirements as currently planned through the
middle of 2001. BioTransplant will need to raise substantial additional funds in
the near term, and may seek to raise these funds through additional financings,
including public or private equity offerings, collaborative arrangements with
corporate partners or a combination of any of the foregoing. There can be no
assurance that funds will be available on terms acceptable to BioTransplant, if
at all. If adequate funds are not available, BioTransplant may be required to
delay, scale back or eliminate some or all of its product development programs
or to license to others the right to commercialize products or technologies that
BioTransplant would otherwise seek to develop and commercialize itself, any of
which would have a material and adverse effect on BioTransplant.


    Even if BioTransplant is able to raise the substantial additional funds
required to finance its operations, BioTransplant's cash requirements may vary
materially from those now planned. Factors that may affect this variability
include, without limitation:

    - the progress of BioTransplant's research and development programs;

                                       91

    - the scope and results of preclinical and clinical testing;

    - changes in existing and potential relationships with corporate
      collaborators;

    - the time and cost in obtaining regulatory approvals;

    - the costs involved in obtaining and enforcing patents, proprietary rights
      and any necessary licenses;

    - the ability of BioTransplant to establish development and
      commercialization capacities or relationships; and

    - the costs of manufacturing.


    BioTransplant expects to incur substantial additional costs, including costs
related to research and development activities, preclinical studies, clinical
trials, obtaining regulatory approvals, manufacturing and the expansion of its
facilities.


QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISKS

    BioTransplant owns financial instruments that are sensitive to market risks
as part of its investment portfolio. The investment portfolio is used to
preserve BioTransplant's capital until it is required to fund operations,
including BioTransplant's research and development activities. All of these
market-risk sensitive instruments are classified as held-to-maturity and are not
held for trading purposes. BioTransplant does not own derivative financial
instruments in its investment portfolio. The investment portfolio contains
interests that are subject to the risk of a decline in interest rates.

    BioTransplant's investment portfolio includes investment-grade debt
instruments. These bonds are subject to interest rate risk and could decline in
value if interest rates fluctuate. Due to the short duration and conservative
nature of these instruments, BioTransplant does not believe that it has a
material exposure to interest rate risk.

                                       92

                                   MANAGEMENT

DIRECTORS AND EXECUTIVE OFFICERS

    Set forth below is each person who is presently a director or executive
officer of BioTransplant. Also included is each person who is presently a
director or executive officer of Eligix and who will become a director or
executive officer of BioTransplant upon consummation of the merger.




NAME                                      AGE            POSITION AT BIOTRANSPLANT
----                                    --------   --------------------------------------
                                             
Elliot Lebowitz, Ph.D.................  60         President, Chief Executive Officer and
                                                   Director
Donald R. Conklin.....................  64         Director
William W. Crouse.....................  58         Director
James C. Foster, J.D..................  50         Director
Daniel O. Hauser, Ph.D................  63         Director
Michael S. Perry, D.V.M., Ph.D........  41         Director
Walter C. Ogier*......................  44         President, Chief Operating Officer and
                                                   Director
Arnold L. Oronsky, Ph.D.*.............  60         Director
Susan M. Racher*......................  47         Director
James R. Fitzgerald, Jr.*.............  56         Executive Vice President, Finance and
                                                   Administration
James Hope, Ph.D......................  49         Senior Vice President, Development
Mary White-Scharf, Ph.D...............  50         Senior Vice President, Research
Richard V. Capasso, C.P.A.............  39         Vice President, Finance and Treasurer
David N. Cook, Ph.D.*.................  42         Senior Vice President, Development
Tara Clark*...........................  39         Vice President, Marketing
James A. Embree*......................  51         Vice President, Manufacturing
Judith Snow*..........................  43         Vice President, Quality Assurance



------------------------

    *Subject to the consummation of the merger.

    ELLIOT LEBOWITZ, PH.D. has served as President and Chief Executive Officer
and as a member of the Board of Directors of BioTransplant since April 1991.
From 1985 to 1991, he served as Vice President for Research and Development at
C.R. Bard, Inc., a medical device company, directing internal and collaborative
research and development programs for Bard's Vascular Systems, Cardiosurgery and
Cardiopulmonary Divisions. From 1981 until 1985, Dr. Lebowitz served as Director
of Long Range Research and Development at DuPont Corporation, a diversified
health care company, developing immunopharmaceuticals. From 1977 until 1981, he
served as Division Manager of the Medical Products Division of New England
Nuclear Corporation, which developed, manufactured and sold radiopharmaceuticals
for in vivo diagnosis. Earlier in his career, Dr. Lebowitz served at Brookhaven
National Laboratories, a United States Department of Energy research facility,
where he developed Thallium-201, a radiopharmaceutical for the diagnosis of
coronary artery disease. Dr. Lebowitz was a founder of Diagnostic
Isotopes, Inc., a radiopharmaceutical company which was subsequently acquired by
Hoffmann-La Roche Inc., a pharmaceutical company. He was also a founder of
Procept, Inc., a biopharmaceutical company which focused on rational drug
design. He holds a B.A. from Columbia College and a Ph.D. from Columbia
University. Upon consummation of the merger, Walter C. Ogier, the President and
Chief Executive Officer of Eligix, will become President and Chief Operating
Officer of BioTransplant, reporting to Dr. Lebowitz as Chief Executive Officer.


    DONALD R. CONKLIN has served as a director of BioTransplant since
January 1997. Mr. Conklin is currently retired. From February to December 1996,
he served as Chairman of Schering-Plough Health Care Products, a wholly-owned
subsidiary of Schering-Plough Corporation, a pharmaceutical company.


                                       93


From 1995 to February 1996, he served as President of Schering-Plough Health
Care, and from 1986 until September 1994, he served as Executive Vice President
and President of Schering-Plough Pharmaceuticals. Mr. Conklin also serves on the
board of directors of Alfacell Corporation, Ventiv Inc. and Vertex
Pharmaceuticals. He received his B.A. from Williams College and his M.B.A. from
Rutgers University. Mr. Conklin has indicated to BioTransplant that he does not
intend to serve as a director upon consummation of the merger.



    WILLIAM W. CROUSE has served as a director of BioTransplant since
June 1995. Since 1994, Mr. Crouse has served as Managing Director of HealthCare
Ventures LLC, a venture capital firm. Mr. Crouse served as Worldwide President
of Ortho Diagnostic Systems, a medical device company, and Vice President of
Johnson & Johnson International, a pharmaceutical company, from 1987 to 1994.
Mr. Crouse has more than 30 years experience in the pharmaceutical industry. He
also serves as a director of Dendreon Corporation, The New York Blood Center and
Liberty Science Center and is a Trustee of Lehigh University. Mr. Crouse
received his B.S. in finance and economics from Lehigh University and his M.B.A.
from Pace University. Mr. Crouse has indicated to BioTransplant that he does not
intend to serve as a director upon consummation of the merger.


    JAMES C. FOSTER, J.D. has served as a director of BioTransplant since
February 1992. Since 1992, he has served as President and Chief Executive
Officer of Charles River Laboratories, Inc., or CRL, a supplier of research
animals and animal-related products and services. Previously, he served in
various other capacities with CRL. Mr. Foster received his B.S. in psychology
from Lake Forest College, his J.D. from the Boston University School of Law and
his M.A. in Science and Management from the Massachusetts Institute of
Technology.


    DANIEL O. HAUSER, PH.D. has served as a director of BioTransplant since
January 1994. Dr. Hauser is currently retired. From 1997 to 1998, he served as
the Senior Vice President of Preclinical Development & Project Management,
Operations in the United States for Novartis AG, a pharmaceutical corporation.
From 1992 until December 1996, he served as President of Sandoz Research
Institute and as Senior Vice President of Research and Development for Sandoz
Pharmaceutical Corporation, the predecessor of Novartis. From 1965 to 1992, he
served in various positions at the Pharma Division of Sandoz Pharma Ltd.
(Switzerland), including Senior Vice President from 1985 to 1992. Dr. Hauser
received his M.S. and Ph.D. in chemistry from the Swiss Federal Institute of
Technology (Switzerland) and was a Post-doctoral Research Fellow in the
Department of Chemistry at the Israel Institute of Technology (Haifa).



    MICHAEL S. PERRY, D.V.M., PH.D. has served as a director of BioTransplant
since January 1999. Since October 2000, he has served as Vice President, Global
Research and Development of Baxter Healthcare Corporation, a hospital supply and
medical technology company. From 1998 until September 2000, he served as
President and Chief Executive Officer of Genetic Therapy, Inc. and since 1997,
he has served as President and Chief Executive Officer of SyStemix, Inc. Genetic
Therapy and SyStemix are biopharmaceutical corporations which are wholly-owned
by Novartis. During 1997, Dr. Perry served as Vice President, Drug Regulatory
Affairs, North America for Novartis. From 1995 to 1996, he served as Vice
President, Drug Registration and Regulatory Affairs (North America) for Sandoz
Pharmaceutical Corporation, the predecessor of Novartis. From 1994 to 1995, he
served as Vice President, Drug Registration and Regulatory Affairs (USA) for
Sandoz. Dr. Perry received his Ph.D. in pharmacology (cardiopulmonary) and his
D.V.M. from the Ontario Veterinary College, University of Guelph (Canada).


    WALTER C. OGIER will become President and Chief Operating Officer and a
director of BioTransplant upon consummation of the merger. Mr. Ogier has served
as President and Chief Executive Officer and as a member of the board of
directors of Eligix since November 1997. From 1994 to 1997, he served as Vice
President, Marketing and, initially, Director of Marketing, at Aastrom
Biosciences, Inc., a cell therapy company based in Ann Arbor, Michigan where his
principal responsibilities included marketing,

                                       94

business development, public relations and the implementation of clinical
trials. From 1987 to 1994, Mr. Ogier held various management positions with
Baxter Healthcare Corporation's Immunotherapy and Fenwal divisions, involving
responsibility for North American and global marketing of a portfolio of
therapeutic products in transplantation and cancer, atherosclerosis, and
autoimmune disorders, including the development and oversight of product
development and distribution alliances and execution of technology licenses. He
has also served from 1986 to 1987 as a financial analyst at Roger G. Ibbotson
and Associates, a financial investment consulting company, and from 1979 to 1985
as an industrial economist and research scientist at Stanford Research Institute
(SRI International), a management consulting and contract research organization.
He received his B.A. degree in chemistry from Williams College and his M.B.A.
degree from the Yale School of Management.

    ARNOLD ORONSKY, PH.D. will become a director of BioTransplant upon
consummation of the merger. Dr. Oronsky has served as the Chairman of the board
of directors of Eligix since February 1997. Dr. Oronsky has been affiliated with
InterWest Partners since 1989, where he became a General Partner in 1994. From
1977 to 1994, he served in positions of increasing responsibility at the Lederle
Laboratories division of American Cyanamid Company, a pharmaceutical company,
most recently serving as Vice President for Discovery Research where he directed
a $90 million research budget and a staff of approximately 300 employees. Dr.
Oronsky has also served as a Research Fellow and an Assistant Professor at
Harvard Medical School. Dr. Oronsky currently serves as a director of Corixa
Corporation. Dr. Oronsky holds a B.S. degree from New York University and a
Ph.D. from Columbia University's College of Physicians and Surgeons.

    SUSAN M. RACHER will become a director of BioTransplant upon consummation of
the merger. Ms. Racher has served as a member of the board of directors of
Eligix since 1999. Since 1998, Ms. Racher has served as Chief Financial Officer
of the Wallace H. Coulter Foundation, a charitable entity dedicated to
furthering Mr. Coulter's lifelong pursuit of the improvement of healthcare
through medical technology and research, and as a member of its executive
committee. From 1978 to 1997, Ms. Racher served in positions of increasing
responsibility with BankAmerica and its predecessor, Continental Bank. Most
recently she served as Senior Vice President and Manager of BankAmerica's
Florida Corporate Division, where she held responsibility for all commercial
banking and investment banking relationships in Florida. Ms. Racher received her
B.A. degree from Smith College and an M.B.A. in Finance and Accounting from the
University of Chicago Graduate School of Business.

    JAMES R. FITZGERALD, JR. will become Executive Vice President, Finance and
Administration of BioTransplant upon consummation of the merger. Mr. Fitzgerald
has served as the Senior Vice President of Finance & Operations and Chief
Financial Officer of Eligix since January 2000. From 1996 to 2000, he served as
Vice President Finance, Treasurer and Chief Financial Officer of ArQule, Inc., a
chemistry and drug discovery company. From 1988 to 1996, Mr. Fitzgerald served
as Chief Financial Officer of Hush Holdings U.S., Inc., an entertainment
company. He previously served as Chief Financial Officer of MediVision, Inc., an
operator of outpatient surgery centers, from 1985 to 1987 and Amicon
Corporation, a manufacturer of separation sciences apparatus and specialty
polymer materials, from 1980 to 1985. Mr. Fitzgerald received a B.A. in
economics and an M.B.A. from Northeastern University and attended the Harvard
Business School Executive Program.

    JAMES HOPE, PH.D. has served as Senior Vice President of Development of
BioTransplant since December 1995 and will become Chief Technology Officer upon
consummation of the merger. From August 1992 until December 1995, he served as
Vice President of Development of BioTransplant. From 1990 until 1992, he served
as Executive Director of Operations Technical Support of Serono
Laboratories, Inc., a pharmaceutical company, where he directed the transfer,
scale-up and validation of biopharmaceutical manufacturing processes. From 1986
until 1990, he served as the Director of Bioprocess Development and Production
at Invitron Corp., a contract manufacturer for the development and scale-up of
mammalian, cell-based biopharmaceutical manufacturing processes.

                                       95

Dr. Hope received a B.S. in microbiology and chemistry from the University of
Reading (U.K.) and a Ph.D. in biochemistry from the University of London (U.K.).


    MARY WHITE-SCHARF, PH.D. has served as Senior Vice President, Research of
BioTransplant since January 2001. From December 1995 until December 1999, she
served as Vice President, Research of BioTransplant. From September 1991 until
December 1995 she served as Director of Monoclonal Antibody Development of
BioTransplant where she directed the BTI-322 program and BioTransplant's
hybridoma discovery, scale-up, antibody purification and antibody engineering.
From 1989 to 1991, she served as a Research Scientist at Repligen Corporation, a
biotechnology company, where she directed its efforts to generate a broadly
neutralizing monoclonal antibody to HIV-1. Dr. White-Scharf received her B.S. in
biology from Southern Methodist University, her M.A. in physiology from the
University of Texas Medical Branch and her Ph.D. in medical microbiology from
Stanford University School of Medicine.



    RICHARD V. CAPASSO, C.P.A. has served as Vice President, Finance and
Treasurer of BioTransplant since May 1997. From December 1994 until May 1997 he
served as Director of Finance of BioTransplant and from December 1991 until
December 1994 he served as Controller of BioTransplant. From 1988 to 1991,
Mr. Capasso served as Manager of Financial Reporting and Controller at
Softbridge, Inc., a computer software development company. From 1984 to 1988, he
served as a member of the professional staff of the Enterprise Group of Arthur
Andersen LLP, an international public accounting firm. Mr. Capasso received his
B.S. from Northeastern University with a major in accounting, his M.B.A. from
Bentley College and received his C.P.A. in 1987.


    DAVID N. COOK, PH.D. will become Senior Vice President, Development of
BioTransplant upon consummation of the merger. Dr. Cook has served as Senior
Vice President, Research and Development of Eligix since October 1999. From 1993
to 1999, he served in a variety of positions at Cerus Corporation, a
biopharmaceutical company focused on developing pathogen inactivation for blood
products. From 1998 to 1999, he served as Vice President for Commercialization
with responsibilities in the areas of pathogen inactivation and cellular
immunotherapy. From 1994 to 1998, he served as Director of Red Cell Development,
and from 1993 to 1994 as a Senior Scientist. From 1990 to 1993, he was a
postdoctoral scientist at the Lawrence Berkely National Laboratory. Dr. Cook has
an A.B. in American Studies from Harvard University and a Ph.D. in chemistry
from the University of California, Berkeley.

    TARA CLARK will become Vice President, Marketing of BioTransplant upon
consummation of the merger. Ms. Clark has served as Vice President, Marketing of
Eligix since September 1999. From 1988 to 1999, Ms. Clark held positions of
increasing responsibility within the Fenwal and Scientific Products Divisions of
Baxter Healthcare Corporation, where she developed and managed sales, marketing
and training initiatives in North America for numerous major product lines,
including, most recently, serving as Director, Cellular Therapies for the Fenwal
Division. Previously, Ms. Clark served in various quality assurance and
microbiology research positions with Invitron, a biopharmaceutical company, from
1986 to 1988, and McDonnell Douglas, an aeronautical, engineering and
manufacturing company, from 1984 to 1986. Ms. Clark received a B.S. degree in
microbiology from the University of Missouri-Columbia.

    JAMES A. EMBREE will become Vice President, Manufacturing of BioTransplant
upon consummation of the merger. Mr. Embree has served as Vice President,
Manufacturing of Eligix since January 1998. From 1993 to 1998, Mr. Embree served
as Director of Manufacturing for SyStemix, a Novartis cell therapy company,
where he developed production and purification processes for several therapeutic
monoclonal antibodies. He previously held manufacturing and development
positions with Cytotherapeutics, a biotechnology company developing cell therapy
based-products for Parkinson Disease, pain management and diabetes, from 1991 to
1993, Immunogen, a biopharmaceutical company developing parenteral oncology
products targeted by monoclonal antibodies, from 1988 to 1991, Seragen, Inc., a
developer of therapeutic protein products, from 1985 to 1988, and New England

                                       96

Nuclear, a research, diagnostic and pharmaceutical company, from 1978 to 1985.
Mr. Embree received a B.S. degree in microbiology from the University of
Massachusetts and an M.A. degree in bacterial genetics and molecular biology
from Northeastern University.

    JUDITH SNOW will become Vice President, Quality Assurance of BioTransplant
upon consummation of the merger. Ms. Snow has served as Vice President, Quality
Assurance of Eligix since September 1998. From 1995 to 1998, Ms. Snow served as
Vice President of Quality, Regulatory and Clinical Affairs at UroMed Corp., a
urological medical device company, where she played a critical role in
developing the quality system and securing CE mark registration for the company.
From 1990 to 1995, she held quality assurance positions at Boston-based
Haemonetics, Inc., a manufacturer of blood and stem cell collection and
processing systems. Earlier in her career, she held quality assurance positions
at Coulter Electronics, Inc., a manufacturer of diagnostic equipment, from 1988
to 1989, and at Cordis Corporation, a manufacturer of cardiac pacemakers and
neurological shunts, from 1985 to 1988. Ms. Snow received a B.S. degree in
medical technology from Wesley College.

EXECUTIVE COMPENSATION


    SUMMARY COMPENSATION TABLE.  The following table sets forth information with
respect to the annual and long-term compensation for the last three fiscal years
of BioTransplant's Chief Executive Officer and its four other most highly
compensated executive officers at year end whose total annual salary and bonus
for 2000 exceeded $100,000, referred to collectively as the "BioTransplant named
executive officers." Dollar amounts in the "All Other Compensation" column
consist of matching contributions under BioTransplant's 401(K) plan. Dr.
Greenstein has resigned as Senior Vice President, Research of BioTransplant,
effective January 2001, in order to assume the position of Chief Executive
Officer of Immerge BioTherapeutics AG, and its wholly-owned subsidiary, Immerge
BioTherapeutics, Inc., the operating entities of BioTransplant's joint venture
with Novartis. Dr. Julia L. Greenstein will continue to serve as an employee at
BioTransplant but will no longer have the duties or title of an officer of
BioTransplant. Dr. Howard Grossberg joined BioTransplant in December 1999 and
resigned in February 2001. Dr. Grossberg will serve as a consultant to
BioTransplant.


                                       97

                           SUMMARY COMPENSATION TABLE



                                                                             LONG-TERM
                                                                            COMPENSATION
                                                                               AWARDS
                                                     ANNUAL COMPENSATION    ------------
                                                    ---------------------    SECURITIES
                                                                  BONUS      UNDERLYING       ALL OTHER
NAME AND PRINCIPAL POSITION                YEAR     SALARY ($)     ($)      OPTIONS (#)    COMPENSATION ($)
---------------------------              --------   ----------   --------   ------------   ----------------
                                                                            
Elliot Lebowitz, Ph.D..................    2000      $266,000    $40,000        64,500          $2,625
  Chief Executive Officer                  1999       252,956         --        67,098              --
                                           1998       252,956         --       100,000              --

James Hope, Ph.D.......................    2000       206,000     20,000        22,000           2,625
  Senior Vice President of Development     1999       195,038      5,000        23,000              --
                                           1998       182,619     22,423        26,800              --

Julia L. Greenstein, Ph.D..............    2000       227,000     33,000        24,500           2,625
  Senior Vice President of Research        1999       187,567         --        16,000              --
                                           1998       200,723     19,372        40,700              --

Mary White-Scharf, Ph.D................    2000       168,000     20,000        26,000           2,625
  Vice President of Research               1999       155,424         --        27,000              --
                                           1998       146,107    $13,622        45,200              --

Howard Grossberg, M.D..................    2000       221,000     50,400        10,500           2,625
  Vice President of Medical Affairs        1999         6,800         --        50,000              --



    OPTION GRANTS IN LAST FISCAL YEAR.  The following table sets forth
information regarding options granted during the year ended December 31, 2000 by
BioTransplant to the BioTransplant named executive officers. Options granted in
2000 become exercisable in four equal annual installments, commencing twelve
months after the vesting commencement date, which is typically the date of
grant. Amounts in the last two columns represent hypothetical gains that could
be achieved for options if exercised at the end of the option term. These gains
are based on assumed rates of stock price appreciation of 5% and 10% compounded
annually from the date options were granted to their expiration date. Actual
gains, if any, on stock option exercises will depend on the future performance
of the BioTransplant common stock on the date on which options are exercised.


                                       98

                       OPTION GRANTS IN LAST FISCAL YEAR



                                                 INDIVIDUAL GRANTS                        POTENTIAL REALIZABLE
                             ---------------------------------------------------------      VALUE AT ASSUMED
                              NUMBER OF                                                   ANNUAL RATES OF STOCK
                             SECURITIES    PERCENT OF TOTAL                              PRICE APPRECIATION FOR
                             UNDERLYING    OPTIONS GRANTED    EXERCISE OR                      OPTION TERM
                               OPTIONS     TO EMPLOYEES IN    BASE PRICE    EXPIRATION   -----------------------
NAME                         GRANTED (#)   FISCAL YEAR (%)      ($/SH)         DATE        5% ($)      10% ($)
----                         -----------   ----------------   -----------   ----------   ----------   ----------
                                                                                    
Elliot Lebowitz, Ph. D.....     4,500             1.4%           $ 6.94      12/20/10     $ 19,634     $ 49,758
                               60,000            18.6              8.89       12/4/10      335,490      850,198

James Hope, Ph.D...........    20,000             6.2             14.25       9/11/10      179,235      454,217

                                2,000             0.6              6.94      12/20/10        8,727       22,115

Julia L. Greenstein,
  Ph.D.....................    21,000             6.5              7.63       1/31/10      100,702      255,198

                                3,500             1.1              6.94      12/20/10       15,271       38,701

Mary White-Scharf, Ph.D....    24,000             7.5             10.00       8/23/10      150,935      382,498

                                2,000             0.6              6.94      12/20/10        8,727       22,115

Howard Grossberg, M.D......     8,000             2.5              7.00      12/26/10       35,218       89,250

                                2,500             0.8              6.94      12/20/10       10,908       27,643


    AGGREGATED OPTION EXERCISES AND YEAR-END OPTION TABLE.  The following table
sets forth information regarding options exercised by each BioTransplant named
executive officer during 2000 and exercisable and unexercisable stock options
held as of December 31, 2000 by each BioTransplant named executive officer. The
value realized upon the exercise of options represents the difference between
the option exercise price and the closing sale price of the BioTransplant common
stock on the date of exercise. The value of the unexercised in-the-money options
at year end has been calculated based on $8.69, which was the closing sales
price of the BioTransplant common stock on the Nasdaq National Market on
December 29, 2000, the last trading day of BioTransplant's 2000 fiscal year,
less the applicable option exercise price.

                AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                       AND FISCAL YEAR-END OPTION VALUES



                                                                  NUMBER OF SECURITIES
                                                                       UNDERLYING               VALUE OF UNEXERCISED
                                                                   UNEXERCISED OPTIONS          IN-THE-MONEY OPTIONS
                                                                 AT FISCAL YEAR-END (#)        AT FISCAL YEAR-END ($)
                            SHARES ACQUIRED   VALUE REALIZED   ---------------------------   ---------------------------
                            ON EXERCISE ($)        ($)         EXERCISABLE   UNEXERCISABLE   EXERCISABLE   UNEXERCISABLE
                            ---------------   --------------   -----------   -------------   -----------   -------------
                                                                                         
Elliot Lebowitz, Ph.D.....           --                --        282,138        179,928      $1,130,552      $526,119

James Hope, Ph.D..........      $12,000          $145,631         84,707         61,675         349,190       162,323

Julia L. Greenstein,
  Ph.D....................        6,000            96,354         96,832         64,298         356,685       223,817

Mary White-Scharf,
  Ph.D....................       11,151           147,329         97,234         79,398         342,014       228,139

Howard Grossberg, M.D.....           --                --         12,500         48,000          35,938       125,692


SEVERANCE AGREEMENTS WITH EXECUTIVE OFFICERS


    Under the terms of an agreement with Dr. Lebowitz, BioTransplant's President
and Chief Executive Officer, in the event of involuntary termination of
Dr. Lebowitz' employment, he is eligible to receive six months of base salary
from BioTransplant. Under the terms of agreements with Dr. Hope, Senior Vice
President of Development, Dr. White-Scharf, Vice President of Research, and
Mr. Capasso, Vice President, Finance and Treasurer, in the event of a
termination of employment without cause, the terminated officer is eligible to
receive six months of base salary, which will be


                                       99


discontinued if the officer secures other employment. Furthermore, if at the end
of the six-month period following his termination Dr. Hope is unable to secure
other employment, then Dr. Hope and BioTransplant have agreed to negotiate an
additional severance payment of up to six months of base salary.


COMPENSATION OF DIRECTORS

    BioTransplant's non-employee directors who are not affiliated with Novartis
each receive $1,500, plus reasonable travel and out-of-pocket expenses, for each
meeting of the board of directors they attend.


    The board of directors intends to make awards of stock options to directors
as compensation for service on the board of directors under BioTransplant's 1997
stock incentive plan. Currently, the board of directors grants each director,
upon his or her initial election to the board of directors, an option to
purchase 15,000 shares of BioTransplant common stock at an exercise price equal
to the then fair market value. In addition, each director is eligible to receive
an option to purchase 6,000 shares of BioTransplant common stock, at an exercise
price equal to the then fair market value, upon his or her reelection to the
board of directors at each annual meeting of stockholders.


CERTAIN TRANSACTIONS


    In March 1991, BioTransplant entered into a supply agreement with Charles
River Laboratories. BioTransplant amended the agreement in 1998. Under the terms
of the agreement, as amended, CRL provides BioTransplant with miniature swine
and miniature swine organs for research and development purposes in exchange for
payments under a research and supply agreement. BioTransplant paid CRL $877,500,
$940,000 and $988,000 under this agreement in 1998, 1999 and 2000, respectively.
James C. Foster, President and Chief Executive Officer of CRL, is a director of
BioTransplant. BioTransplant expects to assign its rights in the field of
xenotransplantation under this agreement to its joint venture with Novartis.



    From 1993 through October 2000, BioTransplant was party to two collaboration
agreements with Novartis to research, develop and commercialize
xenotransplantation products. During the collaboration, BioTransplant received
an aggregate of $33.5 million in research funding and $16.5 million in license
fees and milestone payments from Novartis. In September 2000, BioTransplant
entered into an arrangement with Novartis to combine their respective expertise
in the field of xenotransplantation into a newly-formed, independently-run
company named Immerge BioTherapeutics AG and Novartis and BioTransplant
terminated their prior collaborations in xenotransplantation. In return for
contributing its technology, BioTransplant will retain a 33% share of the joint
venture and will receive royalty payments from Novartis sales of
xenotransplantation products, if any. David Sachs, M.D., Chairman of
BioTransplant's scientific advisory board and the Director of the
Transplantation Biology Research Center at Massachusetts General Hospital;
Elliot Lebowitz, the Chief Executive Officer of BioTransplant; Corinne Savill,
Chief Operating Officer of an affiliate of Novartis; and Clive Morris, Head of
Patents, Pharma Consumer Health and Global Generics at Novartis, are all
directors of Immerge BioTherapeutics AG and of its subsidiary Immerge
BioTherapeutics, Inc. Immerge BioTherapeutics began operations in January 2001.


    Dr. Perry, a director of BioTransplant, was formerly President and Chief
Executive Officer of Genetic Therapy and SyStemix, affiliates of Novartis.

                                      100

                         INFORMATION CONCERNING ELIGIX
                                    BUSINESS

    Eligix is a biomedical company engaged in the research and development of
cellular therapies to enhance human immune response to cancers, autoimmune
disorders and solid organ transplants and to reduce the risk of infection and
hypersensitivity reactions in blood transfusions. Our technology is the result
of research at Coulter Corporation, in collaboration with physicians at Harvard
University's Dana-Farber Cancer Institute.


    Our patented High Density Microparticles, or HDM, technology, in conjunction
with our portfolio of blood and immune cell-specific and tumor cell-specific
monoclonal antibodies is designed to enable the highly efficient selection
and/or immune activation of specific populations of human cells from blood and
bone marrow. We are pursuing research and development of high density
microparticle products for:


    - the removal of malignant cells from stem cell transplants;

    - the removal of immune rejection-causing cells from stem cell transplants
      and immune cell infusions;

    - the removal of potentially infectious cells from blood transfusions; and

    - the selection and activation of disease-specific immune cells to enhance a
      patient's immune response to disease.


    Our lead product candidates, BCell-HDM and TCell-HDM, will target bone
marrow and stem cell transplant procedures. Sources estimate that there are
approximately 44,000 bone marrow and stem cell transplant procedures performed
annually in Europe and the U.S. We believe these procedures represent a large
and rapidly growing market opportunity. We are targeting these products for the
purging of stem cell transplants and related blood products to reduce the risk
of relapse or graft-versus-host disease following bone marrow stem cell
transplantation or donor leukocyte infusion therapy for cancer and other
diseases, including autoimmune and genetic disorders. Both products are
currently being prepared for CE marking and, in the U.S., are poised to enter
pivotal trials. We expect to receive the CE mark for both products within twelve
months, permitting near-term introduction of the products into the European
market.



    We are pursuing research and development of other product candidates,
including PanT-HDM, BrCa-HDM, Neu/RBC-HDM, ReacT-HDM, AcTCell-HDM, AcT-IV and
Leuko-HDM, that will target the bone marrow and stem cell transplant market as
well as solid organ transplants and blood collection procedures. Sources
estimate that there are approximately 30,000 solid organ transplants performed
annually in the United States and Western Europe and 70 million blood collection
procedures performed annually worldwide. We are also targeting what we believe
to be major long-term opportunities in ex vivo and in vivo immune therapies for
cancer, autoimmune disorders and infectious disease. These products are targeted
for the following:


    - removal of potential relapse-causing cancer or autoimmune cells from
      autologous bone marrow stem cell transplants;

    - the removal of T cells and T cell subsets which cause graft-versus-host
      disease in mismatched transplants;

    - the removal of disease-causing cells and pathogens from blood
      transfusions;

    - the selective activation of immune response against cancers and infectious
      diseases; and

    - the removal of cells that interfere with the ability to achieve immune
      system tolerization to prevent chronic immune rejection and resultant
      organ failure in solid organ and tissue transplants.

                                      101

    We believe that our focus on approaches to providing the patient with a
normal immune system to mount an effective attack against malignancies is likely
to improve patient outcomes and reduce disease relapse rates, while enhancing
overall cost effectiveness. We expect our technology to facilitate new
approaches in transplantation with minimal toxicity, including "mini"
transplants to eliminate the risks of myeloablative therapy, donor leukocyte
infusions following allogeneic transplants to enhance immune response against
cancer, and the enablement of successful transplants between tissue mismatched
donors and patients.


    We intend to build value by product development and timely commercialization
to meet significant, unmet clinical needs representing high therapeutic value in
established areas of medicine, focusing on promising technologies to improve
human immune response. To advance our products, we have recruited and trained a
qualified technical and management team expertise in biochemistry, cell biology,
immunology, protein chemistry, microbiology, cell culture, protein purification,
analytical chemistry and mechanical engineering, including medical device as
well as pharmaceutical product development. Additional expertise is held in
marketing, manufacturing, clinical development, quality assurance, regulatory
affairs, finance, administration and business development. As of December 31,
2000, Eligix had 30 full-time employees, five of whom hold Ph.D.s, at its
facility in Medford, Massachusetts.


          MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                      AND RESULTS OF OPERATIONS OF ELIGIX

OVERVIEW


    Since commencement of operations in 1997, Eligix has been engaged primarily
in the research and development of its proprietary high density microparticles
technology for applications in cell selection and cellular therapy for cancer
and infectious diseases, to reduce the risk of infection and hypersensitivity
reactions in blood transfusions and to achieve immune tolerance in transplanted
organs and autoimmune disorders. The major sources of Eligix' working capital
have been the proceeds from sales of equity securities and debt financings.
Eligix has not generated any material revenues from the sale of products to
date. Eligix will be required to conduct significant additional research,
development, testing and regulatory compliance activities that, together with
general and administrative expenses, are expected to result in significant and
increasing operating losses for at least the next several years.


RESULTS OF OPERATIONS


    YEARS ENDED DECEMBER 31, 2000 AND 1999



    Research and development expenses decreased to $8.1 million in 2000 from
$8.3 million in 1999, principally as a result of the staff reduction undertaken
in May 2000 and curtailment of activities other than those necessary to complete
requirements for CE marking and U.S. clinical trials of its lead products,
partially offset by $1.0 million in stock-based compensation recorded in 2000.
General, administrative and marketing expenses increased to $3.7 million in 2000
from $2.2 million in 1999 due to professional services required with financing
and business collaboration activities during 2000, and as Eligix increased its
executive and marketing staff in preparation for initiating sales and marketing
activity in Europe upon obtaining CE marking for its first product.



    Eligix has recorded stock option-based deferred compensation of
$3.6 million as of December 31, 2000. Eligix anticipates recognizing related
compensation expense of approximately $900,000 during each of the next four
years. The related options will fully vest as a result of a change in control of
Eligix at which time any remaining deferred compensation balance will be
expensed.



    Interest income decreased to $0.2 million in 2000 compared to $0.3 million
in 1999. The decrease was due to lower average cash balances available for
investment during 2000.


                                      102


    Interest expense increased to $1.3 million in 2000 from $0.2 million in
1999. This increase was primarily due to increased borrowings under a
convertible bridge financing agreement and amortization of the discount related
to the convertible bridge notes entered into in April and September 2000.



    As a result of the above factors, Eligix incurred a net loss in 2000 of
$13.0 million compared to a net loss of $10.3 million in 1999.


    YEARS ENDED DECEMBER 31, 1999 AND 1998


    Research and development expenses increased to $8.3 million in 1999 from
$3.9 million in 1998. This increase was primarily due to increases in research
and development staff and associated increases in supplies and support services
as Eligix accelerated development efforts of its BCell-HDM and TCell-HDM
products in preparation for initiating further clinical trials and preparing its
products and production systems to be compliant with CE marking requirements.
General, administrative and marketing expenses increased to $2.2 million in 1999
from $1.6 million in 1998. This increase was primarily due to increased staffing
and professional services rendered in connection with financing and market
research and development.


    Interest income increased to $0.3 million in 1999 compared to $0.2 million
in 1998. The increase was due to higher average cash balances available for
investment during 1999.

    Interest expense increased to $0.2 million in 1999 from $0.04 million in
1998. This increase was primarily due to increased borrowings under a debt
financing agreement.


    As a result of the above factors, Eligix incurred a net loss in 1999 of
$10.3 million compared to a net loss of $5.4 million in 1998.



LIQUIDITY AND CAPITAL RESOURCES



    Since its inception, Eligix' operations have been funded principally through
aggregate net proceeds of approximately $32.5 million from issuance of debt and
equity securities. The proceeds have been used to fund operating losses of
approximately $31.6 million from inception, December 27, 1996, through
December 31, 2000, and the investment of approximately $3.7 million in equipment
and leasehold improvements. At December 31, 2000, there were $7.5 million in
borrowings outstanding under convertible subordinated notes, excluding discount
but including accrued interest, and approximately $2.2 million outstanding under
debt obligations. Eligix had no significant commitments as of December 31, 2000
for capital expenditures.



    Eligix anticipates that it will be required to raise additional debt and/or
equity capital to fund its operating and capital requirements as currently
planned through 2001. Eligix will borrow up to $2.0 million from BioTransplant
under the promissory note to fund operations through the anticipated closing
date of the merger contemplated hereby. As of February 28, 2001, Eligix had
borrowed $1.0 million from BioTransplant under the promissory note. The interest
rate on the note is the Fleet Bank prime rate. The debt will be forgiven and the
note cancelled concurrently with the closing of the merger, provided that if the
merger does not close on or before June 30, 2001, then the note will become
immediately due and payable in full. Eligix will also be required to raise
additional debt and/or equity capital to fund repayment of its convertible
subordinated debt should holders of the notes determine not to convert the notes
to preferred stock of Eligix. Holders of $5.2 million of the $7.5 million
principal outstanding under the notes, representing 68.6% of the outstanding
notes, have indicated an intent to convert those notes in connection with the
closing of the merger. Under the terms of the notes, all of the notes will be
converted upon conversion by holders of notes representing at least 66 2/3% of
the aggregate outstanding principal under all of the notes. Eligix' cash
requirements may vary materially from those now planned due to many factors,
including, but not limited to, the progress of Eligix' research and development
programs, the scope and results of preclinical and clinical


                                      103


testing, changes in existing and potential relationships with corporate
collaborators, the time and cost in obtaining regulatory approvals, the costs
involved in obtaining and enforcing patents, proprietary rights and any
necessary licenses, the ability of Eligix to establish development and
commercialization capabilities or relationships, the costs of manufacturing and
other factors.



    Eligix expects to incur substantial additional costs, including costs
related to research and development activities, preclinical studies, clinical
trials, obtaining regulatory approvals, manufacturing, marketing and the
expansion of its facilities. Eligix will need to raise substantial additional
funds, through additional financings including public or private equity
offerings and/or collaborative arrangements with corporate partners. There can
be no assurance that funds will be available on terms acceptable to Eligix, if
at all. If adequate funds are not available, Eligix may be required to delay,
scale back or eliminate some or all of its product development programs or to
license to others the right to commercialize products or technologies that
Eligix would otherwise seek to develop and commercialize itself, any of which
would have a material and adverse effect on Eligix.


QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISKS

    Eligix owns financial instruments that are sensitive to market risks as part
of its investment portfolio. All of these market-risk sensitive instruments are
classified as cash and cash equivalents. Eligix does not own any derivative
financial instruments in its investment portfolio. The investment portfolio
contains instruments that are subject to the risk of a decline in interest
rates.

    INTEREST RATE RISK:  Eligix' investment portfolio includes cash and cash
equivalents. Due to the short duration and conservative nature of these
instruments, Eligix does not believe that it has a material exposure to interest
rate risk.

                                      104


          UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION


    The following unaudited pro forma condensed combined financial information
gives effect to the merger using the purchase method of accounting, after giving
effect to the pro forma adjustments described in the accompanying notes. The
unaudited pro forma condensed combined financial information should be read in
conjunction with the historical financial statements and related notes of
BioTransplant and Eligix, which appear elsewhere in this joint proxy
statement/prospectus.


    Under the terms of the merger agreement, a wholly-owned subsidiary of
BioTransplant, BT/EL Acquisition Co., will merge with and into Eligix and the
security holders of Eligix will be entitled to receive up to an aggregate of
5,610,000 shares of BioTransplant common stock, either in the merger or upon
exercise or conversion of Eligix options, warrants and notes assumed by
BioTransplant in the merger. All Eligix stockholders will have 10% of the
BioTransplant stock they would otherwise be entitled to receive deposited in an
escrow account that may be used to compensate BioTransplant if BioTransplant is
entitled to indemnification under the merger agreement. Any indemnification
escrow shares that, 15 months following the completion of the merger, have not
been used to indemnify BioTransplant and that are not subject to any unresolved
claims for indemnification by BioTransplant, will be distributed to the Eligix
stockholders. In addition, all Eligix stockholders will have an additional 10%
of their BioTransplant stock deposited in an escrow account to secure
achievement by Eligix of CE mark approval by the European Union of Eligix'
TCell-HDM product by December 31, 2001. If the European Union does not allow
Eligix to affix the CE mark, which denotes conformity to European standards for
safety, to its TCell-HDM product by December 31, 2001, the Eligix stockholders
will not receive any of the shares allocated to secure achievement of the
milestone.



    Additionally, twelve members of the Eligix management team will be entitled
to receive an aggregate of 990,000 shares of BioTransplant common stock under
the Eligix management equity incentive plan. These shares vest over a 365-day
period following the closing of the merger, with 33 1/3% of the shares vesting
90 days after closing of the merger, an additional 33 1/3% of the shares vesting
180 days after the closing of the merger, an additional 23 1/3% of the shares
vesting 270 days after the closing of the merger and the remaining 10% of the
shares vesting 365 days after the closing of the merger. If, within 365 days
after the closing of the merger, BioTransplant terminates a former Eligix
management member other than for cause, or a management member terminates his or
her employment for good reason, that management member's shares will vest
immediately in full upon termination. Otherwise, BioTransplant will have the
right to repurchase a terminated management member's unvested shares for $.01
per share. Of these shares, 99,000 will be held in escrow for 15 months
following the completion of the merger to compensate BioTransplant if it is
entitled to indemnification under the merger agreement and 99,000 shares will be
held in escrow to secure achievement by Eligix of CE mark approval by the
European Union of its TCell-HDM product by December 31, 2001. The value of the
990,000 shares will be treated as deferred compensation and will be expensed
over the 365-day vesting period. The per share price used to determine the value
of these shares will be the fair market value of BioTransplant common stock on
the closing date of the merger. Additionally, shares held in escrow to secure
the achievement of CE mark approval will be valued using the fair market value
of BioTransplant common stock on the date these shares are released from escrow.



    The merger will be accounted for using the purchase method of accounting, in
a manner consistent with Accounting Principles Board (APB) No. 16. Accordingly,
the total purchase price will be allocated to the assets acquired and
liabilities assumed based upon their estimated fair values. The purchase price
will be determined using the average market value of BioTransplant common stock
for the period from two days before to two days after the announcement of the
merger, December 11, 2000, which is $8.3564 per share, to value the common
shares deemed to be issued to the Eligix security holders at the closing date,
consisting of the shares issuable at the closing date and the indemnity escrow
shares, and adding the expenses of the merger. Additionally, the fair value of
BioTransplant options and


                                      105


warrants exchanged for Eligix options and warrants in excess of the intrinsic
value of unvested Eligix employee options and warrants will be determined in
accordance with the Black-Scholes option pricing model and will be treated as
purchase price.



    Deferred compensation recorded in connection with the acquisition consists
of the intrinsic value of unvested options issued to Eligix employees and shares
of stock issuable as of the closing date under the Eligix management equity
incentive plan.



    The value of all options and warrants and all shares issuable under the
Eligix management equity incentive plan at the closing date will be valued as of
closing date.



    For purposes of the pro forma disclosure below, the options, warrants and
shares issuable as of the closing date under the Eligix management equity
incentive plan have been valued as of December 31, 2000.



    The estimate of the purchase price and deferred compensation which has been
used for the unaudited pro forma condensed combined financial information as of
December 31, 2000 is as follows, in thousands:




                                      
Purchase price:
  Common stock (4,286,357 shares)....                   $35,819
  Value of BioTransplant's options
    (637,823 shares) and warrants
    (124,820 shares) exchanged for
    Eligix' options and warrants.....                     4,643
  Estimated merger expenses..........                     3,700
                                                        -------
Total purchase price.................                    44,162
                                                        -------
Deferred compensation:
  Deferred compensation related to
    unvested options issued to Eligix
    employees........................                     1,492
  Deferred compensation related to
    restricted shares issued under
    the Eligix management equity
    incentive plan...................                     7,740
                                                        -------
Total deferred compensation..........                     9,232
                                                        -------
Total consideration..................                   $53,394
                                                        =======




    The actual purchase price and deferred compensation will be determined at
closing and will reflect the actual closing balance sheet of Eligix consistent
with APB No. 16. With the assistance of valuation experts, the purchase price
will be allocated to the tangible and intangible assets acquired and liabilities
based on their fair values. Based upon preliminary appraisals, the purchase
price allocation and


                                      106


deferred compensation which has been used for the unaudited pro forma condensed
combined financial information is as follows, in thousands:




                                      
Purchase price:
  Net liabilities assumed............                   $  (417)
  Intangible assets:
    Assembled workforce..............                       969
    Acquired technology..............                    24,228
    In-process research and
      development....................                    19,382
                                                        -------
  Total purchase price...............                    44,162

  Deferred compensation:
    Deferred compensation related to
      unvested options issued to
      Eligix employees...............                     1,492
    Deferred compensation related to
      restricted shares issued under
      the Eligix management equity
      incentive plan.................                     7,740
                                                        -------
  Total deferred compensation........                     9,232
                                                        -------
  Total consideration................                   $53,394
                                                        =======




    The final purchase price allocation will be determined in 2001, after the
closing, and will reflect the final purchase price calculation and the final
appraisals of the tangible and intangible assets acquired. In addition, to the
extent that the 10% escrowed shares relating to CE mark approval of the Eligix
TCell-HDM product are released to the former Eligix stockholders and the Eligix
management members under the Eligix management equity incentive plan, the
purchase price and deferred compensation will be increased by the value of such
shares on the date the relevant escrow release is satisfied.



    With the assistance of our valuation advisors, all the intangible assets
that are part of the purchase of Eligix were identified and a preliminary
valuation was made. It was determined that the intangible assets included
assembled workforce, technology, which included core technology and patents
owned and licensed and in-process research and development.



    Eligix has rights to the technology that it licenses and on which it may pay
royalties and/or license fees. The royalties and license fees have been
negotiated at arms-length and they currently represent fair market royalty
rates. As such, it was determined that no favorable license right existed at
Eligix. The trademarks/names were not valued because it was concluded that their
value was not material. The preliminary valuation of intangibles included
$969,000 for the assembled workforce, $24.2 million for acquired technology and
$19.4 million for in-process research and development. Intangible assets,
excluding in-process research and development, are expected to be amortized over
five to seven years. The fair value of the in-process research and development,
which relates to Eligix' current in-process development projects, will be
recorded as an expense in the period in which the merger is completed. Deferred
compensation will be expensed over the remaining vesting period of the options
and shares of one to five years.


    The acquired in-process research and development, or IPR&D, consists of
development work to date on the projects described below. The technology
resulting from these development efforts offers no alternative use in the event
that they prove to be not feasible. If the technology failed to achieve FDA
approval and was proposed for an alternate indication, it would be subjected to
the risk

                                      107

associated with another series of clinical trials. The new indication would also
face regulatory risks associated with the FDA approval process.

    Most remaining development spending associated with the projects concerns
not only their technical completion but also principally the cost of completing
clinical trials required for ultimate FDA approval. All of these remaining costs
would be incurred in full should the projects fail and need to return to the
laboratory for further development. The development effort for the acquired
IPR&D does not possess alternative future use for Eligix under the terms of SFAS
No. 2.

    The valuation of the in-process research and development was determined
using the income method. Revenue and expense projections as well as technology
assumptions were prepared through 2014 based on information provided by Eligix
management. Revenue projections for each in-process development project were
identified as follows: (1) revenue derived from products relying on current
technology, if any, and (2) revenue derived from projects relying on a new
in-process research and development project. Expense projections including cost
of goods and operating expenses varied depending on the in-process development
project. The projected cash flows, adjusted based on probability of success,
were discounted using an 18% rate. The fair value of in-process research and
development was determined separately from all other acquired assets using the
income approach. The in-process development projects are not expected to reach
technological feasibility until the 2001-2004 timeframe. Management is
responsible for the assumptions used to determine the estimated fair value of
the in-process research and development.

    The following table summarizes the nature, timing and estimated completion
cost for each Eligix IPR&D project, which is measured (1) for the United States
only for BCell-HDM, with the expectation of near-term receipt of CE mark for
BCell-HDM, recognized as acquired technology, and (2) for the earlier of CE mark
approval or FDA approval for TCell-HDM and PanT-HDM:



                                                                                      ESTIMATED COST
                   DESCRIPTION OF PROJECT                     EXPECTED RELEASE DATE    TO COMPLETE
                   ----------------------                     ---------------------   --------------
                                                                                
TCell-HDM...................................................         2001             $4.0 million
PanT-HDM....................................................         2003             $15.0 million
BCell-HDM...................................................         2004             $13.0 million


    Based on the timing of the closing of the transaction, the finalization of
the integration plans and other factors, the final purchase adjustments may
differ materially from those presented in the pro forma condensed combined
financial information. A final appraisal of the intangibles will be performed as
of the closing date and the allocation adjusted accordingly. The effect of these
adjustments on the results of operations will depend on the nature and amount of
the assets or liabilities adjusted.


    The unaudited pro forma condensed combined financial information does not
purport to represent what the consolidated financial position or results of
operations actually would have been if the merger, in fact, had occurred on
December 31, 2000 or on January 1, 2000 or to project the consolidated financial
position or results of operations as of any future date or any future period.
BioTransplant is developing plans for integration of Eligix and has not
determined if there will be any cost savings. This information should be read in
conjunction with the historical consolidated financial statements of
BioTransplant and Eligix, including the related notes and other financial
information included in this joint proxy statement-prospectus.


                                      108


              UNAUDITED PRO FORMA CONDENSED COMBINED BALANCE SHEET
                            AS OF DECEMBER 31, 2000





                                                                                    PRO FORMA
                                                                            --------------------------
                                                 BIOTRANSPLANT    ELIGIX    ADJUSTMENTS      COMBINED
                                                 -------------   --------   -----------      ---------
                                                                    (IN THOUSANDS)
                                                                                 
                                                ASSETS
Current Assets:
  Cash and cash equivalents....................    $ 11,481      $    712     $ (3,700)(B)   $   8,493
  Short-term investments.......................       3,391            --           --           3,391
  Other receivable.............................          19            --           --              19
  Prepaid expenses and other current assets....         824           124           --             948
                                                   --------      --------     --------       ---------
    Total current assets.......................      15,715           836       (3,700)         12,851
                                                   --------      --------     --------       ---------
  Property and equipment, net..................       1,337         2,743           --           4,080
                                                   --------      --------     --------       ---------
Other Assets:
  Assembled workforce..........................          --            --          969(A)          969
  Acquired technology..........................          --            --       24,228(A)       24,228
  Other........................................         105           128           --             233
                                                   --------      --------     --------       ---------
    Total other assets.........................         105           128       25,197          25,430
                                                   --------      --------     --------       ---------
                                                   $ 17,157      $  3,707     $ 21,497       $  42,361
                                                   ========      ========     ========       =========
                            LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
Current Liabilities:
  Current portion of long-term debt............    $    233      $     --     $     --       $     233
  Current portion of capital lease                       37            --           --              37
    obligations................................
  Current portion of loans payable.............          --           945           --             945
  Convertible notes............................          --         7,548       (7,548)(C)          --
  Accounts payable.............................         408           844           --           1,252
  Accrued expenses.............................       1,722           775           --           2,497
  Cash overdraft...............................          --           296           --             296
                                                   --------      --------     --------       ---------
    Total current liabilities..................       2,400        10,408       (7,548)          5,260
                                                   --------      --------     --------       ---------
Long-term debt, net of current portion.........         253            --           --             253
                                                   --------      --------     --------       ---------
Capital lease obligations, net of current                82            --           --              82
  portion......................................
                                                   --------      --------     --------       ---------
Long-term portion of loans payable.............          --         1,264           --           1,264
                                                   --------      --------     --------       ---------
Convertible preferred stock....................          --        21,333      (21,333)(C)          --
                                                   --------      --------     --------       ---------
Stockholders' Equity (Deficit):
  Common stock.................................         118            --           43 (D)         170
                                                                                     9 (E)
  Additional paid-in capital...................      83,130         5,869       (5,869 )(C)    132,772
                                                                                 7,731 (E)
                                                                                40,419 (D)
                                                                                 1,492 (F)
  Deferred compensation........................          --        (3,587)       3,587 (C)      (9,232)
                                                                                (7,740 )(E)
                                                                                (1,492)(F)
  Deficit accumulated during the development        (68,826)      (31,580)     (19,382 )(A)    (88,208)
    stage......................................                                 31,580 (C)
                                                   --------      --------     --------       ---------
    Total stockholders' equity (deficit).......      14,422       (29,298)      50,378          35,502
                                                   --------      --------     --------       ---------
  Total liabilities and stockholders' equity       $ 17,157      $  3,707     $ 21,497       $  42,361
    (deficit)..................................
                                                   ========      ========     ========       =========




   See notes to unaudited pro forma condensed combined financial information.


                                      109


        UNAUDITED PRO FORMA CONDENSED COMBINED STATEMENTS OF OPERATIONS
                      FOR THE YEAR ENDED DECEMBER 31, 2000





                                                                                    PRO FORMA
                                                                              ----------------------
                                                   BIOTRANSPLANT    ELIGIX    ADJUSTMENTS   COMBINED
                                                   -------------   --------   -----------   --------
                                                         (IN THOUSANDS, EXCEPT PER SHARE DATA)
                                                                                
Total Revenues...................................    $  4,563      $     --    $      --    $  4,563
                                                     --------      --------    ---------    --------
Expenses:
  Research and development.......................      14,973         8,097           --      23,070
  General, administrative and marketing..........       2,544         3,683           --       6,227
  Amortization of assembled workforce, acquired
    technology and deferred compensation.........          --            --       11,708(G)   11,708
                                                     --------      --------    ---------    --------
    Total expenses...............................      17,517        11,780       11,708      41,005
                                                     --------      --------    ---------    --------
Operating loss...................................     (12,954)      (11,780)     (11,708)    (36,442)
Other income (expense)...........................       1,275        (1,192)         632(H)      715
                                                     --------      --------    ---------    --------
Net loss.........................................    $(11,679)     $(12,972)   $ (11,076)   $(35,727)
                                                     ========      ========    =========    ========
  Net loss per common share:
    Basic and diluted............................    $  (1.01)     $ (83.15)                $  (2.28)
                                                     ========      ========                 ========
  Common shares used in computing basic and
    diluted net loss per share...................      11,547           156                   15,663
                                                     ========      ========                 ========




   See notes to unaudited pro forma condensed combined financial information.


                                      110

     NOTES TO UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

NOTE 1.  BASIS OF PRESENTATION


    The unaudited pro forma condensed combined statements of operations for the
year ended December 31, 2000 give effect to the merger as if the transaction had
occurred at the beginning of the period presented. The unaudited pro forma
condensed combined balance sheet of December 31, 2000 gives effect to the merger
as if it had occurred on December 31, 2000. The unaudited pro forma condensed
combined financial information is based upon a preliminary calculation of the
purchase price and deferred compensation and a preliminary purchase price and
deferred compensation allocation. The unaudited information will change based
upon the actual closing.



    Below is a table of the estimated purchase price and deferred compensation,
in thousands:





                                                               TOTAL
                                                              --------
                                                           
Estimated purchase price:
  Common stock..............................................  $35,819
  Value of BioTransplant's options and warrants exchanged
    for Eligix' options and warrants........................    4,643
  Estimated merger-related fees and expenses................    3,700
                                                              -------
    Total estimated purchase price..........................   44,162
                                                              -------
Estimated deferred compensation:
  Deferred compensation related to unvested options issued
    to Eligix employees.....................................    1,492
  Deferred compensation related to restricted shares issued
    under the Eligix management equity incentive plan.......    7,740
                                                              -------
Total estimated deferred compensation.......................    9,232
                                                              -------
Total estimated consideration...............................  $53,394
                                                              =======



    Below is a table of the preliminary purchase price allocation, in thousands:




                                                               TOTAL
                                                              --------
                                                           
Estimated purchase price allocation:
  Net liabilities assumed...................................  $  (417)
  Assembled workforce.......................................      969
  Acquired technology.......................................   24,228
  In-process research and development.......................   19,382
                                                              -------
    Total estimated purchase price allocation...............   44,162
                                                              -------
Estimated deferred compensation allocation:
  Deferred compensation related to unvested options issued
    to Eligix employees.....................................    1,492
  Deferred compensation related to restricted shares issued
    to members of Eligix' management under the Eligix
    management equity incentive plan........................    7,740
                                                              -------
Total estimated deferred compensation allocation............    9,232
                                                              -------
Total estimated consideration...............................  $53,394
                                                              =======



                                      111

     NOTES TO UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION
                                  (CONTINUED)

NOTE 2.  PRO FORMA ADJUSTMENTS


    Adjustments to record the purchase of Eligix on the December 31, 2000
unaudited pro forma condensed combined balance sheet, in thousands:




                                                             
(A)  To record assembled workforce...............................  $   969
     To record acquired technology...............................   24,228
     To record write-off of in-process research and
     development.................................................   19,382

(B)  To record payment of merger related expenses................  $(3,700)
(C)  To eliminate convertible notes and related accrued interest,
     convertible preferred stock and equity accounts of Eligix

(D)  To record the issuance of BioTransplant common stock,
     options and warrants for Eligix common stock, options and
     warrants:
     Common stock, $0.01 par value...............................  $    43
     Additional paid-in capital..................................   40,419

(E)  To record the issuance of 891,000 management equity
     incentive shares
     Deferred compensation.......................................  $(7,740)
     Common stock at $0.01 par value.............................        9
     Additional paid-in capital..................................    7,731

(F)  To record deferred compensation related to unvested options
     issued to Eligix employees
     Deferred compensation.......................................  $(1,492)
     Additional paid-in capital..................................    1,492




    Adjustments to record amortization of assembled workforce, acquired
technology and deferred compensation in the unaudited pro forma condensed
combined statement of operations for the year ended December 31, 2000, in
thousands:




                                                             
(G)  Amortization of assembled workforce.........................  $   194
     Amortization of acquired technology.........................    3,461
     Amortization of deferred compensation.......................    8,053
                                                                   -------

     Total.......................................................  $11,708
                                                                   =======

(H)  To eliminate interest expense related to Eligix convertible
     notes




        As required by Article 11 of Regulation S-X, the unaudited pro forma
    condensed combined statement of operations excludes material non-recurring
    charges which result directly from the merger and which will be recorded
    within twelve months following the merger. The following schedule shows the
    effect of the write-off of in-process research and development of
    $19,382,000.





                                                                  YEAR ENDED
                                                              DECEMBER 31, 2000
                                                              ------------------
                                                                (IN THOUSANDS)
                                                           
Pro forma combined net loss.................................       $(55,109)
Pro forma combined basic and diluted net loss per common
  share.....................................................       $  (3.52)



                                      112

     NOTES TO UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION
                                  (CONTINUED)

NOTE 3.  PRO FORMA NET LOSS PER SHARE


    The unaudited basic and diluted net loss per share is based on the weighted
average number of BioTransplant common shares outstanding prior to the merger
plus the number of shares of BioTransplant common stock deemed to be issued upon
the closing of the merger to existing security holders. Shares issuable under
the Eligix management equity incentive plan are included on a weighted average
basis calculated based on the respective vesting periods. Shares related to the
indemnity escrow have been included on a weighted average basis from the date of
expected issuance. Shares related to CE mark approval have not been included.


                                      113

              SECURITY OWNERSHIP OF CERTAIN BENEFICIAL HOLDERS AND
                          MANAGEMENT OF BIOTRANSPLANT


    The following table sets forth information as to the number of shares of
BioTransplant common stock beneficially owned as of February 28, 2001 by:


    - each person that beneficially owns more than 5% of the outstanding shares
      of BioTransplant common stock;

    - each director of BioTransplant;

    - BioTransplant's Chief Executive Officer;

    - the four other named executive officers of BioTransplant; and

    - all BioTransplant executive officers and directors as a group.


    Except as indicated by the notes to the following table, the holders listed
below will have sole voting power and investment power over the shares
beneficially held by them. Beneficial ownership is determined according to the
rules of the Securities and Exchange Commission. The table below includes shares
subject to options and warrants which will be exercisable within 60 days
following February 28, 2001. All percentages assume that the options and
warrants of the particular person or group in question, and no others, have been
exercised.





                                                              BENEFICIAL OWNERSHIP
                                                              ---------------------
NAME OF BENEFICIAL OWNER                                       SHARES      PERCENT
------------------------                                      ---------   ---------
                                                                    
5% BENEFICIAL HOLDERS

Rho Management Trust II(1) .................................   857,815         7.3%
  c/o Rho Management Company, Inc.
  767 Fifth Avenue
  New York, New York 10153

Funds managed by Hambrecht & Quist Capital Management,         740,451         6.3
  Inc.(2) ..................................................
  50 Rowes Wharf
  Boston, Massachusetts 02110

S Squared Technology Corporation(3) ........................   752,500         6.4
  515 Madison Avenue
  Suite 4200
  New York, NY 10022

Joseph A. Cohen(4)..........................................   771,600         6.5

DIRECTORS AND NAMED EXECUTIVE OFFICERS
Elliot Lebowitz, Ph.D.(5)...................................   372,537         3.1
Donald R. Conklin(6)........................................    14,857           *
William W. Crouse(7)........................................   216,528         1.8
James C. Foster, J.D.(8)....................................    23,731           *
Daniel O. Hauser(9).........................................    13,875           *
Michael S. Perry, D.V.M., Ph.D.(10).........................     7,500           *
James Hope, Ph.D.(11).......................................    85,007           *
Julia L. Greenstein, Ph.D.(12)..............................   110,732           *
Mary White-Scharf, Ph.D.(13)................................   108,985           *
Howard Grossberg, M.D.(14)..................................    12,500           *
All directors and executive officers as a group                880,395         7.0
  (9 individuals)(15).......................................



------------------------

*   Beneficial ownership does not exceed 1% of the outstanding shares of
    BioTransplant common stock.

                                      114


(1) Includes 38,466 shares of common stock which Rho Management Trust II has the
    right to acquire within 60 days of February 28, 2001 upon the exercise of
    warrants. Jan Philipp F. Reemtsma, Joshua Ruch and Fero Ventures Limited may
    be deemed to beneficially own the shares held by Rho Management Trust II and
    retain voting and dispositive rights for such shares.



(2) Includes 429,898 shares of common stock held by Hambrecht & Quist Health
    Care Investors, including 10,210 shares which H&Q Health has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of warrants,
    and 310,553 shares of common stock held by Hambrecht & Quist Life Science
    Investors, including 17,722 shares which H&Q Life has the right to acquire
    within 60 days of February 28, 2001 upon the exercise of warrants.
    Hambrecht & Quist Capital Management Inc. serves as the investment advisor
    to H&Q Health and H&Q Life. The respective general partners of H&Q Health
    and H&Q Life exercise sole voting and investment power with respect to the
    shares held by each fund.



(3) This information is based solely on information included in a Schedule 13G
    dated February 12, 2001.



(4) This information is based solely on information included in a
    Schedule 13G/A dated February 8, 2001.



(5) Includes 298,463 shares of common stock which Dr. Lebowitz has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.



(6) Includes 11,875 shares of common stock which Mr. Conklin has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.



(7) Includes the following shares of record:



       - 78,877 shares which HCV II, L.P. has the right to acquire within
         60 days of February 28, 2001 upon the exercise of warrants;



       - 99,705 shares which HCV III, L.P. has the right to acquire within
         60 days of February 28, 2001 upon the exercise of warrants;


       - 29,571 shares which HCV IV, L.P. has the right to acquire upon the
         exercise of warrants; and


       - 7,750 shares of common stock which Mr. Crouse has the right to acquire
         within 60 days of February 28, 2001 upon the exercise of stock options.


    Mr. Crouse is a general partner of HealthCare Partners II, L.P., HealthCare
    Partners III, L.P. and HealthCare Partners IV, L.P., the general partners,
    respectively, of HCV II, L.P., HCV III, L.P. and HCV IV, L.P. Mr. Crouse,
    together with the other general partners of HCV II, HCV III and HCV IV,
    respectively, shares voting and investment control with respect to the
    shares owned by HCV II, HCV III and HCV IV. The same individuals serve as
    general partners of HealthCare Partners II, L.P., HealthCare Partners III,
    L.P. and HealthCare Partners IV, L.P.


(8) Includes 2,856 shares of common stock owned by Charles River
    Laboratories, Inc. Mr. Foster, a director of BioTransplant, is the President
    and Chief Executive Officer of Charles River Laboratories and may be deemed
    to beneficially own the shares of Charles River Laboratories, although he
    disclaims beneficial ownership. Also includes 7,750 shares of common stock
    which Mr. Foster has the right to acquire within 60 days of February 28,
    2001 upon the exercise of stock options.



(9) Includes 13,250 shares of common stock which Dr. Hauser has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.



(10) Includes 7,500 shares of common stock which Dr. Perry has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.


                                      115


(11) Includes 84,707 shares of common stock which Dr. Hope has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options. Includes 300 shares of common stock owned by Dr. Hope's minor
    children.



(12) Dr. Greenstein has resigned as Senior Vice President, Research of
    BioTransplant, effective January 1, 2001, in order to assume the position of
    Chief Executive Officer of Immerge BioTherapeutics AG and Immerge
    BioTherapeutics, Inc., the operating entities of BioTransplant's joint
    venture with Novartis. Dr. Greenstein will continue to serve as an employee
    at BioTransplant but will no longer have the duties or title of an officer
    of BioTransplant. Includes 110,732 shares of common stock which
    Dr. Greenstein has the right to acquire within 60 days of February 28, 2001
    upon the exercise of stock options.



(13) Includes 97,234 shares of common stock which Dr. White-Scharf has the right
    to acquire within 60 days of February 28, 2001 upon the exercise of stock
    options. Also includes 600 shares of common stock owned by Dr.
    White-Scharf's minor children.



(14) Represents 12,500 shares of common stock which Dr. Grossberg has the right
    to acquire within 60 days of February 28, 2001 upon the exercise of stock
    options. Dr. Grossberg resigned in February 2001 and will continue as a
    consultant to BioTransplant.



(15) Includes 774,057 shares of BioTransplant common stock which all directors
    and executive officers as a group may acquire upon the exercise of
    outstanding stock options and warrants exercisable within 60 days of
    February 28, 2001.


                                      116

                SECURITY OWNERSHIP OF CERTAIN BENEFICIAL HOLDERS
                            AND MANAGEMENT OF ELIGIX


    The following table sets forth information as to the number of shares of
Eligix stock beneficially owned as of February 28, 2001 by:


    - each person that beneficially owns more than 5% of the outstanding shares
      of Eligix common stock or Eligix preferred stock;

    - each director of Eligix;

    - Eligix' Chief Executive Officer;

    - the five other most highly compensated Eligix executive officers who
      received annual compensation in excess of $100,000 during 2000; and

    - all Eligix executive officers and directors as a group.


    Except as indicated by the notes to the following table, the holders listed
below will have sole voting power and investment power with respect to the
shares beneficially owned by them. The number of shares of Eligix common stock
listed in the table below does not include the shares of Eligix common stock
issuable upon conversion of Eligix preferred stock. All percentages assume that
the options, warrants and notes of the particular person or group in question,
and no others, have been exercised or converted. Unless indicated otherwise, the
address for each person is to the care of Eligix, Inc., 200 Boston Avenue,
Medford, Massachusetts 02155.





                                                                  BENEFICIAL OWNERSHIP
                                                 -------------------------------------------------------
                                                                                             PERCENT OF
                                                                               PERCENT OF    AGGREGATE
NAME OF BENEFICIAL OWNER                         CLASS OF STOCK     SHARES       CLASS      VOTING POWER
------------------------                         --------------   ----------   ----------   ------------
                                                                                
5% BENEFICIAL HOLDERS

Brinson Venture Capital Fund(1)................     Common            93,194      23.1%          *
                                                  Preferred        1,772,475       7.9           7.8%
Entities affiliated with Advanced Technology
  Ventures L.P.(2).............................     Common           232,058      42.8           1.0
                                                  Preferred        3,658,729      15.9          15.7
Entities affiliated with InterWest
  Partners(3)..................................     Common           300,451      49.2           1.3
                                                  Preferred        6,643,447      28.2          27.9
Beckman Coulter, Inc. (f.k.a. Coulter
  Corporation).................................     Common                --        --          --
                                                  Preferred        2,450,000      11.1          11.0

The Wallace H. Coulter Foundation(4)...........     Common           273,645      46.8           1.2
                                                  Preferred        5,473,618      23.5          23.2

Joseph R. Coulter, III(5)......................     Common           107,713      25.7           *
                                                  Preferred        1,853,498       8.2           8.1



                                      117





                                                                  BENEFICIAL OWNERSHIP
                                                 -------------------------------------------------------
                                                                                             PERCENT OF
                                                                               PERCENT OF    AGGREGATE
NAME OF BENEFICIAL OWNER                         CLASS OF STOCK     SHARES       CLASS      VOTING POWER
------------------------                         --------------   ----------   ----------   ------------
                                                                                
DIRECTORS AND NAMED EXECUTIVE OFFICERS

Walter C. Ogier(6).............................     Common         1,010,000      76.5%          4.3%

James R. Fitzgerald, Jr.(6)....................     Common           225,000      42.0           1.0

David N. Cook, Ph.D.(6)........................     Common           399,000      56.2           1.7

James A. Embree(6).............................     Common           405,750      56.8           1.8

Judith Snow(6).................................     Common           360,000      53.7           1.6

Tara Clark(6)..................................     Common           237,417      43.3           1.0

Laura Coulter-Jones(7).........................     Common           122,301      28.3           *
                                                  Preferred        2,104,532       9.3           9.2

Robert Momsen(3)...............................     Common           300,451      49.2           1.3
                                                  Preferred        6,643,447      28.1          27.8

Arnold L. Oronsky, Ph.D.(8)....................     Common           299,468      49.1           1.3
                                                  Preferred        6,621,705      28.2          27.9

Susan M. Racher(4).............................     Common           273,645      46.8           1.2
                                                  Preferred        5,473,618      23.5          23.2

Pieter Schiller(2).............................     Common           232,058      42.8           1.0
                                                  Preferred        3,658,729      15.9          15.7
All executive officers and directors as a group
  (11 individuals)(9)..........................     Common         3,565,622      92.0          13.7
                                                  Preferred       17,880,326      44.7          44.4



------------------------

*   Beneficial ownership does not exceed 1% of the outstanding Eligix common
    stock.


(1) Represents shares held by Brinson MAP Venture Capital Fund III and Brinson
    Venture Capital Fund III, L.P. Includes 93,194 shares of Eligix common stock
    which Brinson MAP Venture Capital Fund III and Brinson Venture Capital Fund
    III, L.P. have the right to acquire within 60 days of February 28, 2001 upon
    the exercise of warrants. Includes 397,465 shares of Eligix Series C-1
    preferred stock which Brinson MAP Venture Capital Fund III and Brinson
    Venture Capital Fund III, L.P. has the right to acquire within 60 days of
    February 28, 2001 upon the conversion of convertible notes.



(2) Represents shares held by Advanced Technology Ventures V, L.P. and ATV
    Entrepreneurs V, L.P. Pieter Schiller is a general partner of these entities
    and may be deemed to exercise voting and investment control with respect to
    the shares held by Advanced Technology Ventures V, L.P. and ATV
    Entrepreneurs V, L.P. Mr. Schiller disclaims beneficial ownership of these
    shares except to the extent of his pecuniary interest therein. Includes
    232,058 shares of Eligix common stock which Advanced Technology Ventures V,
    L.P. and ATV Entrepreneurs V, L.P. have the right to acquire within 60 days
    of February 28, 2001 upon the exercise of warrants. Includes 898,729 shares
    of Eligix Series C-1 preferred stock which Advanced Technology Ventures V,
    L.P. and ATV Entrepreneurs V, L.P. have the right to acquire within 60 days
    of February 28, 2001 upon the conversion of convertible notes.



(3) Represents shares held by InterWest Partners V, L.P., InterWest Investors V,
    InterWest Partners VI, L.P. and InterWest Investors VI, L.P. Robert Momsen
    is a general partner of InterWest Management Partners V, L.P., the sole
    general partner of InterWest Partners V, L.P. Mr. Momsen is a general
    partner of InterWest Investors V. Mr. Momsen also serves as a Managing
    Director of InterWest Management Partners VI, L.L.C., the sole general
    partner of InterWest Partners VI, L.P. and InterWest Investors VI, L.P.
    Mr. Momsen, together with the other general partners of InterWest Partners
    V, L.P., InterWest Investors V, InterWest Partners VI, L.P., and InterWest


                                      118


    Investors VI, L.P., respectively, share voting and investment control with
    respect to the shares owned by InterWest Partners V, L.P., InterWest
    Investors V, InterWest Partners VI, L.P. and InterWest Investors VI, L.P.
    Mr. Momsen disclaims beneficial ownership of the shares held by InterWest
    Partners V, L.P., InterWest Investors V, L.P., InterWest Partners VI, L.P.
    and InterWest Investors VI, L.P. except to the extent of his pecuniary
    interest therein. Includes an aggregate of 300,451 shares of Eligix common
    stock which InterWest Investors V, InterWest Partners V, L.P., InterWest
    Investors VI, L.P. and InterWest Partners VI, L.P. have the right to acquire
    within 60 days of February 28, 2001 upon the exercise of warrants. Also
    includes an aggregate of 1,393,390 shares of Eligix Series C-1 preferred
    stock which InterWest Investors V, InterWest Partners V, L.P., InterWest
    Investors VI, L.P. and InterWest Partners VI, L.P. have the right to acquire
    within 60 days of February 28, 2001 upon the conversion of convertible
    notes.



(4) Includes 266,799 shares of Eligix common stock which the Wallace H. Coulter
    Foundation has the right to acquire within 60 days of February 28, 2001 upon
    the exercise of warrants. Also includes 1,199,512 shares of Eligix Series
    C-1 preferred stock which the Wallace H. Coulter Foundation has the right to
    acquire within 60 days of February 28, 2001 upon the conversion of
    convertible notes. Susan Racher is the Chief Financial Officer of the
    Wallace H. Coulter Foundation and may be deemed to exercise voting and
    investment control with respect to shares held by the Foundation.
    Ms. Racher disclaims beneficial ownership of these shares.



(5) Represents shares held by the JRC Investment Limited Partnership, the Joseph
    R. Coulter, Jr. Trust, and the Joseph R. Coulter, Jr. Trust, Laura
    Coulter-Jones and Joseph Coulter, III Trustees. Includes 107,713 shares of
    Eligix common stock which Joseph R. Coulter, III has the right to acquire
    within 60 days of February 28, 2001 upon the exercise of warrants. Also
    includes 435,872 shares of Series C-1 preferred stock which Joseph R.
    Coulter, III has the right to acquire within 60 days of February 28, 2001
    upon the conversion of convertible notes.



    With respect to shares held as trustee for the Joseph R. Coulter, Jr. Trust
and the Joseph R. Coulter, Jr. Trust, Laura Coulter-Jones and Joseph Coulter,
III Trustees, Joseph R. Coulter III disclaims beneficial ownership, except to
the extent of his pecuniary interest therein.



(6) The share amounts for each of the individuals listed below includes the
    number of shares of Eligix common stock following their respective names
    which each individual has the right to acquire within 60 days of
    February 28, 2001 upon the exercise or conversion of stock options, warrants
    or notes:





NAME                                                          NUMBER OF SHARES
------------------------------------------------------------  ----------------
                                                           
Walter C. Ogier.............................................      1,010,000
David N. Cook, Ph.D.........................................        399,000
James A. Embree.............................................        405,750
Judith Snow.................................................        360,000
Tara Clark..................................................        237,417
James R. Fitzgerald, Jr.....................................        225,000



    1,614,000 of the above shares are immediately exercisable. However, the
    shares issuable upon exercise of these options vest over a five-year period
    with any unvested shares being subject to repurchase by Eligix. These shares
    vest in full and the repurchase right terminates upon consummation of the
    merger.


(7) Represents shares held by Laura Coulter-Jones directly, by the LGC
    Investment Limited Partnership and as trustee for the Joseph R. Coulter, Jr.
    Trust, and the Joseph R. Coulter, Jr. Trust, Laura Coulter-Jones and Joseph
    Coulter, III Trustees. Includes 122,301 shares of Eligix common stock which
    Ms. Coulter-Jones, the LGC Investment Limited Partnership, the Joseph R.
    Coulter, Jr. Trust, and the Joseph R. Coulter, Jr. Trust, Laura
    Coulter-Jones and Joseph Coulter, III Trustees have the right to acquire
    within 60 days of February 28, 2001 upon the exercise of warrants. Includes
    494,906 shares of Eligix Series C-1 preferred stock which
    Ms. Coulter-Jones, the LGC Investment Limited Partnership, the Joseph R.
    Coulter, Jr. Trust, and the Joseph R. Coulter, Jr. Trust, Laura
    Coulter-Jones and Joseph Coulter, III Trustees have the right to acquire
    within 60 days of February 28, 2001 upon the conversion of convertible
    notes. With


                                      119


    respect to shares held as trustee for the Joseph Coulter, Jr. Trust and the
    Joseph R. Coulter, Jr. Trust, Laura Coulter-Jones and Joseph Coulter, III
    Trustees, Laura Coulter-Jones disclaims beneficial ownership, except to the
    extent of her pecuniary interest therein.



(8) Represents shares held by InterWest Partners V, L.P., InterWest Partners VI,
    L.P. and InterWest Investors VI, L.P. Arnold L. Oronsky is a general partner
    of InterWest Management Partners V, L.P., the sole general partner of
    InterWest Partners V, L.P. Dr. Oronsky also serves as a Managing Director of
    InterWest Management Partners VI, L.L.C., the sole general partner of
    InterWest Partners VI, L.P. and InterWest Investors VI, L.P. Dr. Oronsky,
    together with the other general partners of InterWest Partners V, L.P.,
    InterWest Partners VI, L.P. and InterWest Investors VI, L.P., respectively,
    share voting and investment control with respect to the shares owned by
    InterWest Partners V, L.P., InterWest Partners VI, L.P. and InterWest
    Investors VI, L.P. Dr. Oronsky disclaims beneficial ownership of the shares
    held by InterWest Partners V, L.P., InterWest Partners VI, L.P. and
    InterWest Investors VI, L.P., except to the extent of his pecuniary interest
    therein. Includes an aggregate of 299,468 shares of Eligix common stock
    which InterWest Partners V L.P., InterWest Partners VI, L.P. and InterWest
    Investors VI, L.P. have the right to acquire within 60 days of February 28,
    2001 upon the exercise of warrants. Also includes an aggregate of 1,388,830
    shares of Eligix Series C-1 preferred stock which InterWest Partners V,
    L.P., InterWest Partners VI, L.P. and InterWest Investors VI, L.P. have the
    right to acquire within 60 days of February 28, 2001 upon the conversion of
    convertible notes.



(9) Includes an aggregate of 3,644,281 shares of Eligix common stock which all
    executive officers and directors have the right to acquire within 60 days of
    February 28, 2001 upon the exercise of all outstanding options, notes and
    warrants.


                                      120

              SECURITY OWNERSHIP OF CERTAIN BENEFICIAL HOLDERS AND
                MANAGEMENT OF BIOTRANSPLANT FOLLOWING THE MERGER


    The following table sets forth pro forma information as of February 28, 2001
as to the number of shares of BioTransplant common stock that will be
beneficially owned, assuming consummation of the merger on April 30, 2001, by:


    - each person that will beneficially own more than 5% of the outstanding
      shares of the combined company;

    - each individual who will be a director of the combined company;

    - the Chief Executive Officer of the combined company and the four other
      most highly compensated executive officers of the combined company based
      on fiscal year 2000 compensation; and

    - the combined company's executive officers and directors as a group.


    Except as indicated by the notes to the following table, the holders listed
below will have sole voting power and investment power over the shares
beneficially held by them. The table below includes shares subject to options
and warrants which will be exercisable within 60 days following February 28,
2001 and assumes that options held by officers and directors of Eligix, that by
their terms accelerate in full upon the closing of the merger, have accelerated.
All percentages assume the issuance of 5,940,594 shares of BioTransplant common
stock, which represents shares issued (1) to Eligix stockholders in connection
with the merger, (2) to Eligix management members under the Eligix management
equity incentive plan and (3) to holders of Eligix warrants and notes, which are
expected to be exercised or converted prior to the consummation of the merger.
All percentages assume that the BioTransplant options and warrants of the
particular person or group in question, and no others, have been exercised.





                                                                PRO FORMA BENEFICIAL
                                                                     OWNERSHIP
                                                              ------------------------
NAME OF BENEFICIAL OWNER                                       SHARES         PERCENT
------------------------                                      ---------       --------
                                                                        
5% BENEFICIAL OWNERS

Entities affiliated with InterWest Partners V, L.P.(1)......  1,217,327          6.9%
  c/o Eligix, Inc.
  200 Boston Avenue
  Medford, Massachusetts 02155

The Wallace H. Coulter Foundation(2)........................  1,012,651          5.7
  c/o Eligix, Inc.
  200 Boston Avenue
  Medford, Massachusetts 02155

DIRECTORS AND NAMED EXECUTIVE OFFICERS

Elliot Lebowitz, Ph.D.(3)...................................    372,537          2.1
James C. Foster, J.D.(4)....................................     23,731            *
Daniel O. Hauser(5).........................................     13,875            *
Walter C. Ogier(6)..........................................    271,855          1.5
Arnold L. Oronsky, Ph.D.(7).................................  1,213,440          6.8
Michael S. Perry, D.V.M., Ph.D.(8)..........................      7,500            *
Susan M. Racher(2)..........................................  1,012,651          5.7
James Hope, Ph.D.(9)........................................     85,007            *
James R. Fitzgerald, Jr.(10)................................    179,547          1.0
All directors and executive officers as a group (14           3,735,044         21.1
  individuals)(11)..........................................



------------------------

*   Beneficial ownership does not exceed 1% of the outstanding shares of
    BioTransplant common stock.

                                      121


(1) Represents shares held by InterWest Partners V, L.P., InterWest Investors V,
    InterWest Partners VI, L.P. and InterWest Investors VI, L.P. Includes 27,431
    shares of common stock which InterWest Partners V, L.P., InterWest Investors
    V, InterWest Partners VI, L.P. and InterWest Investors VI, L.P. have the
    right to acquire within 60 days of February 28, 2001 upon the exercise of
    warrants.



(2) Susan Racher is the Chief Financial Officer of the Wallace H. Coulter
    Foundation and may be deemed to exercise voting and investment control with
    respect to shares held by the Foundation. Ms. Racher disclaims beneficial
    ownership of these shares. Includes 24,984 shares of common stock which the
    Wallace H. Coulter Foundation has the right to acquire within 60 days of
    February 28, 2001 upon the exercise of warrants.



(3) Includes 298,463 shares of common stock which Dr. Lebowitz has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.



(4) Includes 2,856 shares of common stock owned by Charles River
    Laboratories, Inc. Mr. Foster, a director of BioTransplant, is the President
    and Chief Executive Officer of Charles River Laboratories and may be deemed
    to beneficially own the shares of Charles River Laboratories, although he
    disclaims beneficial ownership. Also includes 7,750 shares of common stock
    which Mr. Foster has the right to acquire within 60 days of February 28,
    2001 upon the exercise of stock options.



(5) Includes 13,250 shares of common stock which Dr. Hauser has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.



(6) Includes 109,560 shares of common stock which Mr. Ogier has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.



(7) Represents shares held by InterWest Partners V, L.P., InterWest
    Partners VI, L.P. and InterWest Investors VI, L.P. Arnold L. Oronsky is
    general partner of InterWest Management Partners V, L.P., the sole general
    partner of InterWest Partners V, L.P. Dr. Oronsky also serves as Managing
    Director of InterWest Management Partners VI, L.L.C., the sole general
    partner of InterWest Partners VI, L.P. and InterWest Investors VI, L.P.
    Dr. Oronsky, together with the other general partners of InterWest
    Partners V, L.P., InterWest Partners VI, L.P. and InterWest
    Investors VI, L.P., respectively, shares voting and investment control with
    respect to the shares owned by InterWest Partners V, L.P., InterWest
    Partners VI, L.P. and InterWest Investors VI, L.P. Dr. Oronsky disclaims
    beneficial ownership of the shares held by InterWest Partners V, L.P.,
    InterWest Partners VI, L.P. and InterWest Investors VI, L.P. except to the
    extent of his pecuniary interest therein. Includes 27,341 shares of common
    stock which InterWest Partners V, L.P., InterWest Partners VI, L.P. and
    InterWest Investors VI, L.P. have the right to acquire within 60 days of
    February 28, 2001 upon the exercise of warrants.



(8) Includes 7,500 shares of common stock which Dr. Perry has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.



(9) Includes 84,707 shares of common stock which Dr. Hope has the right to
    acquire within 60 days of February 28, 2001 upon the exercise of stock
    options. Includes 300 shares of common stock owned by Dr. Hope's minor
    children.



(10) Includes 82,170 shares of common stock which Mr. Fitzgerald has the right
    to acquire within 60 days of February 28, 2001 upon the exercise of stock
    options.



(11) Includes 821,118 shares of BioTransplant common stock which all directors
    and executive officers as a group may acquire upon the exercise of
    outstanding stock options and warrants exercisable within 60 days of
    February 28, 2001.


                                      122

                   DESCRIPTION OF BIOTRANSPLANT CAPITAL STOCK

    THIS SECTION SUMMARIZES THE TERMS OF BIOTRANSPLANT'S CAPITAL STOCK. BECAUSE
THIS SUMMARY DOES NOT ADDRESS ALL OF THE INFORMATION THAT MAY BE IMPORTANT TO
YOU, YOU SHOULD READ THE MORE DETAILED PROVISIONS OF BIOTRANSPLANT'S CERTIFICATE
OF INCORPORATION AND BYLAWS.

GENERAL


    As of the date of this joint proxy statement/prospectus, BioTransplant is
authorized to issue up to 50,000,000 shares of BioTransplant common stock, par
value $.01 per share, and 2,000,000 shares of preferred stock, par value $.01
per share. The issued and outstanding shares of BioTransplant common stock are,
and the shares that BioTransplant will issue in connection with the merger will
be, when authorized, approved, issued and delivered subject to the terms of the
merger agreement, fully paid and nonassessable. As of February 28, 2001,
11,796,120 shares of BioTransplant common stock were issued and outstanding,
held by approximately 87 stockholders of record, and no shares of BioTransplant
preferred stock issued and outstanding.


BIOTRANSPLANT COMMON STOCK

    Each holder of BioTransplant common stock is entitled to one vote per share
of BioTransplant common stock held of record by the holder. Holders of
BioTransplant common stock have no preemptive, redemption or conversion rights.
The holders of BioTransplant common stock are only entitled to receive dividends
when and as declared by the BioTransplant board out of funds legally available
for payments of dividends. Upon BioTransplant's liquidation, dissolution or
winding up, the holders of BioTransplant common stock may share ratably in
BioTransplant's net assets after payment of liquidating distributions to holders
of BioTransplant preferred stock, if any. The registrar and transfer agent for
the BioTransplant common stock is The American Stock Transfer and Trust Company.

BIOTRANSPLANT PREFERRED STOCK


    The BioTransplant board has the power, without further vote of stockholders,
to authorize the issuance of up to 2,000,000 shares of BioTransplant preferred
stock and to fix and determine the terms, limitations and relative rights and
preferences of any shares of BioTransplant preferred stock. This power includes
the authority to establish voting, dividend, redemption, conversion, liquidation
and other rights of any preferred shares. Dividend, conversion, exchange and
redemption provisions to the extent that some or all of these features may be
present when shares of BioTransplant preferred stock are issued, could have an
adverse effect on the availability of earnings for distribution to the holders
of BioTransplant common stock or for other corporate purposes.


DELAWARE LAW AND BYLAW PROVISIONS

    BioTransplant is subject to the provisions of Section 203 of the Delaware
General Corporation Law. Section 203 prohibits a publicly held Delaware
corporation from engaging in a "business combination" with an "interested
stockholder" for a period of three years after the person becomes an interested
stockholder, unless the business combination is approved in a prescribed manner.
A "business combination" includes mergers, asset sales and other transactions
resulting in a financial benefit to the interested stockholder. In general, an
"interested stockholder" is a person who, together with affiliates and
associates, owns, or within the prior three years did own, 15% or more of the
corporation's voting stock.


    BioTransplant's bylaws provide that special meetings of the stockholders may
be called by the board of directors, the chairman of the board, the president,
the secretary or the record holders of at least 20% of the shares of stock of
BioTransplant issued and outstanding and entitled to vote at the special meeting
of stockholders. This provision could have the effect of delaying until the next
stockholder meeting actions which are favored by a significant percentage of our
stockholders.


                                      123

                        COMPARISON OF STOCKHOLDER RIGHTS

GENERAL

    BioTransplant and Eligix are corporations organized under the laws of
Delaware and are therefore subject to the Delaware General Corporation Law.
However, there are differences in the charters and bylaws of BioTransplant and
Eligix.

CAPITALIZATION


    BIOTRANSPLANT.  BioTransplant is authorized to issue 50,000,000 shares of
common stock and 2,000,000 shares of preferred stock. On February 28, 2001,
11,796,120 shares of BioTransplant common stock were issued and outstanding and
no shares of preferred stock were issued and outstanding. BioTransplant's board
has the authority, without stockholder approval, to issue shares of authorized
preferred stock from time to time in one or more series and to fix the rights
and preferences, including voting rights, of each series of preferred stock,
which rights and preferences may be superior to that of BioTransplant common
stock.



    ELIGIX.  Eligix' capitalization as of February 28, 2001 is as follows:





CLASS AND SERIES OF STOCK                      AUTHORIZED   ISSUED AND OUTSTANDING
-------------------------                      ----------   ----------------------
                                                      
Common.......................................  66,000,000            310,602
Series A.....................................  11,100,000         10,911,332
Series B.....................................  12,500,000         11,214,755
Series C-1...................................  10,000,000                  0
Series C-2...................................  11,100,000                  0
Series C-3...................................  12,500,000                  0



VOTING RIGHTS

    BIOTRANSPLANT.  Each holder of BioTransplant common stock is entitled to one
vote for each share and may not cumulate votes for the election of directors.


    ELIGIX.  Each holder of Eligix common stock is entitled to one vote for each
share and may not cumulate votes for the election of directors. Each holder of
Eligix Series A preferred stock, Series B preferred stock, Series C-1 preferred
stock, Series C-2 preferred stock and Series C-3 preferred stock is entitled to
the number of votes equal to the whole number of shares of common stock into
which the preferred share is convertible. For so long as 2,000,000 shares of
preferred stock remain outstanding, 66 2/3% of Eligix' outstanding preferred
shares must approve the following actions:


    - any amendment to the certificate of incorporation or bylaws that alters
      the voting powers, preferences or other special rights of the preferred
      shares;

    - any increase or decrease (other than by redemption or conversion) in the
      authorized number of shares of common or preferred stock;

    - any authorization of, or any increase in the authorized amount of, any
      class of shares or series of equity securities ranking on a parity with or
      senior to the preferred stock in right of redemption, liquidation
      preference, voting or dividends;

    - any redemption, repurchase, payment of dividends or other distributions
      with respect to the common stock;

    - any agreement by Eligix or its stockholders regarding an asset transfer or
      acquisition;

    - any increase or decrease in the authorized number of members of the Eligix
      board;

                                      124

    - any action that results in the payment or declaration of any dividend on
      any shares of common stock or preferred stock; or

    - any voluntary dissolution or liquidation of Eligix.

NUMBER AND CLASSIFICATION OF DIRECTORS

    BIOTRANSPLANT.  The BioTransplant bylaws provide that the BioTransplant
board shall consist of three members or such other number as shall be fixed from
time to time by the board, with each director serving a one-year term. The
number of directors of BioTransplant currently designated is seven, with one
seat vacant.

    ELIGIX.  The Eligix bylaws provide that the Eligix board shall consist of
not less than three and not more than seven members, the number of directors to
be determined from time to time by resolution of the board, with each director
serving a one-year term. The number of directors of Eligix currently designated
is six. The Eligix certificate of incorporation provides that any increase or
decrease in the number of authorized members of the board must be approved by a
vote of stockholders holding 66 2/3% of the outstanding shares of preferred
stock.

REMOVAL OF DIRECTORS


    BIOTRANSPLANT.  Any director or the entire board may be removed from office,
with or without cause, at any time by affirmative vote of the holders of a
majority of the outstanding shares then entitled to vote at an election of
directors, or by written consent of the stockholders as provided by Delaware
law.


    ELIGIX.  Any director or the entire board may be removed from office at any
time with cause by the affirmative vote of the holders of a majority of the
voting power of all the outstanding shares then entitled to vote at an election
of directors, or without cause by the affirmative vote of the holders of at
least 75% of the outstanding shares then entitled to vote at an election of
directors.

FILLING VACANCIES ON THE BOARD OF DIRECTORS


    BIOTRANSPLANT.  Vacancies occurring in the board may be filled by a vote of
the stockholders or by a vote of the board. The board may fill a vacancy by vote
of a majority of the directors then in office, whether or not less than a
quorum.


    ELIGIX.  Vacancies occurring in the board resulting from a resignation or an
increase in the number of authorized directors may be filled by a majority of
the directors then in office, although less than a quorum, and each director so
elected shall hold office for the unexpired portion of the term of the director
whose vacancy was filled and until the director's successor shall have been duly
elected.

CHARTER AMENDMENTS


    BIOTRANSPLANT.  The BioTransplant charter provides that any amendment to
BioTransplant's charter must have board approval of a resolution recommending
that the amendment be adopted and approval of a majority of the outstanding
stock entitled to vote on the amendment.



    ELIGIX.  The Eligix charter provides that any amendment to Eligix' charter
must have board approval of a resolution recommending that the amendment be
adopted and approval of a majority of the outstanding stock entitled to vote on
the amendment. In addition, 66 2/3% of the holders of preferred must approve any
amendment to the charter that:


    - alters the power, preferences, restrictions or privileges of the preferred
      shares;

    - increases or decreases the authorized number of preferred or common
      shares; or

                                      125

    - authorizes or increases any class of shares of equity ranking on parity
      with or senior to the preferred shares in right of redemption, liquidation
      preference, voting or dividends.

AMENDMENTS TO BYLAWS

    BIOTRANSPLANT.  The BioTransplant bylaws provide that the stockholders may
amend, adopt or repeal the bylaws by the affirmative vote of a majority of the
shares outstanding and entitled to vote or by a vote of the board.

    ELIGIX.  The Eligix bylaws provide that the stockholders may amend, adopt or
repeal the bylaws by an affirmative vote of at least 75% of the voting power of
the shares outstanding and entitled to vote. The Eligix bylaws provide that the
provisions relating to indemnification may not be replaced or amended in a
manner that would adversely affect the right or protection of any person in
respect of any act or omission occurring prior to the amendment or repeal. The
Eligix bylaws also provide that the board may amend the bylaws to the extent
permitted in the Eligix certificate of incorporation. The Eligix certificate of
incorporation authorizes the board of directors to amend, supplement or repeal
the bylaws. Any bylaw or bylaws adopted by the board of directors may, however,
be further amended or repealed by an affirmative vote of at least a majority of
the voting power of shares outstanding and entitled to vote.

ACTION BY WRITTEN CONSENT

    BIOTRANSPLANT.  BioTransplant's bylaws provide that any action required or
permitted to be taken by stockholders may be taken by written consent.

    ELIGIX.  Eligix' bylaws provide that any action required or permitted to be
taken by stockholders may be taken by written consent.

NOTICE OF STOCKHOLDER ACTIONS


    BIOTRANSPLANT.  BioTransplant's bylaws require written or telephonic notice
of the hour, date and place of each annual or special meeting of the
stockholders. In the case of a special meeting, stockholders must be informed of
the purposes for which the meeting is called. If a stockholder will attend the
meeting in person or by proxy, or provides a written waiver of the right to
receive notice, notice of the annual or special meeting is not necessary. The
waiver of notice need not specify the business to be transacted at, nor the
purpose of, any meeting of the stockholders. In order for a stockholder owning
less than 5% of the outstanding capital stock of BioTransplant to bring business
before an annual meeting, the stockholder must give written notice to the
Secretary of BioTransplant at least 60 days, but not more than 90 days, before
the annual meeting. However, if notice of the meeting is given less than
70 days prior to the meeting date, then stockholders must give notice no later
than ten days after the day on which public announcement of the meeting date is
first made. Included in the notice to the Secretary must be:



    - a brief description of the business the stockholder wants to bring before
      the meeting and the reasons for conducting that business at the annual
      meeting;


    - the name and address of the stockholder proposing the action;

    - the class and number of shares of BioTransplant beneficially owned by the
      stockholder;


    - any material interest of the stockholder in the business the stockholder
      is bringing before the meeting; and


    - other information required to be disclosed under the Securities and
      Exchange Commission's regulations relating to proxy statements.

                                      126


    ELIGIX.  Eligix' bylaws require written notice of the hour, date and place
of each meeting of the stockholders. If the stockholder will attend the meeting
in person or by proxy, or provides written waiver of the right to receive
notice, notice of the meeting is not necessary, except when the stockholder
attends the meeting to object to the transaction of any business on the grounds
the meeting was not lawfully called or convened. Eligix' bylaws provide that for
stockholders to bring business before an annual meeting, the stockholders must
give written notice to the Secretary of Eligix at least 60 days, but not more
than 90 days, before the first anniversary of the preceding year's annual
meeting. However, if public announcement is given less than 70 days prior to the
meeting date, then stockholders must give notice no later than ten days after
the day on which public announcement of the meeting date is first made. Included
in the notice to the Secretary must be:



    - a brief description of the business the stockholder wants to bring before
      the meeting and the reasons for conducting that business at the annual
      meeting;


    - the name and address of the stockholder proposing the action;

    - the class and number of shares of Eligix beneficially owned by the
      stockholder;


    - any material interest of the stockholder in the business the stockholder
      is bringing before the meeting; and


    - other information required to be disclosed under the Securities and
      Exchange Commission's regulations relating to proxy statements.

RIGHT TO CALL SPECIAL MEETING OF STOCKHOLDERS

    BIOTRANSPLANT.  BioTransplant's charter and bylaws provide that a special
meeting of the stockholders may be called by:

    - the board;

    - the chairman of the board;

    - the president;

    - the secretary; or


    - holders of 20% of the outstanding stock of BioTransplant entitled to vote
      at the special meeting.



    The place, date and hour of any special meeting of stockholders shall be
designated in the notice, or waiver of notice, to be sent to stockholders.


    ELIGIX.  Eligix' bylaws provide that a special meeting of the stockholders
may be called, for any purpose, by:


    - the board of directors, by a resolution adopted by a majority of the
      authorized directors;


    - the chairman of the board; or

    - the president.


    If a special meeting is called by any person other than the board, the
person calling the special meeting shall inform the chairman of the board, the
president, any vice president or the secretary by mail, telegraph or facsimile,
of the time of the meeting and the business to be transacted at the special
meeting. Only business outlined in the notice may be conducted at the special
meeting of the stockholders. The special meeting must be held no later than
60 days, but no earlier than 35 days, after receipt of the request.


                                      127

LIMITATION OF PERSONAL LIABILITY OF DIRECTORS


    The Delaware General Corporation Law provides that a corporation's charter
may include a provision limiting the personal liability of a director to the
corporation or its stockholders for monetary damage for breach of fiduciary duty
as a director. However, no provision in a corporation's charter can eliminate or
limit the liability of a director for:


    - any breach of the director's duty of loyalty to the corporation or its
      stockholders;

    - acts or omissions not in good faith or which involve intentional
      misconduct or a knowing violation of the law;

    - willful or negligent violation of the laws governing the payment of
      dividends or the purchase or redemption of stock; or

    - any transaction from which the director devised an improper personal
      benefit.

    BIOTRANSPLANT.  BioTransplant's charter and bylaws provide that a director
will not be liable to BioTransplant or its stockholders for monetary damages for
a breach of his or her fiduciary duty as a director, subject to the exceptions
in the Delaware General Corporation Law cited above.

    ELIGIX.  Eligix' charter provides that a director will not be liable to
Eligix or its stockholders for monetary damages resulting from a breach of his
or her fiduciary duty as a director, subject to the exceptions in the Delaware
General Corporation Law cited above.

DIVIDENDS

    BIOTRANSPLANT.  BioTransplant's charter provides that BioTransplant's board
may declare and pay dividends upon shares of BioTransplant common stock, but
only out of funds available for the payment of dividends as provided by law, and
subject to any preferential dividend rights of any outstanding preferred stock.
The board is given discretion to establish dividend rights for any and all
classes of preferred stock.

    ELIGIX.  Eligix' charter provides that Eligix' board may declare and pay
dividends upon shares of Eligix common stock, but only out of funds available
for the payment of dividends as provided by law, and subject to any preferential
dividend rights of any outstanding preferred stock. In respect to dividend
rights of preferred stock, the Eligix' charter provides that the Series C-1,
Series C-2 and Series C-3 Preferred are entitled to receive, when the board
declares and pays cash dividends, and prior to the payment of any dividends with
respect to common or Series A or Series B preferred, cash dividend payments in
the following amounts:

    - Series C-1 will receive $0.36 per share on an annual basis;

    - Series C-2 will receive $0.10664 per share on an annual basis; and

    - Series C-3 will receive $0.12 per share on an annual basis.

    Any dividend payment made to the Series C-1, Series C-2 and Series C-3
preferred stockholders may only be paid out of funds available for the payment
of dividends as provided by law. In the event cash dividends are paid on any
share of Series A preferred, Series B preferred or common stock, an additional
dividend shall be paid to all outstanding shares of Series C-1, Series C-2 and
Series C-3 preferred, as if the holder had exercised the right to convert the
Series C-1, Series C-2 and Series C-3 into common stock prior to the declaration
of the dividend.

    Only after full and adequate payment of the cash dividend to the Series C-1
preferred, Series C-2 preferred and Series C-3 preferred stockholders, are the
holders of Series A and Series B preferred

                                      128

stock entitled to receive any cash dividend declared and paid by the board of
directors. Assuming funds available for the payment of dividends as provided by
law,

    - Series A will receive $0.10664 per share on an annual basis; and

    - Series B will receive $0.12 per share on an annual basis.

    Only after full and adequate payment of the cash dividends to the Series A
and Series B Preferred stockholders, are the holders of the common stock
entitled to receive any cash dividends declared and paid by the board. Any
dividend payment made to the common stockholders may only be paid out of funds
available for the payment of dividends as provided by law.

    In the event cash dividends are paid on any share of common stock, an
additional dividend shall be paid to all outstanding Series A and Series B
preferred as if the holder had exercised the right to convert the Series A or
Series B preferred into common stock prior to the declaration of the dividend.

CONVERSION

    BIOTRANSPLANT.  Holders of BioTransplant common stock have no right to
convert their shares into any other shares of capital stock of BioTransplant or
any other securities.

    ELIGIX.  Holders of Eligix common stock have no right to convert their
shares into any other shares of capital stock of Eligix or any other securities.
Holders of Eligix Series A, Series B, Series C-1, Series C-2 and Series C-3
preferred stock have the right to convert their preferred stock into Eligix
common stock, at the option of the holder, at any time after the date of
issuance of the shares.

    Holders of Series A preferred stock have the right to convert their shares
into a number of shares of common stock determined by dividing $1.3333 by the
then current conversion price, as calculated based on the provisions of the
charter, which is currently $1.3333 per share. Shares of Series A preferred
stock automatically convert into common stock:

    - upon the request of 66 2/3% of the then outstanding Series A, Series B,
      Series C-1, Series C-2 and Series C-3 preferred stock; and

    - upon the closing of a public offering of shares of common stock at a price
      of at least $5.00 per share resulting in gross proceeds to Eligix of at
      least $10,000,000.

    Holders of Series B preferred stock have the right to convert their shares
into a number of shares of common stock determined by dividing $1.50 by the then
current conversion price, as calculated based on the provisions of the charter,
which is currently $1.50 per share. Shares of Series B preferred stock
automatically convert into common stock:

    - upon the request of 66 2/3% of the then outstanding Series A, Series B,
      Series C-1, Series C-2 and Series C-3 preferred stock; and

    - upon the closing of a public offering of shares of common stock at a price
      of at least $5.00 per share resulting in gross proceeds to Eligix of at
      least $10,000,000.

    Holders of Series C-1 preferred stock have the right to convert their shares
into a number of shares of common stock determined by dividing $4.50 by the then
current conversion price, as calculated based on the provisions of the charter,
which is currently $4.50 per share. Shares of Series C-1 preferred stock
automatically convert into common stock:

    - upon the request of 66 2/3% of the then outstanding Series A, Series B,
      Series C-1, Series C-2 and Series C-3 preferred stock; and

    - upon the closing of a public offering of shares of common stock at a price
      of at least $5.00 per share resulting in gross proceeds to Eligix of at
      least $10,000,000.

                                      129

    Holders of Series C-2 preferred stock have the right to convert their shares
into a number of shares of common stock determined by dividing $1.3333 by the
then current conversion price, as calculated based on the provisions of the
charter, which is currently $1.3333 per share. Shares of Series C-2 preferred
stock automatically convert into common stock:

    - upon the request of 66 2/3% of the then outstanding Series A, Series B,
      Series C-1, Series C-2 and Series C-3 preferred stock; and

    - upon the closing of a public offering of shares of common stock at a price
      of at least $5.00 per share resulting in gross proceeds to Eligix of at
      least $10,000,000.

    Holders of Series C-3 preferred stock have the right to convert their shares
into a number of shares of common stock determined by dividing $1.50 by the then
current conversion price, as calculated based on the provisions of the charter,
which is currently $1.50 per share. Shares of Series C-3 preferred stock
automatically convert into common stock:

    - upon the request of 66 2/3% of the then outstanding Series A, Series B,
      Series C-1, Series C-2 and Series C-3 preferred stock; and

    - upon the closing of a public offering of shares of common stock at a price
      of at least $5.00 per share resulting in gross proceeds to Eligix of at
      least $10,000,000.

LIQUIDATION

    BIOTRANSPLANT.  BioTransplant's charter provides that upon dissolution or
liquidation of BioTransplant, whether voluntary or involuntary, holders of
BioTransplant common stock will be entitled to receive all assets of
BioTransplant available for distribution to its stockholders, subject to any
preferential rights of any then outstanding preferred stock.

    ELIGIX.  Eligix' charter provides that upon dissolution or liquidation of
Eligix, whether voluntary or involuntary, holders of Eligix common stock will be
entitled to receive all assets of Eligix available for distribution to its
stockholders, subject to any preferential rights of any then outstanding
preferred stock. Eligix charter further provides that upon any liquidation,
dissolution or winding up of Eligix, no distribution shall be made:


    - to the holders of stock ranking junior to the Series C-1, Series C-2 and
      Series C-3 preferred stock until the holders of the Series C-1,
      Series C-2 and Series C-3 preferred stock have received $4.50, $1.3333 and
      $1.50 per share, respectively, plus all declared and unpaid dividends on
      shares of Series C-1, Series C-2 and Series C-3 preferred stock for each
      share of Series C-1, Series C-2 and Series C-3 preferred stock held
      respectively by them; or



    - to the holders of stock ranking junior to the Series A and Series B
      preferred stock until the holders of the Series A and Series B preferred
      stock have received $1.3333 and $1.50 per share, respectively, plus all
      declared and unpaid dividends on shares of Series A and Series B preferred
      stock for each share of Series A and Series B preferred stock held
      respectively by them.


RIGHTS IN AN ACQUISITION EVENT

    BIOTRANSPLANT.  The holders of BioTransplant common and preferred stock have
no rights comparable to those of Eligix stockholders.


    ELIGIX.  Eligix' charter provides that each holder of Eligix preferred stock
shall be entitled to receive the liquidation preference described above if
Eligix enters into any reorganization, merger, consolidation or sale, lease or
other disposition of all or substantially all of its assets in which the shares
of Eligix common stock are changed for or changed into other stock or
securities, cash and/or any other property.


                                      130

APPRAISAL RIGHTS


    BIOTRANSPLANT.  BioTransplant is a Delaware corporation. Under the Delaware
General Corporation Law, dissenters' rights of appraisal are available to a
stockholder of a corporation only in connection with specified mergers or
consolidations involving that corporation. Appraisal rights are not available
under the Delaware General Corporation Law if the corporation's stock is either:


    - listed on a national securities exchange or designated as a national
      market system security on an interdealer quotation system by the National
      Association of Securities Dealers, Inc. as the BioTransplant common stock
      is; or

    - held of record by more than 2,000 stockholders;

provided that appraisal rights will be available if the merger or consolidation
requires stockholders to exchange their shares of BioTransplant common stock for
anything other than:

    - shares of the surviving corporation;

    - shares of another corporation that will be listed on a national securities
      exchange, designated as a national market system security on an
      interdealer quotation system by the NASD or held of record by more than
      2000 stockholders; or

    - cash in lieu of fractional shares.

    Additionally, no appraisal rights are available if the corporation is the
surviving corporation, and no vote of its stockholders is required for the
merger.

    ELIGIX.  Eligix is also a Delaware corporation and dissenters' rights of
appraisal are available for shares of Eligix common and preferred stock in
connection with certain mergers or consolidations involving Eligix.

                                      131

                        APPROVAL OF AMENDMENT TO ELIGIX'
               AMENDED AND RESTATED CERTIFICATE OF INCORPORATION


    On December 8, 2000, the Eligix board of directors adopted, subject to
stockholder approval, an amendment to Eligix' certificate of incorporation
adjusting the manner of determining the value of property to be distributed to
the preferred stockholders in a liquidation event, such as a merger. The
certificate of incorporation currently states that, in the event of a
liquidation, where the distribution made to preferred stockholders is in the
form of securities traded on a securities exchange, the Nasdaq National Market
or the over-the-counter market, the value of these securities will be the
average of the closing sale prices of those securities on the exchange over the
thirty-day period ending three days prior to the date established for the
DISTRIBUTION of the securities. If the amendment is approved, the certificate of
incorporation will provide that the value of the securities to be distributed in
the liquidation event will be the average of the closing prices of the
securities on the exchange over the thirty-day period ending three days prior to
the date of SIGNING AN AGREEMENT relating to an acquisition or asset transfer.


    Thus, approval of the amendment to the certificate of incorporation fixes
the exact number of shares of BioTransplant common stock that an Eligix
preferred stockholder will receive in satisfaction of the preferred liquidation
preference. Fluctuation in the BioTransplant common stock price prior to the
closing of the merger would not alter the number of shares of BioTransplant
common stock issuable to an Eligix preferred stockholder. Approval of the
amendment to the certificate of incorporation is a condition to closing the
merger.


    Additionally, the amendment clarifies that upon a liquidation, distribution
or winding up of Eligix, if the assets to be distributed are insufficient to
satisfy all preferred stockholders, then the assets shall first be distributed
to the holders of the Series C preferred stock in proportion to the full amounts
to which they would be entitled. If, after payment to the Series C preferred
stockholders, the remaining assets are insufficient to satisfy the Series A and
Series B preferred stockholders, the remaining assets will be distributed to the
Series A and Series B stockholders in proportion to the full amounts to which
they would be entitled. This amendment is a technical amendment designed to
clarify that the existing liquidation preference of the Series C preferred stock
would remain with respect to a liquidation in which there were insufficient
assets to be distributed to preferred stockholders.


    The board of directors of Eligix believes that the approval of the amendment
to the certificate of incorporation is advisable and in the best interests of
Eligix and its stockholders and therefore recommends a vote "FOR" the proposal.

                             STOCKHOLDER PROPOSALS


    In order to be included on the proxy card and included in the proxy
statement for the 2001 BioTransplant annual meeting of stockholders, under
Rule 14a-8 of the Securities Exchange Act of 1934, stockholder proposals must
have been received by BioTransplant at its offices, Building 75, Third Avenue,
Charlestown Navy Yard, Charlestown, Massachusetts 02129 by December 29, 2000.



    If a BioTransplant stockholder wishes to present a proposal before the 2001
annual meeting of stockholders, under Rule 14a-4 of the Exchange Act, the
stockholder must give written notice to the Secretary of BioTransplant at the
address noted above. The Secretary must receive this notice at least 45 days
prior to the anniversary of the mailing of the proxy materials for the 2000
annual meeting of stockholders. If a stockholder fails to provide timely notice
of a proposal to be presented at the 2001 annual meeting of stockholders, the
proxies designated by our board of directors will have discretionary authority
to vote on the stockholder's proposal.


                                      132

                                 LEGAL MATTERS


    The validity of the shares of BioTransplant common stock to be issued in
connection with the merger will be passed upon for BioTransplant by Hale and
Dorr LLP, Boston, Massachusetts. Customary legal matters with respect to the
federal income tax consequences of the merger will be passed upon for
BioTransplant by Hale and Dorr LLP, Boston, Massachusetts and for Eligix by
Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., Boston, Massachusetts.


                                    EXPERTS


    The consolidated financial statements of BioTransplant as of December 31,
1999 and 2000, for each of the three years in the period ended December 31, 2000
and for the period from inception (March 20, 1990) through December 31, 2000
included in this joint proxy statement/prospectus have been audited by Arthur
Andersen, LLP, independent public accountants, and have been so included in
reliance on their report given on the authority of said firm as experts in
auditing and accounting.



    The financial statements of Eligix as of December 31, 1999 and 2000, for
each of the three years in the period ended December 31, 2000 and for the period
from inception (December 27, 1996) to December 31, 2000 included in this joint
proxy statement/prospectus have been so included in reliance on the report
(which contains an explanatory paragraph relating to Eligix' ability to continue
as a going concern as described in Note A to the financial statements) of
PricewaterhouseCoopers LLP, independent accountants, given on the authority of
said firm as experts in auditing and accounting.


                                      133

                      WHERE YOU CAN FIND MORE INFORMATION

    BioTransplant files annual, quarterly and special reports, and other
information with the SEC. You may read and copy any reports, statements or other
information we file at the SEC's public reference rooms in Washington, D.C., New
York, New York and Chicago, Illinois. Please call the SEC at 1-800-SEC-0330 for
further information on the public reference rooms. Our SEC filings are also
available to the public from commercial document retrieval services and at the
web site maintained by the SEC at "http://www.sec.gov."


    BioTransplant filed with the SEC a registration statement on Form S-4 under
the Securities Act of 1933 to register with the SEC the BioTransplant common
stock issuable in connection with the merger agreement. This joint proxy
statement/prospectus does not contain all the information you can find in the
registration statement or the exhibits and schedules to the registration
statement. For further information with respect to BioTransplant, Eligix and the
BioTransplant common stock, please refer to the registration statement,
including the exhibits and schedules. You can obtain the additional information
in the registration statement by contacting BioTransplant at the following
address and telephone number:


                           BIOTRANSPLANT INCORPORATED
                            BUILDING 75, 3RD AVENUE
                             CHARLESTOWN NAVY YARD
                             CHARLESTOWN, MA 02129
                            ATTN: RICHARD V. CAPASSO
                           TELEPHONE: (617) 241-5200

    Statements contained in this joint proxy statement/prospectus about the
contents of any contract or other document are not necessarily complete, and we
refer you, in each case, to the copy of such contract or other document filed as
an exhibit to the registration statement.

    To obtain timely delivery of requested documents prior to the special
meeting of BioTransplant stockholders or the special meeting of Eligix
stockholders, you must request them no later than             , 2001, which is
five business days prior to the date of such meetings.

                                      134

                         INDEX TO FINANCIAL STATEMENTS
        CONSOLIDATED FINANCIAL STATEMENTS OF BIOTRANSPLANT INCORPORATED




                                                                PAGE
                                                              --------
                                                           
Report of Independent Public Accountants....................     F-2

Consolidated Balance Sheets as of December 31, 1999 and
  2000......................................................     F-3

Consolidated Statements of Operations for the years ended
  December 31, 1998, 1999 and 2000, and for the period from
  inception (March 20, 1990) through December 31, 2000......     F-4

Consolidated Statements of Stockholders' Equity (Deficit)
  since inception (March 20, 1990)..........................     F-5

Consolidated Statements of Cash Flows for the years ended
  December 31, 1998, 1999 and 2000, and for the period from
  inception (March 20, 1990) through December 31, 2000......     F-6

Notes to Consolidated Financial Statements..................     F-7



                      FINANCIAL STATEMENTS OF ELIGIX, INC.




                                                                PAGE
                                                              --------
                                                           
Report of Independent Accountants...........................    F-21

Balance Sheets as of December 31, 1999 and 2000.............    F-22

Statements of Operations for the years ended December 31,
  1998, 1999 and 2000 and for the period from inception
  (December 27, 1996) to December 31, 2000..................    F-23

Statements of Convertible Preferred Stock and Stockholders'
  Deficit for the period from inception (December 27, 1996)
  to December 31, 2000......................................    F-24

Statements of Cash Flows for the years ended December 31,
  1998, 1999 and 2000 and for the period from inception
  (December 27, 1996) to December 31, 2000..................    F-25

Notes to Financial Statements...............................    F-26



                                      F-1


                    REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS



To BioTransplant Incorporated:



    We have audited the accompanying consolidated balance sheets of
BioTransplant Incorporated (a Delaware corporation in the development stage) and
subsidiary as of December 31, 1999 and 2000, and the related consolidated
statements of operations, stockholders' equity (deficit) and cash flows for each
of the three years in the period ended December 31, 2000, and for the period
from inception (March 20, 1990) to December 31, 2000. These financial statements
are the responsibility of the Company's management. Our responsibility is to
express an opinion on these financial statements based on our audits.



    We conducted our audits in accordance with auditing standards generally
accepted in the United States. Those standards require that we plan and perform
the audit to obtain reasonable assurance about whether the financial statements
are free of material misstatement. An audit includes examining, on a test basis,
evidence supporting the amounts and disclosures in the financial statements. An
audit also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation. We believe that our audits provide a reasonable basis
for our opinion.



    In our opinion, the financial statements referred to above present fairly,
in all material respects, the financial position of BioTransplant Incorporated
and subsidiary as of December 31, 1999 and 2000, and the results of their
operations and their cash flows for each of the three years in the period ended
December 31, 2000, and for the period from inception (March 20, 1990) to
December 31, 2000, in conformity with accounting principles generally accepted
in the United States.



    The accompanying financial statements have been prepared assuming the
Company will continue as a going concern. As discussed in Note 1 to the
financial statements, the Company has incurred significant recurring losses from
operations and has entered into an agreement to purchase Eligix, Inc. The
Company will need to obtain additional funding in order to continue as a going
concern. Given these factors, there is substantial doubt about the Company's
ability to continue as a going concern. Management's plans in regard to these
matters are also described in Note 1. The financial statements do not include
any adjustments that might result from the outcome of this uncertainty.



                                                             ARTHUR ANDERSEN LLP



Boston, Massachusetts



February 15, 2001


                                      F-2


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



                          CONSOLIDATED BALANCE SHEETS





                                                                    DECEMBER 31,
                                                              -------------------------
                                                                 1999          2000
                                                              -----------   -----------
                                                                      
Assets
Current assets:
  Cash and cash equivalents.................................  $17,648,789   $11,481,297
  Short-term investments....................................    3,718,033     3,391,568
  Other receivables.........................................      400,500        18,995
  Prepaid expenses and other current assets.................      169,733       823,899
                                                              -----------   -----------

      Total current assets..................................   21,937,055    15,715,759
                                                              -----------   -----------
Property and equipment, at cost:
  Equipment under capital leases............................           --       119,772
  Laboratory equipment......................................    3,707,833     3,726,821
  Leasehold improvements....................................      795,017       795,017
  Office equipment..........................................      792,605       932,706
                                                              -----------   -----------
                                                                5,295,455     5,574,316
  Less -- Accumulated depreciation..........................    3,813,455     4,237,110
                                                              -----------   -----------
                                                                1,482,000     1,337,206
                                                              -----------   -----------
Investment in Stem Cell Sciences Ltd........................           --       105,000
                                                              -----------   -----------
                                                              $23,419,055   $17,157,965
                                                              ===========   ===========

Liabilities and Stockholders' Equity
Current liabilities:
  Current portion of long-term debt.........................  $   233,333   $   233,333
  Current obligation under capital leases...................           --        37,486
  Accounts payable..........................................      433,067       408,115
  Accrued expenses..........................................    2,516,173     1,721,745
  Deferred revenue..........................................    4,125,000            --
                                                              -----------   -----------
      Total current liabilities.............................    7,307,573     2,400,679
                                                              -----------   -----------

Long-term debt, net of current portion......................      466,667       252,778
Long-term obligation under capital leases, net of current
  portion...................................................           --        82,285
                                                              -----------   -----------
      Total long-term liabilities...........................      466,667       335,063
                                                              -----------   -----------
Commitments (Notes 9 and 13)
Stockholders' equity:
  Preferred stock, $.01 par value --
    Authorized -- 2,000,000 shares
    Issued and outstanding -- no shares.....................           --            --
  Common stock, $.01 par value --
    Authorized -- 25,000,000 and 50,000,000 shares at
    December 31, 1999 and December 31, 2000, respectively
    Issued and outstanding -- 10,300,890 and 11,796,120
    shares at December 31, 1999 and 2000, respectively......      103,010       117,962
Additional paid-in capital..................................   72,688,036    83,129,855
Deficit accumulated during the development stage............  (57,146,231)  (68,825,594)
                                                              -----------   -----------

      Total stockholders' equity............................   15,644,815    14,422,223
                                                              -----------   -----------
                                                              $23,419,055   $17,157,965
                                                              ===========   ===========




  The accompanying notes are an integral part of these consolidated financial
                                  statements.


                                      F-3


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



                     CONSOLIDATED STATEMENTS OF OPERATIONS





                                               FOR THE YEARS ENDED DECEMBER 31,        CUMULATIVE
                                           ----------------------------------------      SINCE
                                              1998          1999           2000        INCEPTION
                                           -----------   -----------   ------------   ------------
                                                                          
Operating revenues:
  License fees...........................  $ 1,000,000   $ 3,500,000   $         --   $ 18,500,000
  Research and development...............    5,688,500     5,188,475      4,563,475     36,815,450
                                           -----------   -----------   ------------   ------------
      Total revenues.....................    6,688,500     8,688,475      4,563,475     55,315,450

Operating Expenses:
  Research and development...............   14,729,825    15,680,281     14,973,719    107,915,277
  General and administrative.............    2,477,460     2,445,912      2,543,624     21,375,619
                                           -----------   -----------   ------------   ------------
      Total expenses.....................   17,207,285    18,126,193     17,517,343    129,290,896
                                           -----------   -----------   ------------   ------------

      Operating loss.....................  (10,518,785)   (9,437,718)   (12,953,868)   (73,975,446)

  Interest income........................    1,317,780       782,182      1,334,486      6,987,325
  Interest expense.......................       (9,602)      (17,914)       (59,981)    (1,837,473)
                                           -----------   -----------   ------------   ------------
Net loss.................................  $(9,210,607)  $(8,673,450)  $(11,679,363)  $(68,825,594)
                                           ===========   ===========   ============   ============

Net loss per common share:
  Basic and diluted......................  $     (1.07)  $     (1.01)  $      (1.01)
                                           ===========   ===========   ============
Weighted average common shares
  outstanding:
  Basic and diluted......................    8,578,941     8,598,085     11,547,262
                                           ===========   ===========   ============




  The accompanying notes are an integral part of these consolidated financial
                                  statements.


                                      F-4


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



           CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)





                                                                                            DEFICIT
                                                       COMMON STOCK                       ACCUMULATED        TOTAL
                                                  ----------------------   ADDITIONAL     DURING THE     STOCKHOLDERS'
                                                    NUMBER       $.01        PAID-IN      DEVELOPMENT       EQUITY
                                                  OF SHARES    PAR VALUE     CAPITAL         STAGE         (DEFICIT)
                                                  ----------   ---------   -----------   -------------   -------------
                                                                                          
Inception, March 20, 1990.......................          --   $     --    $        --   $          --   $         --
  Net loss......................................          --         --             --        (142,353)      (142,353)
                                                  ----------   --------    -----------   -------------   ------------
  Balance, December 31, 1990....................          --         --             --        (142,353)      (142,353)
  Sale of common stock..........................     102,572      1,026          3,077              --          4,103
  Issuance of warrants..........................          --         --         22,000              --         22,000
  Net loss......................................          --         --             --      (2,637,206)    (2,637,206)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1991......................     102,572      1,026         25,077      (2,779,559)    (2,753,456)
  Net loss......................................          --         --             --      (6,188,344)    (6,188,344)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1992......................     102,572      1,026         25,077      (8,967,903)    (8,941,800)
  Issuance of warrants..........................          --         --        476,800              --        476,800
  Exercise of stock options.....................          63          1             46              --             47
  Deferred compensation on stock options........          --         --        105,546              --        105,546
  Net loss......................................          --         --             --      (7,748,627)    (7,748,627)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1993......................     102,635      1,027        607,469     (16,716,530)   (16,108,034)
  Exercise of stock options.....................      17,406        174          1,448              --          1,622
  Restricted stock sold to Directors............       1,250         12          8,738              --          8,750
  Issuance of warrants..........................          --         --        165,937              --        165,937
  Deferred compensation on stock options........          --         --        170,225              --        170,225
  Net loss......................................          --         --             --     (11,268,042)   (11,268,042)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1994......................     121,291      1,213        953,817     (27,984,572)   (27,029,542)
  Issuance of warrants..........................          --         --         99,000              --         99,000
  Exercise of stock options.....................       5,303         53          7,301              --          7,354
  Deferred compensation on stock options........          --         --        170,225              --        170,225
  Net loss......................................          --         --             --      (2,087,239)    (2,087,239)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1995......................     126,594      1,266      1,230,343     (30,071,811)   (28,840,202)
  Conversion of preferred stock into common
    stock.......................................   4,770,430     47,704     36,154,586              --     36,202,290
  Issuance of common stock in initial public
    offering, net of issuance costs of
    $2,681,920..................................   3,220,000     32,200     27,875,880              --     27,908,080
  Issuance of common stock pursuant to
    antidilution rights.........................     431,724      4,317         (4,317)             --             --
  Exercise of stock options.....................      10,154        102         28,546              --         28,648
  Net loss......................................          --         --             --      (6,037,108)    (6,037,108)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1996......................   8,558,902     85,589     65,285,038     (36,108,919)    29,261,708
  Exercise of stock options.....................      15,238        153         45,407              --         45,560
  Restricted stock sold to directors............       1,250         12             38              --             50
  Net loss......................................          --         --             --      (3,153,254)    (3,153,254)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1997......................   8,575,390     85,754     65,330,483     (39,262,173)    26,154,064
  Exercise of stock options.....................       6,073         61         14,745              --         14,806
  Net loss......................................          --         --             --      (9,210,607)    (9,210,607)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1998......................   8,581,463     85,815     65,345,228     (48,472,780)    16,958,263
  Exercise of stock options.....................      11,265        113         24,803              --         24,916
  Restricted stock sold to directors............       1,875         19          4,433              --          4,452
  Issuance of common stock in private placement,
    net of issuance costs of $517,215...........   1,706,287     17,063      7,313,571              --      7,330,634
  Net loss......................................          --         --             --      (8,673,450)    (8,673,450)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 1999......................  10,300,890    103,010     72,688,036     (57,146,231)    15,644,815
  Exercise of stock options.....................     221,514      2,215        902,307              --        904,522
  Exercise of warrants..........................      58,716        587        392,512              --        393,099
  Net gain on investment in Stem Cell Sciences
    Ltd. .......................................          --         --        160,000              --        160,000
  Issuance of common stock in private placement,
    net of issuance costs of $720,150...........   1,215,000     12,150      8,987,000              --      8,999,150
  Net loss......................................          --         --             --     (11,679,363)   (11,679,363)
                                                  ----------   --------    -----------   -------------   ------------
Balance, December 31, 2000......................  11,796,120   $117,962    $83,129,855   $ (68,825,594)  $ 14,422,223
                                                  ==========   ========    ===========   =============   ============




  The accompanying notes are an integral part of these consolidated financial
                                  statements.


                                      F-5


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



                     CONSOLIDATED STATEMENTS OF CASH FLOWS





                                                                 FOR THE YEARS ENDED DECEMBER 31,
                                                             ----------------------------------------     CUMULATIVE
                                                                1998          1999           2000       SINCE INCEPTION
                                                             -----------   -----------   ------------   ---------------
                                                                                            
Cash flows from operating activities:
  Net loss.................................................  $(9,210,607)  $(8,673,450)  $(11,679,363)   $(68,825,594)
  Adjustments to reconcile net loss to net cash used in
    operating activities-
    Depreciation and amortization..........................      358,052       392,865        430,970       4,308,116
    Noncash interest expense on convertible notes payable
      to stockholders......................................           --            --             --         465,477
    Noncash expenses related to options and warrants.......       33,186         1,541             --       1,186,785
    Changes in current assets and liabilities-
      Accounts receivable..................................           --      (400,500)       381,505         (18,995)
      Prepaid expenses and other current assets............       26,206     1,042,561       (654,166)       (823,899)
      Accounts payable.....................................      (62,179)      205,711        (24,952)        408,115
      Accrued expenses.....................................      (69,558)      403,514       (794,428)      1,721,745
      Deferred revenue.....................................     (750,000)      750,000     (4,125,000)             --
                                                             -----------   -----------   ------------    ------------
        Net cash used in operating activities..............   (9,674,900)   (6,277,758)   (16,465,434)    (61,578,250)
                                                             -----------   -----------   ------------    ------------
Cash flows from investing activities:
  Purchases of property and equipment......................     (812,828)     (416,839)      (299,114)     (5,035,062)
  Disposal of property and equipment, net..................           --            --         12,940          40,980
  Purchases of investments.................................   (8,887,022)   (4,086,657)    (6,508,538)    (76,732,935)
  Proceeds from sale of investments........................   22,921,877     7,211,587      6,835,000      73,341,363
  (Increase) decrease in investment in Stem Cell Sciences
    Ltd....................................................           --            --         55,000          55,000
                                                             -----------   -----------   ------------    ------------
        Net cash provided by (used in) investing
          activities.......................................   13,222,027     2,708,091         95,288      (8,330,654)
                                                             -----------   -----------   ------------    ------------
Cash flows from financing activities:
  Proceeds from convertible notes payable to
    stockholders...........................................           --            --             --       9,400,000
  Payments of obligations under capital leases.............     (177,666)      (10,042)            --      (2,194,210)
  Proceeds from sale/leaseback of equipment................           --            --             --         771,968
  Payments on long-term debt...............................                                  (213,889)       (213,889)
  Proceeds from equipment leases...........................           --            --        119,771       1,542,010
  Proceeds from long-term debt.............................           --       700,000             --         700,000
  Net proceeds from sale of redeemable convertible
    preferred stock........................................           --            --             --      25,661,526
  Net proceeds from sale of common stock...................       14,806     7,360,002     10,296,772      45,722,796
                                                             -----------   -----------   ------------    ------------
        Net cash provided by (used in) financing
          activities.......................................     (162,860)    8,049,960     10,202,654      81,390,201
                                                             -----------   -----------   ------------    ------------
Net increase in cash and cash equivalents..................    3,384,267     4,480,293     (6,167,492)     11,481,297
Cash and cash equivalents, beginning of period.............    9,784,229    13,168,496     17,648,789              --
                                                             -----------   -----------   ------------    ------------
Cash and cash equivalents, end of period...................  $13,168,496   $17,648,789   $ 11,481,297    $ 11,481,297
                                                             ===========   ===========   ============    ============

Supplemental disclosure of noncash investing and financing
  transactions:
  Equipment acquired under capital leases..................  $        --   $        --   $         --    $ (2,329,941)
                                                             ===========   ===========   ============    ============
  Net gain related to investment in Stem Cell Sciences
    Ltd....................................................  $        --   $        --   $    160,000    $    160,000
                                                             ===========   ===========   ============    ============
  Conversion of convertible notes payable to stockholders
    and accrued interest into redeemable convertible
    preferred stock........................................  $        --   $        --   $         --    $  9,905,710
                                                             ===========   ===========   ============    ============
  Conversion of preferred stock into common stock..........  $        --   $        --   $         --    $ 36,202,290
                                                             ===========   ===========   ============    ============
  Issuance of warrants.....................................  $        --   $        --   $         --    $    741,737
                                                             ===========   ===========   ============    ============
  Leasehold improvements acquired through issuance of
    redeemable convertible preferred stock.................  $        --   $        --   $         --    $    619,584
                                                             ===========   ===========   ============    ============
Supplemental disclosure of cash flow information:
                                                             ===========   ===========   ============    ============
  Interest paid during the period..........................  $     6,975   $    16,159   $     54,922    $  1,465,427
                                                             ===========   ===========   ============    ============




  The accompanying notes are an integral part of these consolidated financial
                                  statements.


                                      F-6


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



(1) OPERATIONS



    BioTransplant Incorporated (the "Company") was incorporated on March 20,
1990. The Company is developing pharmaceutical products and systems to enable
the body's immune system to better tolerate the transplantation of foreign
cells, tissues and organs. Based on BioTransplant's proprietary technology, both
alone and in collaboration with others, BioTransplant is seeking to develop a
portfolio of products designed to improve therapies associated with organ and
bone marrow transplantation as well as to improve the treatment of cancer,
autoimmune disease and blood disorders.



    The Company is in the development stage and is devoting substantially all of
its efforts toward product research and development and raising capital. The
Company is subject to a number of risks similar to those of other development
stage companies, including risks related to: its dependence on key individuals
and collaborative research partners, competition from substitute products and
larger companies, its ability to develop and market commercially usable products
and obtain regulatory approval for its products under development, and its
ability to obtain the substantial additional financing necessary to adequately
fund the development of its products.



    The Company incurred a net loss of approximately $11.7 million for the year
ended December 31, 2000, and had an accumulated deficit of approximately
$68.8 million as of December 31, 2000. The Company has funded these losses
principally through equity financing. Additionally, the Company has entered into
an agreement to purchase Eligix, Inc. (See Note 13). The Company will require
additional financing to fund operations; however, there can be no assurance that
such funding will be available or adequate to allow the Company to continue as a
going concern. Management is currently pursuing additional funding from various
sources. The financial statements do not include any adjustments that might
result from the outcome of this uncertainty.



(2)  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES



    The accompanying consolidated financial statements reflect the application
of certain accounting policies described below and elsewhere in the notes to
consolidated financial statements.



(A)  PRINCIPLES OF CONSOLIDATION



    The accompanying consolidated financial statements include the accounts of
the Company and its wholly owned subsidiary. All material intercompany accounts
and transactions have been eliminated in consolidation.



(B)  USE OF ESTIMATES IN THE PREPARATION OF FINANCIAL STATEMENTS



    The preparation of financial statements in conformity with accounting
principles generally accepted in the United States requires management to make
estimates and assumptions that affect the reported amounts of assets and
liabilities and disclosure of contingent assets and liabilities at the date of
the financial statements and the reported amounts of revenues and expenses
during the reporting period. Actual results could differ from those estimates.



(C)  CASH AND CASH EQUIVALENTS AND INVESTMENTS



    Cash and cash equivalents include short-term, highly liquid investments with
original maturities of ninety days or less from the date of purchase. Short-term
investments consist primarily of corporate notes with maturities of less than
one year. In accordance with Statement of Financial Accounting


                                      F-7


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(2)  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)


Standards (SFAS) No. 115, "Accounting for Certain Investments in Debt and Equity
Securities", the Company's investments are classified as held-to-maturity and
are stated at amortized cost, which approximates market value.



    The Company held the following cash equivalents and investments at
December 31, 1999 and 2000:





                                                        1999          2000
                                                     -----------   -----------
                                                             
Cash and cash equivalents..........................  $17,648,789   $11,481,297
                                                     -----------   -----------
Short-term investments:
  Corporate Bonds (average maturity of 2 months at
    December 31, 2000).............................           --     1,897,640
  Commercial Paper (average maturity of 2 months
    and 1 month at December 31, 1999 and 2000,
    respectively)..................................    3,718,033     1,493,928
                                                     -----------   -----------
                                                       3,718,033     3,391,568
                                                     -----------   -----------
Total cash, cash equivalents and investments.......  $21,366,822   $14,872,866
                                                     ===========   ===========




    There were no realized gains or losses in the years ended December 31, 1998,
1999 and 2000.



(D)  DEPRECIATION AND AMORTIZATION



    The Company provides for depreciation using the straight-line method by
charges to operations in amounts estimated to allocate the cost of these assets
over a three to five-year life. Amortization of equipment under capital lease
and leasehold improvements is computed using the straight-line method over the
shorter of the estimated useful life of the asset or the lease term.



(E)  REVENUE RECOGNITION



    Substantially all of the Company's license and research and development
revenues have been derived from three collaborative research arrangements (see
Note 7). Annual research and development payments are recognized on a
straight-line basis over the period of the contract, which approximates when
work is performed and costs are incurred. License fee revenue represents
technology transfer fees received for rights to certain technology of the
Company. License fees are recognized as revenue when all obligations as defined
in the individual arrangements are fulfilled by the Company and there is no risk
of refund. Deferred revenue represents amounts received in advance for research
and development. Research and development expenses in the accompanying
consolidated statements of operations include funded and unfunded expenses.



    SEC Staff Accounting Bulletin (SAB) No. 101 (SAB 101), "Revenue
Recognition," was issued in December 1999. SAB 101 requires companies to
recognize certain upfront non-refundable fees over the life of the related
alliance when such fees are received in conjunction with alliances which have
multiple elements. The Company was required to adopt this new accounting
principle through a cumulative charge to the statement of operations, in
accordance with Accounting Principle Board Opinion (APB) No. 20, "Accounting
Changes," no later than the fourth quarter of 2000, effective


                                      F-8


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(2)  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)


January 1, 2000. The adoption of this statement, consisting of the cumulative
effect of the accounting change and the current year effect, did not have a
material impact on the Company's financial statements for the year ended
December 31, 2000. As required under SAB 101, the Company is required to
disclose the pro forma effect of applying the principles of SAB 101 for all
periods presented. The application of SAB 101 for the years ended December 31,
1999 and 2000 did not result in a material change in reported revenues. For the
year ended December 31, 1998, the application of SAB 101 would have resulted in
revenues of $5,833,000 as compared to the $4,750,000 of revenues reported.



(F)  NET LOSS PER COMMON SHARE



    The Company applies SFAS No. 128, "Earnings Per Share" ("SFAS 128").
SFAS 128 establishes standards for computing and presenting earnings per share
and applies to entities with publicly held common stock or potential common
stock. Diluted weighted average shares is the same as basic weighted average
shares since the inclusion of shares issuable pursuant to the exercise of stock
options and warrants would have been antidilutive.



    Calculations of basic and diluted net loss per common share are as follows:





                                           1998          1999           2000
                                        -----------   -----------   ------------
                                                           
Net loss..............................  $(9,210,607)  $(8,673,450)  $(11,679,363)
                                        ===========   ===========   ============
Weighted average common shares
  outstanding -- basic and diluted....    8,578,941     8,598,085     11,547,262
                                        ===========   ===========   ============
Basic and diluted net loss per common
  share...............................  $     (1.07)  $     (1.01)  $      (1.01)
                                        ===========   ===========   ============
Antidilutive securities not included--
  Common stock options................       48,266       296,396        853,297
                                        ===========   ===========   ============
  Common stock warrants...............      133,007       151,998        282,471
                                        ===========   ===========   ============




(G)  COMPREHENSIVE INCOME



    SFAS No. 130, "Reporting Comprehensive Income," requires disclosure of all
components of comprehensive income. Comprehensive income is defined as the
change in equity of a business enterprise during a period from transactions and
other events and circumstances from nonowner sources. The Company does not have
any items of comprehensive net loss other than its net loss.



(H)  SEGMENT REPORTING



    The Company applies SFAS No. 131, "Disclosures about Segments of an
Enterprise and Related Information," ("SFAS 131") which establishes standards
for the way that public business enterprises report information about operating
segments in annual financial statements and requires that enterprises report
selected information about operating segments in interim financial reports
issued to


                                      F-9


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(2)  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)


stockholders. In accordance with SFAS 131, the Company believes that it operates
in one operating segment.



(I)  RECENT ACCOUNTING PRONOUNCEMENTS



    In June 1999, the Financial Accounting Standards Board issued SFAS No. 133,
"Accounting for Derivative Instruments and Hedging Activities" ("SFAS 133").
SFAS No. 133, as amended by SFAS No. 137, is effective for all fiscal quarters
of all fiscal years beginning after June 15, 2000. SFAS 133 establishes
accounting and reporting standards for derivative instruments including certain
derivative instruments embedded in other contracts (collectively referred to as
derivatives) and for hedging activities. The Company does not expect that the
adoption of this statement will have a material impact on the Company's
financial statements.



(3)  TERM NOTE



    In September 1997, the Company entered into a term note with a bank, whereby
the Company may borrow up to $500,000 for certain equipment and fixtures during
a specified drawdown period, after which time the outstanding balance will
become payable in 36 equal monthly principal installments plus interest. During
1999, the Company extended the drawdown period and increased its availability to
$1.0 million under the same conditions as this term note. Borrowings under the
term note bear annual floating interest at the bank's Prime Rate (9.25% at
December 31, 2000) during the drawdown period with an option to convert during
the repayment period to an annual fixed rate at the three-month London Interbank
Offered Rate ("LIBOR") (6.578% at December 31, 2000) plus 2.25%. Borrowings
under the term note are secured by equipment and fixtures purchased using the
proceeds of the note. There were $486,111 in borrowings outstanding under this
term note at December 31, 2000. The Company is required to maintain certain
financial covenants under the agreement. As of December 31, 2000, the Company
was in compliance with these covenants.



(4)  ACCRUED EXPENSES



    Accrued expenses consist of the following at December 31, 1999 and 2000:





                                                          1999         2000
                                                       ----------   ----------
                                                              
Consulting and contract research.....................  $1,067,988   $  748,342
Payroll and payroll related..........................     309,209        4,148
Professional fees....................................     538,646      587,587
Other................................................     600,330      381,668
                                                       ----------   ----------
                                                       $2,516,173   $1,721,745
                                                       ==========   ==========




(5)  COMMON STOCK



    In December 1999, the Company completed a private placement of 1,706,287
shares of its common stock at $4.50 per share for net proceeds of approximately
$7.3 million.


                                      F-10


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(5)  COMMON STOCK (CONTINUED)


    In February 2000, the Company completed a private placement of 1,215,000
shares of its common stock at $8.00 per share for net proceeds of approximately
$9.0 million.



    As of December 31, 1999 and 2000, the Company has reserved the following
shares of common stock for issuance:





                                                          1999         2000
                                                        ---------   ----------
                                                              
1991 Stock Option Plan................................    688,364      552,382
1994 Directors' Equity Plan...........................     99,375       52,064
1997 Stock Option Plan................................  1,496,757    1,417,350
Outstanding warrants..................................    425,147      463,179
                                                        ---------   ----------
                                                        2,709,643    2,484,975
                                                        =========   ==========




(6)  OPTIONS AND WARRANTS



(A)  COMMON STOCK PLANS



    In May 1997, the stockholders approved the 1997 Stock Incentive Plan (the
"1997 Plan"), which was intended to replace the Company's Amended 1991 Stock
Incentive Plan (the "1991 Plan"), under which it may grant incentive stock
options, nonqualified stock options and stock appreciation rights. In May 1999,
the stockholders approved an amendment to increase the number of shares of
common stock reserved for issuance under the 1997 Plan to 1,500,000 from
750,000. These options generally vest ratably over a four-to-five-year period.



    In May 1997, the stockholders approved an amendment to the Company's 1994
Directors' Equity Plan (the "Directors' Plan"). The amendment increased from
50,000 to 100,000 the number of shares of common stock reserved for issuance
under the Directors' Plan. The Director's Plan was terminated on June 27, 2000.
Future grants to the the board of directors will be made under the 1997 Plan.
Currently, the board of directors grants each director, upon his or her initial
election to the board of directors, an option to purchase 15,000 shares of
BioTransplant common stock at an exercise price equal to the then fair market
value. In addition, each director is eligible to receive an option to purchase
6,000 shares of BioTransplant common stock, at an exercise price equal to the
then fair market value, upon his or her reelection to the board of directors at
each annual meeting of stockholders.


                                      F-11


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(6)  OPTIONS AND WARRANTS (CONTINUED)


    The following table summarizes the employee and director stock option
activity under the plans discussed above:





                                                      NUMBER     WEIGHTED AVERAGE
                                                    OF OPTIONS    EXERCISE PRICE
                                                    ----------   ----------------
                                                           
Outstanding, December 31, 1997....................   1,014,425        $5.65
Granted...........................................     493,290         2.79
Exercised.........................................      (6,073)        2.43
Canceled..........................................    (129,188)        6.98
                                                    ----------        -----
Outstanding, December 31, 1998....................   1,372,454        $4.51
Granted...........................................     329,745         4.46
Exercised.........................................     (11,265)        2.21
Canceled..........................................     (69,326)        4.61
                                                    ----------        -----
Outstanding, December 31, 1999....................   1,621,608        $4.53
Granted...........................................     321,889         9.91
Exercised.........................................    (221,514)        4.10
Canceled..........................................     (44,270)        4.57
                                                    ----------        -----
Outstanding, December 31, 2000....................   1,677,713        $5.59
                                                    ==========        =====
Exercisable, December 31, 1998....................     472,608        $4.70
                                                    ==========        =====
Exercisable, December 31, 1999....................     747,266        $4.70
                                                    ==========        =====
Exercisable, December 31, 2000....................     862,733        $4.92
                                                    ==========        =====




    The following tables summarize certain information about options outstanding
at December 31, 2000:





                                  WEIGHTED AVERAGE
     RANGE OF                        REMAINING
     EXERCISE         OPTIONS       CONTRACTUAL      WEIGHTED AVERAGE
      PRICES        OUTSTANDING    LIFE IN YEARS      EXERCISE PRICE
------------------  -----------   ----------------   ----------------
                                            
$0.04- 4.00            638,554          6.43              $2.72
 4.13- 6.75            702,054          6.89               6.20
 6.88-18.63            337,105          9.15               9.76
------------------   ---------          ----              -----
$0.04-18.63          1,677,713          7.17              $5.59
==================   =========          ====              =====



                                      F-12


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(6)  OPTIONS AND WARRANTS (CONTINUED)


The following tables summarize certain information about options exercisable at
December 31, 2000:





     RANGE OF
     EXERCISE         OPTIONS     WEIGHTED AVERAGE
      PRICES        EXERCISABLE    EXERCISE PRICE
------------------  -----------   ----------------
                            
$0.04- 4.00           365,722          $2.96
 4.13- 6.75           460,452           6.22
 6.88-18.63            36,559           8.18
------------------    -------          -----
$0.04-18.63           862,733          $4.92
==================    =======          =====




    SFAS No. 123, "Accounting for Stock-Based Compensation" ("SFAS 123"),
requires the measurement of the fair value of stock options or warrants granted
to employees be included in the statement of operations or disclosed in the
notes to financial statements. The Company accounts for stock-based compensation
for employees under APB Opinion No. 25 and follows the pro forma disclosure-only
alternative under SFAS 123. The Company has computed the pro forma disclosures
required under SFAS 123 for options granted using the Black-Scholes option
pricing model prescribed by SFAS 123. The assumptions used for the years ended
December 31, 1998, 1999 and 2000 are as follows: risk-free interest rates of
4.73%, 6.72% and 4.93%; expected common stock volatility factors of 85%, 87% and
92%; and a weighted-average expected life of the stock options of seven years.
The Company does not currently pay any dividends, and it does not expect to pay
cash dividends in the foreseeable future; therefore, dividend yields for 1998,
1999 and 2000 are assumed to be 0%. The weighted average fair value of options
granted in 1998, 1999 and 2000 was $2.18, $3.57 and $8.14, respectively.



    The Black-Scholes option-pricing model was developed for use in estimating
the fair value of traded options that have no vesting restrictions and are fully
transferable. In addition, option-pricing models require the input of highly
subjective assumptions including expected stock price volatility. Because the
Company's employee stock options have characteristics significantly different
from those of traded options, and because changes in the subjective input
assumptions can materially affect the fair value estimate, in management's
opinion, the existing models do not necessarily provide a reliable single
measure of the fair value of its employee stock options.



    The total fair value of the options granted during the years ended
December 31, 1998, 1999 and 2000 was computed as approximately $1,074,000,
$1,177,000 and $2,619,000, respectively. These amounts are assumed to be
amortized over the related vesting periods. The resulting pro forma compensation
expense may not be representative of the amount to be expected in future years,
as pro forma compensation expense may vary, based upon the number of options
granted and the assumptions used in valuing these options.



    The pro forma net loss and pro forma net loss per common share presented
below have been computed assuming no tax benefit. The effect of a tax benefit
has not been considered since a substantial portion of the stock options granted
are incentive stock options and the Company does not


                                      F-13


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(6)  OPTIONS AND WARRANTS (CONTINUED)


anticipate a future deduction associated with the exercise of these stock
options. The pro forma effect of SFAS 123 for the years ended December 31, 1998,
1999 and 2000 is as follows:





                                                           1998          1999           2000
                                                       ------------   -----------   ------------
                                                                           
Net loss
    As reported......................................  $ (9,210,607)  $(8,673,450)  $(11,679,363)
    Pro forma........................................   (10,123,353)   (9,769,704)   (13,032,181)

Basic and diluted net loss per common share
    As reported......................................  $      (1.07)  $     (1.01)  $      (1.01)
    Pro forma........................................         (1.18)        (1.14)         (1.13)




(B)  WARRANTS



    In connection with certain financing and facility leasing transactions that
occurred in 1991 through 1995, the Company issued warrants to purchase 377,133
shares of common stock at prices ranging from $.04 to $17.52. In December 1999,
the Company issued warrants to purchase 71,391 shares of common stock at a price
of $5.63 per share in connection with a private placement of the Company's
common stock. In February 2000, the Company issued warrants to purchase 97,200
shares of common stock at a price of $10.00 per share in connection with a
private placement of the Company's common stock. As of December 31, 2000,
warrants to purchase 23,829 shares of common stock had expired or been
cancelled. During 2000, warrants to purchase 58,716 shares of common stock were
exercised for net proceeds of approximately $393,000.



    The following table summarizes certain information about warrants
outstanding at December 31, 2000:





                                   WEIGHTED AVERAGE
                                      REMAINING
     RANGE OF         WARRANTS       CONTRACTUAL      WEIGHTED AVERAGE
  EXERCISE PRICES    OUTSTANDING    LIFE IN YEARS      EXERCISE PRICE
  ---------------    -----------   ----------------   ----------------
                                             
$ 0.04-10.00           451,350           3.53              $ 3.97
 10.80-17.52.......     11,829           0.87               14.89
-------------------    -------           ----              ------
$ 0.04-17.52.......    463,179           3.46              $ 4.24
===================    =======           ====




(7)  COLLABORATIVE RESEARCH AGREEMENTS



(A)  NOVARTIS



    In April 1993, as amended and restated in September 1995, the Company
entered into a five-year collaboration agreement with Novartis to develop and
commercialize xenotransplantation technology utilizing gene transduction.
Pursuant to this agreement, all committed research funding of $20.0 million and
all committed license fees of $10.0 million had been received as of
December 31, 1997. In October 1997, the Company and Novartis expanded their
relationship in xenotransplantation by entering into a collaboration and license
agreement for the development and commercialization of xenotransplantation
products utilizing the Company's proprietary mixed bone marrow chimerism


                                      F-14


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(7)  COLLABORATIVE RESEARCH AGREEMENTS (CONTINUED)


technology. Under this agreement, Novartis committed up to $36.0 million in
research funding, license fees and milestone payments, assuming the agreement
continues for its full term. As of December 31, 2000, $13.5 million of research
funding, $4.0 million of license fees and $2.5 million of milestone payments had
been received.



    In September 2000, the Company entered into an agreement with Novartis to
combine their respective expertise in the field of xenotransplantation into a
newly-formed, independently-run company named Immerge BioTherapeutics AG
("Immerge"). The formation of Immerge supersedes and terminates the 1993 and
1997 Novartis agreements as amended and restated. Immerge began operations in
January 2001. In return for contributing its technology and an aggregate of
$30 million in funding over three years beginning January 1, 2001, Novartis
retains a 67% ownership share of Immerge and retains the exclusive worldwide,
royalty-bearing rights to the development and commercialization of any
xenotransplantation products resulting from Immerge's research. In return for
contributing its technology, BioTransplant retains a 33% share of Immerge and
will receive royalty payments from Novartis sales of xenotransplantation
products, if any.



    In December 2000, Immerge BioTherapeutics AG formed a wholly-owned Delaware
subsidiary, Immerge BioTherapeutics, Inc. BioTransplant expects to enter into a
contract research agreement with the Delaware subsidiary, under which
BioTransplant will commit approximately 20 full-time employees to perform
research and will agree to provide administrative services, all at a rate to be
agreed upon.



    In addition to these agreements, Novartis purchased $5.0 million of the
Company's Series B convertible preferred stock in 1992, which converted into
532,125 shares of common stock upon the Company's initial public offering in
1996.



(B)  MEDIMMUNE, INC.



    In October 1995, the Company and MedImmune, Inc. ("MedImmune") formed a
collaborative agreement for the development and commercialization of products to
treat and prevent organ transplant rejection. The collaboration is based upon
the development of products derived from BTI-322, MEDI-500 and future
generations of products derived from these two molecules (including MEDI-507,
the humanized version of BTI-322). Pursuant to the collaboration, the Company
granted MedImmune an exclusive worldwide license to develop and commercialize
BTI-322 and any products based on BTI-322, other than the use of BTI-322 in kits
or systems for xenotransplantation or allotransplantation. MedImmune paid the
Company a $2.0 million license fee at the time of formation of the
collaboration, and agreed to fund and assume responsibility for clinical testing
and commercialization of any resulting products. MedImmune had provided
$2.0 million in non-refundable research support through December 31, 1997.
Additionally, MedImmune has agreed to make milestone payments that could total
up to an additional $11.0 million, all of which is repayable from royalties on
BTI-322/MEDI-507 or MEDI-500, as well as pay royalties on any sales of
BTI-322/MEDI-507, MEDI-500 and future generations of products, if any. The
Company has not received any milestone payments to date. MedImmune is entitled
to a credit against royalty payments for certain milestone payments that it
makes.


                                      F-15


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(8)  INCOME TAXES



    The Company accounts for income taxes in accordance with SFAS No. 109,
"Accounting for Income Taxes." At December 31, 2000 the Company had net
operating loss carryforwards for income tax purposes of approximately
$64,562,000. The Company also has available tax credit carryforwards of
$2,000,000 at December 31, 1999 to reduce future federal income taxes, if any.
The net operating loss carryforwards and tax credit carryforwards expire
commencing in the year 2006 through 2020, and are subject to review and possible
adjustment by the Internal Revenue Service. Net operating loss carryforwards and
tax credit carryforwards may be limited in the event of certain changes in the
ownership interests of significant stockholders.



    The components of the deferred tax asset as of December 31, 1999 and 2000
are approximately as follows:





                                                        1999          2000
                                                     -----------   -----------
                                                             
Operating loss carryforwards.......................  $19,350,000   $25,999,000
Tax credit carryforwards...........................    2,000,000     2,200,000
Other temporary differences........................    1,550,000       607,000
                                                     -----------   -----------
                                                      22,900,000    28,806,000
Less--Valuation allowance..........................   22,900,000    28,806,000
                                                     -----------   -----------
                                                     $        --   $        --
                                                     ===========   ===========




    Because of the history of operating losses, a valuation allowance has been
provided for the entire deferred tax asset since it is uncertain if the Company
will realize the benefit of the deferred tax asset.



(9)  COMMITMENTS



(A) RESEARCH AND LICENSE AGREEMENTS



    The Company has entered into several research and license agreements with a
hospital whereby the Company obtained the rights to the hospital's research
pertaining to the transplantation of organs and tissues and other related
technologies. The Company also obtained an exclusive license to commercially
develop, manufacture, use and distribute worldwide any products developed
pursuant to the agreements, in exchange for research funding and royalties on
any future sales. These agreements have initial terms of one to ten years;
however, either party may terminate the agreements at various times, as defined,
with written notice.



    The Company has entered into research and license agreements with
universities whereby the Company funds research and development. The Company
also obtained exclusive worldwide licenses for certain patents, patent rights
and research information and rights to develop, manufacture, use and sell any
product developed pursuant to the licensed technology in exchange for royalties
on any future sales, as defined.



    The Company has entered into a miniature swine transfer and maintenance
agreement with a breeding laboratory and was granted exclusive, worldwide rights
to the miniature swine. Pursuant to this agreement, the Company has agreed to
pay specified maintenance costs, as defined in the agreement.


                                      F-16


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(9)  COMMITMENTS (CONTINUED)


    Commitments as of December 31, 2000, pursuant to these research and license
agreements are as follows:





                                                            TOTAL
                                                          ----------
                                                       
Year Ending December 31,
  2001..................................................  $3,390,000
  2002..................................................     777,000
  2003..................................................     775,000
                                                          ----------
                                                          $4,942,000
                                                          ==========




(B)  OPERATING LEASE COMMITMENTS



    The Company leases its facility under an operating lease that expires in
2009. In addition, the Company is responsible for the real estate taxes and
operating expenses related to this facility. Minimum annual rental payments,
excluding taxes and operating costs, under this lease agreement are as follows:




                                                       
2001....................................................  $1,025,000
2002....................................................   1,025,000
2003....................................................   1,025,000
2004....................................................   1,025,000
2005....................................................   1,025,000
Thereafter..............................................   4,100,000
                                                          ----------
                                                          $9,225,000
                                                          ==========




    Rental expense, which includes facility lease, ground lease and real estate
tax costs, for the years ended December 31, 1998, 1999 and 2000 was
approximately $1,219,000, $1,192,000 and $1,188,000, respectively.



(C)  CAPITAL LEASE COMMITMENTS



    The Company has capital lease commitments related to certain property and
equipment.


                                      F-17


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(9)  COMMITMENTS (CONTINUED)


    Future minimum payments under these capital lease agreements as of
December 31, 2000 are as follows:





YEAR ENDING DECEMBER 31,                                       AMOUNT
------------------------                                      --------
                                                           
2001........................................................  $ 50,396
2002........................................................    50,396
2003........................................................    37,797
  Total minimum payments....................................   138,589
Less -- Amount representing interest........................    18,818
                                                              --------
  Present value of minimum lease payments...................   119,771
Less -- Current obligation under capital leases.............    37,486
                                                              --------
                                                              $ 82,285
                                                              ========




    Equipment under capital leases collateralize these lease obligations.



(10)  INVESTMENT IN STEM CELL SCIENCES LTD.



    In April 1994, the Company entered into a shareholders' agreement and a
research and license agreement (the "Agreements") with Stem Cell Sciences Ltd.
("Stem Cell"). Under the Agreements, the Company paid $1.0 million for 30% of
the outstanding common stock of Stem Cell, an exclusive license to certain
technology and other intellectual property and support of certain research in
the field of animal genetic engineering and an option to maintain its pro rata
equity ownership at 30% through December 31, 1998. The Company recorded the
$1,000,000 payment as research and development expense during the year ended
December 31, 1994.



    The Company made capital contributions of $924,000 in 1996 and $676,000 in
1997 to maintain its pro rata ownership in Stem Cell. The Company recorded these
contributions as research and development expense during the years ended
December 31, 1996 and 1997, respectively.



    In December 1997, the Company made a capital contribution of $700,000 to
Stem Cell to maintain its pro rata ownership of Stem Cell for 1998, which was
recorded as research and development expense on a straight-line basis over the
year ended December 31, 1998. During 1998, the Company committed to a capital
contribution of $825,000 to Stem Cell to maintain its pro rata ownership of Stem
Cell for 1999 which was recognized as research and development expense on a
straight-line basis over the year ended December 31, 1999. The Company paid
$175,000 of this commitment in December 1998 and paid the remaining amount
during 1999.



    During 2000, Stem Cell received approximately $1.8 million from the issuance
of convertible notes to parties other than the Company. Certain noteholders of
Stem Cell converted their interest into common stock during the year. This
conversion diluted the Company's ownership interest in Stem Cell to 25.5%.
Additionally, in connection with the conversion the Company recognized a gain in
stockholders' equity of $160,000 on its investment in accordance with SAB
No. 51, "Accounting for Sales of Stock by a Subsidiary." The Company also
recorded its equity in the loss of Stem Cell of $55,000 for the year ended
December 31, 2000. This loss is included in research and development expense.


                                      F-18


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(11)  EMPLOYMENT RETIREMENT/SAVINGS PLAN



    The Company maintains an employee retirement/savings plan (the "Plan") which
permits participants to make tax deferred contributions by salary reduction
pursuant to section 401(k) of the Internal Revenue Code. All active employees,
21 years of age or older, who have completed a calendar quarter of service are
eligible to participate in the Plan. The Company pays all administrative costs
of the Plan. During 2000, the Company began making matching contributions into
the Plan and contributed a total of approximately $82,000.



(12)  RELATED PARTY TRANSACTIONS



    In March 1991, the Company entered into a supply agreement with Charles
River Laboratories (CRL), which was amended in 1998. Under the terms of the
amended agreement, CRL provides the Company with miniature swine and miniature
swine organs for research and development purposes in exchange for payment of
the costs of maintaining the miniature swine herd. Upon commencement of
commercial sales of miniature swine organs, the Company and CRL may enter into a
definitive supply agreement for the ongoing supply of miniature swine. In the
years ended December 31, 1999 and 2000, the Company paid CRL approximately
$940,000 and 988,000, respectively, under this agreement. James C. Foster,
President and Chief Executive Officer of CRL, is a director of the Company.



(13)  PENDING ACQUISITION



    On December 8, 2000, the Company entered into a definitive agreement to
acquire Eligix, Inc. through a reverse triangular merger. Upon consummation of
the merger, Eligix will become a wholly-owned subsidiary of the Company. Under
the terms of the merger, the Company will issue up to 5,610,000 shares of common
stock in exchange for the fully diluted common stock of Eligix and 990,000
shares of common stock to members of Eligix management over a one-year period.
The Company will account for the merger as a purchase of Eligix. The merger is
expected to close in the second quarter of 2001, subject to BioTransplant and
Eligix stockholder approval. Based upon the Company's average trading price for
the period from two days before to two days after the date the merger was
announced, December 11, 2000, of $8.3565, the transaction is valued at
approximately $55,000,000. Additionally, the Company anticipates the closing
costs of the merger to total approximately $3.7 million.



    If the Company or Eligix terminates the merger agreement in accordance with
its terms, all obligations of the parties under the merger agreement terminate
and there will be no liability, except that if the merger agreement is
terminated by either party as a result of the other party's failure to perform
or comply in all material respects with the agreements and covenants under the
merger agreement, the nonterminating party will pay the terminating party
$2.0 million.



    Additionally, the Company has entered into a promissory note with Eligix
whereby Eligix may borrow up to $2.0 million to fund operations through the
closing date of the merger. The loan bears interest at the prime rate. Upon
consummation of the merger, the loan will be forgiven, provided that if the
merger does not close on or before June 30, 2001, the note will become
immediately due and payable in full.


                                      F-19


                   BIOTRANSPLANT INCORPORATED AND SUBSIDIARY



                         (A DEVELOPMENT STAGE COMPANY)



             NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)



(14)  QUARTERLY RESULTS OF OPERATIONS (UNAUDITED)



    The following tables present a condensed summary of quarterly results of
operations for the years ended December 31, 1999 and 2000 (in thousands, except
per share data).





                                                                 YEAR ENDED DECEMBER 31, 2000
                                                           -----------------------------------------
                                                            FIRST      SECOND     THIRD      FOURTH
                                                           QUARTER    QUARTER    QUARTER    QUARTER
                                                           --------   --------   --------   --------
                                                                                
Total revenues...........................................  $ 1,488    $ 1,488    $ 1,476    $   106
Net loss.................................................  $(2,499)   $(2,408)   $(2,501)   $(4,271)
Basic and diluted net loss per share.....................  $ (0.23)   $ (0.21)   $ (0.21)   $ (0.36)






                                                                 YEAR ENDED DECEMBER 31, 1999
                                                           -----------------------------------------
                                                            FIRST      SECOND     THIRD      FOURTH
                                                           QUARTER    QUARTER    QUARTER    QUARTER
                                                           --------   --------   --------   --------
                                                                                
Total revenues...........................................  $ 1,239    $ 1,238    $ 3,735    $ 2,477
Net loss.................................................  $(2,892)   $(2,968)   $  (602)   $(2,213)
Basic and diluted net loss per share.....................  $ (0.34)   $ (0.35)   $ (0.07)   $ (0.26)



                                      F-20


                       REPORT OF INDEPENDENT ACCOUNTANTS



To the Board of Directors and Stockholders of
Eligix, Inc.:



    In our opinion, the accompanying balance sheets and the related statements
of operations, of changes in convertible preferred stock and stockholders'
deficit and cash flows present fairly, in all material respects, the financial
position of Eligix, Inc. (a development stage enterprise) at December 31, 2000
and 1999, and the results of its operations and its cash flows for the years
ended December 31, 2000, 1999 and 1998 and the period from inception
(December 27, 1996) to December 31, 2000 in conformity with accounting
principles generally accepted in the United States of America. These financial
statements are the responsibility of the Company's management; our
responsibility is to express an opinion on these financial statements based on
our audits. We conducted our audits of these statements in accordance with
auditing standards generally accepted in the United States of America, which
require that we plan and perform the audit to obtain reasonable assurance about
whether the financial statements are free of material misstatement. An audit
includes examining, on a test basis, evidence supporting the amounts and
disclosures in the financial statements, assessing the accounting principles
used and significant estimates made by management, and evaluating the overall
financial statement presentation. We believe that our audits provide a
reasonable basis for the opinion expressed above.



    The accompanying financial statements have been prepared assuming that the
Company will continue as a going concern. As discussed in Note A to the
financial statements, the Company has suffered recurring losses from operations
since inception and requires additional financing. These circumstances raise
substantial doubt about its ability to continue as a going concern. Management's
plans in regard to these matters are also described in Note A. The financial
statements do not include any adjustments that might result from the outcome of
this uncertainty.



/s/ PricewaterhouseCoopers LLP
Boston, Massachusetts
March 7, 2001


                                      F-21


                                  ELIGIX, INC.



                        (A DEVELOPMENT STAGE ENTERPRISE)



                                 BALANCE SHEETS





                                                                     DECEMBER 31,
                                                              ---------------------------
                                                                  1999           2000
                                                              ------------   ------------
                                                                       
                                         ASSETS
Current assets:
  Cash and cash equivalents.................................  $  3,269,306   $    711,774
  Prepaid and other current assets..........................       162,638        124,556
                                                              ------------   ------------
    Total current assets....................................     3,431,944        836,330
Other assets................................................       131,700        128,000
Property and equipment, net (Note C)........................     3,197,382      2,742,755
                                                              ------------   ------------
    Total assets............................................  $  6,761,026   $  3,707,085
                                                              ============   ============

                          LIABILITIES AND STOCKHOLDERS' DEFICIT
Current liabilities:
  Accounts payable..........................................  $    400,303   $    844,298
  Accrued expenses..........................................       479,359        774,556
  Cash overdraft............................................       190,363        295,926
  Current portion of loans payable..........................       831,756        944,747
  Convertible notes.........................................            --      7,547,708
                                                              ------------   ------------
    Total current liabilities...............................     1,901,781     10,407,235
Long-term portion of loans payable..........................     2,121,800      1,264,474
Convertible preferred stock, $.001 par value, 57,500,000
  shares authorized:
  Series A convertible preferred stock:
    11,100,000 shares authorized; 10,911,332 shares issued
      and outstanding as of December 31, 1999 and 2000;
      liquidation value of $14,512,072......................     4,555,581      4,555,581
  Series B convertible preferred stock:
    12,500,000 shares authorized; 11,214,755 shares issued
      and outstanding at December 31, 1999 and 2000;
      liquidation value of $16,822,133......................    16,777,679     16,777,679
  Series C convertible preferred stock:
    33,900,000 shares authorized; no shares issued or
      outstanding...........................................            --             --

Commitments and contingencies (Note D)

Stockholders' deficit:
  Common stock, $.001 par value: 66,000,000 shares
    authorized; 131,825 and 251,220 shares issued and
    outstanding at December 31, 1999 and 2000,
    respectively............................................           132            251
  Additional paid-in capital................................        12,142      5,868,847
  Deferred compensation.....................................            --     (3,587,356)
  Deficit accumulated during development stage..............   (18,608,089)   (31,579,626)
                                                              ------------   ------------
    Total stockholders' deficit.............................   (18,595,815)   (29,297,884)
                                                              ------------   ------------
    Total liabilities and stockholders' deficit.............  $  6,761,026   $  3,707,085
                                                              ============   ============




   The accompanying notes are an integral part of these financial statements.


                                      F-22


                                  ELIGIX, INC.



                        (A DEVELOPMENT STAGE ENTERPRISE)



                            STATEMENTS OF OPERATIONS





                                                                                        CUMULATIVE
                                                                                      FROM INCEPTION
                                                                                      (DECEMBER 27,
                                                  YEARS ENDED DECEMBER 31,               1996) TO
                                          -----------------------------------------    DECEMBER 31,
                                             1998           1999           2000            2000
                                          -----------   ------------   ------------   --------------
                                                                          
General, administrative and marketing
  expenses..............................  $ 1,648,663   $  2,161,841   $  3,682,360    $  8,583,785
Research and development expenses.......    3,925,165      8,257,023      8,097,164      22,201,097
                                          -----------   ------------   ------------    ------------
Loss from operations....................   (5,573,828)   (10,418,864)   (11,779,524)    (30,784,882)
Interest income.........................      220,219        305,510        150,212         813,801
Interest expense........................      (44,030)      (221,514)    (1,342,225)     (1,608,545)
                                          -----------   ------------   ------------    ------------
Net loss................................  $(5,397,639)  $(10,334,868)  $(12,971,537)   $(31,579,626)
                                          ===========   ============   ============    ============



   The accompanying notes are an integral part of these financial statements.

                                      F-23


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)
 STATEMENTS OF CHANGES IN CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' DEFICIT
     FOR THE PERIOD FROM INCEPTION (DECEMBER 27, 1996) TO DECEMBER 31, 2000





                                                                                          
                                     SERIES A CONVERTIBLE       SERIES B CONVERTIBLE
                                        PREFERRED STOCK           PREFERRED STOCK           COMMON STOCK       ADDITIONAL
                                    -----------------------   ------------------------   -------------------    PAID-IN
                                      SHARES       AMOUNT       SHARES       AMOUNT      SHARES     AMOUNT      CAPITAL
                                    ----------   ----------   ----------   -----------   --------   --------   ----------
Balance at December 27, 1996......
Issuance of Series A convertible
  preferred stock
  for technology..................   7,500,000   $    7,500                                                    $  (7,500)
Issuance of Series A convertible
  preferred stock.................   3,336,332    4,448,331
Issuance of Series A convertible
  preferred stock for office space
  and services....................      75,000       99,750
Net loss..........................
                                    ----------   ----------   ----------   -----------   -------      ----     ----------
Balance at December 31, 1997......  10,911,332    4,555,581                                                       (7,500)
Issuance of Series B convertible
  preferred stock.................                             9,500,468   $14,250,702
Conversion of promissory notes and
  accrued interest in Series B
  convertible preferred stock.....                             1,352,621     2,028,932
Issuance of Series B convertible
  preferred stock for services....                                13,333        20,000
Issuance of common stock..........                                                        55,600      $ 56         8,284
Net loss..........................
                                    ----------   ----------   ----------   -----------   -------      ----     ----------
Balance at December 31, 1998......  10,911,332    4,555,581   10,866,422    16,299,634    55,600        56           784
Issuance of Series B convertible
  preferred stock, net issuance
  costs of $44,454................                               348,333       478,045
Issuance of common stock..........                                                        76,225        76        11,358
Net loss..........................
                                    ----------   ----------   ----------   -----------   -------      ----     ----------
Balance at December 31, 1999......  10,911,332    4,555,581   11,214,755    16,777,679   131,825       132        12,142
Issuance of common stock..........                                                       119,395       119        17,691
Issuance of warrants with
  convertible notes...............                                                                               907,156
Deferred stock-based compensation
  related to employees............                                                                             4,526,816
Amortization of deferred
  compensation related to
  employees.......................
Stock-based compensation related
  to nonemployees.................                                                                               265,465
Other stock-based compensation....                                                                               139,577
Net loss..........................
                                    ----------   ----------   ----------   -----------   -------      ----     ----------
Balance at December 31, 2000......  10,911,332   $4,555,581   11,214,755   $16,777,679   251,220      $251     $5,868,847
                                    ==========   ==========   ==========   ===========   =======      ====     ==========



                                                          
                                                      DEFICIT
                                                    ACCUMULATED
                                                       DURING         TOTAL
                                      DEFERRED      DEVELOPMENT    STOCKHOLDERS'
                                    COMPENSATION       STAGE         DEFICIT
                                    -------------   ------------   ------------
Balance at December 27, 1996......
Issuance of Series A convertible
  preferred stock
  for technology..................                                 $     (7,500)
Issuance of Series A convertible
  preferred stock.................
Issuance of Series A convertible
  preferred stock for office space
  and services....................
Net loss..........................                  $(2,875,582)     (2,875,582)
                                     -----------    ------------   ------------
Balance at December 31, 1997......                   (2,875,582)     (2,883,082)
Issuance of Series B convertible
  preferred stock.................
Conversion of promissory notes and
  accrued interest in Series B
  convertible preferred stock.....
Issuance of Series B convertible
  preferred stock for services....
Issuance of common stock..........                                        8,340
Net loss..........................                   (5,397,639)     (5,397,639)
                                     -----------    ------------   ------------
Balance at December 31, 1998......                   (8,273,221)     (8,272,381)
Issuance of Series B convertible
  preferred stock, net issuance
  costs of $44,454................
Issuance of common stock..........                                       11,434
Net loss..........................                  (10,334,868)    (10,334,868)
                                     -----------    ------------   ------------
Balance at December 31, 1999......                  (18,608,089)    (18,595,815)
Issuance of common stock..........                                       17,810
Issuance of warrants with
  convertible notes...............                                      907,156
Deferred stock-based compensation
  related to employees............   $(4,526,816)                            --
Amortization of deferred
  compensation related to
  employees.......................       939,460                        939,460
Stock-based compensation related
  to nonemployees.................                                      265,465
Other stock-based compensation....                                      139,577
Net loss..........................                  (12,971,537)    (12,971,537)
                                     -----------    ------------   ------------
Balance at December 31, 2000......   $(3,587,356)   $(31,579,626)  $(29,297,884)
                                     ===========    ============   ============




   The accompanying notes are an integral part of these financial statements.


                                      F-24


                                  ELIGIX, INC.



                        (A DEVELOPMENT STAGE ENTERPRISE)



                            STATEMENTS OF CASH FLOWS





                                                                                                         CUMULATIVE
                                                                                                       FROM INCEPTION
                                                                                                       (DECEMBER 27,
                                                                         DECEMBER 31,                     1996) TO
                                                           -----------------------------------------    DECEMBER 31,
                                                              1998           1999           2000            2000
                                                           -----------   ------------   ------------   --------------
                                                                                           
Cash flows from operating activities:
  Net loss...............................................  $(5,397,639)  $(10,334,868)  $(12,971,537)   $(31,579,626)
  Adjustments to reconcile net loss to net cash used in
    operating activities:
    Depreciation and amortization........................       54,529        360,949        438,552         868,652
    Noncash charges......................................       28,312             --             --         119,750
    Stock compensation expense...........................                                  1,344,502       1,344,502
    Amortization of debt discount........................                                    632,314         632,314
    Loss on disposal of fixed assets.....................                                     78,249          78,249
    Changes in operating assets and liabilities:
      Prepaid and other current assets...................      (87,719)       (21,545)        38,082        (116,366)
      Other assets.......................................     (113,700)       (14,000)         3,700        (128,000)
      Accounts payable...................................      490,742       (363,204)       443,995         844,298
      Accrued expenses...................................      501,238       (229,327)       295,197         774,556
                                                           -----------   ------------   ------------    ------------
Net cash used by operating activities....................   (4,524,237)   (10,601,995)    (9,696,946)    (27,161,671)
                                                           -----------   ------------   ------------    ------------
Cash flows from investing activities:
    Purchase of property and equipment...................   (1,376,288)    (2,021,899)       (62,174)     (3,670,651)
                                                           -----------   ------------   ------------    ------------
Net cash used by investing activities....................   (1,376,288)    (2,021,899)       (62,174)     (3,670,651)
                                                           -----------   ------------   ------------    ------------
Cash flows from financing activities:
  Payments on notes payable..............................      (52,000)      (481,871)      (744,335)     (1,283,472)
  Proceeds from notes payable............................      268,000      3,116,631        349,355       3,843,785
  Cash overdraft.........................................           --        190,363        105,563         295,926
  Prepaid stock subscription.............................      300,000             --             --         300,000
  Proceeds from issuance of convertible promissory
    notes................................................    2,000,000             --      7,473,195       9,473,195
  Proceeds from issuance of Series B convertible
    preferred stock......................................   14,250,702        178,045             --      14,428,747
  Proceeds from issuance of Series A convertible
    preferred stock......................................           --             --             --       4,448,331
  Proceeds from issuance of common stock.................        8,340         11,434         17,810          37,584
                                                           -----------   ------------   ------------    ------------
Net cash provided by financing activities................   16,775,042      3,014,602      7,201,588      31,544,096
                                                           -----------   ------------   ------------    ------------
Net increase (decrease) in cash and cash equivalents.....   10,874,517     (9,609,292)    (2,557,532)        711,774
Cash and cash equivalents at beginning of year...........    2,004,081     12,878,598      3,269,306              --
                                                           -----------   ------------   ------------    ------------
Cash and cash equivalents at end of year.................  $12,878,598   $  3,269,306   $    711,774    $    711,774
                                                           ===========   ============   ============    ============
Supplemental disclosure of cash flow information:
  Interest paid..........................................  $    15,098   $    221,514   $    319,726    $    556,338
Noncash transactions:
  Conversion of convertible promissory notes (see
    Note I)
  Issuance of Series A convertible preferred stock for
    use of research facility (see Note M)
  Issuance of Series A convertible preferred stock for
    technology (see Note F)



   The accompanying notes are an integral part of these financial statements.

                                      F-25


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                         NOTES TO FINANCIAL STATEMENTS



A. NATURE OF BUSINESS



    Eligix, Inc. (the "Company") was incorporated in the State of Delaware on
December 27, 1996. The Company is focused on the development and
commercialization of enabling and novel cell therapies for the treatment of
cancer and immune disorders. The Company is a development stage enterprise as
defined in Statement of Financial Accounting Standards No. 7, and is devoting
substantially all of its efforts to conducting research and development and
raising capital to fund operations.



    The Company's financial statements have been presented on the basis of a
going concern, which contemplates the realization of assets and the satisfaction
of liabilities in the normal course of business. The Company has incurred losses
since inception and has a retained deficit which has been primarily funded by
issuing equity securities as well as debt securities and lease financing.
Management intends to issue additional debt and equity securities to existing
and third-party investors to finance the commercialization of existing
technologies.



    On December 8, 2000, the Company entered into a definitive agreement to be
acquired by BioTransplant Incorporated ("BioTransplant"), as further described
in Note O. The Company expects to borrow up to $2,000,000 from BioTransplant in
the form of a promissory note to fund operations through the anticipated closing
date of the merger. If the merger with BioTransplant is not completed, the
Company will be required to obtain additional capital in the short term to
satisfy its ongoing capital needs and to continue its operations. Although
management continues to pursue additional funding arrangements and/or strategic
partnering, no assurance can be given that such financing will in fact be
available to the Company. If the Company is unable to obtain financing on
acceptable terms in order to maintain operations through the next fiscal year,
it could be forced to curtail or discontinue its operations. The financial
statements do not include any adjustments that might result from the outcome of
this uncertainty.



B. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES



    BASIS OF PRESENTATION



    The financial statements have been prepared under the accrual method of
accounting in conformity with generally accepted accounting principles.



    CASH AND CASH EQUIVALENTS



    Cash and cash equivalents consist of cash in banks and money market funds
with original maturities of three months or less.



    PROPERTY AND EQUIPMENT



    Property and equipment are stated at cost. Expenditures for repairs and
maintenance are charged to expense as incurred. When assets are retired or
disposed of, the assets and related accumulated depreciation are eliminated from
the accounts and any resulting gain or loss is reflected in operations.


                                      F-26


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



B. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)


For financial reporting purposes, depreciation is calculated using the
straight-line method over the estimated useful lives of the assets, which are as
follows:






                                    
Computer equipment and software......                3 years
Furniture and fixtures...............                5 years
Lab equipment........................                10 years
                                        Shorter of the life of the lease or
Leasehold improvements...............        the estimated useful life




    CONCENTRATION OF CREDIT RISK



    The Company's significant concentrations of credit risk consist principally
of cash and cash equivalents. The Company maintains cash and cash equivalents
with major financial institutions.



    UNCERTAINTIES



    The Company is subject to risks common to companies in the biotechnology
industry, including but not limited to, development by the Company or its
competitors of new technological innovations, dependence on key personnel,
protection of proprietary technology, health care cost containment initiatives,
uncertainty of market acceptance of products, product liability and compliance
with government regulations, including those of the U.S. Department of Health
and Human Services and the U.S. Food and Drug Administration.



    FAIR VALUE OF FINANCIAL INSTRUMENTS



    The carrying values of cash and cash equivalents, loans payable and
convertible notes approximate fair value given the short-term nature of the
instruments.



    RESEARCH AND DEVELOPMENT COSTS



    Research and development costs are charged to expense as incurred.



    INCOME TAXES



    Deferred tax assets and liabilities are determined based on the difference
between the financial statement and the tax basis of assets and liabilities
using current statutory tax rates. A valuation allowance against deferred tax
assets is recorded if, based on available evidence, it is more likely than not
that some or all of the deferred tax assets will not be realized.



    USE OF ESTIMATES



    The preparation of financial statements in conformity with generally
accepted accounting principles requires management to make estimates and
assumptions that affect the reported amounts of assets and contingent
liabilities at the date of the financial statements and the reported amounts of
revenues and expenses during the reporting periods. Actual results could differ
from those estimates.



    ACCOUNTING FOR STOCK-BASED COMPENSATION



    Stock options issued to employees under the Company's stock option plan are
accounted for in accordance with Accounting Principles Board Opinion ("APB")
No. 25, "Accounting for Stock Issued to


                                      F-27


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



B. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)


Employees," and related interpretations. Accordingly, no compensation expense is
recorded for options issued to employees in fixed amounts and with fixed
exercise prices at least equal to the fair market value of the Company's common
stock at the date of grant. The Company applies the provisions of Statement of
Financial Accounting Standards ("SFAS") No. 123, "Accounting for Stock-Based
Compensation," through disclosure only (Note G). All stock-based awards to
nonemployees are accounted for at their fair value in accordance with SFAS
No. 123 and Emerging Issues Task Force ("EITF") Issue No. 96-18, "Accounting for
Equity Instruments that are Issued to Other than Employees for Acquiring, or in
Conjunction with Selling, Goods or Services."



    RECENT ACCOUNTING PRONOUNCEMENTS



    In June 1999, the Financial Accounting Standards Board issued Statement of
Financial Accounting Standards No. 133 "Accounting for Derivative Instruments
and Hedging Activities" ("FAS No. 133"). FAS No. 133, as amended by FAS
No. 137, is effective for fiscal quarters of all fiscal years beeginning after
June 15, 2000. FAS No. 133 establishes accounting and reporting standards for
derivative instruments including certain derivative instruments embedded in
other contracts (collectively referred to as derivatives) and for hedging
activities. The Company does not expect that the adoption of this statement will
have a material impact on the Company's financial statements.



    RECLASSIFICATION OF PRIOR YEAR BALANCES



    Certain reclassifications have been made to prior year financial statements
to conform to the current presentation.



C. PROPERTY AND EQUIPMENT



    Property and equipment consists of the following at December 31, 1999 and
2000:





                                                          1999         2000
                                                          ----         ----
                                                              
Equipment............................................  $  988,202   $1,021,613
Computer and equipment...............................     285,232      285,232
Furniture and fixtures...............................     280,067      234,830
Leasehold improvements...............................   2,073,980    2,069,731
                                                       ----------   ----------
  Total property and equipment.......................   3,627,481    3,611,406
Less: accumulated depreciation.......................    (430,099)    (868,651)
                                                       ----------   ----------
Property and equipment, net..........................  $3,197,382   $2,742,755
                                                       ==========   ==========




D. COMMITMENTS AND CONTINGENCIES



    LEASE OBLIGATIONS



    Effective October 1, 1998, the Company entered into a five year operating
lease for its office facility in Medford, Massachusetts. In addition, the
Company has entered into operating leases for office and lab equipment. Total
rent expense was $291,240, $641,107 and $708,032 for the years ended
December 31, 1998, 1999 and 2000, respectively, and $1,811,060 for the period
from inception through December 31, 2000.


                                      F-28


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



D. COMMITMENTS AND CONTINGENCIES (CONTINUED)


    At December 31, 2000, the Company has commitments under these long-term
leases requiring annual payments as follows:





                                                              OPERATING
                                                                LEASES
                                                              ----------
                                                           
2001........................................................     770,616
2002........................................................     753,826
2003........................................................     564,261
2004........................................................       2,759
Thereafter..................................................          --
                                                              ----------
Total payments..............................................  $2,091,462
                                                              ==========




    The Company leases a portion of its Medford, Massachusetts office facility
to a third party. The third party does not have a formal sublease agreement with
the Company and pays rent on a monthly basis. The Company recorded $0, $197,676
and $214,935 of sublease income for the years ended December 31, 1998, 1999 and
2000, respectively, and $412,611 for the period from inception through
December 31, 2000, as a reduction of rent expense.



E. INCOME TAXES



    The Company's deferred income taxes as of December 31, 1999 and 2000 were as
follows:





                                                         1999         2000
                                                         ----         ----
                                                             
Deferred income tax assets:
  Net operating losses..............................  $5,115,140   $11,462,655
  Tax credit carryforwards..........................     426,474       617,487
  Capitalized research and development..............   2,336,052     1,099,046
  Other.............................................     (25,276)      226,515
                                                      ----------   -----------
  Total deferred tax assets.........................   7,852,390    13,405,703
  Valuation allowance...............................  (7,852,390)  (13,405,703)
                                                      ----------   -----------
  Net deferred tax assets...........................  $       --   $        --
                                                      ==========   ===========




    At December 31, 2000, the Company has federal and state net operating loss
carryforwards of $28,710,000 and $28,370,000, respectively, available to reduce
future taxable income which expire at various dates through 2020. The Company
also has federal and state research and development credit carryforwards of
approximately $413,000 and $310,000, respectively, available to reduce future
tax liabilities which expire at various dates through 2020. Under Section 382 of
the Internal Revenue Code, changes in the Company's ownership could limit the
amount of loss and credit carryforwards which can be utilized by the Company.



    Management of the Company has evaluated the positive and negative evidence
bearing upon the realizability of its deferred tax assets, which are comprised
principally of net operating loss carryforwards and capitalized research and
development costs. Due to the uncertainty of the Company's ability to use the
net operating losses in the future, management has recorded a full valuation
allowance.


                                      F-29


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



F. CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY



    COMMON STOCK



    The Company has authorized 66,000,000 shares of common stock, $.001 par
value. Dividend and liquidation rights of common stock are subordinated to those
of all series of preferred stock.



    CONVERTIBLE PREFERRED STOCK



    The Company has authorized 57,500,000 shares of preferred stock of which
11,100,000 are designated as Series A convertible preferred stock and 12,500,000
are designated as Series B convertible preferred stock. The convertible
preferred stock is classified in the balance sheet as mezzanine financing due to
liquidation rights which are not within control of the Company.



    The holders of Series A and Series B convertible preferred stock have the
following rights:



    CONVERSION



    Each share of Series A and Series B convertible preferred stock is
convertible at the option of the holder into one share of common stock, subject
to antidilution and other adjustments. The shares will automatically convert
upon the closing of a public offering of the Company's common stock in which the
per share price is at least $5.00 and the gross proceeds to the Company are at
least $10,000,000.



    DIVIDENDS



    The holders of Series A and Series B convertible preferred shares shall be
entitled to receive, when and as declared by the Board of Directors,
noncumulative dividends in preference to any dividend on the common stock at the
rate of 8% of the original issue price of $1.3333 and $1.50, respectively, per
annum. The holders of Series A and Series B convertible preferred shares shall
also be entitled to receive any cash dividend declared on common stock equal to
the amount they would be entitled to if such preferred stock had been converted
into common stock.



    VOTING



    Series A and Series B convertible preferred stockholders are entitled to a
number of votes equal to the number of shares of common stock into which the
preferred shares are convertible.



    LIQUIDATION



    In the event of liquidation, dissolution or winding up of the Company, the
holders of Series A and Series B convertible preferred stock shall be entitled
to receive, in preference to the holders of the common stock, an amount equal to
$1.3333 per share and $1.50 per share, respectively, plus any declared but
unpaid dividends. If upon any liquidation, distribution, or winding up, the
assets of the Company shall be insufficient to make payment in full to all
holders of Series Preferred, then such assets shall be distributed among the
holders of Series Preferred at the time outstanding, ratably in proportion to
the full amounts to which they would otherwise be respectively entitled.


                                      F-30


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



F. CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY (CONTINUED)



    In connection with its formation, the Company issued 7,500,000 shares of
Series A convertible preferred stock to Coulter Corporation in exchange for
rights to certain dense particle technology. At the time of the transaction,
Coulter Corporation held approximately 75% of the outstanding voting shares of
the Company. Because Coulter Corporation had voting control of the Company, the
technology rights were recorded at Coulter Corporation's historical cost basis
of $0. In 1997, Coulter Corporation transferred 4,900,000 of its shares of
Series A preferred stock to members of the Coulter family in connection with the
sale of Coulter Corporation to Beckman and, as a result, Coulter Corporation
(now Beckman Coulter Corporation) ceased to have voting control over Eligix.



    WARRANTS



    During 1997, the Company issued warrants in connection with a loan and
security agreement, which, at December 31, 2000, allow the holders to purchase
31,250 shares of Series B convertible preferred stock. The warrants are
exercisable, in whole or in part, at any time from the date of grant,
September 4, 1997, through the later of ten years after the date of grant or
five years after the closing of the Company's initial public offering of its
common stock. The estimated fair value of warrant was insignificant.



    In connection with a loan agreement entered into during June 1999, the
Company issued a warrant to purchase 80,000 shares of common stock at a price of
$1.50 per share. The warrant is exercisable, in whole or in part, at any time
from the date of grant, June 1999, through June 2004. The estimated fair value
of the warrant was insignificant.



    See Note N for description of warrants issued in connection with the Bridge
Financing.



G. EQUITY INCENTIVE PLAN



    In June 1997, the Board of Directors (the "Board") established the 1997
Equity Incentive Plan (the "Incentive Plan"). The Incentive Plan provides for
the issuance of incentive stock options to employees and nonstatutory options to
employees, directors and consultants of the Company. The Company has reserved
8,000,000 shares of common stock for issuance under the Incentive Plan. As of
December 31, 2000, 602,217 shares of common stock were available for future
awards.



    All options granted under the Incentive Plan are subject to terms and
conditions, as determined by the Board, including exercise price, vesting and
expiration period. The Board shall establish the exercise price and vesting
period at the time each option is granted and specify this information in the
applicable option agreement. Incentive stock options are granted at an exercise
price equal to at least 100% of the fair value of the Company's common stock at
the date of grant. Nonstatutory stock options are granted at an exercise price
equal to at least 85% of the fair value of the Company's common stock on the
date of grant. Options issued to employees generally vest over five years.
Options issued to consultants vest over the period determined by the Board at
the grant date. Options expire ten years from the date of grant.


                                      F-31


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



G. EQUITY INCENTIVE PLAN (CONTINUED)


    The following is a summary of the Incentive Plan activity as of
December 31, 2000 and for the years ended December 31, 2000, 1999, 1998 and 1997
and for the period from inception (December 27, 1996) to December 31, 2000:





                                                                       WEIGHTED
                                                                       AVERAGE
                                                            NUMBER     EXERCISE
OPTIONS                                                   OF SHARES     PRICE
-------                                                   ----------   --------
                                                                 
Outstanding at December 27, 1996
  Granted...............................................   1,686,100    $0.15
  Exercised.............................................          --       --
  Canceled..............................................    (175,000)    0.15
                                                          ----------    -----
Outstanding at December 31, 1997........................   1,511,100     0.15
  Granted...............................................     976,600     0.15
  Exercised.............................................     (55,600)    0.15
  Canceled..............................................        (600)    0.15
                                                          ----------    -----
Outstanding at December 31, 1998........................   2,431,500     0.15
  Granted...............................................   2,626,000     0.15
  Exercised.............................................     (76,225)    0.15
  Canceled..............................................    (748,775)    0.15
                                                          ----------    -----
Outstanding at December 31, 1999........................   4,232,500     0.15
  Granted...............................................   4,398,800     0.06
  Exercised.............................................    (119,395)    0.15
  Canceled..............................................  (1,114,122)    0.15
                                                          ----------    -----
Outstanding at December 31, 2000........................   7,397,783    $0.10
                                                          ==========    =====




    The following table summarizes information about stock options outstanding
at December 31, 2000:





                                      OPTIONS OUTSTANDING                     OPTIONS EXERCISABLE
                        -----------------------------------------------   ----------------------------
                                                WEIGHTED       WEIGHTED                       WEIGHTED
                             NUMBER             AVERAGE        AVERAGE         NUMBER         AVERAGE
      RANGE OF           OUTSTANDING AT        REMAINING       EXERCISE    EXERCISABLE AT     EXERCISE
   EXERCISE PRICES      DECEMBER 31, 2000   CONTRACTUAL LIFE    PRICE     DECEMBER 31, 2000    PRICE
   ---------------      -----------------   ----------------   --------   -----------------   --------
                                                                               
0$.01-$0.15.........        7,397,783       8.6 years           $0.10         2,204,469        $0.13




    The estimated weighted average fair value of stock options granted to
employees in 1998, 1999 and 2000 was $0.05 per share, respectively, determined
using the minimum value method assuming an interest rate of 5.18% for 1998,
5.84% for 1999 and 5.60% for 2000, an expected life of 7 years, and no
dividends. The pro forma effect of accounting for options granted to employees
since inception using the fair value method on the 1998, 1999 and 2000 net loss
was to increase the net loss to $5,407,493 in 1998, $10,357,790 in 1999 and
$13,275,194 in 2000.



    In May 2000, the Company granted to employees approximately 2.8 million
options to purchase common stock with an exercise price of $0.01 per share. The
options were immediately exercisable in full but the underlying stock is subject
to certain repurchase rights and certain restrictions on transfer


                                      F-32


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



G. EQUITY INCENTIVE PLAN (CONTINUED)


for a period of five years. The repurchase rights and restrictions lapse upon
consummation of a change of control of the Company or upon the closing of an
equity financing of the Company in which proceeds of at least $5 million are
received by the Company.



    The Company recorded compensation expense of approximately $784,000 for the
year ended December 31, 2000 relating to options granted to employees with
exercise prices which, based upon management's consideration of subsequent
events including the proposed merger with BioTransplant, were determined to be
less than fair value of the common stock at the grant date.



    In September 2000, the Company extended the exercise period through
December 31, 2000 for approximately 213,000 fully vested common stock options
held by recently terminated employees. The Company recorded compensation expense
of approximately $140,000 related to this extension for the year ended
December 31, 2000.



    In September 2000, the Company canceled an employee common stock option
grant of 450,000 shares with an exercise price of $0.15 per share and issued the
employee a grant to purchase 450,000 shares of common stock at an exercise price
of $0.01. The options vest over a period of five years and fully vest based on a
change of control. The Company recorded compensation expense of approximately
$155,000 for the year ended December 31, 2000 related to this cancellation and
reissuance. These options will be accounted for as variable options through the
date of exercise in accordance with FASB Interpretation No. 44.



    The Company recorded compensation expense of approximately $265,000 during
the year ended December 31, 2000 for stock options granted to non-employees.



H. DEBT



    In September 1997, the Company entered into a loan and security agreement
which allows the Company to borrow up to $750,000. The minimum funding amount is
$100,000 with a maximum of five loans. Loans under the agreement bear interest
at a fixed rate equal to the yield to maturity for the U.S. Treasury note having
a term equivalent with the loan's term on the date of funding plus 300 basis
points. The loans are collateralized by certain equipment.



    In June 1999, the Company entered into a loan and security agreement which
allows the Company to borrow up to $2,700,000. The minimum funding amount is
$35,000. Each note will have a fixed term of 42 months. Loans under the
agreement bear interest at a fixed rate equal to the prime rate on the date of
commencement plus the average interest rate of a similar term U.S. Treasury note
for the week preceding the date of commencement. The loans are collateralized by
certain equipment.



    The weighted average interest rate on loans outstanding at December 31, 2000
is 11.8%.



    Long-term debt consists of the following:




                                                           
Loans payable...............................................  $2,209,221
Less: current portion.......................................     944,747
                                                              ----------
Long-term portion of loans payable..........................  $1,264,474
                                                              ==========



                                      F-33


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



H. DEBT (CONTINUED)


    Future minimum payments of long-term loans as of December 31, 2000 are as
follows:




                                                           
2001........................................................   1,186,769
2002........................................................   1,109,962
2003........................................................     322,979
Thereafter..................................................          --
                                                              ----------
Total minimum payments......................................   2,619,710
Less: interest..............................................     410,489
                                                              ----------
Loans payable...............................................  $2,209,221
                                                              ==========




I. CONVERTIBLE PROMISSORY NOTES



    On June 5, 1998, the Company issued $2,000,000 of convertible promissory
notes (the "Notes") bearing 6% interest per annum due on or prior to
December 5, 1998. Per the terms of the Notes agreement, principal and interest
were automatically convertible into shares of the Company's Series B convertible
preferred stock or other similar equity securities upon the closing of a
financing on or prior to December 5, 1998. The Company received financing from
the issuance of Series B convertible preferred stock at $1.50 per share on
September 3, 1998. Accordingly, the principal and accrued interest of $2,028,932
was converted into 1,352,621 shares of the Series B convertible preferred stock.
See Note N for description of notes issued in connection with Bridge Financing.



J. AGREEMENTS



    Effective December 31, 1998, the Company entered into a collaborative
research agreement with Johns Hopkins University ("JHU"). The research agreement
has a term of two and one-half years. The Company may terminate the research
agreement for any reason upon giving JHU sixty days notice. In connection with
the research agreement, the Company issued 125,000 options to purchase the
Company's common stock to each of two JHU scientists.



    The Company entered into a license agreement with JHU for the licensing of
certain patent rights and inventions effective December 31, 1998. The license
agreement requires the Company to pay a $5,000 nonrefundable annual maintenance
fee. JHU is also entitled to receive royalty payments based on a percentage of
the net sales of products and services developed using JHU's licensed patent
rights and innovations. The Company may terminate the license agreement for any
reason upon giving JHU sixty days notice. In May 1999, the Company issued JHU
250,000 options to purchase the Company's common stock related to the license
agreement. The options have a term of ten years and vest based on the
achievement of certain milestones.



K. EMPLOYEE BENEFIT PLAN



    The Company maintains the Eligix, Inc. 401(k) Plan (the "Plan") to provide
retirement benefits for its employees. As allowed under Section 401(k) of the
Internal Revenue Code, the Plan provides tax-deferred salary deductions for
eligible employees. Eligible employees may contribute from 1% to 15% of their
annual compensation to the Plan, limited to a maximum amount as set by the
Internal Revenue Service. To date, the Company has not made any contributions to
the Plan.


                                      F-34


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



K. EMPLOYEE BENEFIT PLAN (CONTINUED)


    On May 25, 2000, the board of directors adopted a management equity
incentive plan. The board subsequently amended and restated the plan on
December 8, 2000. Pursuant to the amended plan, the Company's management team
will receive an aggregate of 15% of the total consideration received in the
event of a merger or similar business transaction involving the Company.



L. RELATED PARTIES



    Prior to 1999, the Company leased office space from two stockholders,
Beckman Coulter, formerly Coulter Corporation ("Coulter") and Massachusetts
Biotechnology Research Institute ("MBRI"). Rent expense of $65,426 was incurred
during the year ended December 31, 1998 for the use of the Coulter facility.
Rent expense of $139,650 was incurred during the year ended December 31, 1998
for the use of the MBRI facility. No rent expense was incurred during years
ended December 31, 1999 and 2000.



    The Company also reimburses Coulter and MBRI for supplies and lab equipment
expenditures made on behalf of the Company. Total reimbursed costs to Coulter
were approximately $157,000, $78,500 and $32,981 for the years ended
December 31, 1998, 1999 and 2000, respectively, and $623,081 from inception
through December 31, 2000. Total reimbursed costs to MBRI were $315,664, $9,174
and $0 for the years ended December 31, 1998, 1999 and 2000, respectively, and
$445,570 from inception through December 31, 2000.



    The Company leases lab equipment under operating leases with Coulter Leasing
Corporation. Total payments were $18,012, $38,335 and $40,260 for the years
ended December 31, 1998, 1999 and 2000, respectively, and $96,607 from inception
through December 31, 2000.



M. SUPPLEMENTAL CASH FLOW INFORMATION



    In 1997, the Company issued 75,000 shares of Series A convertible preferred
stock to the Massachusetts Biotechnology Research Institute in exchange for use
of their biotechnology research facility. As a result of this transaction, the
Company recorded additional paid-in capital of $99,675 and a corresponding
amount to rent expense.



N. BRIDGE FINANCING



    On April 6, 2000, the Company entered into a bridge financing agreement
("Agreement") with certain existing investors pursuant to which the Company may
issue and sell to the investors 8% subordinated convertible notes ("Notes")
having an aggregate principal amount of up to $15,000,000 and warrants to
purchase up to an aggregate of 4,250,000 shares of common stock of the Company.
In the event that the Company closes a private placement of equity securities
(the "Private Financing Securities") resulting in at least $15 million in gross
proceeds to the Company prior to December 31, 2000, then the Notes shall
automatically be converted without any action on part of the holder thereof into
that number of shares of the Private Financing Securities determined by dividing
the outstanding principal amount by the per share purchase price in effect in
the Private Financing. At the election of the holders, the Notes are convertible
into Series C-1 convertible preferred stock at a price per share equal to $1.50.



    On April 6, 2000, the Company sold approximately $4.8 million of the Notes
and issued warrants to purchase approximately 480,000 shares of common stock at
an exercise price per share of $0.15. Approximately $331,000 of the proceeds
from the Notes has been allocated to the warrants based on


                                      F-35


                                  ELIGIX, INC.
                        (A DEVELOPMENT STAGE ENTERPRISE)



                   NOTES TO FINANCIAL STATEMENTS (CONTINUED)



N. BRIDGE FINANCING (CONTINUED)


the warrants' relative fair value. The resulting debt discount is being accreted
to interest expense over one year, the expected life of the debt.



    On September 7, 2000, the Company sold approximately $2.7 million of the
Notes and issued warrants to purchase approximately 838,000 shares of common
stock at an exercise price per share of $0.15. Approximately $577,000 of the
proceeds from the Notes has been allocated to the warrants based on the
warrants' relative fair value. The resulting debt discount is being accreted to
interest expense over one year, the expected life of the debt.



    On September 7, 2000, the Company filed revised articles of incorporation to
authorize 10,000,000 shares of Series C-1 convertible preferred stock,
11,100,000 shares of Series C-2 convertible preferred stock and 12,500,000
shares of Series C-3 convertible preferred stock. Each share of Series A and B
convertible preferred stock held by certain investors of the Company who have
elected to participate in the Company's convertible note financings is, at the
election of such holder, convertible into one share of Series C-2 convertible
preferred stock, in the case of Series A, and C-3 convertible preferred stock,
in the case of Series B. The liquidation preferences for Series C-1, C-2 and C-3
are $4.50, $1.3333 and $1.50, respectively. Each share of Series C-1, C-2 and
C-3 convertible preferred stock is convertible at the option of the holder into
one share of common stock, subject to antidilution and other adjustments.



O. PROPOSED MERGER



    On December 8, 2000, the Company entered into a definitive agreement to be
acquired by BioTransplant. Under the terms of the proposed transaction,
BioTransplant will issue up to 6,600,000 shares of common stock for all of the
Company's fully diluted shares. Of the 6,600,000 shares, 990,000 shares will be
issued to management of the Company as a result of the management equity
incentive plan adopted by the board of directors on May 25, 2000, as amended and
restated on December 8, 2000. Based on the Company's average trading price for
the period from two days before to two days after the date the merger was
announced, December 11, 2000, of $8.3564, the transaction is valued at
approximately $55,000,000. The transaction is intended to be accounted for as a
purchase and is subject to approval by stockholders of Eligix and BioTransplant
and other customary conditions. The transaction is expected to close in the
second quarter of fiscal year 2001.



    The Company expects to borrow up to $2,000,000 from BioTransplant in the
form of a promissory note to fund operations through the anticipated closing
date of the merger. As of February 28, 2001, Eligix had borrowed $1.0 million of
the $2.0 million from BioTransplant.



    If the Company or Eligix terminates the merger agreement in accordance with
its terms, all obligations of the parties under the merger agreement terminate
and there will be no liability, except that if the merger agreement is
terminated by either party as a result of the other party's failure to perform
or comply in all material respects with the agreements and covenants under the
merger agreement, the nonterminating party will pay the terminating party
$2,000,000.


                                      F-36

                                                                         ANNEX A

                                                                  EXECUTION COPY

                          AGREEMENT AND PLAN OF MERGER

                                  BY AND AMONG

                           BIOTRANSPLANT INCORPORATED

                             BT/EL ACQUISITION CO.

                                      AND

                                  ELIGIX, INC.

                                DECEMBER 8, 2000

                               TABLE OF CONTENTS



                                                                                        PAGE
                                                                                      --------
                                                                                
ARTICLE I THE MERGER................................................................     A-1
  1.1                   The Merger..................................................     A-1
  1.2                   The Closing.................................................     A-1
  1.3                   Actions at the Closing......................................     A-1
  1.4                   Additional Action...........................................     A-2
  1.5                   Conversion of Shares........................................     A-2
  1.6                   Dissenting Shares...........................................     A-5
  1.7                   Exchange of Shares..........................................     A-5
  1.8                   Fractional Shares...........................................     A-6
  1.9                   Options, Warrants and Notes.................................     A-6
  1.10                  Escrow......................................................     A-9
  1.11                  Certificate of Incorporation and By-laws....................     A-9
  1.12                  No Further Rights...........................................    A-10
  1.13                  Closing of Transfer Books...................................    A-10
  1.14                  Satisfaction of Company's Management Incentive Liability....    A-10
  1.15                  Priority on Issuance of Buyer Common Stock..................    A-10
ARTICLE II REPRESENTATIONS AND WARRANTIES OF THE COMPANY............................    A-11
  2.1                   Organization, Qualification and Corporate Power.............    A-11
  2.2                   Capitalization..............................................    A-12
  2.3                   Authorization of Transaction................................    A-13
  2.4                   Noncontravention............................................    A-13
  2.5                   Subsidiaries................................................    A-14
  2.6                   Financial Statements........................................    A-14
  2.7                   Absence of Certain Changes..................................    A-14
  2.8                   Undisclosed Liabilities.....................................    A-14
  2.9                   Tax Matters.................................................    A-15
  2.10                  Assets......................................................    A-16
  2.11                  Owned Real Property.........................................    A-16
  2.12                  Real Property Leases........................................    A-16
  2.13                  Preclinical Testing and Clinical Trials.....................    A-17
  2.14                  Intellectual Property.......................................    A-17
  2.15                  Contracts...................................................    A-19
  2.16                  Powers of Attorney..........................................    A-20
  2.17                  Insurance...................................................    A-20
  2.18                  Litigation..................................................    A-20
  2.19                  Employees...................................................    A-20
  2.20                  Employee Benefits...........................................    A-21
  2.21                  Environmental Matters.......................................    A-23
  2.22                  Legal Compliance............................................    A-24
  2.23                  Permits.....................................................    A-25
  2.24                  Certain Business Relationships With Affiliates..............    A-25
  2.25                  Brokers' Fees...............................................    A-25
  2.26                  Books and Records...........................................    A-25
  2.27                  Disclosure..................................................    A-25
  2.28                  Information Supplied........................................    A-25


                                       i




                                                                                        PAGE
                                                                                      --------
                                                                                
ARTICLE III REPRESENTATIONS AND WARRANTIES OF THE BUYER AND THE TRANSITORY
  SUBSIDIARY........................................................................    A-26
  3.1                   Organization, Qualification and Corporate Power.............    A-26
  3.2                   Capitalization..............................................    A-26
  3.3                   Authorization of Transaction................................    A-27
  3.4                   Noncontravention............................................    A-27
  3.5                   Reports and Financial Statements............................    A-28
  3.6                   Absence of Certain Changes..................................    A-28
  3.7                   Tax Matters.................................................    A-29
  3.8                   Preclinical Testing and Clinical Trials.....................    A-29
  3.9                   Intellectual Property.......................................    A-29
  3.10                  Contracts...................................................    A-30
  3.11                  Litigation..................................................    A-31
  3.12                  Employees...................................................    A-31
  3.13                  Employee Benefits...........................................    A-31
  3.14                  Interim Operations of the Transitory Subsidiary.............    A-33
  3.15                  Environmental Matters.......................................    A-33
  3.16                  Legal Compliance............................................    A-34
  3.17                  Brokers' Fees...............................................    A-34
  3.18                  Books and Records...........................................    A-34
  3.19                  Disclosure..................................................    A-34
  3.20                  Information Supplied........................................    A-35
ARTICLE IV COVENANTS................................................................    A-35
  4.1                   Closing Efforts.............................................    A-35
  4.2                   Governmental and Third-Party Notices and Consents...........    A-35
                        Special Meeting, Prospectus/Proxy Statement and Registration
  4.3                     Statement.................................................    A-35
  4.4                   Company Operation of Business...............................    A-37
  4.5                   Buyer Operation of Business.................................    A-38
  4.6                   Access to Company Information...............................    A-39
  4.7                   Access to Buyer Information.................................    A-40
  4.8                   Exclusivity.................................................    A-40
  4.9                   Expenses....................................................    A-41
  4.10                  Indemnification.............................................    A-41
  4.11                  Lock-Up and Affiliate Agreements............................    A-41
  4.12                  Listing of Merger Shares....................................    A-42
  4.13                  Executive Officers and Board of Directors of the Buyer......    A-42
  4.14                  Delivery of Tax Notices.....................................    A-42
ARTICLE V CONDITIONS TO CONSUMMATION OF MERGER......................................    A-43
  5.1                   Conditions to Each Party's Obligations......................    A-43
                        Conditions to Obligations of the Buyer and the Transitory
  5.2                     Subsidiary................................................    A-43
  5.3                   Conditions to Obligations of the Company....................    A-45
ARTICLE VI INDEMNIFICATION..........................................................    A-47
  6.1                   Indemnification by the Company Stockholders.................    A-47
  6.2                   Indemnification Claims......................................    A-48
  6.3                   Survival of Representations and Warranties..................    A-51
  6.4                   Limitations.................................................    A-51
ARTICLE VII TERMINATION.............................................................    A-53
  7.1                   Termination of Agreement....................................    A-53
  7.2                   Effect of Termination.......................................    A-53
ARTICLE VIII DEFINITIONS............................................................    A-54


                                       ii




                                                                                        PAGE
                                                                                      --------
                                                                                
ARTICLE IX MISCELLANEOUS............................................................    A-56
  9.1                   Press Releases and Announcements............................    A-56
  9.2                   No Third Party Beneficiaries................................    A-57
  9.3                   Entire Agreement............................................    A-57
  9.4                   Succession and Assignment...................................    A-57
  9.5                   Counterparts and Facsimile Signature........................    A-57
  9.6                   Headings....................................................    A-57
  9.7                   Notices.....................................................    A-57
  9.8                   Governing Law...............................................    A-58
  9.9                   Amendments and Waivers......................................    A-58
  9.10                  Severability................................................    A-58
  9.11                  Submission to Jurisdiction..................................    A-59
  9.12                  Construction................................................    A-59


EXHIBITS AND SCHEDULES


                   
Company Disclosure Schedule
Buyer Disclosure Schedule
Exhibit A-- Escrow Agreement
          Attachment A to Escrow Agreement
Exhibit B--Form of Lock-up Agreement
Exhibit C--Form of Affiliate Agreement
Exhibit D--Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
Exhibit E--Form of Voting and Transfer Restriction Agreement
Exhibit F-- Form of Certificate of Amendment to Amended and Restated Certificate
           of Incorporation
Exhibit G--Form of Employment Offer Letter
Exhibit H--Form of Non-Competition and Non-Solicitation Agreement
Exhibit I--Opinion of Hale and Dorr LLP


                                      iii

                          AGREEMENT AND PLAN OF MERGER

    Agreement entered into as of December 8, 2000 by and among BioTransplant
Incorporated, a Delaware corporation (the "Buyer"), BT/EL Acquisition Co., a
Delaware corporation and a wholly-owned subsidiary of the Buyer (the "Transitory
Subsidiary"), and Eligix, Inc., a Delaware corporation (the "Company"). The
Buyer, the Transitory Subsidiary and the Company are referred to collectively
herein as the "Parties."

    This Agreement contemplates a merger of the Transitory Subsidiary into the
Company. In such merger, the stockholders of the Company will receive common
stock of the Buyer in exchange for their capital stock of the Company.

    The Parties intend that the merger shall constitute a "reorganization"
within the meaning of Section 368(a) of the Code (as defined herein) and that
this Agreement shall be a "plan of reorganization."

    Now, therefore, in consideration of the representations, warranties and
covenants herein contained, the Parties agree as follows.

                                   ARTICLE I
                                   THE MERGER

    1.1  THE MERGER.  Upon and subject to the terms and conditions of this
Agreement, the Transitory Subsidiary shall merge with and into the Company (with
such merger referred to herein as the "Merger") at the Effective Time (as
defined below). From and after the Effective Time, the separate corporate
existence of the Transitory Subsidiary shall cease and the Company shall
continue as the surviving corporation in the Merger (the "Surviving
Corporation"). The "Effective Time" shall be the time at which the Surviving
Corporation files a certificate of merger or other appropriate documents
prepared and executed in accordance with Section 251(c) of the Delaware General
Corporation Law (the "Certificate of Merger") with the Secretary of State of the
State of Delaware. The Merger shall have the effects set forth in Section 259 of
the Delaware General Corporation Law.

    1.2  THE CLOSING.  The closing of the transactions contemplated by this
Agreement (the "Closing") shall take place at the offices of Hale and Dorr LLP
in Boston, Massachusetts, commencing at 9:00 a.m. local time as soon as
practicable (and in any event not later than three business days) after the
satisfaction or waiver of all conditions (excluding the delivery of any
documents to be delivered at the Closing by any of the Parties) set forth in
Article V hereof (the "Closing Date").

    1.3  ACTIONS AT THE CLOSING.  At the Closing:

        (a) the Company shall deliver to the Buyer and the Transitory Subsidiary
    the various certificates, instruments and documents referred to in
    Section 5.2;

        (b) the Buyer and the Transitory Subsidiary shall deliver to the Company
    the various certificates, instruments and documents referred to in
    Section 5.3;

                                      A-1

        (c) the Surviving Corporation shall file with the Secretary of State of
    the State of Delaware the Certificate of Merger;

        (d) each of the stockholders of record of the Company immediately prior
    to the Effective Time (the "Company Stockholders") shall deliver to the
    Buyer the certificate(s) representing his, her or its Company Shares (as
    defined below);

        (e) the Buyer shall deliver certificates for the Initial Shares (as
    defined below) to each Company Stockholder in accordance with Section 1.5;
    and

        (f) the Buyer, Robert Momsen and Pieter Schiller (the "Escrow
    Representatives"), the Management Members (as defined below) and The
    American Stock Transfer and Trust Company (the "Escrow Agent") shall execute
    and deliver the Escrow Agreement attached hereto as Exhibit A (the "Escrow
    Agreement"), and the Buyer shall deliver to the Escrow Agent a certificate
    for the Escrow Shares (as defined in Section 1.14) being placed in escrow on
    the Closing Date pursuant to Section 1.10.

    1.4  ADDITIONAL ACTION.  The Surviving Corporation may, at any time after
the Effective Time, take any action, including executing and delivering any
document, in the name and on behalf of either the Company or the Transitory
Subsidiary, in order to consummate the transactions contemplated by this
Agreement.

    1.5  CONVERSION OF SHARES.  In consideration of the transactions
contemplated hereby, the Buyer has agreed to issue an aggregate of 6,600,000
shares (the "Total Consideration") of its common stock, $0.01 par value per
share ("Buyer Common Stock") (i) in exchange for all of the Company Shares (as
defined below) outstanding immediately prior to the Effective Time, (ii) in
satisfaction of the Company's management incentive liability set forth in
Section 1.14 below, and (iii) upon exercise or conversion, as the case may be,
of all of the Company Options, Company Warrants and Company Notes (each as
defined below), whether vested or unvested, outstanding immediately prior to the
Effective Time. At the Effective Time, by virtue of the Merger and without any
action on the part of any Party or the holder of any of the following
securities:

        (a) Each share of common stock, $0.001 par value per share, of the
    Company ("Common Shares") issued and outstanding immediately prior to the
    Effective Time (other than Common Shares owned beneficially by the Buyer or
    the Transitory Subsidiary, Dissenting Shares (as defined below) and Common
    Shares held in the Company's treasury) shall be converted into and represent
    the right to receive (subject to the provisions of Section 1.10) such number
    of shares of Buyer Common Stock as is equal to the Common Conversion Ratio.

    The "Common Conversion Ratio" shall initially be equal to a fraction
expressed as a decimal carried out to four places, the numerator of which is
(i) the Total Consideration minus (ii) the sum of (A) the aggregate number of
shares of Buyer Common Stock, if any, issued pursuant to subsections 1.5(b),
(c), (d), (e) and (f) below; (B) the aggregate number of shares of Buyer Common
Stock, if any, reserved for issuance upon exercise or conversion of the Company
Series A Warrants (as defined below) and Company Series B Warrants (as defined
below) and the Company Notes; and (C) the Management Incentive Shares (as
defined below), and the denominator of which is the total number of issued and
outstanding Common Shares at the

                                      A-2

Effective Time, including, but not limited to for this purpose all Common Shares
which are issued or issuable upon exercise of outstanding Company Options and
Company Common Warrants (as defined below), whether vested, unvested or subject
to repurchase by the Company following such exercise. The Common Conversion
Ratio shall be subject to equitable adjustment in the event of any stock split,
stock dividend, reverse stock split or similar event affecting the Buyer Common
Stock between the date of this Agreement and the Effective Time.

        (b) Each share (if any) of Series A Preferred Stock, $0.001 par value
    per share, of the Company ("Series A Preferred Shares") issued and
    outstanding immediately prior to the Effective Time (other than Series A
    Preferred Shares owned beneficially by the Buyer or the Transitory
    Subsidiary, Dissenting Shares and Series A Preferred Shares held in the
    Company's treasury) shall be converted into and represent the right to
    receive (subject to the provisions of Section 1.10) such number of shares of
    Buyer Common Stock as is equal to the Series A Preferred Conversion Ratio.
    The "Series A Preferred Conversion Ratio" shall initially be equal to a
    fraction expressed as a decimal carried out to four places, the numerator of
    which is $1.3333 and the denominator of which is $11.5714. The Series A
    Conversion Ratio shall be subject to equitable adjustment in the event of
    any stock split, stock dividend, reverse stock split or similar event
    affecting the Buyer Common Stock between the date of this Agreement and the
    Effective Time.

        (c) Each share (if any) of Series B Preferred Stock, $0.001 par value
    per share, of the Company ("Series B Preferred Shares") issued and
    outstanding immediately prior to the Effective Time (other than Series B
    Preferred Shares owned beneficially by the Buyer or the Transitory
    Subsidiary, Dissenting Shares and Series B Preferred Shares held in the
    Company's treasury) shall be converted into and represent the right to
    receive (subject to the provisions of Section 1.10) such number of shares of
    Buyer Common Stock as is equal to the Series B Preferred Conversion Ratio.
    The "Series B Preferred Conversion Ratio" shall initially be equal to a
    fraction expressed as a decimal carried out to four places, the numerator of
    which is $1.50 and the denominator of which is $11.5714. The Series B
    Conversion Ratio shall be subject to equitable adjustment in the event of
    any stock split, stock dividend, reverse stock split or similar event
    affecting the Buyer Common Stock between the date of this Agreement and the
    Effective Time.

        (d) Each share (if any) of Series C-1 Preferred Stock, $0.001 par value
    per share, of the Company ("Series C-1 Preferred Shares") issued and
    outstanding immediately prior to the Effective Time (other than Series C-1
    Preferred Shares owned beneficially by the Buyer or the Transitory
    Subsidiary, Dissenting Shares and Series C-1 Preferred Shares held in the
    Company's treasury) shall be converted into and represent the right to
    receive (subject to the provisions of Section 1.10) such number of shares of
    Buyer Common Stock as is equal to the Series C-1 Preferred Conversion Ratio.
    The "Series C-1 Preferred Conversion Ratio" shall initially be equal to a
    fraction expressed as a decimal carried out to four places, the numerator of
    which is $4.50 and the denominator of which is $11.5714. The Series C-1
    Conversion Ratio shall be subject to equitable adjustment in the event of
    any stock split, stock dividend, reverse stock split or similar event
    affecting the Buyer Common Stock between the date of this Agreement and the
    Effective Time.

                                      A-3

        (e) Each share (if any) of Series C-2 Preferred Stock, $0.001 par value
    per share, of the Company ("Series C-2 Preferred Shares") issued and
    outstanding immediately prior to the Effective Time (other than Series C-2
    Preferred Shares owned beneficially by the Buyer or the Transitory
    Subsidiary, Dissenting Shares and Series C-2 Preferred Shares held in the
    Company's treasury) shall be converted into and represent the right to
    receive (subject to the provisions of Section 1.10) such number of shares of
    Buyer Common Stock as is equal to the Series C-2 Preferred Conversion Ratio.
    The "Series C-2 Preferred Conversion Ratio" shall initially be equal to a
    fraction expressed as a decimal carried out to four places, the numerator of
    which is $1.3333 and the denominator of which is $11.5714. The Series C-2
    Conversion Ratio shall be subject to equitable adjustment in the event of
    any stock split, stock dividend, reverse stock split or similar event
    affecting the Buyer Common Stock between the date of this Agreement and the
    Effective Time.

        (f) Each share (if any) of Series C-3 Preferred Stock, $0.001 par value
    per share, of the Company ("Series C-3 Preferred Shares" and, together with
    the Series A Preferred Shares, Series B Preferred Shares, Series C-1
    Preferred Shares and Series C-2 Preferred Shares, the "Preferred Shares")
    issued and outstanding immediately prior to the Effective Time (other than
    Series C-3 Preferred Shares owned beneficially by the Buyer or the
    Transitory Subsidiary, Dissenting Shares and Series C-3 Preferred Shares
    held in the Company's treasury) shall be converted into and represent the
    right to receive (subject to the provisions of Section 1.10) such number of
    shares of Buyer Common Stock as is equal to the Series C-3 Preferred
    Conversion Ratio. The "Series C-3 Preferred Conversion Ratio" shall
    initially be equal to a fraction expressed as a decimal carried out to four
    places, the numerator of which is $1.50 and the denominator of which is
    $11.5714. The Series C-3 Conversion Ratio shall be subject to equitable
    adjustment in the event of any stock split, stock dividend, reverse stock
    split or similar event affecting the Buyer Common Stock between the date of
    this Agreement and the Effective Time.

        (g) At the Effective Time, Company Stockholders shall be entitled to
    receive eighty percent (80%) of the shares of Buyer Common Stock into which
    their Common Shares and/or Preferred Shares (collectively, the "Company
    Shares") were converted pursuant to this Section 1.5 (the "Initial Shares");
    the remaining twenty percent (20%) of the shares of Buyer Common Stock into
    which their Company Shares were converted pursuant to this Section 1.5,
    rounded to the nearest whole number (the "Company Stockholder Escrow
    Shares"), shall be deposited in escrow pursuant to Section 1.10 and shall be
    held and disposed of in accordance with the terms of the Escrow Agreement.
    The Initial Shares and the Company Stockholder Escrow Shares shall together
    be referred to herein as the "Merger Shares."

        (h) Each Company Share held in the Company's treasury immediately prior
    to the Effective Time and each Company Share owned beneficially by the Buyer
    or the Transitory Subsidiary shall be cancelled and retired without payment
    of any consideration therefor.

        (i) Each share of common stock, $.01 par value per share, of the
    Transitory Subsidiary issued and outstanding immediately prior to the
    Effective Time shall be converted into and thereafter evidence one share of
    common stock, $.01 par value per share, of the Surviving Corporation.

                                      A-4

    1.6  DISSENTING SHARES.

        (a) For purposes of this Agreement, "Dissenting Shares" means Company
    Shares held as of the Effective Time by a Company Stockholder who has not
    voted such Company Shares in favor of the adoption of this Agreement and the
    Merger and with respect to which appraisal shall have been duly demanded and
    perfected in accordance with Section 262 of the Delaware General Corporation
    Law and not effectively withdrawn or forfeited prior to the Effective Time.
    Dissenting Shares shall not be converted into or represent the right to
    receive Merger Shares, unless such Company Stockholder shall have forfeited
    his, her or its right to appraisal under the Delaware General Corporation
    Law or properly withdrawn, his, her or its demand for appraisal. If such
    Company Stockholder has so forfeited or withdrawn his, her or its right to
    appraisal of Dissenting Shares, then (i) as of the occurrence of such event,
    such holder's Dissenting Shares shall cease to be Dissenting Shares and
    shall be converted into and represent the right to receive the Merger Shares
    issuable in respect of such Company Shares pursuant to Section 1.5, and
    (ii) promptly following the occurrence of such event, the Buyer shall
    deliver to such Company Stockholder a certificate representing eighty
    percent (80%) of the Merger Shares to which such holder is entitled pursuant
    to Section 1.5 (which shares shall be considered Initial Shares for all
    purposes of this Agreement) and shall deliver to the Escrow Agent a
    certificate representing the remaining twenty percent (20%) of the Merger
    Shares to which such holder is entitled pursuant to Section 1.5 (which
    shares shall be considered Company Stockholder Escrow Shares for all
    purposes of this Agreement).

        (b) The Company shall give the Buyer (i) prompt notice of any written
    demands for appraisal of any Company Shares, withdrawals of such demands,
    and any other instruments that relate to such demands received by the
    Company and (ii) the opportunity to direct all negotiations and proceedings
    with respect to demands for appraisal under the Delaware General Corporation
    Law. The Company shall not, except with the prior written consent of the
    Buyer, make any payment with respect to any demands for appraisal of Company
    Shares or offer to settle or settle any such demands.

    1.7  EXCHANGE OF SHARES.

        (a) From and after the Effective Time, each holder of an outstanding
    certificate or certificates which represented, immediately prior to the
    Effective Time, Company Shares converted into Merger Shares pursuant to
    Section 1.5 ("Certificates") shall have the right to surrender each
    Certificate to the Buyer, and receive in exchange therefor a certificate
    representing the whole number of Initial Shares issuable pursuant to
    Section 1.5. Until surrendered, each outstanding Certificate which prior to
    the Effective Time represented Company Shares shall be deemed for all
    purposes to evidence the right to receive the whole number of Initial Shares
    into which the Company Shares have been converted. From and after the
    Effective Time, the holders of Company Shares shall cease to have any rights
    in respect to such Company Shares and their rights shall be solely in
    respect to the Buyer Common Stock into which such Company Shares have been
    converted. From and after the Effective Time, there shall be no further
    registration of transfers on the records of the Company of Company Shares
    outstanding immediately prior to the Effective Time.

                                      A-5

        (b) Unless otherwise agreed to in writing, Initial Shares will not be
    issued in the name of a person other than the person in whose name the
    Certificate(s) surrendered in exchange therefor is registered.

        (c) In the event any Certificate shall have been lost, stolen or
    destroyed, upon the making of an affidavit of that fact by the person
    claiming such Certificate to be lost, stolen or destroyed, the Buyer shall
    issue in exchange for such lost, stolen or destroyed Certificate the Initial
    Shares issuable in exchange therefor pursuant to Section 1.5. The Board of
    Directors of the Buyer may, in its discretion and as a condition precedent
    to the issuance thereof, require the owner of such lost, stolen or destroyed
    Certificate to submit to the Buyer an affidavit and to give to the Buyer an
    indemnity against any claim that may be made against the Buyer with respect
    to the Certificate alleged to have been lost, stolen or destroyed.

    1.8  FRACTIONAL SHARES.  No certificates or scrip representing fractional
Initial Shares shall be issued to former Company Stockholders upon the surrender
for exchange of Certificates, and such former Company Stockholders shall not be
entitled to any voting rights, rights to receive any dividends or distributions
or other rights as a stockholder of the Buyer with respect to any fractional
Initial Shares that would have otherwise been issued to such former Company
Stockholders. In lieu of any fractional Initial Shares that would have otherwise
been issued, each former Company Stockholder that would have been entitled to
receive a fractional Initial Share shall, upon proper surrender of such person's
Certificates, receive a cash payment equal to $11.5714 (which equals the average
of the closing prices for a share of Buyer Common Stock as quoted on the Nasdaq
National Market ("Nasdaq"), as reported by Nasdaq, for the thirty (30) trading
days immediately preceding the date which is three (3) calendar days prior to
the date of this Agreement (subject to the equitable adjustment in the event of
any stock split, stock dividend, reverse stock split or similar event affecting
the Buyer Common Stock since the beginning of such thirty-day period))
multiplied by the fraction of a share that such Company Stockholder would
otherwise be entitled to receive.

    1.9  OPTIONS, WARRANTS AND NOTES.

        (a) As of the Effective Time, all options to purchase Common Shares
    issued by the Company pursuant to its stock option plans or otherwise
    ("Company Options"), whether vested or unvested, shall be assumed by the
    Buyer. Immediately after the Effective Time, each Company Option outstanding
    immediately prior to the Effective Time shall be deemed to constitute an
    option to acquire, on the same terms and conditions as were applicable under
    such Company Option at the Effective Time, such number of shares of Buyer
    Common Stock as is equal to the number of Common Shares subject to the
    unexercised portion of such Company Option multiplied by the Common
    Conversion Ratio (with any fraction resulting from such multiplication to be
    rounded down to the nearest whole number). The exercise price per share of
    each such assumed Company Option shall be equal to the exercise price of
    such Company Option immediately prior to the Effective Time, divided by the
    Common Conversion Ratio (rounded up to the nearest whole cent). The term,
    exercisability, vesting schedule, status as an "incentive stock option"
    under Section 422 of the Internal Revenue Code of 1986 (as amended, the
    "Code"), if applicable, and all of the other terms of the Company Options
    shall otherwise remain unchanged. It is intended that any assumption of an
    option which is an "incentive stock option" as defined in Section 422 of the
    Code will comply with Section 424 of the Code.

                                      A-6

        (b) As soon as practicable after the Effective Time, the Buyer or the
    Surviving Corporation shall deliver to the holders of Company Options
    appropriate notices setting forth such holders' rights pursuant to such
    Company Options, as amended by this Section 1.9, and the agreements
    evidencing such Company Options shall continue in effect on the same terms
    and conditions (subject to the amendments provided for in this Section 1.9
    and such notice).

        (c) The Buyer shall take all corporate action necessary to reserve for
    issuance a sufficient number of shares of Buyer Common Stock for delivery
    upon exercise of the Company Options assumed in accordance with this
    Section 1.9. Within seventy-five (75) days after the Effective Time, the
    Buyer shall file a Registration Statement on Form S-8 (or any successor
    form) under the Securities Act of 1933, as amended (the "Securities Act"),
    with respect to all shares of Buyer Common Stock subject to such Company
    Options that are eligible for registration on a Form S-8, and shall use its
    best efforts to maintain the effectiveness of such Registration Statement
    for so long as such Company Options remain outstanding.

        (d) The Company shall use its Reasonable Best Efforts (as defined below)
    to cause the exercise prior to the Effective Time of any outstanding
    warrants to purchase Company Shares (the "Company Warrants").
    Notwithstanding the foregoing, each Company Warrant which remains
    outstanding as of the Effective Time shall be assumed by the Buyer in
    accordance with the following terms:

           (i) as of the Effective Time, all Company Warrants which are
       exercisable for Common Shares ("Company Common Warrants"), whether
       exercisable or unexercisable, shall be assumed by the Buyer. Immediately
       after the Effective Time, each Company Common Warrant outstanding
       immediately prior to the Effective Time shall be deemed to constitute a
       warrant to acquire, on the same conditions as were applicable under such
       Company Common Warrant at the Effective Time (as modified by this
       Agreement), such number of shares of Buyer Common Stock as is equal to
       the number of Common Shares subject to the unexercised portion of such
       Company Common Warrant multiplied by the Common Conversion Ratio (with
       any fraction resulting from such multiplication to be rounded down to the
       nearest whole number). The exercise price per share of each such assumed
       Company Common Warrant shall be equal to the exercise price of such
       Company Common Warrant immediately prior to the Effective Time, divided
       by the Common Conversion Ratio (rounded up to the nearest whole cent).
       The term, exercisability and other terms of the Company Common Warrants
       shall otherwise remain unchanged;

           (ii) as of the Effective Time, all Company Warrants which are
       exercisable for Series A Preferred Shares ("Company Series A Warrants"),
       whether exercisable or unexercisable, shall be assumed by the Buyer.
       Immediately after the Effective Time, each Company Series A Warrant
       outstanding immediately prior to the Effective Time shall be deemed to
       constitute a warrant to acquire, on the same conditions as were
       applicable under such Company Series A Warrant at the Effective Time (as
       modified by this Agreement), such number of shares of Buyer Common Stock
       as is equal to the number of Series A Preferred Shares subject to the
       unexercised portion of such Company Series A Warrant multiplied by the
       Series A Preferred Conversion Ratio (with any fraction resulting from
       such multiplication to be rounded down to the nearest whole number). The
       exercise price per share of each such assumed Company Series A Warrant
       shall be equal to the exercise price of such Company Series A

                                      A-7

       Warrant immediately prior to the Effective Time, divided by the Series A
       Preferred Conversion Ratio (rounded up to the nearest whole cent). The
       term, exercisability and other terms of the Company Series A Warrants
       shall otherwise remain unchanged; and

           (iii) as of the Effective Time, all Company Warrants which are
       exercisable for Series B Preferred Shares ("Company Series B Warrants"),
       whether exercisable or unexercisable, shall be assumed by the Buyer.
       Immediately after the Effective Time, each Company Series B Warrant
       outstanding immediately prior to the Effective Time shall be deemed to
       constitute a warrant to acquire, on the same conditions as were
       applicable under such Company Series B Warrant at the Effective Time (as
       modified by this Agreement), such number of shares of Buyer Common Stock
       as is equal to the number of Series B Preferred Shares subject to the
       unexercised portion of such Company Series B Warrant multiplied by the
       Series B Preferred Conversion Ratio (with any fraction resulting from
       such multiplication to be rounded down to the nearest whole number). The
       exercise price per share of each such assumed Company Series B Warrant
       shall be equal to the exercise price of such Company Series B Warrant
       immediately prior to the Effective Time, divided by the Series B
       Preferred Conversion Ratio (rounded up to the nearest whole cent). The
       term, exercisability and other terms of the Company Series B Warrants
       shall otherwise remain unchanged.

        (e) The Company shall obtain, prior to the Closing, the consent from
    each holder of a Company Option, to the amendment of such Company Option
    pursuant to this Section 1.9 (unless such consent is not required under the
    terms of the applicable agreement, instrument or plan). The Company shall
    use its Reasonable Best Efforts to obtain, prior to the Closing, the consent
    from each holder of a Company Warrant or Company Note to the termination of
    any registration rights granted to the holders of Company Warrants or
    Company Notes.

        (f) The Company shall use its Reasonable Best Efforts to cause the
    conversion, prior to the Effective Time, of any outstanding convertible debt
    securities which are convertible into shares of capital stock of the Company
    (the "Company Notes"). Notwithstanding the foregoing, each Company Note
    which remains outstanding as of the Effective Time shall be assumed by the
    Buyer in accordance with the following terms:

           (i) At the Effective Time, each Company Note which is convertible
       into Series A Preferred Shares (a "Company Series A Note") outstanding
       immediately prior to the Effective Time shall be deemed to constitute a
       note which is convertible, on the same terms and conditions as were
       applicable under such Company Series A Note (as modified by this
       Agreement), into such number of shares of Buyer Common Stock as is equal
       to the number of Series A Preferred Shares into which such Company
       Series A Note is convertible immediately prior to the Effective Time
       multiplied by the Series A Preferred Conversion Ratio (with any fraction
       resulting from such multiplication to be rounded down to the nearest
       whole number). The maturity date, payment, subordination, subrogation and
       all other terms of the Company Series A Notes shall otherwise remain
       unchanged;

           (ii) At the Effective Time, each Company Note which is convertible
       into Series B Preferred Shares (a "Company Series B Note") outstanding
       immediately prior to the Effective Time shall be deemed to constitute a
       note which is convertible, on the same terms

                                      A-8

       and conditions as were applicable under such Company Series B Note (as
       defined by this Agreement), into such number of shares of Buyer Common
       Stock as is equal to the number of Series B Preferred Shares into which
       such Company Series B Note is convertible immediately prior to the
       Effective Time multiplied by the Series B Preferred Conversion Ratio
       (with any fraction resulting from such multiplication to be rounded down
       to the nearest whole number). The maturity date, payment, subordination,
       subrogation and all other terms of the Company Series B Notes shall
       otherwise remain unchanged; and

           (iii) At the Effective Time, each Company Note which is convertible
       into Series C-1 Preferred Shares (a "Company Series C-1 Note")
       outstanding immediately prior to the Effective Time shall be deemed to
       constitute a note which is convertible, on the same terms and conditions
       as were applicable under such Company Series C-1 Note (as modified by
       this Agreement), into such number of shares of Buyer Common Stock as is
       equal to the number of Series C-1 Preferred Shares into which such
       Company Series C-1 Note is convertible immediately prior to the Effective
       Time multiplied by the Series C-1 Preferred Conversion Ratio (with any
       fraction resulting from such multiplication to be rounded down to the
       nearest whole number). The maturity date, payment, subordination,
       subrogation and all other terms of the Company Series C-1 Notes shall
       otherwise remain unchanged;

    1.10  ESCROW.

        (a) On the Closing Date, the Buyer shall deliver to the Escrow Agent a
    certificate (issued in the name of the Escrow Agent or its nominee)
    representing the Escrow Shares, of which (i) fifty percent (50%) shall be
    held for the purpose of securing the indemnification obligations of the
    Holders (as defined in Section 6.1) set forth in this Agreement (the
    "Indemnification Escrow Shares") and (ii) fifty percent (50%) shall be held
    by the Escrow Agent subject to the satisfaction of the specified regulatory
    event set forth in the Escrow Agreement (the "Milestone Escrow Shares"). The
    Escrow Shares shall be held by the Escrow Agent under the Escrow Agreement
    pursuant to the terms thereof. The Escrow Shares shall be held as a trust
    fund and shall not be subject to any lien, attachment, trustee process or
    any other judicial process of any creditor of any party, and shall be held
    and disbursed solely for the purposes and in accordance with the terms of
    the Escrow Agreement.

        (b) The adoption of this Agreement and the approval of the Merger by the
    Company Stockholders shall constitute approval of the Escrow Agreement and
    of all of the arrangements relating thereto, including without limitation
    the placement of the Escrow Shares in escrow and the appointment of the
    Escrow Representatives.

    1.11  CERTIFICATE OF INCORPORATION AND BY-LAWS.

        (a) The Certificate of Incorporation of the Surviving Corporation
    immediately following the Effective Time shall be the same as the
    Certificate of Incorporation of the Transitory Subsidiary immediately prior
    to the Effective Time, except that (1) the name of the corporation set forth
    therein shall be changed to the name of the Company and (2) the identity of
    the incorporator shall be deleted.

                                      A-9

        (b) The By-laws of the Surviving Corporation immediately following the
    Effective Time shall be the same as the By-laws of the Transitory Subsidiary
    immediately prior to the Effective Time, except that the name of the
    corporation set forth therein shall be changed to the name of the Company.

    1.12  NO FURTHER RIGHTS.  From and after the Effective Time, no Company
Shares shall be deemed to be outstanding, and holders of Certificates shall
cease to have any rights with respect thereto, except as provided herein or by
law.

    1.13  CLOSING OF TRANSFER BOOKS.  At the Effective Time, the stock transfer
books of the Company shall be closed and no transfer of Company Shares shall
thereafter be made. If, after the Effective Time, Certificates are presented to
the Buyer or the Surviving Corporation, they shall be cancelled and exchanged
for Initial Shares in accordance with Section 1.5, subject to Section 1.10 and
to applicable law in the case of Dissenting Shares.

    1.14  SATISFACTION OF COMPANY'S MANAGEMENT INCENTIVE LIABILITY.  Within
seventy-five (75) days after the Effective Time, the Buyer shall, in
satisfaction of the Company's incentive payment obligation to each of the
persons set forth on Section 1.14 of the Company Disclosure Schedule (as defined
below) (the "Management Members") convey to such Management Members, out of the
Total Consideration, an aggregate of 990,000 shares of Buyer Common Stock (the
"Management Incentive Shares"), it being understood that the issuance of such
Management Incentive Shares to such Management Members shall be subject to the
terms and conditions of the Amended and Restated Management Equity Incentive
Plan (the "Management Incentive Plan"), which was approved by the Board of
Directors of the Company pursuant to a written action of directors dated
December 8, 2000. Of the total number of Management Incentive Shares, twenty
percent (20%), rounded to the nearest whole number, shall be deposited into
escrow pursuant to Section 1.10 (the "Management Escrow Shares" and, together
with the Company Stockholder Escrow Shares, the "Escrow Shares") and shall be
held and disposed of in accordance with the terms of the Escrow Agreement.
Within seventy-five (75) days after the Effective Time, the Buyer shall file a
Registration Statement on Form S-8 (or any successor form) under the Securities
Act, with respect to all Management Incentive Shares issued or issuable pursuant
to the Management Incentive Plan.

    1.15  PRIORITY ON ISSUANCE OF BUYER COMMON STOCK.  Of the Total
Consideration to be issued by the Buyer, the Buyer agrees to first reserve for
issuance to the Management Members the aggregate number of Management Incentive
Shares. After reserving for issuance the Management Incentive Shares, in
accordance with the Company's Certificate of Incorporation, the Buyer shall
issue to the holders of the Series C-1, Series C-2 and Series C-3 Preferred
Shares, and reserve for issuance to holders of Company Series C-1 Notes, the
number of shares of Buyer Common Stock to which they are entitled pursuant to
the provisions of Sections 1.5(d), (e) and (f) and 1.9(f)(iii) above. After
issuance (or reservation for issuance) of the Management Incentive Shares and
the shares of Buyer Common Stock issued or issuable to the holders of
Series C-1, C-2 and C-3 Preferred Shares and holders of Company Series C-1
Notes, the Buyer shall issue to the holders of Series A and Series B Preferred
Shares, and reserve for issuance to holders of Company Series A Notes, Company
Series B Notes, Company Series A Warrants and Company Series B Warrants, the
number of shares of Buyer Common Stock to which they are entitled pursuant to
Sections 1.5(b) and (e), 1.9(d)(ii) and (iii) and 1.9(f)(i) and (ii) above. If
after

                                      A-10

reserving for issuance the Management Incentive Shares there shall be
insufficient shares of Buyer Common Stock remaining to make payment in full to
all holders of Series C-1, Series C-2 and Series C-3 Preferred Shares and
Company Series C-1 Notes, the number of shares of Buyer Common Stock to which
such holders of Series C-1, Series C-2 and Series C-3 Preferred Shares and
Company Series C-1 Notes are entitled pursuant to Sections 1.5(d), (e) and
(f) and 1.9(f)(iii), then such shares of Buyer Common Stock shall be distributed
(or reserved for distribution) ratably to the holders of Series C-1, Series C-2
and Series C-3 Preferred Shares and Company Series C-1 Notes in proportion to
the full amounts to which they would otherwise be respectively entitled. If
after reserving for issuance the Management Incentive Shares and issuing (or
reserving for issuance) the shares of Buyer Common Stock issued or issuable to
the holders of Series C-1, Series C-2 and Series C-3 Preferred Shares and
Company Series C-1 Notes there shall be insufficient shares of Buyer Common
Stock remaining to make payment in full to all holders of Series A and Series B
Preferred Shares and holders of Company Series A Notes, Company Series B Notes,
Company Series A Warrants and Company Series B Warrants, the number of shares of
Buyer Common Stock to which such holders of Series A and Series B Preferred
Shares and holders of Company Series A Notes, Company Series B Notes, Company
Series A Warrants and Company Series B Warrants are entitled pursuant to
Sections 1.5(b) and (c), 1.9(d)(ii) and (iii) and 1.9(f)(i) and (ii) above, then
such shares of Buyer Common Stock shall be distributed (or reserved for
distribution) ratably to the holders of Series A and Series B Preferred Shares
and holders of Company Series A Notes, Company Series B Notes, Company Series A
Warrants and Company Series B Warrants in proportion to the full amounts to
which they would otherwise be respectively entitled. After issuance (or
reservation for issuance) of the Management Incentive Shares and the shares of
Buyer Common Stock issued or issuable to the holders of the Preferred Shares and
holders of the Company Notes, Company Series A Warrants and Company Series B
Warrants, the remaining shares of Buyer Common Stock, if any, will be issued (or
reserved for issuance) to the holders of the Common Shares, Company Options and
Company Common Warrants.

                                   ARTICLE II
                 REPRESENTATIONS AND WARRANTIES OF THE COMPANY

    The Company represents and warrants to the Buyer that the statements
contained in this Article II are true and correct, except as set forth in the
disclosure schedule provided by the Company to the Buyer on the date hereof and
accepted in writing by the Buyer (the "Company Disclosure Schedule"). The
Company Disclosure Schedule shall be arranged in sections corresponding to the
numbered and lettered paragraphs contained in this Article II, and any
information disclosed in the Company Disclosure Schedule under any section
number shall be deemed to have been disclosed and incorporated into any other
sections in this Article II where such disclosure would be appropriate.

    2.1  ORGANIZATION, QUALIFICATION AND CORPORATE POWER.  The Company is a
corporation duly organized, validly existing and in corporate and tax good
standing under the laws of the State of Delaware. The Company is duly qualified
to conduct business and is in corporate and tax good standing under the laws of
each jurisdiction in which the nature of its businesses or the ownership or
leasing of its properties requires such qualification, except where the failure
to be so qualified or in good standing, individually or in the aggregate, has
not had and would not reasonably be expected to have a Company Material Adverse
Effect (as defined below). The

                                      A-11

Company has all requisite corporate power and authority to carry on the
businesses in which it is engaged and to own and use the properties owned and
used by it. The Company has furnished to the Buyer complete and accurate copies
of its Certificate of Incorporation and By-laws. The Company is not in default
under or in violation of any provision of its Certificate of Incorporation or
By-laws. For purposes of this Agreement, "Company Material Adverse Effect" means
a material adverse effect on the assets, business, condition (financial or
otherwise), results of operations or future prospects of the Company.

    2.2  CAPITALIZATION.  The authorized capital stock of the Company consists
of (a) sixty-six million (66,000,000) Common Shares, of which, as of the date of
this Agreement, 196,969 shares were issued and outstanding and no shares were
held in the treasury of the Company and (b) fifty-seven million two hundred
thousand (57,200,000) shares of Preferred Stock, $0.001 par value per share, of
which (i) eleven million one hundred thousand (11,100,000) shares have been
designated as Series A Preferred Stock, $0.001 par value per share, of which, as
of the date of this Agreement, 10,911,332 shares were issued and outstanding,
(ii) twelve million five hundred thousand (12,500,000) shares have been
designated as Series B Preferred Stock, $0.001 par value per share, of which, as
of the date of this Agreement, 11,214,755 shares were issued and outstanding,
(iii) ten million (10,000,000) shares have been designated as Series C-1
Preferred Stock, $0.001 par value per share, of which, as of the date of this
Agreement, no shares were issued and outstanding, (iv) eleven million one
hundred thousand (11,100,000) shares have been designated as Series C-2
Preferred Stock, $0.001 par value per share, of which, as of the date of this
Agreement, no shares were issued and outstanding, and (v) twelve million five
hundred thousand (12,500,000) shares have been designated as Series C-3
Preferred Stock, $0.001 par value per share, of which, as of the date of this
Agreement, no shares were issued and outstanding. Section 2.2 of the Company
Disclosure Schedule sets forth a complete and accurate list of (i) all
stockholders of the Company, indicating the number and class or series of
Company Shares held by each stockholder and (for Company Shares other than
Common Shares) the number of Common Shares (if any) into which such Company
Shares are convertible, (ii) all outstanding Company Options, Company Warrants
and Company Notes, indicating (A) the holder thereof, (B) the number and class
or series of Company Shares subject to each Company Option, Company Warrant and
Company Note and (for Company Shares other than Common Shares) the number of
Common Shares (if any) into which such Company Shares are convertible, (C) the
exercise or conversion price, date of grant or issuance, vesting schedule and
expiration or maturity date for each Company Option, Company Warrant and Company
Note, and (D) any terms regarding the acceleration of vesting, and (iii) all
stock option plans and other stock or equity-related plans of the Company. All
of the issued and outstanding Company Shares are, and all Company Shares that
may be issued upon exercise or conversion of Company Options Company Warrants or
Company Notes will be (upon issuance in accordance with their terms), duly
authorized, validly issued, fully paid, nonassessable and free of all preemptive
rights. Other than the Company Options, Company Warrants and Company Notes
listed in Section 2.2 of the Company Disclosure Schedule, there are no
outstanding or authorized options, warrants, notes, rights, agreements or
commitments to which the Company is a party or which are binding upon the
Company providing for the issuance or redemption of any of its capital stock.
There are no outstanding or authorized stock appreciation, phantom stock or
similar rights with respect to the Company. There are no agreements to which the
Company is a party or by which it is bound with respect to the voting (including
without limitation voting trusts or proxies), registration under the Securities
Act, or sale or transfer (including without limitation

                                      A-12

agreements relating to pre-emptive rights, rights of first refusal, co-sale
rights or "drag-along" rights) of any securities of the Company. To the
knowledge of the Company, there are no agreements among other parties, to which
the Company is not a party and by which it is not bound, with respect to the
voting (including without limitation voting trusts or proxies) or sale or
transfer (including without limitation agreements relating to rights of first
refusal, co-sale rights or "drag-along" rights) of any securities of the
Company. The Company has not repurchased any Company Shares, or terminated,
cancelled or otherwise extinguished any options, warrants, notes or other
securities exercisable for, convertible into or exchangeable for any Company
Shares, in breach of any contract, agreement or instrument to which the Company
is a party or in contravention of any law, rule, statute or regulation. All of
the issued and outstanding Company Shares were issued in compliance with
applicable federal and state securities laws.

    2.3  AUTHORIZATION OF TRANSACTION.  The Company has all requisite power and
authority to execute and deliver this Agreement and to perform its obligations
hereunder. The execution and delivery by the Company of this Agreement and,
subject to the adoption of this Agreement and the approval of the Merger by
(a) a majority of the votes represented by the outstanding Company Shares
entitled to vote on this Agreement and the Merger and (b) at least sixty-six and
two-thirds percent (66 2/3%) of the votes represented by the outstanding
Preferred Shares, voting together as a class (collectively, the "Requisite
Company Stockholder Approval"), the consummation by the Company of the
transactions contemplated hereby have been duly and validly authorized by all
necessary corporate action on the part of the Company. Without limiting the
generality of the foregoing, the Board of Directors of the Company, at a meeting
duly called and held, by the unanimous vote of all directors (i) determined that
the Merger is fair and in the best interests of the Company and its
stockholders, (ii) adopted this Agreement in accordance with the provisions of
the Delaware General Corporation Law, and (iii) directed that this Agreement and
the Merger be submitted to the stockholders of the Company for their adoption
and approval and resolved to recommend that the stockholders of Company vote in
favor of the adoption of this Agreement and the approval of the Merger. This
Agreement has been duly and validly executed and delivered by the Company and
constitutes a valid and binding obligation of the Company, enforceable against
the Company in accordance with its terms.

    2.4  NONCONTRAVENTION.  Subject to the filing of the Certificate of Merger
as required by the Delaware General Corporation Law and approval by the Company
Stockholders of an amendment to the Amended and Restated Certificate of
Incorporation of the Company (as described in Section 5.2(q) below) and except
as set forth in Section 2.4 of the Company Disclosure Schedule, neither the
execution and delivery by the Company of this Agreement, nor the consummation by
the Company of the transactions contemplated hereby, will (a) conflict with or
violate any provision of the Certificate of Incorporation or By-laws of the
Company, (b) require on the part of the Company any filing with, or any permit,
authorization, consent or approval of, any court, arbitrational tribunal,
administrative agency or commission or other governmental or regulatory
authority or agency (a "Governmental Entity"), (c) conflict with, result in a
breach of, constitute (with or without due notice or lapse of time or both) a
default under, result in the acceleration of obligations under, create in any
party the right to terminate, modify or cancel, or require any notice, consent
or waiver under, any contract or instrument to which the Company is a party or
by which the Company is bound or to which any of its assets is subject, except
for (i) any conflict, breach, default, acceleration, termination, modification
or

                                      A-13

cancellation which would not have a Company Material Adverse Effect and would
not adversely affect the consummation of the transactions contemplated hereby or
(ii) any notice, consent or waiver the absence of which would not have a Company
Material Adverse Effect and would not adversely affect the consummation of the
transactions contemplated hereby, (d) result in the imposition of any Security
Interest (as defined below) upon any assets of the Company or (e) violate any
order, writ, injunction, decree, statute, rule or regulation applicable to the
Company or any of its properties or assets. For purposes of this Agreement:
"Security Interest" means any mortgage, pledge, security interest, encumbrance,
charge or other lien (whether arising by contract or by operation of law), other
than (i) mechanic's, materialmen's, and similar liens, (ii) liens arising under
worker's compensation, unemployment insurance, social security, retirement, and
similar legislation, and (iii) liens on goods in transit incurred pursuant to
documentary letters of credit, in each case arising in the Ordinary Course of
Business (as defined below) of the Company and not material to the Company; and
"Ordinary Course of Business" means the ordinary course of the Company's
business, consistent with past custom and practice (including with respect to
frequency and amount).

    2.5  SUBSIDIARIES.  The Company does not control directly or indirectly or
have any direct or indirect equity participation or similar interest in any
corporation, partnership, limited liability company, joint venture, trust or
other business association.

    2.6  FINANCIAL STATEMENTS.  The Company has provided to the Buyer (a) the
audited balance sheets and statements of income, changes in stockholders' equity
and cash flows of the Company as of and for each of the last three fiscal years;
and (b) the unaudited balance sheet and statements of income, changes in
stockholders' equity and cash flows as of and for the ten months ended
October 31, 2000 (the "Most Recent Balance Sheet Date"). Such financial
statements (collectively, the "Financial Statements") have been prepared in
accordance with United States generally accepted accounting principles ("GAAP")
applied on a consistent basis throughout the periods covered thereby, fairly
present the financial condition, results of operations and cash flows of the
Company as of the respective dates thereof and for the periods referred to
therein and are consistent with the books and records of the Company; PROVIDED,
HOWEVER, that the Financial Statements referred to in clause (b) above are
subject to normal recurring year-end adjustments and do not include footnotes.

    2.7  ABSENCE OF CERTAIN CHANGES.  Except as disclosed in Section 2.7 of the
Company Disclosure Schedule, since the Most Recent Balance Sheet Date,
(a) there has occurred no event or development which has had, or could
reasonably be expected to have in the future, a Company Material Adverse Effect,
and (b) the Company has not taken any of the actions set forth in paragraphs
(a) through (o) of Section 4.4.

    2.8  UNDISCLOSED LIABILITIES.  The Company has no liability (whether known
or unknown, whether absolute or contingent, whether liquidated or unliquidated
and whether due or to become due), except (a) as disclosed in Section 2.8 of the
Company Disclosure Schedule, (b) liabilities shown on the balance sheet referred
to in clause (b) of Section 2.6 (the "Most Recent Balance Sheet"),
(c) liabilities which have arisen since the Most Recent Balance Sheet Date in
the Ordinary Course of Business and which are similar in nature and amount to
the liabilities which arose during the comparable period of time in the
immediately preceding fiscal

                                      A-14

period and (d) contractual and other liabilities incurred in the Ordinary Course
of Business which are not required by GAAP to be reflected on a balance sheet.

    2.9  TAX MATTERS.

        (a) For purposes of this Agreement, the following terms shall have the
    following meanings:

           (i) "Taxes" means all taxes, charges, fees, levies or other similar
       assessments or liabilities, including without limitation income, gross
       receipts, ad valorem, premium, value-added, excise, real property,
       personal property, sales, use, transfer, withholding, employment,
       unemployment insurance, social security, business license, business
       organization, environmental, workers compensation, payroll, profits,
       license, lease, service, service use, severance, stamp, occupation,
       windfall profits, customs, duties, franchise and other taxes imposed by
       the United States of America or any state, local or foreign government,
       or any agency thereof, or other political subdivision of the United
       States or any such government, and any interest, fines, penalties,
       assessments or additions to tax resulting from, attributable to or
       incurred in connection with any tax or any contest or dispute thereof.

           (ii) "Tax Returns" means all reports, returns, declarations,
       statements or other information required to be supplied to a taxing
       authority in connection with Taxes.

        (b) The Company has filed on a timely basis all Tax Returns that it was
    required to file, and all such Tax Returns were complete and accurate in all
    material respects. The Company is not and has never been a member of a group
    of corporations with which it has filed (or been required to file)
    consolidated, combined or unitary Tax Returns. The Company has paid on a
    timely basis all Taxes that were due and payable. The unpaid Taxes of the
    Company for tax periods through the Most Recent Balance Sheet Date do not
    exceed the accruals and reserves for Taxes (excluding accruals and reserves
    for deferred Taxes established to reflect timing differences between book
    and Tax income) set forth on the Most Recent Balance Sheet. The Company has
    no actual or potential liability for any Tax obligation of any taxpayer
    (including without limitation any affiliated group of corporations or other
    entities that included the Company during a prior period) other than the
    Company. All Taxes that the Company is or was required by law to withhold or
    collect have been duly withheld or collected and, to the extent required,
    have been paid to the proper Governmental Entity.

        (c) The Company has delivered to the Buyer complete and accurate copies
    of all federal income Tax Returns, examination reports and statements of
    deficiencies assessed against or agreed to by the Company since
    December 31, 1995. The federal income Tax Returns of the Company have been
    audited by the Internal Revenue Service or are closed by the applicable
    statute of limitations for all taxable years through the taxable year
    specified in Section 2.9(c) of the Company Disclosure Schedule. The Company
    has delivered or made available to the Buyer complete and accurate copies of
    all other Tax Returns of the Company together with all related examination
    reports and statements of deficiency for all periods from and after
    December 31, 1995. No examination or audit of any Tax Return of the Company
    by any Governmental Entity is currently in progress or, to the knowledge of
    the Company, threatened or contemplated. The Company has not been informed
    by any jurisdiction that the

                                      A-15

    jurisdiction believes that the Company was required to file any Tax Return
    that was not filed. The Company has not waived any statute of limitations
    with respect to Taxes or agreed to an extension of time with respect to a
    Tax assessment or deficiency.

        (d) The Company: (i) is not a "consenting corporation" within the
    meaning of Section 341(f) of the Code, and none of the assets of the Company
    are subject to an election under Section 341(f) of the Code; (ii) has not
    been a United States real property holding corporation within the meaning of
    Section 897(c)(2) of the Code during the applicable period specified in
    Section 897(c)(l)(A)(ii) of the Code; (iii) has not made any payments, is
    not obligated to make any payments, and is not a party to any agreement that
    could obligate it to make any payments that may be treated as an "excess
    parachute payment" under Section 280G of the Code; or (iv) has no actual or
    potential liability for any Taxes of any person (other than the Company)
    under Treasury Regulation Section 1.1502-6 (or any similar provision of
    federal, state, local, or foreign law), or as a transferee or successor, by
    contract, or otherwise.

        (e) None of the assets of the Company: (i) is property that is required
    to be treated as being owned by any other person pursuant to the provisions
    of former Section 168(f)(8) of the Code; (ii) is "tax-exempt use property"
    within the meaning of Section 168(h) of the Code; or (iii) directly or
    indirectly secures any debt the interest on which is tax exempt under
    Section 103(a) of the Code.

        (f) The Company has not undergone a change in its method of accounting
    resulting in an adjustment to its taxable income pursuant to Section 481 of
    the Code.

        (g) Except as set forth in Section 2.9(g) of the Company Disclosure
    Schedule, no state or federal "net operating loss" of the Company determined
    as of the Closing Date is subject to limitation on its use pursuant to
    Section 382 of the Code or comparable provisions of state law as a result of
    any "ownership change" within the meaning of Section 382(g) of the Code or
    comparable provisions of any state law occurring prior to the Closing Date.

        (h) The Company has never participated in or cooperated with an
    international boycott within the meaning of Section 999 of the Code.

    2.10  ASSETS.  Except as set forth in Section 2.10 of the Company Disclosure
Schedule, the Company owns or leases all tangible assets necessary for the
conduct of its business as presently conducted and as presently proposed to be
conducted. Each such tangible asset is free from material defects, has been
maintained in accordance with normal industry practice, is in good operating
condition and repair (subject to normal wear and tear) and is suitable for the
purposes for which it presently is used. No asset of the Company (tangible or
intangible) is subject to any Security Interest.

    2.11  OWNED REAL PROPERTY.  The Company does not own any real property.

    2.12  REAL PROPERTY LEASES.  Section 2.12 of the Company Disclosure Schedule
lists all real property leased or subleased to or by the Company and lists the
term of such lease, any extension and expansion options, and the rent payable
thereunder. The Company has delivered to the Buyer complete and accurate copies
of the leases and subleases (as amended to date) listed

                                      A-16

in Section 2.12 of the Company Disclosure Schedule. With respect to each lease
and sublease listed in Section 2.12 of the Company Disclosure Schedule:

        (a) the lease or sublease is legal, valid, binding, enforceable and in
    full force and effect;

        (b) the lease or sublease will continue to be legal, valid, binding,
    enforceable and in full force and effect immediately following the Closing
    in accordance with the terms thereof as in effect immediately prior to the
    Closing;

        (c) neither the Company nor, to the knowledge of the Company, any other
    party, is in breach or violation of, or default under, any such lease or
    sublease, and no event has occurred, is pending or, to the knowledge of the
    Company, is threatened, which, after the giving of notice, with lapse of
    time, or otherwise, would constitute a breach or default by the Company or,
    to the knowledge of the Company, any other party under such lease or
    sublease;

        (d) the Company has not assigned, transferred, conveyed, mortgaged,
    deeded in trust or encumbered any interest in the leasehold or subleasehold;
    and

        (e) the Company is not aware of any Security Interest, easement,
    covenant or other restriction applicable to the real property subject to
    such lease, except for recorded easements, covenants and other restrictions
    which do not materially impair the current uses or the occupancy by the
    Company of the property subject thereto.

    2.13  PRECLINICAL TESTING AND CLINICAL TRIALS.  Section 2.13 of the Company
Disclosure Schedule sets forth all (i) human clinical trials, and (ii) animal
studies and other preclinical tests that have been conducted in support of human
clinical trials, in each case conducted by the Company or in which the Company
has participated (the "Company Ongoing Clinical Programs"). The Company Ongoing
Clinical Programs conducted on behalf of the Company were and, if still pending,
are being conducted in accordance with applicable laws and regulations,
including but not limited to 21 CFR part 50 (informed consent), part 56
(institutional review boards), part 58 (good laboratory practices), part 812
(investigational device exemptions), and all other applicable laws and
regulations, except to the extent of any such conduct that would not reasonably
be expected to have a Company Material Adverse Effect. Neither the Company, nor
any agent or representative of the Company, has received any notices or
correspondence from the United States Food and Drug Administration or any other
governmental agency requiring the delay, termination, suspension or modification
of any animal studies, preclinical tests or clinical trials conducted by or on
behalf of the Company or in which the Company has participated, or any
disqualification of testing facilities used by the Company. To the Company's
knowledge, no clinical investigator acting for the Company has been, is or is
threatened to become, the subject of any disbarment or disqualification
proceedings by any regulatory agency or has been terminated or threatened to be
terminated from any such investigation.

    2.14  INTELLECTUAL PROPERTY.

        (a) Section 2.14 of the Company Disclosure Schedule sets forth a true
    and complete list of each of the following items: (1) all patents and
    applications therefor, including

                                      A-17

    any patent term extensions or supplementary protection certificates,
    registrations of trademarks (including service marks) and applications
    therefor, domain names and registrations of copyrights and applications
    therefor that are owned by the Company or that are licensed or sublicensed
    to the Company, (2) all licenses, agreements and contracts relating to
    Intellectual Property Rights (as defined below) pursuant to which the
    Company is entitled to use any Intellectual Property Rights owned by any
    third party (the "Company Third Party Licenses"), other than commercially
    available, mass marketed shrink-wrap software, and (3) all agreements under
    which the Company has granted any third party the right to use any
    Intellectual Property Rights.

        (b) To the Company's knowledge, the Company exclusively owns, or is
    licensed, sublicensed or otherwise possesses legally enforceable rights to
    use, pursuant to the licenses, agreements and contracts listed on
    Section 2.14 of the Company Disclosure Schedule, all Intellectual Property
    Rights that are used or necessary to conduct business of the Company as
    currently conducted, or would be used or necessary as such business is
    planned to be conducted, including without limitation all Intellectual
    Property Rights used or necessary to conduct each of the Company Ongoing
    Clinical Programs and all Intellectual Property Rights that are now used or
    planned to be used or are necessary to make, use or sell any products under
    development after those products are approved for marketing and sale by the
    appropriate health regulatory authorities (the "Company Intellectual
    Property Rights"). For purposes hereof, "Intellectual Property Rights" means
    all patents, including patent term extensions and supplementary protection
    certificates, trademarks, trade names, domain names, service marks and
    copyrights, any applications for and registrations of such patents,
    trademarks, trade names, domain names, service marks and copyrights, and all
    processes, formulae, methods, schematics, technology, know-how, computer
    software programs or applications and tangible or intangible proprietary
    information or material.

        (c) The execution and delivery of this Agreement and consummation of the
    Merger will not result in the breach of, or create on behalf of any third
    party the right to terminate or modify, any license, sublicense or other
    agreement relating to the Company Intellectual Property Rights, including
    any Company Third Party License.

        (d) To the Company's knowledge, all patents, including all patent term
    extensions and supplementary protection certificates, registered trademarks,
    service marks and copyrights under which the Company holds any rights and
    which are material to the business of the Company are valid and subsisting,
    and all applications for such patents, trademarks, service marks and
    copyrights are subsisting and were filed in good faith. The Company has
    taken reasonable measures to protect the proprietary nature of the Company
    Intellectual Property Rights that are material to the business of the
    Company and to maintain in confidence all trade secrets and confidential
    information owned or used by the Company and that are material to the
    business of the Company. To the knowledge of the Company, no other person or
    entity is infringing, violating or misappropriating any of the Company
    Intellectual Property Rights.

        (e) To the Company's knowledge, none of the activities or business
    previously or currently conducted by the Company or planned to be conducted
    by the Company (including the manufacture, use or sale of the future
    products which are the subject of Company Ongoing Clinical Programs for any
    clinical indications) infringes, violates or constitutes a

                                      A-18

    misappropriation of, any Intellectual Property Rights of any other person or
    entity. The Company has not received any complaint, claim or notice alleging
    any such infringement, violation or misappropriation, present or future.

        (f) The Company is not a party to any agreement under which, following
    the Closing, a third party would be entitled to receive a license or any
    other right in or to Intellectual Property Rights of Buyer or any of Buyer's
    Affiliates (other than the Company) or which, following the Closing, would
    restrict or limit the business or operations of Buyer or any of its
    Affiliates (other than the Company).

    2.15  CONTRACTS.

        (a) Section 2.15 of the Company Disclosure Schedule lists the following
    agreements (written or oral) to which the Company is a party as of the date
    of this Agreement:

           (i) any agreement (or group of related agreements) for the lease of
       personal property from or to third parties providing for lease payments
       in excess of $50,000 per annum;

           (ii) any agreement (or group of related agreements) for the purchase
       or sale of products or for the furnishing or receipt of services
       (A) which calls for performance over a period of more than one year,
       (B) which involves more than the sum of $50,000, or (C) in which the
       Company has granted manufacturing rights, "most favored nation" pricing
       provisions or marketing or distribution rights relating to any products
       under development or any territory or has agreed to purchase a minimum
       quantity of goods or services or has agreed to purchase goods or services
       exclusively from a certain party;

          (iii) any agreement establishing a partnership, limited liability
       company or joint venture;

           (iv) any agreement (or group of related agreements) under which it
       has created, incurred, assumed or guaranteed (or may create, incur,
       assume or guarantee) indebtedness (including capitalized lease
       obligations) involving more than $50,000 or under which it has imposed
       (or may impose) a Security Interest on any of its assets, tangible or
       intangible;

           (v) any agreement concerning confidentiality or non-competition;

           (vi) any employment or consulting agreement;

          (vii) any agreement involving any officer, director or stockholder of
       the Company or any affiliate (an "Affiliate"), as defined in Rule 12b-2
       under the Securities Exchange Act of 1934, as amended (the "Exchange
       Act"), thereof;

         (viii) any agreement which contains any provisions requiring the
       Company to indemnify any other party thereto (excluding indemnities
       contained in agreements for the purchase, sale or license of products
       entered into in the Ordinary Course of Business); and

                                      A-19

           (ix) any other agreement (or group of related agreements) either
       involving more than $50,000 or not entered into in the Ordinary Course of
       Business.

        (b) The Company has delivered to the Buyer a complete and accurate copy
    of each agreement listed in Section 2.14 or Section 2.15 of the Company
    Disclosure Schedule. With respect to each agreement so listed: (i) the
    agreement is legal, valid, binding and enforceable and in full force and
    effect; (ii) the agreement will continue to be legal, valid, binding and
    enforceable and in full force and effect immediately following the Closing
    in accordance with the terms thereof as in effect immediately prior to the
    Closing; and (iii) neither the Company nor, to the knowledge of the Company,
    any other party, is in breach or violation of, or default under, any such
    agreement, and no event has occurred, is pending or, to the knowledge of the
    Company, is threatened, which, after the giving of notice, with lapse of
    time, or otherwise, would constitute a breach or default by the Company or,
    to the knowledge of the Company, any other party under such contract.

    2.16  POWERS OF ATTORNEY.  There are no outstanding powers of attorney
executed on behalf of the Company.

    2.17  INSURANCE.  Section 2.17 of the Company Disclosure Schedule lists each
insurance policy (including fire, theft, casualty, general liability, workers
compensation, business interruption, environmental, product liability and
automobile insurance policies and bond and surety arrangements) to which the
Company is a party. Such insurance policies are of the type and in amounts
customarily carried by organizations conducting businesses or owning assets
similar to those of the Company. There is no material claim pending under any
such policy as to which coverage has been questioned, denied or disputed by the
underwriter of such policy. All premiums due and payable under all such policies
have been paid, the Company is not liable for retroactive premiums or similar
payments, and the Company is otherwise in compliance in all material respects
with the terms of such policies. The Company has no knowledge of any threatened
termination of, or material premium increase with respect to, any such policy.
Each such policy will continue to be enforceable and in full force and effect
immediately following the Closing in accordance with the terms thereof as in
effect immediately prior to the Closing.

    2.18  LITIGATION.  Except as set forth in Section 2.18 of the Company
Disclosure Schedule, there is no action, suit, proceeding, claim, arbitration or
investigation before any Governmental Entity or before any arbitrator (together,
"Legal Proceedings") which is pending or has been threatened in writing against
the Company which (a) if determined adversely to the Company, could have,
individually or in the aggregate, a Company Material Adverse Effect or (b) in
any manner challenges or seeks to prevent, enjoin, alter or delay the
transactions contemplated by this Agreement.

    2.19  EMPLOYEES.

        (a) Section 2.19 of the Company Disclosure Schedule contains a list of
    all employees of the Company whose annual rate of compensation exceeds
    $50,000 per year, along with the position and the annual rate of
    compensation of each such person. Each such employee has entered into a
    confidentiality/assignment of inventions agreement with the Company, a copy
    of which has previously been delivered to the Buyer. Section 2.19 of the
    Company Disclosure

                                      A-20

    Schedule contains a list of all employees of the Company who are a party to
    a non-competition agreement with the Company; copies of such agreements have
    previously been delivered to the Buyer. To the knowledge of the Company, no
    key employee or group of employees has any plans to terminate employment
    with the Company.

        (b) The Company is not a party to or bound by any collective bargaining
    agreement, nor has it experienced any strikes, grievances, claims of unfair
    labor practices or other collective bargaining disputes. The Company has no
    knowledge of any organizational effort made or threatened, either currently
    or within the past two years, by or on behalf of any labor union with
    respect to employees of the Company.

    2.20  EMPLOYEE BENEFITS.

        (a) For purposes of this Agreement, the following terms shall have the
    following meanings:

           (i) "Employee Benefit Plan" means any "employee pension benefit plan"
       (as defined in Section 3(2) of ERISA), any "employee welfare benefit
       plan" (as defined in Section 3(1) of ERISA), and any other written or
       oral plan, agreement or arrangement involving direct or indirect
       compensation, including without limitation insurance coverage, severance
       benefits, disability benefits, deferred compensation, bonuses, stock
       options, stock purchase, phantom stock, stock appreciation or other forms
       of incentive compensation or post-retirement compensation.

           (ii) "ERISA" means the Employee Retirement Income Security Act of
       1974, as amended.

           (iii) "Company ERISA Affiliate" means any entity which is, or at any
       applicable time was, a member of (1) a controlled group of corporations
       (as defined in Section 414(b) of the Code), (2) a group of trades or
       businesses under common control (as defined in Section 414(c) of the
       Code), or (3) an affiliated service group (as defined under
       Section 414(m) of the Code or the regulations under Section 414(o) of the
       Code), any of which includes or included the Company.

        (b) Section 2.20(b) of the Company Disclosure Schedule contains a
    complete and accurate list of all Employee Benefit Plans maintained, or
    contributed to, by the Company or any Company ERISA Affiliate. Complete and
    accurate copies of (i) all Employee Benefit Plans which have been reduced to
    writing, (ii) written summaries of all unwritten Employee Benefit Plans,
    (iii) all related trust agreements, insurance contracts and summary plan
    descriptions, and (iv) all annual reports filed on IRS Form 5500, 5500C or
    5500R and (for all funded plans) all plan financial statements for the last
    three (3) plan years for each Employee Benefit Plan, have been delivered to
    the Buyer. Each Employee Benefit Plan has been administered in all material
    respects in accordance with its terms and each of the Company and the
    Company ERISA Affiliates has in all material respects met its obligations
    with respect to such Employee Benefit Plan and has made all required
    contributions thereto. The Company, each Company ERISA Affiliate and each
    Employee Benefit Plan are in compliance in all material respects with the
    currently applicable provisions of ERISA and the Code and the regulations
    thereunder (including

                                      A-21

    without limitation Section 4980B of the Code, Subtitle K, Chapter 100 of the
    Code and Sections 601 through 608 and Section 701 et seq. of ERISA). All
    filings and reports as to each Employee Benefit Plan required to have been
    submitted to the Internal Revenue Service or to the United States Department
    of Labor have been duly submitted.

        (c) There are no Legal Proceedings (except claims for benefits payable
    in the normal operation of the Employee Benefit Plans and proceedings with
    respect to qualified domestic relations orders) against or involving any
    Employee Benefit Plan or asserting any rights or claims to benefits under
    any Employee Benefit Plan that could give rise to any material liability.

        (d) All the Employee Benefit Plans that are intended to be qualified
    under Section 401(a) of the Code have received or are the subject of
    determination letters from the Internal Revenue Service to the effect that
    such Employee Benefit Plans are qualified and the plans and the trusts
    related thereto are exempt from federal income taxes under Sections 401(a)
    and 501(a), respectively, of the Code, no such determination letter has been
    revoked and to the Company's knowledge revocation has not been threatened,
    and no such Employee Benefit Plan has been amended or operated since the
    date of its most recent determination letter or application therefor in any
    respect, and no act or omission has occurred, that could be reasonably
    expected to adversely affect its qualification or materially increase its
    cost. Each Employee Benefit Plan which is required to satisfy
    Section 401(k)(3) or Section 401(m)(2) of the Code has been tested for
    compliance with, and satisfies the requirements of, Section 401(k)(3) and
    Section 401(m)(2) of the Code for each plan year ending prior to the Closing
    Date.

        (e) Neither the Company, nor any Company ERISA Affiliate has ever
    maintained an Employee Benefit Plan subject to Section 412 of the Code or
    Title IV of ERISA.

        (f) At no time has the Company, or any Company ERISA Affiliate been
    obligated to contribute to any "multiemployer plan" (as defined in
    Section 4001(a)(3) of ERISA).

        (g) There are no unfunded obligations under any Employee Benefit Plan
    providing benefits after termination of employment to any employee of the
    Company (or to any beneficiary of any such employee), including but not
    limited to retiree health coverage and deferred compensation, but excluding
    continuation of health coverage required to be continued under
    Section 4980B of the Code or other applicable law and insurance conversion
    privileges under state law. The assets of each Employee Benefit Plan which
    is funded are reported at their fair market value on the books and records
    of such Employee Benefit Plan.

        (h) No act or omission has occurred and no condition exists with respect
    to any Employee Benefit Plan maintained by the Company or any Company ERISA
    Affiliate that could be reasonably expected to subject the Company or any
    Company ERISA Affiliate to (i) any material fine, penalty, tax or liability
    of any kind imposed under ERISA or the Code or (ii) any contractual
    indemnification or contribution obligation protecting any fiduciary, insurer
    or service provider with respect to any Employee Benefit Plan.

                                      A-22

        (i) No Employee Benefit Plan is funded by, associated with or related to
    a "voluntary employee's beneficiary association" within the meaning of
    Section 501(c)(9) of the Code.

        (j) Each Employee Benefit Plan is amendable and terminable unilaterally
    by the Company at any time without liability to the Company as a result
    thereof and no Employee Benefit Plan, plan documentation or agreement,
    summary plan description or other written communication distributed
    generally to employees by its terms prohibits the Company from amending or
    terminating any such Employee Benefit Plan.

        (k) Section 2.20(k) of the Company Disclosure Schedule discloses each:
    (i) agreement with any stockholder, director, executive officer or other key
    employee of the Company (A) the benefits of which are contingent, or the
    terms of which are materially altered, upon the occurrence of a transaction
    involving the Company of the nature of any of the transactions contemplated
    by this Agreement, (B) providing any term of employment or compensation
    guarantee or (C) providing severance benefits or other benefits after the
    termination of employment of such director, executive officer or key
    employee; (ii) agreement, plan or arrangement under which any person may
    receive payments from the Company that may be subject to the tax imposed by
    Section 4999 of the Code or included in the determination of such person's
    "parachute payment" under Section 280G of the Code; and (iii) agreement or
    plan binding the Company, including without limitation any stock option
    plan, stock appreciation right plan, restricted stock plan, stock purchase
    plan, severance benefit plan or Employee Benefit Plan, any of the benefits
    of which will be increased, or the vesting of the benefits of which will be
    accelerated, by the occurrence of any of the transactions contemplated by
    this Agreement or the value of any of the benefits of which will be
    calculated on the basis of any of the transactions contemplated by this
    Agreement.

        (l) Section 2.20(l) of the Company Disclosure Schedule sets forth the
    policy of the Company with respect to accrued vacation, accrued sick time
    and earned time-off and the amount of such liabilities.

        (m) Section 2.20(m) of the Company Disclosure Schedule sets forth a true
    and correct copy of the Management Incentive Plan, which has been duly
    authorized by the Board of Directors of the Company and is in full force and
    effect as of the date of this Agreement.

    2.21  ENVIRONMENTAL MATTERS.

        (a) The Company has complied with all applicable Environmental Laws (as
    defined below), except for noncompliance with any Environmental Laws that,
    individually or in the aggregate, has not had and would not reasonably be
    expected to have a Company Material Adverse Effect. There is no pending or,
    to the knowledge of the Company or reflected in the Company's files,
    threatened civil or criminal litigation, written notice of violation or
    formal administrative proceeding by any Governmental Entity, relating to any
    Environmental Law involving the Company, except for litigation, notices of
    violations or formal administrative proceedings that, individually or in the
    aggregate, have not had and would not reasonably be expected to have a
    Company Material Adverse Effect. For purposes of this Agreement,
    "Environmental Law" means any federal, state or local law, statute, rule or
    regulation or the

                                      A-23

       common law relating to protection of the environment or occupational
       health and safety, including without limitation any statute, regulation,
       administrative decision or order pertaining to (i) treatment, storage,
       disposal, generation, handling and transportation of Materials of
       Environmental Concern (as defined below); (ii) air, water and noise
       pollution; (iii) groundwater and soil contamination; (iv) the release or
       threatened release into the environment of Materials of Environmental
       Concern, including without limitation emissions, discharges, injections,
       spills, escapes or dumping; (v) storage tanks, vessels, containers,
       abandoned or discarded barrels, and other closed receptacles; and
       (vi) health and safety of employees. As used above, the terms "release"
       and "environment" shall have the meaning set forth in the Comprehensive
       Environmental Response, Compensation and Liability Act of 1980, as
       amended ("CERCLA").

        (b) There have been no releases of any Materials of Environmental
    Concern into the environment that could reasonably be expected to have a
    Company Material Adverse Effect (i) at any facility formerly or currently
    owned, operated or controlled by the Company; (ii) to the knowledge of the
    Company, at any parcel of real property on which any such facility is
    located; or (iii) to the knowledge of the Company, at any parcel of real
    property or facility other than those owned, operated or controlled by the
    Company. For the purpose of this Agreement, "Materials of Environmental
    Concern" means any hazardous substances (as such term is defined under
    CERCLA), solid wastes and hazardous wastes (as such terms are defined under
    the Resource Conservation and Recovery Act), oil or petroleum and petroleum
    products.

        (c) Set forth in Section 2.21(c) of the Company Disclosure Schedule is a
    list of all documents (whether in hard copy or electronic form) that contain
    any environmental reports, investigations and audits in the Company's
    possession, custody or control relating to premises currently or previously
    owned or operated by the Company (whether conducted by or on behalf of the
    Company or a third party, and whether done at the initiative of the Company
    or directed by a Governmental Entity or other third party) which were issued
    or conducted during the past five years. A complete and accurate copy of
    each such document has been provided to the Buyer.

        (d) The Company is not aware of any material environmental liability of
    any solid or hazardous waste transporter or treatment, storage or disposal
    facility that has been used by the Company which reasonably could be
    expected to result in a claim or liability under any Environmental Law
    against the Company, Transitory Subsidiary or Buyer.

        (e) Any representations by the Company respecting (i) compliance with,
    or liabilities, litigation, notices of violation or administrative
    proceedings relating to, any Environmental Law; or (ii) releases of
    Materials of Environmental Concern appear only in this Section 2.21. No
    other representations in this Agreement (including, but not limited to,
    those in Sections 2.8 and 2.18) apply to such compliance with, or
    liabilities, litigation, notices of violation or administrative proceedings
    relating to, any Environmental Law, or such releases of Materials of
    Environmental Concern.

    2.22  LEGAL COMPLIANCE.  The Company, and the conduct and operations of its
business, is in compliance with each applicable law (including rules and
regulations thereunder) of any federal, state, local or foreign government, or
any Governmental Entity, except for any violations

                                      A-24

or defaults that, individually or in the aggregate, have not had and would not
reasonably be expected to have a Company Material Adverse Effect.

    2.23  PERMITS.  Section 2.23 of the Company Disclosure Schedule sets forth a
list of all permits, licenses, registrations, certificates, orders or approvals
from any Governmental Entity (including without limitation those issued or
required under Environmental Laws and those relating to the occupancy or use of
owned or leased real property) ("Permits") issued to or held by the Company.
Except as set forth in Section 2.23 of the Company Disclosure Schedule, such
listed Permits are the only Permits that are required for the Company to conduct
its business as presently conducted or as proposed to be conducted, except for
those the absence of which, individually or in the aggregate, have not had and
would not reasonably be expected to have a Company Material Adverse Effect. Each
such Permit is in full force and effect and, to the knowledge of the Company, no
suspension or cancellation of such Permit is threatened. Each such Permit will
continue in full force and effect immediately following the Closing.

    2.24  CERTAIN BUSINESS RELATIONSHIPS WITH AFFILIATES.  No Affiliate of the
Company (a) owns any property or right, tangible or intangible, which is used in
the business of the Company, (b) has any claim or cause of action against the
Company, or (c) owes any money to, or is owed any money by, the Company.
Section 2.24 of the Company Disclosure Schedule describes any transactions or
relationships between the Company and any Affiliate thereof

    2.25  BROKERS' FEES.  Except as set forth in Section 2.25 of the Company
Disclosure Schedule, the Company has no liability or obligation to pay any fees
or commissions to any broker, finder or agent with respect to the transactions
contemplated by this Agreement.

    2.26  BOOKS AND RECORDS.  The minute books and other similar records of the
Company contain complete and accurate records of all actions taken at any
meetings of the Company's stockholders, Board of Directors or any committee
thereof and of all written consents executed in lieu of the holding of any such
meeting. The books and records of the Company accurately reflect in all material
respects the assets, liabilities, business, financial condition and results of
operations of the Company and have been maintained in accordance with good
business and bookkeeping practices.

    2.27  DISCLOSURE.  No representation or warranty by the Company contained in
this Agreement, and no statement contained in the Company Disclosure Schedule or
any other document, certificate or other instrument delivered or to be delivered
by or on behalf of the Company pursuant to this Agreement, contains or will
contain any untrue statement of a material fact or omits or will omit to state
any material fact necessary, in light of the circumstances under which it was or
will be made, in order to make the statements herein or therein not misleading.

    2.28  INFORMATION SUPPLIED.  None of the information supplied or to be
supplied by the Company specifically for inclusion or incorporation by reference
in the Registration Statement (as defined below), at the time the Registration
Statement becomes effective under the Securities Act, will contain any untrue
statement of a material fact or omit to state any material fact required to be
stated therein or necessary to make the statements therein not misleading,
except that no representation or warranty is made by the Company with respect to
statements made or

                                      A-25

incorporated by reference therein based on information supplied by the Buyer
specifically for inclusion or incorporation by reference in the Registration
Statement.

                                  ARTICLE III
                  REPRESENTATIONS AND WARRANTIES OF THE BUYER
                         AND THE TRANSITORY SUBSIDIARY

    Each of the Buyer and the Transitory Subsidiary represents and warrants to
the Company that the statements contained in this Article III are true and
correct, except as set forth in the disclosure schedule provided by the Buyer
and the Transitory Subsidiary to the Company on the date hereof and accepted in
writing by the Company (the "Buyer Disclosure Schedule"). The Buyer Disclosure
Schedule shall be arranged in sections corresponding to the numbered and
lettered paragraphs contained in this Article III, and any information disclosed
in the Buyer Disclosure Schedule under any section number shall be deemed to
have been disclosed and incorporated into any other paragraph of this
Article III where such disclosure would also be appropriate.

    3.1  ORGANIZATION, QUALIFICATION AND CORPORATE POWER.  Each of the Buyer and
the Transitory Subsidiary is a corporation duly organized, validly existing and
in good standing under the laws of the state of its incorporation. The Buyer is
duly qualified to conduct business and is in corporate and tax good standing
under the laws of each jurisdiction in which the nature of its business or the
ownership or leasing of its properties requires such qualification, except where
the failure to be so qualified or in good standing would not have a Buyer
Material Adverse Effect (as defined below). The Buyer has all requisite
corporate power and authority to carry on the businesses in which it is engaged
and to own and use the properties owned and used by it. The Buyer has furnished
or made available to the Company complete and accurate copies of its Certificate
of Incorporation and By-laws. The Buyer is not in default under or in violation
of any provision of its Certificate of Incorporation or By-laws. For purposes of
this Agreement, "Buyer Material Adverse Effect" means a material adverse effect
on the assets, business, condition (financial or otherwise), results of
operations or future prospects of the Buyer.

    3.2  CAPITALIZATION.  The authorized capital stock of the Buyer consists of
(a) fifty million (50,000,000) shares of Buyer Common Stock, of which 11,710,793
shares were issued and outstanding as of September 30, 2000, and (b) two million
(2,000,000) shares of Preferred Stock, $0.01 par value per share ("Buyer
Preferred Stock" and, together with the Buyer Common Stock, the "Buyer Stock"),
of which no shares were issued or outstanding as of September 30, 2000. All of
the issued and outstanding shares of Buyer Common Stock are duly authorized,
validly issued, fully paid, nonassessable and free of all preemptive rights.
Section 3.2 of the Buyer Disclosure Schedule sets forth a summary as of
September 30, 2000 of (i) all outstanding options to purchase shares of Buyer
Stock issued by the Buyer pursuant to its stock option plans or otherwise
("Buyer Options") and warrants to purchase shares of Buyer Stock ("Buyer
Warrants"), indicating (A) the aggregate number and class or series of the
shares of Buyer Stock subject to the Buyer Options and Buyer Warrants, and
(B) the weighted-average exercise price of the Buyer Options and Buyer Warrants,
and (ii) all stock option plans and other stock or equity-related plans of the
Buyer. All of the Merger Shares and Management Incentive Shares will be, when
issued in accordance with this Agreement, duly authorized, validly issued, fully
paid, nonassessable and free of all preemptive rights. All shares of Buyer Stock
that may be issued

                                      A-26

upon exercise of Buyer Options or Buyer Warrants will be (upon issuance in
accordance with their terms), duly authorized, validly issued, fully paid,
nonassessable and free of all preemptive rights. Other than the Buyer Options
and Buyer Warrants listed in Section 3.2 of the Buyer Disclosure Schedule, there
are no outstanding or authorized options, warrants, rights, agreements or
commitments to which the Buyer is a party or which are binding upon the Buyer
providing for the issuance or redemption of any of its capital stock. Except as
disclosed in Section 3.2 of the Buyer Disclosure Schedule, there are no
outstanding or authorized stock appreciation, phantom stock or similar rights
with respect to the Buyer. Except as disclosed in Section 3.2 of the Buyer
Disclosure Schedule, there are no agreements to which the Buyer is a party or by
which it is bound with respect to the voting (including without limitation
voting trust or proxies), registration under the Securities Act, or sale or
transfer (including without limitation agreements relating to pre-emptive
rights, rights of first refusal, co-sale rights or "drag-along" rights) of any
securities of the Buyer. All of the issued and outstanding shares of Buyer Stock
were issued in compliance with applicable federal and state securities laws.

    3.3  AUTHORIZATION OF TRANSACTION.  Each of the Buyer and the Transitory
Subsidiary has all requisite power and authority to execute and deliver this
Agreement and (in the case of the Buyer) the Escrow Agreement and to perform its
obligations hereunder and thereunder. The execution and delivery by the Buyer
and the Transitory Subsidiary of this Agreement and (in the case of the Buyer)
the Escrow Agreement and, subject to the approval of the issuance of the Merger
Shares and the Management Incentive Shares by a majority of the total Buyer
Common Stock votes cast on such proposal (the "Requisite Buyer Stockholder
Approval"), the consummation by the Buyer and the Transitory Subsidiary of the
transactions contemplated hereby and thereby have been duly and validly
authorized by all necessary corporate action on the part of the Buyer and the
Transitory Subsidiary, respectively. Without limiting the generality of the
foregoing, the Boards of Directors of the Buyer and the Transitory Subsidiary,
at a meeting duly called and held or by written action of directors in lieu of a
meeting, by the unanimous vote of all directors (i) determined that the Merger
is fair and in the best interests of the Buyer and the Transitory Subsidiary,
respectively, and their stockholders, (ii) adopted this Agreement in accordance
with the provisions of the Delaware General Corporation Law, and (iii) directed
that the issuance of the Merger Shares and the Management Incentive Shares and
this Agreement and the Merger be submitted to the stockholders of the Buyer and
the Transitory Subsidiary, respectively, for their adoption and approval and
resolved to recommend that the stockholders of the Buyer and the Transitory
Subsidiary, respectively, vote in favor of the issuance of the Merger Shares and
the Management Incentive Shares and the adoption of this Agreement and the
approval of the Merger. This Agreement has been duly and validly executed and
delivered by the Buyer and the Transitory Subsidiary and constitutes a valid and
binding obligation of the Buyer and the Transitory Subsidiary, enforceable
against them in accordance with its terms.

    3.4  NONCONTRAVENTION.  Subject to compliance with the applicable
requirements of the Securities Act and any applicable state securities laws, the
Exchange Act and the filing of the Certificate of Merger as required by the
Delaware General Corporation Law and except as set forth in Section 3.4 of the
Buyer Disclosure Schedule, neither the execution and delivery by the Buyer or
the Transitory Subsidiary of this Agreement or (in the case of the Buyer) the
Escrow Agreement, nor the consummation by the Buyer or the Transitory Subsidiary
of the transactions contemplated hereby or thereby, will (a) conflict with or
violate any provision of the Certificate

                                      A-27

of Incorporation or By-laws of the Buyer or the Transitory Subsidiary,
(b) require on the part of the Buyer or the Transitory Subsidiary any filing
with, or any permit, authorization, consent or approval of, any Governmental
Entity, (c) conflict with, result in breach of, constitute (with or without due
notice or lapse of time or both) a default under, result in the acceleration of
obligations under, create in any party any right to terminate, modify or cancel,
or require any notice, consent or waiver under, any contract or instrument to
which the Buyer or the Transitory Subsidiary is a party or by which either is
bound or to which any of their assets are subject, except for (i) any conflict,
breach, default, acceleration, termination, modification or cancellation which
would not have a Buyer Material Adverse Effect and would not adversely affect
the consummation of the transactions contemplated hereby or (ii) any notice,
consent or waiver the absence of which would not have a Buyer Material Adverse
Effect and would not adversely affect the consummation of the transactions
contemplated hereby, or (d) violate any order, writ, injunction, decree,
statute, rule or regulation applicable to the Buyer or the Transitory Subsidiary
or any of their properties or assets. The restrictions contained in Section 203
of the Delaware General Corporation Law applicable to a "business combination"
(as defined in Section 203) do not apply to the execution, delivery or
performance of this Agreement or to the consummation of the Merger or the other
transactions contemplated by this Agreement.

    3.5  REPORTS AND FINANCIAL STATEMENTS.  The Buyer has previously furnished
or made available to the Company complete and accurate copies, as amended or
supplemented, of its (a) Annual Report on Form 10-K for the fiscal year ended
December 31, 1999, as filed with the Securities and Exchange Commission (the
"SEC"), and (b) all other reports filed by the Buyer under Section 13 or
subsections (a) or (c) of Section 14 of the Exchange Act with the SEC since
December 31, 1999 (such reports are collectively referred to herein as the
"Buyer Reports"). The Buyer Reports constitute all of the documents required to
be filed by the Buyer under Section 13 or subsections (a) or (c) of Section 14
of the Exchange Act with the SEC from December 31, 1999 through the date of this
Agreement. The Buyer Reports complied in all material respects with the
requirements of the Exchange Act and the rules and regulations thereunder when
filed. As of their respective dates, the Buyer Reports did not contain any
untrue statement of a material fact or omit to state a material fact required to
be stated therein or necessary to make the statements therein, in light of the
circumstances under which they were made, not misleading. The Buyer has filed in
the Buyer Reports all exhibits to any such Buyer Reports as are required to be
filed under Item 601(b)(10) of Regulation S-K of the Securities Act. The audited
financial statements and unaudited interim financial statements of the Buyer
included in the Buyer Reports (i) complied as to form in all material respects
with applicable accounting requirements and the published rules and regulations
of the SEC with respect thereto when filed, (ii) were prepared in accordance
with GAAP applied on a consistent basis throughout the periods covered thereby
(except as may be indicated therein or in the notes thereto, and in the case of
quarterly financial statements, as permitted by Form 10-Q under the Exchange
Act), (iii) fairly present the consolidated financial condition, results of
operations and cash flows of the Buyer as of the respective dates thereof and
for the periods referred to therein, and (iv) are consistent with the books and
records of the Buyer.

    3.6  ABSENCE OF CERTAIN CHANGES.  Since September 30, 2000, (a) there has
occurred no event or development which has had, or could reasonably be expected
to have in the future, a Buyer Material Adverse Effect and (b) the Buyer has not
taken any of the actions prohibited by Section 4.5 of this Agreement.

                                      A-28

    3.7  TAX MATTERS.  The Buyer has filed on a timely basis all Tax Returns
that it was required to file, and all such Tax Returns were complete and
accurate in all material respects. The Buyer is not and has never been a member
of a group of corporations with which it has filed (or been required to file)
consolidated, combined or unitary Tax Returns. The Buyer has paid on a timely
basis all Taxes that were due and payable. The unpaid Taxes of the Buyer for tax
periods through September 30, 2000 do not exceed the accruals and reserves for
Taxes (excluding accruals and reserves for deferred Taxes established to reflect
timing differences between book and Tax income) set forth on the Buyer's most
recent balance sheet contained in the Buyer Reports. The Buyer has no actual or
potential liability for any Tax obligation of any taxpayer (including without
limitation any affiliated group of corporations or other entities that included
the Buyer during a prior period) other than the Buyer. All Taxes that the Buyer
is or was required by law to withhold or collect have been duly withheld or
collected and, to the extent required, have been paid to the proper Governmental
Entity. Except as set forth in Section 3.7 of the Buyer Disclosure Schedule, no
examination or audit of any Tax Return of the Buyer by any Governmental Entity
is currently in progress or, to the knowledge of the Buyer, threatened or
contemplated.

    3.8  PRECLINICAL TESTING AND CLINICAL TRIALS.  Section 3.8 of the Buyer
Disclosure Schedule sets forth all (i) human clinical trials, and (ii) animal
studies and other preclinical tests that have been conducted in support of human
clinical trails, in each case conducted by the Buyer or in which the Buyer has
participated (the "Buyer Ongoing Clinical Programs"). The Buyer Ongoing Clinical
Programs conducted on behalf of the Buyer were and, if still pending, are being
conducted in accordance with applicable laws and regulations including but not
limited to 21 CFR part 50 (informed consent), part 56 (institutional review
boards), part 58 (good laboratory practices), part 812 (investigational device
exemptions), and all other applicable laws and regulations, except to the extent
of any such conduct that would not reasonably be expected to have a Buyer
Material Adverse Effect. Neither the Buyer, nor any agent or representative of
the Buyer, has received any notices or correspondence from the United States
Food and Drug Administration or any other governmental agency requiring the
delay, termination, suspension or modification of any animal studies,
preclinical tests or clinical trials conducted by or on behalf of the Buyer or
in which the Buyer has participated, or any disqualification of testing
facilities used by the Buyer. To the Buyer's knowledge, no clinical investigator
acting for the Buyer has been, is or is threatened to become, the subject of any
disbarment or disqualification proceedings by any regulatory agency or has been
terminated or threatened to be terminated, from any such investigation.

    3.9  INTELLECTUAL PROPERTY.

        (a) The Buyer has furnished to the Company a true and complete list of
    each of the following items: (1) all patents and applications therefor,
    including any patent term extensions or supplementary protection
    certificates, registrations of trademarks (including service marks) and
    applications therefor, domain names and registrations of copyrights and
    applications therefor that are owned by the Buyer or that are licensed or
    sublicensed to the Buyer, (2) all licenses, agreements and contracts
    relating to Intellectual Property Rights pursuant to which the Buyer is
    entitled to use any Intellectual Property Rights owned by any third party
    (the "Buyer Third Party Licenses"), other than commercially available, mass
    marketed shrink-

                                      A-29

    wrap software, and (3) all agreements under which the Buyer has granted any
    third party the right to use any Intellectual Property Rights.

        (b) To the Buyer's knowledge, except as set forth in Section 3.9 of the
    Buyer Disclosure Schedule, the Buyer exclusively owns, or is licensed,
    sublicensed or otherwise possesses legally enforceable rights to use,
    pursuant to the licenses, agreements and contracts previously furnished to
    the Company pursuant to Section 3.9(a), all Intellectual Property Rights
    that are used or necessary to conduct business of the Buyer as currently
    conducted, or would be used or necessary as such business is planned to be
    conducted, including without limitation all Intellectual Property Rights
    used or necessary to conduct each of the Buyer Ongoing Clinical Programs and
    all Intellectual Property Rights that are now used or planned to be used or
    are necessary to make, use or sell any products under development after
    those products are approved for marketing and sale by the appropriate health
    regulatory authorities (the "Buyer Intellectual Property Rights").

        (c) The execution and delivery of this Agreement and consummation of the
    Merger will not result in the breach of, or create on behalf of any third
    party the right to terminate or modify, any license, sublicense or other
    agreement relating to the Buyer Intellectual Property Rights, including any
    Buyer Third Party License.

        (d) To the Buyer's knowledge, all patents, including all patent term
    extensions and supplementary protection certificates, registered trademarks,
    service marks and copyrights under which the Buyer holds any rights and
    which are material to the business of the Buyer are valid and subsisting,
    and all applications for such patents, trademarks, service marks and
    copyrights are subsisting and were filed in good faith. The Buyer has taken
    reasonable measures to protect the proprietary nature of the Buyer
    Intellectual Property Rights that are material to the business of the Buyer
    and to maintain in confidence all trade secrets and confidential information
    owned or used by the Buyer and that are material to the business of the
    Buyer. To the knowledge of the Buyer, no other person or entity is
    infringing, violating or misappropriating any of the Buyer Intellectual
    Property Rights.

        (e) To the Buyer's knowledge, and except as set forth in Section 3.9(e)
    of the Buyer Disclosure Schedule, none of the activities or business
    previously or currently conducted by the Buyer or planned to be conducted by
    the Buyer (including the manufacture, use or sale of the future products
    which are the subject of Buyer Ongoing Clinical Programs for any clinical
    indications) infringes, violates or constitutes a misappropriation of, any
    Intellectual Property Rights of any other person or entity. The Buyer has
    not received any complaint, claim or notice alleging any such infringement,
    violation or misappropriation, present or future.

    3.10  CONTRACTS.  With respect to each agreement to which the Buyer is a
party and which is material to the Buyer and by its terms remains executory:
(a) the agreement is legal, valid, binding and enforceable and in full force and
effect; (b) the agreement will continue to be legal, valid, binding and
enforceable and in full force and effect immediately following the Closing in
accordance with the terms thereof as in effect immediately prior to the Closing;
and (c) neither the Buyer nor, to the knowledge of the Buyer, any other party,
is in breach or violation of, or default under, any such agreement, and no event
has occurred, is pending or, to the knowledge of the Buyer, is threatened,
which, after the giving of notice, with lapse of time,

                                      A-30

or otherwise, would constitute a breach or default by the Buyer or, to the
knowledge of the Buyer, any other party under such contract.

    3.11  LITIGATION.  Except as disclosed in the Buyer Reports, as of the date
of this Agreement, there is no Legal Proceeding which is pending or, to the
Buyer's knowledge, threatened against the Buyer which, (a) if determined
adversely to the Buyer, could have, individually or in the aggregate, a Buyer
Material Adverse Effect or (b) in any manner challenges or seeks to prevent,
enjoin, alter or delay the transactions contemplated by this Agreement.

    3.12  EMPLOYEES.

        (a) The Buyer is not a party to or bound by any collective bargaining
    agreement, nor has it experienced any strikes, grievances, claims of unfair
    labor practices or other collective bargaining disputes. The Buyer has no
    knowledge of any organizational effort made or threatened, either currently
    or within the past two years, by or on behalf of any labor union with
    respect to employees of the Buyer.

        (b) Each employee of the Buyer has entered into a
    confidentiality/assignment of inventions agreement with the Buyer, a copy of
    which has previously been delivered to the Company. To the knowledge of the
    Buyer, no key employee or group of employees has any plans to terminate
    employment with the Buyer.

    3.13  EMPLOYEE BENEFITS.

        (a) For purposes of this Agreement, "Buyer ERISA Affiliate" means any
    entity which is, or at any applicable time was, a member of (1) a controlled
    group of corporations (as defined in Section 414(b) of the Code), (2) a
    group of trades or businesses under common control (as defined in
    Section 414(c) of the Code), or (3) an affiliated service group (as defined
    under Section 414(m) of the Code or the regulations under Section 414
    (o) of the Code), any of which includes or included the Buyer.

        (b) Section 3.13(b) of the Buyer Disclosure Schedule contains a complete
    and accurate list of all Employee Benefit Plans maintained, or contributed
    to, by the Buyer or any Buyer ERISA Affiliate. Complete and accurate copies
    of (i) all Employee Benefit Plans which have been reduced to writing,
    (ii) written summaries of all unwritten Employee Benefit Plans, (iii) all
    related trust agreements, insurance contracts and summary plan descriptions,
    and (iv) all annual reports filed on IRS Form 5500, 5500C or 5500R and (for
    all funded plans) all plan financial statements for the last three (3) plan
    years for each Employee Benefit Plan, have been made available to the
    Company. Each Employee Benefit Plan has been administered in all material
    respects in accordance with its terms and each of the Buyer and the Buyer
    ERISA Affiliates has in all material respects met its obligations with
    respect to such Employee Benefit Plan and has made all required
    contributions thereto. The Buyer, each Buyer ERISA Affiliate and each
    Employee Benefit Plan are in compliance in all material respects with the
    currently applicable provisions of ERISA and the Code and the regulations
    thereunder (including without limitation Section 4980B of the Code, Subtitle
    K, Chapter 100 of the Code and Sections 601 through 608 and Section 701 et
    seq. of ERISA). All filings and reports as to each Employee

                                      A-31

    Benefit Plan required to have been submitted to the Internal Revenue Service
    or to the United States Department of Labor have been duly submitted.

        (c) There are no Legal Proceedings (except claims for benefits payable
    in the normal operation of the Employee Benefit Plans and proceedings with
    respect to qualified domestic relations orders) against or involving any
    Employee Benefit Plan or asserting any rights or claims to benefits under
    any Employee Benefit Plan that could give rise to any material liability.

        (d) All the Employee Benefit Plans that are intended to be qualified
    under Section 401(a) of the Code have received or are the subject of
    determination letters from the Internal Revenue Service to the effect that
    such Employee Benefit Plans are qualified and the plans and the trusts
    related thereto are exempt from federal income taxes under Sections 401(a)
    and 501(a), respectively, of the Code, no such determination letter has been
    revoked and to the Buyer's knowledge revocation has not been threatened, and
    no such Employee Benefit Plan has been amended or operated since the date of
    its most recent determination letter or application therefor in any respect,
    and no act or omission has occurred, that could be reasonably expected to
    adversely affect its qualification or materially increase its cost. Each
    Employee Benefit Plan which is required to satisfy Section 401(k)(3) or
    Section 401(m)(2) of the Code has been tested for compliance with, and
    satisfies the requirements of, Section 401(k)(3) and Section 401(m)(2) of
    the Code for each plan year ending prior to the Closing Date.

        (e) Neither the Buyer, nor any Buyer ERISA Affiliate has ever maintained
    an Employee Benefit Plan subject to Section 412 of the Code or Title IV of
    ERISA.

        (f) At no time has the Buyer, or any Buyer ERISA Affiliate been
    obligated to contribute to any "multiemployer plan" (as defined in
    Section 4001(a)(3) of ERISA).

        (g) There are no unfunded obligations under any Employee Benefit Plan
    providing benefits after termination of employment to any employee of the
    Buyer (or to any beneficiary of any such employee), including but not
    limited to retiree health coverage and deferred compensation, but excluding
    continuation of health coverage required to be continued under
    Section 4980B of the Code or other applicable law and insurance conversion
    privileges under state law. The assets of each Employee Benefit Plan which
    is funded are reported at their fair market value on the books and records
    of such Employee Benefit Plan.

        (h) No act or omission has occurred and no condition exists with respect
    to any Employee Benefit Plan maintained by the Buyer or any Buyer ERISA
    Affiliate that could be reasonably expected to subject the Buyer or any
    Buyer ERISA Affiliate to (i) any material fine, penalty, tax or liability of
    any kind imposed under ERISA or the Code or (ii) any contractual
    indemnification or contribution obligation protecting any fiduciary, insurer
    or service provider with respect to any Employee Benefit Plan.

        (i) No Employee Benefit Plan is funded by, associated with or related to
    a "voluntary employee's beneficiary association" within the meaning of
    Section 501(c)(9) of the Code.

                                      A-32

        (j) Each Employee Benefit Plan is amendable and terminable unilaterally
    by the Buyer at any time without liability to the Buyer as a result thereof
    and no Employee Benefit Plan, plan documentation or agreement, summary plan
    description or other written communication distributed generally to
    employees by its terms prohibits the Buyer from amending or terminating any
    such Employee Benefit Plan.

        (k) Section 3.13(k) of the Buyer Disclosure Schedule discloses each:
    (i) agreement with any stockholder, director, executive officer or other key
    employee of the Buyer (A) the benefits of which are contingent, or the terms
    of which are materially altered, upon the occurrence of a transaction
    involving the Buyer of the nature of any of the transactions contemplated by
    this Agreement, (B) providing any term of employment or compensation
    guarantee or (C) providing severance benefits or other benefits after the
    termination of employment of such director, executive officer or key
    employee; (ii) agreement, plan or arrangement under which any person may
    receive payments from the Buyer that may be subject to the tax imposed by
    Section 4999 of the Code or included in the determination of such person's
    "parachute payment" under Section 280G of the Code; and (iii) agreement or
    plan binding the Buyer, including without limitation any stock option plan,
    stock appreciation right plan, restricted stock plan, stock purchase plan,
    severance benefit plan or Employee Benefit Plan, any of the benefits of
    which will be increased, or the vesting of the benefits of which will be
    accelerated, by the occurrence of any of the transactions contemplated by
    this Agreement or the value of any of the benefits of which will be
    calculated on the basis of any of the transactions contemplated by this
    Agreement.

        (l) Section 3.13(l) of the Buyer Disclosure Schedule sets forth the
    policy of the Buyer with respect to accrued vacation, accrued sick time and
    earned time-off and the amount of such liabilities.

    3.14  INTERIM OPERATIONS OF THE TRANSITORY SUBSIDIARY.  The Transitory
Subsidiary was formed solely for the purpose of engaging in the transactions
contemplated by this Agreement and has engaged in no business activities other
than as contemplated by this Agreement.

    3.15  ENVIRONMENTAL MATTERS.

        (a) The Buyer has complied with all applicable Environmental Laws,
    except for noncompliance with any Environmental Laws that, individually or
    in the aggregate, has not had and would not reasonably be expected to have a
    Buyer Material Adverse Effect. There is no pending or, to the knowledge of
    the Buyer or as reflected in the Buyer's files, threatened civil or criminal
    litigation, written notice of violation or formal administrative proceeding
    by any Governmental Entity, relating to any Environmental Law involving the
    Buyer, except for litigation, notices of violations or formal administrative
    proceedings that, individually or in the aggregate, have not had and would
    not reasonably be expected to have a Buyer Material Adverse Effect.

        (b) There have been no releases of any Materials of Environmental
    Concern into the environment that could reasonably be expected to have a
    Buyer Material Adverse Effect: (i) at any facility formerly or currently
    owned, operated or controlled by the Buyer; (ii) to the knowledge of the
    Buyer, at any parcel of real property on which any such facility is located;
    or

                                      A-33

    (iii) to the knowledge of the Buyer, at any parcel of real property or
    facility other than those owned, operated or controlled by the Buyer.

        (c) The Buyer has made available to the Company a complete and accurate
    copy of all environmental reports, investigations and audits in the Buyer's
    possession, custody or control relating to premises currently or previously
    owned or operated by the Buyer (whether conducted by or on behalf of the
    Buyer or a third party, and whether done at the initiative of the Buyer or
    directed by a Governmental Entity or other third party) which were issued or
    conducted during the past five years.

        (d) The Buyer is not aware of any material environmental liability of
    any solid or hazardous waste transporter or treatment, storage or disposal
    facility that has been used by the Buyer which reasonably could be expected
    to result in a claim or liability under any Environmental Law against the
    Buyer, Transitory Subsidiary or Company.

        (e) Any representations by the Buyer respecting (i) compliance with, or
    liabilities, litigation, notices of violation or administrative proceedings
    relating to, any Environmental Law; or (ii) releases of Materials of
    Environmental Concern appear only in this Section 3.15. No other
    representations in this Agreement (including, but not limited to, those in
    Section 3.11) apply to such compliance with, or liabilities, litigation,
    notices of violation or administrative proceedings relating to, any
    Environmental Law, or such releases of Materials of Environmental Concern.

    3.16  LEGAL COMPLIANCE.  The Buyer, and the conduct and operations of its
business, is in compliance with each applicable law (including rules and
regulations thereunder) of any federal, state, local or foreign government, or
any Governmental Entity, except for any violations or defaults that,
individually or in the aggregate, have not had and would not reasonably be
expected to have a Buyer Material Adverse Effect.

    3.17  BROKERS' FEES.  Except as set forth in Section 3.17 of the Buyer
Disclosure Schedule, neither the Buyer nor the Transitory Subsidiary has any
liability or obligation to pay any fees or commissions to any broker, finder or
agent with respect to the transactions contemplated by this Agreement.

    3.18  BOOKS AND RECORDS.  The minute books and other similar records of the
Buyer contain complete and accurate records of all actions taken at any meetings
of the Buyer's stockholders, Board of Directors or any committee thereof and of
all written consents executed in lieu of the holding of any such meeting. The
books and records of the Buyer accurately reflect in all material respects the
assets, liabilities, business, financial condition and results of operations of
the Buyer and have been maintained in accordance with good business and
bookkeeping practices.

    3.19  DISCLOSURE.  No representation or warranty by the Buyer contained in
this Agreement, and no statement contained in the Buyer Disclosure Schedule or
any other document, certificate or other instrument delivered or to be delivered
by or on behalf of the Buyer pursuant to this Agreement, contains or will
contain any untrue statement of a material fact

                                      A-34

or omit or will omit to state any material fact necessary, in light of the
circumstances under which it was or will be made, in order to make the
statements herein or therein not misleading.

    3.20  INFORMATION SUPPLIED.  None of the information supplied or to be
supplied by the Buyer specifically for inclusion or incorporation by reference
in the Registration Statement, at the time the Registration Statement becomes
effective under the Securities Act, will contain any untrue statement of a
material fact or omit to state any material fact required to be stated therein
or necessary to make the statements therein not misleading. The Registration
Statement will comply as to form in all material respects with the requirements
of the Securities Act and the Exchange Act and the rules and regulations
thereunder, except that no representation or warranty is made by the Buyer with
respect to statements made or incorporated by reference therein based on
information supplied by the Company specifically for inclusion or incorporation
by reference in the Registration Statement.

                                   ARTICLE IV
                                   COVENANTS

    4.1  CLOSING EFFORTS.  Each of the Parties shall use its best efforts, to
the extent commercially reasonable ("Reasonable Best Efforts"), to take all
actions and to do all things necessary, proper or advisable to consummate the
transactions contemplated by this Agreement, including without limitation using
its Reasonable Best Efforts to ensure that (i) its representations and
warranties remain true and correct in all material respects through the Closing
Date and (ii) the conditions to the obligations of the other Parties to
consummate the Merger are satisfied.

    4.2  GOVERNMENTAL AND THIRD-PARTY NOTICES AND CONSENTS.

        (a) Each Party shall use its Reasonable Best Efforts to obtain, at its
    expense, all waivers, permits, consents, approvals or other authorizations
    from Governmental Entities, and to effect all registrations, filings and
    notices with or to Governmental Entities, as may be required for such Party
    to consummate the transactions contemplated by this Agreement and to
    otherwise comply with all applicable laws and regulations in connection with
    the consummation of the transactions contemplated by this Agreement.

        (b) The Company shall use its Reasonable Best Efforts to obtain, at its
    expense, all such waivers, consents or approvals from third parties, and to
    give all such notices to third parties, as are required to be listed in
    Section 2.4 of the Company Disclosure Schedule.

    4.3  SPECIAL MEETING, PROSPECTUS/PROXY STATEMENT AND REGISTRATION STATEMENT.

        (a) The Company shall use its Reasonable Best Efforts to obtain, as
    promptly as practicable, the Requisite Company Stockholder Approval, either
    at a special meeting of stockholders or pursuant to a written stockholder
    consent, in accordance with the applicable requirements of the Delaware
    General Corporation Law. The Buyer shall use its Reasonable Best Efforts to
    obtain, as promptly as practicable, the Requisite Buyer Stockholder Approval
    at a special meeting of the stockholders of the Buyer, as required by the
    rules of the Nasdaq Stock Market, in accordance with the applicable
    requirements of the Delaware General Corporation Law. In connection
    therewith, the Buyer shall prepare, with the assistance and cooperation of

                                      A-35

    the Company, a Registration Statement on Form S-4 (the "Registration
    Statement"). The Registration Statement shall include a prospectus/proxy
    statement to be used for the purpose of offering the Merger Shares to the
    stockholders of the Company, soliciting proxies or written consents from the
    stockholders of the Company for the purpose of obtaining the Requisite
    Company Stockholder Approval, and soliciting proxies from the stockholders
    of the Buyer for the purpose of obtaining the Requisite Buyer Stockholder
    Approval (such prospectus/proxy statement, together with any accompanying
    letter to stockholders, notice of meeting and form of proxy or written
    consent, shall be referred to herein as the "Prospectus/Proxy Statement").
    The summary of the Merger in the Prospectus/Proxy Statement shall include a
    summary of the terms relating to the indemnification obligations of the
    Company Stockholders, the escrow arrangements and the authority of the
    Escrow Representatives, and a statement that the adoption of this Agreement
    by the stockholders of the Company and the Buyer shall constitute approval
    of such terms. The Buyer shall use its Reasonable Best Efforts to file the
    Registration Statement with the SEC on or before the 28th day following the
    date of this Agreement (it being understood that the Buyer shall not be so
    obligated to the extent that the Buyer's failure to file the Registration
    Statement within such period is the consequence of events beyond its
    control, including the failure of the Company, the Company's financial
    advisors or any other third party not affiliated with or retained by the
    Buyer to furnish to the Buyer for inclusion in the Registration Statement
    information which is required to be included therein prior to filing) and
    shall, with the assistance of the Company, promptly respond to any SEC
    comments on the Registration Statement and shall otherwise use its
    Reasonable Best Efforts to have the Registration Statement declared
    effective under the Securities Act as promptly as practicable. Promptly
    following such time as the Registration Statement is declared effective, the
    Company shall distribute the Prospectus/Proxy Statement to its stockholders
    and the Buyer shall distribute the Prospectus/Proxy Statement to its
    stockholders. If the Requisite Company Stockholder Approval is obtained by
    means of a written consent, the Company shall send, pursuant to Sections 228
    and 262(d) of the Delaware General Corporation Law, a written notice to all
    stockholders of the Company that did not execute such written consent
    informing them that this Agreement and the Merger were adopted and approved
    by the stockholders of the Company and that appraisal rights are available
    for their Company Shares pursuant to Section 262 of the Delaware General
    Corporation Law (which notice shall include a copy of such Section 262), and
    shall promptly inform the Buyer of the date on which such notice was sent.

        (b) The Company, acting through its Board of Directors, shall include in
    the Prospectus/Proxy Statement the unanimous recommendation of its Board of
    Directors that the stockholders of the Company vote in favor of the adoption
    of this Agreement and the approval of the Merger.

        (c) The Buyer, acting through its Board of Directors, shall include in
    the Prospectus/Proxy Statement the unanimous recommendation of its Board of
    Directors that the stockholders of the Buyer vote in favor of the adoption
    of this Agreement, the approval of the Merger and the issuance of the Merger
    Shares and Management Incentive Shares. Such approval shall not be withdrawn
    or modified by the Buyer's Board of Directors, nor shall the Buyer's Board
    of Directors support any other transaction comparable to that contemplated
    hereby prior to the Closing.

                                      A-36

        (d) The Buyer shall ensure that the Registration Statement does not
    contain an untrue statement of a material fact or omit to state a material
    fact required to be stated therein or necessary to make the statements
    therein not misleading (provided that the Buyer shall not be responsible for
    the accuracy or completeness of any information relating to the Company or
    furnished by the Company in writing for inclusion in the Registration
    Statement).

        (e) The Company shall ensure that the Prospectus/Proxy Statement does
    not contain any untrue statement of a material fact or omit to state a
    material fact necessary in order to make the statements made, in light of
    the circumstances under which they were made, not misleading (provided that
    the Company shall not be responsible for the accuracy or completeness of any
    information relating to the Buyer or furnished by the Buyer in writing for
    inclusion in the Prospectus/Proxy Statement).

    4.4  COMPANY OPERATION OF BUSINESS.  Except as contemplated by this
Agreement, during the period from the date of this Agreement to the Effective
Time, the Company shall conduct its operations in the Ordinary Course of
Business and in compliance with all applicable laws and regulations and, to the
extent consistent therewith, use its Reasonable Best Efforts to preserve intact
its current business organization, keep its physical assets in good working
condition, keep available the services of its current officers and employees and
preserve its relationships with customers, suppliers and others having business
dealings with it to the end that its goodwill and ongoing business shall not be
impaired in any material respect. Without limiting the generality of the
foregoing, prior to the Effective Time and except as set forth in Section 4.4 of
the Company Disclosure Schedule or as contemplated by this Agreement, the
Company shall not, without the written consent of the Buyer:

        (a) issue or sell, or redeem or repurchase, any stock or other
    securities of the Company or any rights, warrants or options to acquire any
    such stock or other securities (except pursuant to the conversion or
    exercise of convertible securities or Company Options or Company Warrants
    outstanding on the date hereof), or amend any of the terms of (including
    without limitation the vesting of) any such convertible securities or
    Company Options or Company Warrants;

        (b) split, combine or reclassify any shares of its capital stock;
    declare, set aside or pay any dividend or other distribution (whether in
    cash, stock or property or any combination thereof) in respect of its
    capital stock;

        (c) create, incur or assume any indebtedness (including obligations in
    respect of capital leases); assume, guarantee, endorse or otherwise become
    liable or responsible (whether directly, contingently or otherwise) for the
    obligations of any other person or entity; or make any loans, advances or
    capital contributions to, or investments in, any other person or entity;

        (d) enter into, adopt or amend the Management Incentive Plan, any
    Employee Benefit Plan or any employment or severance agreement or
    arrangement of the type described in Section 2.20(k) or (except for normal
    increases in the Ordinary Course of Business for employees who are not
    Affiliates) increase in any manner the compensation or fringe benefits of,
    or materially modify the employment terms of, its directors, officers or
    employees, generally or individually, or pay any bonus or other benefit to
    its directors, officers or employees;

                                      A-37

        (e) acquire, sell, lease, license or dispose of any assets or property
    with a value of greater than $25,000 per transaction and $100,000 in the
    aggregate, other than purchases and sales of assets in the Ordinary Course
    of Business;

        (f) mortgage or pledge any of its property or assets or subject any such
    property or assets to any Security Interest;

        (g) discharge or satisfy any Security Interest or pay any obligation or
    liability other than in the Ordinary Course of Business;

        (h) amend its charter, by-laws or other organizational documents;

        (i) change in any material respect its accounting methods, principles or
    practices, except insofar as may be required by a generally applicable
    change in GAAP;

        (j) enter into, amend, terminate, take or omit to take any action that
    would constitute a violation of or default under, or waive any rights under,
    any material contract or agreement;

        (k) make or commit to make any capital expenditure in excess of $25,000
    per item or $100,000 in the aggregate;

        (l) institute or settle any Legal Proceeding;

        (m) take any action or fail to take any action permitted by this
    Agreement with the knowledge that such action or failure to take action
    would result in (i) any of the representations and warranties of the Company
    set forth in this Agreement becoming untrue or (ii) any of the conditions to
    the Merger set forth in Article V not being satisfied;

        (n) make or change any material election in respect of Taxes, adopt or
    change any accounting method in respect of Taxes, file any amendment to an
    income Tax Return, enter into any closing agreement, settle any claim or
    assessment in respect of material Taxes, or consent to any extension or
    waiver of the limitation period applicable to any claim or assessment in
    respect of material Taxes; or

        (o) agree in writing or otherwise to take any of the foregoing actions.

    4.5  BUYER OPERATION OF BUSINESS.  Except as contemplated by this Agreement,
during the period from the date of this Agreement to the Effective Time, the
Buyer shall use Reasonable Best Efforts to conduct its operations in the
ordinary course of business and in compliance with all applicable laws and
regulations material to its business and, to the extent consistent therewith,
use its Reasonable Best Efforts to preserve intact its current business
organization, keep its physical assets in good working condition, keep available
the services of its current officers and preserve its relationships with
customers, suppliers and others having business dealings with it to the end that
its goodwill and ongoing business shall not be impaired in any material respect.
Without limiting the generality of the foregoing, prior to the Effective Time,
the Buyer shall not, without the written consent of the Company:

                                      A-38

        (a) amend its charter, bylaws or other organizational documents;

        (b) change in any material respect its accounting methods, principles or
    practices, except insofar as may be required by a generally applicable
    change in GAAP;

        (c) take any action or fail to take any action permitted by this
    Agreement with the knowledge that such action or failure to take such action
    would result in (i) any of the representations and warranties of the Buyer
    set forth in this Agreement becoming untrue or (ii) any of the conditions to
    the Merger set forth in Article V not being satisfied;

        (d) enter into a term sheet or letter of intent to acquire, acquire, or
    agree to acquire, by merging or consolidating with, or by purchasing any
    assets or equity securities of, or by any other manner, any business or any
    corporation, partnership, association or other business organization or
    division thereof, or otherwise acquire or agree to acquire any assets,
    (i) the purchase price of which exceeds (A) Five Million Dollars
    ($5,000,000) in cash, in the event of an acquisition or other transaction,
    the consideration for which is cash, or (B) ten percent (10%) of the Buyer's
    outstanding capital stock, in the event of an acquisition or other
    transaction, the consideration for which is the Buyer's capital stock, or
    (ii) which requires the approval of the stockholders of the Buyer;

        (e) issue or sell shares of capital stock, or any securities exercisable
    for or convertible into shares of capital stock, of the Buyer, at a
    purchase, exercise or conversion price which is (i) less than the fair
    market value of such shares at the time the obligation to issue or sell such
    securities arises, and (ii) not commercially reasonable given the nature of
    the transaction involved, in each case as reasonably determined by the Board
    of Directors of the Buyer; provided, however, that nothing in this
    clause (e) shall prohibit the Buyer from (i) granting options or other
    awards (or issuing any shares upon the exercise of any options or awards)
    under its employee stock option, purchase or other equity incentive plans,
    (ii) issuing shares of its Buyer Common Stock upon the exercise of warrants
    outstanding on the date of this Agreement, (iii) issuing shares of Buyer
    Common Stock to the holders of Buyer Common Stock in connection with any
    stock split, stock dividend or similar event affecting the Buyer Common
    Stock or (iv) issuing shares of Buyer Common Stock in an underwritten public
    offering; or

        (f) agree in writing or otherwise to take any of the foregoing actions.

    4.6  ACCESS TO COMPANY INFORMATION.

        (a) The Company shall permit representatives of the Buyer to have full
    access (at all reasonable times, and in a manner so as not to interfere with
    the normal business operations of the Company) to all premises, properties,
    financial and accounting records, contracts, other records and documents
    (excluding confidential employee medical records unless authorized by the
    employee whose record is to be reviewed), and personnel, of or pertaining to
    the Company.

        (b) Within twenty (20) days after the end of each month ending prior to
    the Closing, beginning with December 31, 2000, the Company shall furnish to
    the Buyer an unaudited income statement for such month and a balance sheet
    as of the end of such month, prepared on a basis consistent with the
    Financial Statements; provided that the Company shall

                                      A-39

    not be required to deliver an unaudited balance sheet for the month ended
    December 31, 2000 to the extent it is reasonably impracticable for the
    Company to do so. Such financial statements shall present fairly the
    financial condition and results of operations of the Company as of the dates
    thereof and for the periods covered thereby, and shall be consistent with
    the books and records of the Company.

    4.7  ACCESS TO BUYER INFORMATION.

        (a) The Buyer shall permit representatives of the Company to have full
    access (at all reasonable times, and in a manner so as not to interfere with
    the normal business operations of the Buyer) to all premises, properties,
    financial and accounting records, contracts, other records and documents
    (excluding confidential employee medical records unless authorized by the
    employee whose record is to be reviewed) and personnel, of or pertaining to
    the Buyer.

        (b) Within twenty (20) days after the end of each month ending prior to
    the Closing, beginning with December 31, 2000, the Buyer shall furnish to
    the Company an unaudited income statement for such month and a balance sheet
    as of the end of such month, prepared on a basis consistent with the audited
    financial statements and unaudited interim financial statements of the
    Buyers included in the Buyer Reports; provided that the Buyer shall not be
    required to deliver an unaudited balance sheet for the month ended
    December 31, 2000 to the extent it is reasonably impracticable for the Buyer
    to do so. Such financial statement shall present fairly the financial
    condition and results of operations of the Buyer as of the dates thereof and
    for the periods covered thereby, and shall be consistent with the books and
    records of the Buyer.

    4.8  EXCLUSIVITY.

        (a) Except for transactions set forth on Section 4.8 of the Company
    Disclosure Schedule, the Company shall not, and the Company shall require
    each of its officers, directors, employees, representatives and agents not
    to, directly or indirectly, (i) initiate, solicit, encourage or otherwise
    facilitate any inquiry, proposal, offer or discussion with any party (other
    than the Buyer) concerning any merger, reorganization, consolidation,
    recapitalization, business combination, liquidation, dissolution, share
    exchange, sale of stock, sale, license or other disposition of material
    assets or similar business transaction involving the Company or any division
    of the Company, (ii) furnish any non-public information concerning the
    business, properties or assets of the Company or any division of the Company
    to any party (other than the Buyer), (iii) engage in discussions or
    negotiations with any party (other than the Buyer) concerning any such
    transaction or (iv) execute an agreement with respect to, or otherwise enter
    into, any such transaction without the consent of the Buyer.

        (b) The Company shall immediately notify any party with which
    discussions or negotiations of the nature described in paragraph (a) above
    were pending that the Company is terminating such discussions or
    negotiations. If the Company receives any inquiry, proposal or offer of the
    nature described in paragraph (a) above, the Company shall, within one
    business day after such receipt, notify the Buyer of such inquiry, proposal
    or offer, including the identity of

                                      A-40

    the other party and the terms of such inquiry, proposal or offer and shall
    forward to the Buyer a copy of any electronic or written correspondence
    relating to such inquiry, proposal or offer.

    4.9  EXPENSES.  Except as set forth in Article VI and the Escrow Agreement,
each of the Parties shall bear its own costs and expenses (including legal fees
and expenses) incurred in connection with this Agreement and the transactions
contemplated hereby; provided, however, that if the Merger is consummated, the
Company shall not incur more than an aggregate of $375,000 in legal and
accounting fees and expenses in connection with the Merger.

    4.10  INDEMNIFICATION.

        (a) The Buyer shall not, for a period of six years after the Effective
    Time, take any action to alter or impair any exculpatory or indemnification
    provisions now existing in the Certificate of Incorporation or By-laws of
    the Company for the benefit of any individual who served as a director or
    officer of the Company at any time prior to the Effective Time, except for
    any changes which may be required to conform with changes in applicable law
    and any changes which do not affect the application of such provisions to
    acts or omissions of such individuals prior to the Effective Time.

        (b) From and after the Effective Time, the Buyer agrees that it will,
    and will cause the Surviving Corporation to, indemnify and hold harmless
    each present and former director and officer of the Company (the
    "Indemnified Executives") against any costs or expenses (including
    attorneys' fees), judgments, fines, losses, claims, damages, liabilities or
    amounts paid in settlement incurred in connection with any claim, action,
    suit, proceeding or investigation, whether civil, criminal, administrative
    or investigative, arising out of or pertaining to matters existing or
    occurring at or prior to the Effective Time, whether asserted or claimed
    prior to, at or after the Effective Time, to the fullest extent permitted
    under Delaware law (and the Buyer and the Surviving Corporation shall also
    advance expenses as incurred to the fullest extent permitted under Delaware
    law, provided the Indemnified Executive to whom expenses are advanced
    provides an undertaking to repay such advances if it is ultimately
    determined that such Indemnified Executive is not entitled to
    indemnification).

    4.11  LOCK-UP AND AFFILIATE AGREEMENTS.

        (a) The Company shall use its Reasonable Best Efforts to deliver or
    cause to be delivered to the Buyer as soon as practicable and in any case
    prior to the Effective Date, a Lock-Up Agreement, in the form attached
    hereto as Exhibit B (a "Lock-Up Agreement"), executed by each of the persons
    or entities set forth in Section 4.11(a) of the Company Disclosure Schedule.
    The Buyer shall be entitled to place appropriate legends on the certificates
    evidencing any shares of Buyer Common Stock to be issued to such persons or
    entities hereunder, and to issue appropriate stop transfer instructions to
    the transfer agent for the Buyer Common Stock, setting forth restrictions on
    transfer consistent with the terms of the Lock-Up Agreement.

        (b) In order to help ensure that the issuance of and any resale of the
    Merger Shares will comply with the Securities Act, the Company shall use its
    Reasonable Best Efforts to deliver or cause to be delivered to the Buyer, as
    soon as practicable and in any case prior to the

                                      A-41

    mailing of the Prospectus/Proxy Statement (or, in the case of any person who
    becomes an Affiliate after such date, as soon as practicable after such
    person becomes an Affiliate), an Affiliate Agreement, in the form attached
    hereto as Exhibit C, executed by each of its Affiliates set forth in
    Section 4.11(b) of the Company Disclosure Schedule (unless such Affiliate
    has previously delivered to the Buyer a Voting and Transfer Restriction
    Agreement, as provided in Section 5.2(m) below). The Buyer shall be entitled
    to place appropriate legends on the certificates evidencing any Merger
    Shares to be issued to Affiliates of the Company, and to issue appropriate
    stop transfer instructions to the transfer agent for the Buyer Common Stock,
    setting forth restrictions on transfer consistent with the terms of the
    Affiliate Agreement.

    4.12  LISTING OF MERGER SHARES.  Prior to the Effective Time, the Buyer
shall file a Nasdaq National Market Notification for Listing of Additional
Shares (or comparable notice) (the "Nasdaq Notice") with Nasdaq with respect to
the listing of the Total Consideration on Nasdaq.

    4.13  EXECUTIVE OFFICERS AND BOARD OF DIRECTORS OF THE BUYER.

        (a) Prior to the Effective Time, the Boards of Directors of the Buyer
    and the Company shall each comply as applicable with the provisions of the
    SEC's no-action letter dated January 12, 1999 addressed to Skadden, Arps,
    Slate, Meagher and Flom LLP relating to Section 16(b) of the Exchange Act.

        (b) The Board of Directors of the Buyer shall use its best efforts to
    take all actions necessary to cause the Board of Directors of the Buyer,
    immediately after the Effective Time, to include two members designated by
    the Company. In the event that an open position of the Board of Directors of
    the Buyer is otherwise to be filled prior to the Effective Time, the Buyer
    will seek the concurrence of the Company in the appointment of a third
    person as well, which concurrence will not be unreasonably withheld. The
    Buyer agrees to continue to nominate each director designated by the Company
    pursuant to this Section 4.13, except to the extent such designee dies,
    resigns, refuses to stand for re-election or is otherwise removed from
    office in accordance with the Buyer's Certificate of Incorporation and
    By-laws.

    4.14  DELIVERY OF TAX NOTICES.  If requested by the Buyer, on or before the
Closing (i) the Company will deliver to the Buyer and to the Internal Revenue
Service notices that the Company Shares are not a "U.S. real property interest"
in accordance with the Treasury Regulations under Sections 897 and 1445 of the
Code, or (ii) the Company Stockholders will deliver to the Buyer certifications
that they are not foreign persons in accordance with the Treasury Regulations
under Section 1445 of the Code; provided that if the Company does not provide
the Buyer and the Internal Revenue Service with the notice required under
clause (i) or the Company Stockholders do not timely deliver the certificates
required under clause (ii), the Buyer shall have the right to withhold from the
amount payable (including any Buyer Common Stock) to the Company Stockholders
all amounts required under Section 1445 of the Code.

                                      A-42

                                   ARTICLE V
                      CONDITIONS TO CONSUMMATION OF MERGER

    5.1  CONDITIONS TO EACH PARTY'S OBLIGATIONS.  The respective obligations of
each Party to consummate the Merger are subject to the satisfaction of the
following conditions:

        (a) this Agreement and the Merger shall have received the Requisite
    Company Stockholder Approval and Requisite Buyer Stockholder Approval; and

        (b) the Registration Statement shall have become effective in accordance
    with the provisions of the Securities Act, and there shall not be in effect
    any stop order suspending the effectiveness of the Registration Statement or
    any proceedings seeking such a stop order.

    5.2  CONDITIONS TO OBLIGATIONS OF THE BUYER AND THE TRANSITORY
SUBSIDIARY.  The obligation of each of the Buyer and the Transitory Subsidiary
to consummate the Merger is subject to the satisfaction (or waiver by the Buyer)
of the following additional conditions:

        (a) the number of Dissenting Shares shall not exceed ten percent (10%)
    of the number of outstanding Common Shares as of the Effective Time
    (calculated after giving effect to the conversion into Common Shares of all
    outstanding Preferred Shares);

        (b) the Company shall have obtained (and shall have provided copies
    thereof to the Buyer) all of the waivers, permits, consents, approvals or
    other authorizations, and effected all of the registrations, filings and
    notices, referred to in Section 4.2 which are required on the part of the
    Company;

        (c) the representations and warranties of the Company set forth in the
    first sentence of Section 2.1 and in Section 2.3 and any representations and
    warranties of the Company set forth in this Agreement that are qualified as
    to materiality shall be true and correct in all respects, and all other
    representations and warranties of the Company set forth in this Agreement
    shall be true and correct in all material respects, in each case as of the
    date of this Agreement and as of the Effective Time as though made as of the
    Effective Time, except to the extent such representations and warranties are
    specifically made as of a particular date or as of the date of this
    Agreement (in which case such representations and warranties shall be true
    and correct as of such date);

        (d) the Company shall have performed or complied with in all material
    respects its agreements and covenants required to be performed or complied
    with under this Agreement as of or prior to the Effective Time;

        (e) no Legal Proceeding shall be pending or threatened wherein an
    unfavorable judgment, order, decree, stipulation or injunction would
    (i) prevent consummation of any of the transactions contemplated by this
    Agreement, (ii) cause any of the transactions contemplated by this Agreement
    to be rescinded following consummation or (iii) have a Company Material
    Adverse Effect, and no such judgment, order, decree, stipulation or
    injunction shall be in effect;

        (f) the Company shall have delivered to the Buyer and the Transitory
    Subsidiary a certificate (the "Company Certificate") to the effect that each
    of the conditions specified in clause (a) of Section 5.1 (insofar as it
    relates to the Company) and clauses (a)

                                      A-43

    through (e) (insofar as clause (e) relates to Legal Proceedings involving
    the Company) of this Section 5.2 is satisfied in all respects;

        (g) the Buyer shall have received a "comfort letter" dated as of a date
    not more than two days prior to the date that the Registration Statement is
    declared effective and shall have received a subsequent similar letter dated
    as of a date not more than two days prior to the Effective Time, from
    PricewaterhouseCoopers LLP, auditors for the Company, addressed to the Buyer
    in a customary form reasonably satisfactory to the Buyer;

        (h) the Buyer shall have received from counsel to the Company an opinion
    with respect to the matters set forth in Exhibit D attached hereto,
    addressed to the Buyer and dated as of the Closing Date;

        (i) the Buyer shall have received copies of the resignations, effective
    as of the Effective Time, of each director and officer of the Company (other
    than any such resignations which the Buyer designates, by written notice to
    the Company, as unnecessary);

        (j) the Buyer shall have received an opinion from Hale and Dorr LLP, in
    a form reasonably satisfactory to the Buyer, dated the Closing Date, to the
    effect that the Merger will constitute a reorganization for federal income
    tax purposes within the meaning of Section 368(a) of the Code; provided that
    if Hale and Dorr LLP does not render such opinion, this condition shall
    nonetheless be deemed satisfied if Mintz, Levin, Cohn, Ferris, Glovsky and
    Popeo, P.C. renders such opinion to the Buyer. In rendering such opinion,
    counsel may require and rely upon representations and covenants made by the
    Parties that are customary in transactions of this form;

        (k) the Buyer shall have received such other certificates and
    instruments (including without limitation certificates of good standing of
    the Company in its jurisdiction of organization and the various foreign
    jurisdictions in which it is qualified, certified charter documents,
    certificates as to the incumbency of officers and the adoption of
    authorizing resolutions) as it shall reasonably request in connection with
    the Closing;

        (l) the holders of at least (i) 95% of the Company Shares subject to
    outstanding Options, and (ii) at least 95% of the total number of
    outstanding Company Shares as of the Effective Time shall have signed a
    Lock-up Agreement or Voting and Transfer Restriction Agreement, as
    applicable, by the Closing Date; provided that, not withstanding the
    foregoing subsection (l)(ii), the Company is not required to obtain a
    Lock-up Agreement from any person who holds, in the aggregate, less than
    40,000 Company Shares as of the Effective Time, so long as the aggregate
    number of persons excluded pursuant to this proviso does not exceed the
    lesser of (A) 2% of the total number of outstanding Company Shares as of the
    Effective Time or (B) 20 persons in the aggregate;

        (m) the Buyer shall have received originally-executed Voting and
    Transfer Restriction Agreements in the form attached hereto as Exhibit E
    from each individual or entity set forth in Section 5.2(m) of the Company
    Disclosure Schedule;

        (n) the Escrow Representatives, the Management Members and the Escrow
    Agent (as defined in the Escrow Agreement) shall have executed the Escrow
    Agreement;

                                      A-44

        (o) there shall have been no material adverse change in the business,
    properties, operations, condition (financial or otherwise), assets or
    liabilities of the Company and no event or events shall have occurred that
    could reasonably be expected to have a Company Material Adverse Effect
    (other than as a result of (i) general economic conditions, (ii) business
    and economic conditions generally affecting the biotechnology industry,
    (iii) liabilities directly incurred in connection with this Agreement or the
    transactions contemplated hereby (including litigation brought or threatened
    against the Company or any member of its Board of Directors in respect of
    this Agreement), or (iv) directly attributable to the announcement of the
    transactions contemplated hereby (including loss of personnel, customers or
    suppliers, the delay or cancellation of orders or products or the revision
    of analyst expectations relating to the Company)), and the Buyer shall have
    received a certificate signed on behalf of the Company by its Chief
    Executive Officer and Chief Financial Officer to such effect;

        (p) each of the stockholder agreements, investor rights agreements and
    voting agreements entered into by the Company Stockholders prior to the date
    hereof, registration rights agreements entered into by the Company and other
    parties thereto (including without limitation the holders of Company
    Warrants and Company Notes) prior to the date hereof and any other
    agreements or arrangements by and between the Company and any Company
    Stockholders shall have been terminated by the Company and each of the other
    parties thereto;

        (q) The Board of Directors of the Company shall have recommended to the
    stockholders of the Company, and the stockholders of the Company shall have
    approved, an amendment to the Amended and Restated Certificate of
    Incorporation of the Company substantially in the form of Exhibit F. The
    Company shall have taken all necessary or appropriate action to cause such
    amendment to the Amended and Restated Certificate of Incorporation of the
    Company to be, and the Amended and Restated Certificate of Incorporation of
    the Company as so amended shall be, in full force and effect; and

        (r) each of the employees of the Company listed in Section 5.2(r) of the
    Company Disclosure Schedule shall have entered into (i) a form of Employment
    Offer Letter substantially in the form attached hereto as Exhibit G, setting
    forth such key terms and conditions of employment for each such employee as
    are set forth in Section 5.2(r) of the Company Disclosure Schedule, and
    (ii) a form of Invention, Non-Disclosure and Non-Competition Agreement in
    the form attached hereto as Exhibit H.

    5.3  CONDITIONS TO OBLIGATIONS OF THE COMPANY.  The obligation of the
Company to consummate the Merger is subject to the satisfaction of the following
additional conditions:

        (a) the Buyer shall have filed a Nasdaq Notice with Nasdaq with respect
    to the listing of the Merger Shares thereon;

        (b) the Buyer shall have obtained (and shall have provided copies
    thereof to the Company) all of the waivers, permits, consents, approvals or
    other authorizations, and effected all of the registrations, filings and
    notices, referred to in Section 3.4 which are required on the part of the
    Buyer;

                                      A-45

        (c) the Buyer shall have effected all of the registrations, filings and
    notices referred to in Section 4.2 which are required on the part of the
    Buyer;

        (d) the representations and warranties of the Buyer and the Transitory
    Subsidiary set forth in the first sentence of Section 3.1 and Section 3.3
    and any representations and warranties of the Buyer and the Transitory
    Subsidiary set forth in this Agreement that are qualified as to materiality
    shall be true and correct in all respects, and the representations and
    warranties of the Buyer and the Transitory Subsidiary set forth in this
    Agreement that are not so qualified (other than those set forth in
    Section 3.1 and Section 3.3) shall be true and correct in all material
    respects, in each case as of the date of this Agreement and as of the
    Effective Time as though made as of the Effective Time, except to the extent
    such representations and warranties are specifically made as of a particular
    date or as of the date of this Agreement (in which case such representations
    and warranties shall be true and correct as of such date);

        (e) each of the Buyer and the Transitory Subsidiary shall have performed
    or complied with in all material respects its agreements and covenants
    required to be performed or complied with under this Agreement as of or
    prior to the Effective Time;

        (f) no Legal Proceeding shall be pending or threatened wherein an
    unfavorable judgment, order, decree, stipulation or injunction would
    (i) prevent consummation of any of the transactions contemplated by this
    Agreement, (ii) cause any of the transactions contemplated by this Agreement
    to be rescinded following consummation or (iii) have a Buyer Material
    Adverse Effect, and no such judgment, order, decree, stipulation or
    injunction shall be in effect;

        (g) the Buyer shall have delivered to the Company a certificate (the
    "Buyer Certificate") to the effect that each of the conditions specified in
    clause (a) of Section 5.1 (insofar as it relates to the Buyer),
    Section 5.1(b), and clauses (a) through (f) (insofar as clause (f) relates
    to Legal Proceedings involving the Buyer) of this Section 5.3 is satisfied
    in all respects;

        (h) the Company shall have received a "comfort letter" dated as of the
    date not more than two days prior to the date that the Registration
    Statement is declared effective and shall have received a subsequent similar
    letter dated as of a date not more than two days prior to the Effective
    Time, from Arthur Andersen LLP, auditors for the Buyer, addressed to the
    Company in a customary form reasonably satisfactory to the Company;

        (i) the Company shall have received from counsel to the Buyer and the
    Transitory Subsidiary an opinion with respect to the matters set forth in
    Exhibit I attached hereto, addressed to the Company and dated as of the
    Closing Date;

        (j) the Company shall have received an opinion from Mintz, Levin, Cohn,
    Ferris, Glovsky and Popeo, P.C., in a form reasonably satisfactory to the
    Company, dated the Closing Date, to the effect that the Merger will
    constitute a reorganization for federal income tax purposes within the
    meaning of Section 368(a) of the Code; provided that if Mintz, Levin, Cohn,
    Ferris, Glovsky and Popeo, P.C., does not render such opinion, this
    condition shall nonetheless be deemed satisfied if Hale and Dorr LLP renders
    such opinion to the Company.

                                      A-46

    In rendering such opinion, counsel may require and rely upon representations
    and covenants made by the Parties that are customary in transactions of this
    form;

        (k) the Company shall have received such other certificates and
    instruments (including without limitation certificates of good standing of
    the Buyer and the Transitory Subsidiary in their jurisdiction of
    organization, certified charter documents, certificates as to the incumbency
    of officers and the adoption of authorizing resolutions) as it shall
    reasonably request in connection with the Closing;

        (l) the Buyer, the Escrow Representatives, the Management Members and
    the Escrow Agent shall have executed the Escrow Agreement;

        (m) the Buyer shall have entered into (i) a form of Employment Offer
    Letter attached hereto as Exhibit G with each employee of the Company listed
    in Section 5.2(r) of the Company Disclosure Schedule, setting forth such key
    terms and conditions of employment for each such employee as are set forth
    in Section 5.2(r) of the Company Disclosure Schedule, and (ii) a form of
    Invention, Non-Disclosure and Non-Competition Agreement attached hereto as
    Exhibit H with each such employee; and

        (n) there shall have been no material adverse change in the business,
    properties, operations, condition (financial or otherwise), assets or
    liabilities of the Buyer and no event or events shall have occurred that
    could reasonably be expected to have a Buyer Material Adverse Effect (other
    than as a result of (i) general economic conditions, (ii) business and
    economic conditions generally affecting the biotechnology industry,
    (iii) liabilities directly incurred in connection with this Agreement or the
    transactions contemplated hereby (including litigation brought or threatened
    against the Buyer or any member of its Board of Directors in respect of this
    Agreement), or (iv) directly attributable to the announcement of the
    transactions contemplated hereby (including loss of personnel, customers or
    suppliers, the delay or cancellation of orders of products or the revision
    of analyst expectations relating to the Buyer)) and the Company shall have
    received a certificate signed on behalf of the Buyer by its Chief Executive
    Officer and Chief Financial Officer to such effect, it being understood for
    purposes of this Section 5.3(n) that a decline in the trading price of the
    Buyer Common Stock, in and of itself, shall not constitute a Buyer Material
    Adverse Effect.

                                   ARTICLE VI
                                INDEMNIFICATION

    6.1  INDEMNIFICATION BY THE COMPANY STOCKHOLDERS.  The Company Stockholders
receiving the Merger Shares pursuant to Section 1.5 and the Management Members
receiving the Management Incentive Shares pursuant to Section 1.14
(collectively, the "Holders") shall indemnify the Buyer in respect of, and hold
it harmless against, any and all debts, obligations and other liabilities
(whether absolute, accrued, contingent, fixed or otherwise, or whether known or
unknown, or due or to become due or otherwise), monetary damages, fines, fees,
penalties, interest obligations, deficiencies, losses and expenses (including
without limitation amounts paid in settlement, interest, court costs, costs of
investigators, fees and expenses of attorneys, accountants, financial advisors
and other experts, and other expenses of litigation and, with respect to
Section 6.1(c) below, any amount which the Delaware Court of Chancery determines
a

                                      A-47

Company Stockholder is entitled to receive from the Surviving Corporation or the
Buyer as the fair value of any Dissenting Shares, including any interest to be
paid thereon, in accordance with Section 262 of the Delaware General Corporation
Law ("Damages") incurred or suffered by the Surviving Corporation or the Buyer
or any Affiliate thereof resulting from, relating to or constituting:

        (a) any misrepresentation, breach of warranty or failure to perform any
    covenant or agreement of the Company contained in this Agreement or the
    Company Certificate;

        (b) any failure of any Company Stockholder to have good, valid and
    marketable title to the issued and outstanding Company Shares issued in the
    name of such Company Stockholder, free and clear of all Security Interests;
    or

        (c) any written demand by a Company Stockholder for a judicial
    determination of the fair value of his, hers or its Dissenting Shares in
    accordance with Section 262 of the Delaware General Corporation Law, whether
    or not such Company Stockholder withdraws his or her demand for appraisal at
    any time before or after the Effective Time; provided, however, that the
    Holders shall be liable for Damages incident to this Section 6.1(c) solely
    with respect to Dissenting Shares in excess of five percent (5%) and less
    than or equal to ten percent (10%) of the outstanding Common Shares as of
    the Effective Time (calculated after giving effect to the conversion into
    Common Shares of all outstanding Preferred Shares).

    6.2  INDEMNIFICATION CLAIMS.

        (a) A party entitled, or seeking to assert rights, to indemnification
    under this Article VI (an "Indemnified Party") shall give written
    notification to the party from whom indemnification is sought (the
    "Indemnifying Party") of the commencement of any suit or proceeding relating
    to a third party claim for which indemnification pursuant to this
    Article VI may be sought. Such notification shall be given within 20
    business days after receipt by the Indemnified Party of notice of such suit
    or proceeding, and shall describe in reasonable detail (to the extent known
    by the Indemnified Party) the facts constituting the basis for such suit or
    proceeding and the amount of the claimed damages; provided, however, that no
    delay on the part of the Indemnified Party in notifying the Indemnifying
    Party shall relieve the Indemnifying Party of any liability or obligation
    hereunder except to the extent of any damage or liability caused by or
    arising out of such failure. Within 20 days after delivery of such
    notification, the Indemnifying Party may, upon written notice thereof to the
    Indemnified Party, assume control of the defense of such suit or proceeding
    with counsel reasonably satisfactory to the Indemnified Party; provided that
    (i) the Indemnifying Party may only assume control of such defense if
    (A) it acknowledges in writing to the Indemnified Party that any damages,
    fines, costs or other liabilities that may be assessed against the
    Indemnified Party in connection with such suit or proceeding constitute
    Damages for which the Indemnified Party shall be indemnified pursuant to
    this Article VI and (B) the AD DAMNUM is less than or equal to the amount of
    Damages for which the Indemnifying Party is liable under this Article VI and
    (ii) the Indemnifying Party may not assume control of the defense of a suit
    or proceeding involving criminal liability or in which equitable relief is
    sought against the Indemnified Party. If the Indemnifying Party does not so
    assume control of such defense, the Indemnified Party shall control such
    defense. The party not controlling such defense (the "Non-controlling
    Party") may participate therein at its own

                                      A-48

    expense; provided that if the Indemnifying Party assumes control of such
    defense and the Indemnified Party reasonably concludes that the Indemnifying
    Party and the Indemnified Party have conflicting interests or different
    defenses available with respect to such suit or proceeding, the reasonable
    fees and expenses of counsel to the Indemnified Party shall be considered
    "Damages" for purposes of this Agreement. The party controlling such defense
    (the "Controlling Party") shall keep the Non-controlling Party advised of
    the status of such suit or proceeding and the defense thereof and shall
    consider in good faith recommendations made by the Non-controlling Party
    with respect thereto. The Non-controlling Party shall furnish the
    Controlling Party with such information as it may have with respect to such
    suit or proceeding (including copies of any summons, complaint or other
    pleading which may have been served on such party and any written claim,
    demand, invoice, billing or other document evidencing or asserting the same)
    and shall otherwise cooperate with and assist the Controlling Party in the
    defense of such suit or proceeding. The Indemnifying Party shall not agree
    to any settlement of, or the entry of any judgment arising from, any such
    suit or proceeding without the prior written consent of the Indemnified
    Party, which shall not be unreasonably withheld or delayed. The Indemnified
    Party shall not agree to any settlement of, or the entry of any judgment
    arising from, any such suit or proceeding without the prior written consent
    of the Indemnifying Party, which shall not be unreasonably withheld or
    delayed.

        (b) In order to seek indemnification under this Article VI, the
    Indemnified Party shall give written notification (a "Claim Notice") to the
    Indemnifying Party which contains (i) a description and the amount (the
    "Claimed Amount") of any Damages incurred or reasonably expected to be
    incurred by the Indemnified Party, (ii) a statement that the Indemnified
    Party is entitled to indemnification under this Article VI for such Damages
    and a reasonable explanation of the basis therefor, and (iii) a demand for
    payment (in the manner provided in paragraph (c) below) in the amount of
    such Damages. The Indemnifying Party shall deliver a copy of the Claim
    Notice to the Escrow Agent.

        (c) Within 20 days after delivery of a Claim Notice, the Indemnifying
    Party shall deliver to the Indemnified Party a written response (the
    "Response") in which the Indemnifying Party shall: (i) agree that the
    Indemnified Party is entitled to receive all of the Claimed Amount (in which
    case the Indemnifying Party and the Indemnified Party shall deliver to the
    Escrow Agent, within three days following the delivery of the Response, a
    written notice executed by both parties instructing the Escrow Agent to
    distribute to the Buyer such number of Indemnification Escrow Shares as have
    an aggregate Value (as defined below) equal to the Claimed Amount),
    (ii) agree that the Indemnified Party is entitled to receive part, but not
    all, of the Claimed Amount (the "Agreed Amount") (in which case the
    Indemnifying Party and the Indemnified Party shall deliver to the Escrow
    Agent, within three days following the delivery of the Response, a written
    notice executed by both parties instructing the Escrow Agent to distribute
    to the Buyer such number of Indemnification Escrow Shares as have an
    aggregate Value equal to the Agreed Amount) or (iii) dispute that the
    Indemnified Party is entitled to receive any of the Claimed Amount. If the
    Indemnifying Party in the Response disputes its liability for all or part of
    the Claimed Amount, the Indemnifying Party and the Indemnified Party shall
    follow the procedures set forth in Section 6.2(d) for the resolution of such
    dispute (a "Dispute"). For purposes of this Article VI, the "Value" of any
    Indemnification Escrow Shares delivered in satisfaction of an indemnity
    claim shall be the average of the closing prices for a share of Buyer Common
    Stock as quoted on Nasdaq, as reported by Nasdaq, for the thirty (30)

                                      A-49

    consecutive trading days immediately preceding the date which is three
    (3) calendar days prior to the date of distribution of such Indemnification
    Escrow Shares pursuant to this Article VI (subject to equitable adjustment
    in the event of any stock split, stock dividend, reverse stock split or
    similar event affecting the Buyer Common Stock since the beginning of such
    thirty-day period), multiplied by the number of such Indemnification Escrow
    Shares.

        (d) During the 60-day period following the delivery of a Response that
    reflects a Dispute, the Indemnifying Party and the Indemnified Party shall
    use good faith efforts to resolve the Dispute. If the Dispute is not
    resolved within such 60-day period, the Indemnifying Party and the
    Indemnified Party shall discuss in good faith the submission of the Dispute
    to a mutually acceptable alternative dispute resolution procedure (which may
    be non-binding or binding upon the parties, as they agree in advance) (the
    "ADR Procedure"). In the event the Indemnifying Party and the Indemnified
    Party agree upon an ADR Procedure, such parties shall, in consultation with
    the chosen dispute resolution service (the "ADR Service"), promptly agree
    upon a format and timetable for the ADR Procedure, agree upon the rules
    applicable to the ADR Procedure, and promptly undertake the ADR Procedure.
    The provisions of this Section 6.2(d) shall not obligate the Indemnifying
    Party and the Indemnified Party to pursue an ADR Procedure or prevent either
    such party from pursuing the Dispute in a court of competent jurisdiction;
    provided that, if the Indemnifying Party and the Indemnified Party agree to
    pursue an ADR Procedure, neither the Indemnifying Party nor the Indemnified
    Party may commence litigation or seek other remedies with respect to the
    Dispute prior to the completion of such ADR Procedure. Any ADR Procedure
    undertaken by the Indemnifying Party and the Indemnified Party shall be
    considered a compromise negotiation for purposes of federal and state rules
    of evidence, and all statements, offers, opinions and disclosures (whether
    written or oral) made in the course of the ADR Procedure by or on behalf of
    the Indemnifying Party, the Indemnified Party or the ADR Service shall be
    treated as confidential and, where appropriate, as privileged work product.
    Such statements, offers, opinions and disclosures shall not be discoverable
    or admissible for any purposes in any litigation or other proceeding
    relating to the Dispute (provided that this sentence shall not be construed
    to exclude from discovery or admission any matter that is otherwise
    discoverable or admissible). The fees and expenses of any ADR Service used
    by the Indemnifying Party and the Indemnified Party shall be shared equally
    by the Indemnifying Party and the Indemnified Party. The Indemnifying Party
    and the Indemnified Party shall deliver to the Escrow Agent, promptly
    following the resolution of the Dispute (whether by mutual agreement,
    pursuant to an ADR Procedure, as a result of a judicial decision or
    otherwise), a written notice executed by both parties instructing the Escrow
    Agent as to what (if any) portion of the Indemnification Escrow Shares shall
    be distributed to the Buyer (which notice shall be consistent with the terms
    of the resolution of the Dispute).

        (e) Notwithstanding the other provisions of this Section 6.2, if a third
    party asserts (other than by means of a lawsuit) that the Indemnified Party
    is liable to such third party for a monetary or other obligation which may
    constitute or result in Damages for which the Indemnified Party may be
    entitled to indemnification pursuant to this Article VI, and the Indemnified
    Party reasonably determines that it has a valid business reason to fulfill
    such obligation, then (i) the Indemnified Party shall be entitled to satisfy
    such obligation, without prior notice to or consent from the Indemnifying
    Party, (ii) the Indemnified Party may subsequently make a claim for
    indemnification in accordance with the provisions of this Article VI, and
    (iii) the Indemnified Party shall be reimbursed, in accordance with the
    provisions

                                      A-50

    of this Article VI, for any such Damages for which it is entitled to
    indemnification pursuant to this Article VI (subject to the right of the
    Indemnifying Party to dispute the Indemnified Party's entitlement to
    indemnification, or the amount for which it is entitled to indemnification,
    under the terms of this Article VI).

        (f) For purposes of this Section 6.2 and the last three sentences of
    Section 6.3, any references to the Indemnifying Party (except provisions
    relating to an obligation to make payments provided for in Section 6.2 or
    Section 6.3) shall be deemed to refer to the Escrow Representatives. The
    Escrow Representatives shall have full power and authority on behalf of each
    Holder to take any and all actions on behalf of, execute any and all
    instruments on behalf of, and execute or waive any and all rights of, the
    Holders under this Article VI. The Escrow Representatives shall have no
    liability to any Holder for any action taken or omitted on behalf of the
    Holders pursuant to this Article VI.

    6.3  SURVIVAL OF REPRESENTATIONS AND WARRANTIES.  All representations and
warranties contained in this Agreement, the Company Certificate or the Buyer
Certificate shall (a) survive the Closing and any investigation at any time made
by or on behalf of an Indemnified Party and (b) shall expire on the date which
is the end of the fifteenth (15th) full month following the Closing Date. If the
Indemnified Party delivers to an Indemnifying Party, before expiration of a
representation or warranty, either a Claim Notice based upon a breach of such
representation or warranty, or a notice that, as a result of a legal proceeding
instituted by or written claim made by a third party, the Indemnified Party
reasonably expects to incur Damages as a result of a breach of such
representation or warranty (an "Expected Claim Notice"), then such
representation or warranty shall survive until, but only for purposes of, the
resolution of the matter covered by such notice. The Indemnified Party shall
deliver a copy of the Expected Claim Notice to the Escrow Agent and
Indemnification Escrow Shares shall be retained in escrow after the Termination
Date (as defined in the Escrow Agreement) with respect to such Expected Claim
Notice. If the legal proceeding or written claim with respect to which an
Expected Claim Notice has been given is definitively withdrawn or resolved in
favor of the Indemnified Party, the Indemnified Party shall promptly so notify
the Indemnifying Party; and the Indemnifying Party and the Indemnified Party
shall promptly deliver to the Escrow Agent a written notice executed by both
parties instructing the Escrow Agent to distribute such retained Indemnification
Escrow Shares to the Holders in accordance with the terms of the Escrow
Agreement.

    6.4  LIMITATIONS.

        (a) Notwithstanding anything to the contrary herein, (i) the aggregate
    liability of the Holders for Damages under this Article VI shall not exceed
    the aggregate Value (as defined in the Escrow Agreement) of the
    Indemnification Escrow Shares and (ii) the Holders shall be liable under
    this Article VI only for that portion of the aggregate Damages for which
    they would otherwise be liable which exceeds Five Hundred Thousand Dollars
    ($500,000). For purposes solely of this Article VI, all representations and
    warranties of the Company in Article II (other than Section 2.27) shall be
    construed as if the term "material" and any reference to "Company Material
    Adverse Effect" (and variations thereof) were omitted from such
    representations and warranties.

                                      A-51

        (b) The Escrow Agreement is intended to secure the indemnification
    obligations of the Holders under this Agreement.

        (c) Except with respect to claims based on fraud, after the Closing, the
    rights of the Indemnified Party under this Article VI and the Escrow
    Agreement shall be the exclusive remedy of the Indemnified Party with
    respect to claims resulting from or relating to any misrepresentation,
    breach of warranty or failure to perform any covenant or agreement contained
    in this Agreement.

        (d) No Holder shall have any right of contribution against the Company
    or the Surviving Corporation with respect to any breach by the Company of
    any of its representations, warranties, covenants or agreements.

                                      A-52

                                  ARTICLE VII
                                  TERMINATION

    7.1  TERMINATION OF AGREEMENT.  The Parties may terminate this Agreement
prior to the Effective Time (whether before or after Requisite Company
Stockholder Approval or Requisite Buyer Stockholder Approval), as provided
below:

        (a) the Parties may terminate this Agreement by mutual written consent;

        (b) the Buyer may terminate this Agreement by giving written notice to
    the Company in the event the Company is in breach of any representation,
    warranty or covenant contained in this Agreement, and such breach,
    individually or in combination with any other such breach, (i) would cause
    the conditions set forth in clauses (c) or (d) of Section 5.2 not to be
    satisfied and (ii) is not cured within 20 days following delivery by the
    Buyer to the Company of written notice of such breach;

        (c) the Company may terminate this Agreement by giving written notice to
    the Buyer in the event the Buyer or the Transitory Subsidiary is in breach
    of any representation, warranty or covenant contained in this Agreement, and
    such breach, individually or in combination with any other such breach,
    (i) would cause the conditions set forth in clauses (c) or (d) of
    Section 5.3 not to be satisfied and (ii) is not cured within 20 days
    following delivery by the Company to the Buyer of written notice of such
    breach;

        (d) any Party may terminate this Agreement by giving written notice to
    the other Parties at any time after either the Buyer's stockholders entitled
    to vote upon the issuance of the Merger Shares or the Company Stockholders
    have voted on whether to approve this Agreement and the Merger in the event
    this Agreement and the Merger failed to receive the Requisite Buyer
    Stockholder Approval or Requisite Company Stockholder Approval, as the case
    may be;

        (e) the Buyer may terminate this Agreement by giving written notice to
    the Company if the Closing shall not have occurred on or before April 30,
    2001 by reason of the failure of any condition precedent under Section 5.1
    or 5.2 hereof (unless the failure results primarily from a breach by the
    Buyer or the Transitory Subsidiary of any representation, warranty or
    covenant contained in this Agreement); or

        (f) the Company may terminate this Agreement by giving written notice to
    the Buyer and the Transitory Subsidiary if the Closing shall not have
    occurred on or before April 30, 2001 by reason of the failure of any
    condition precedent under Section 5.1 or 5.3 hereof (unless the failure
    results primarily from a breach by the Company of any representation,
    warranty or covenant contained in this Agreement).

    7.2  EFFECT OF TERMINATION.  If any Party terminates this Agreement pursuant
to Section 7.1, all obligations of the Parties hereunder shall terminate without
any liability of any Party to any other Party; provided that, if this Agreement
is terminated by either party as a result of the other party's failure to
perform or comply in all material respects with the agreements and covenants
required by it to be performed or complied with under this Agreement, then the
non-terminating party will tender a cash payment of Two Million Dollars
($2,000,000) to the

                                      A-53

terminating party within five (5) business days after notice from the
terminating party of its termination of this Agreement.

                                  ARTICLE VIII
                                  DEFINITIONS

    For purposes of this Agreement, each of the following defined terms is
defined in the Section of this Agreement indicated below.



DEFINED TERM                                              SECTION
------------                                              -------
                                                       
ADR Procedure...........................................  6.2(d)
ADR Service.............................................  6.2(d)
Affiliate...............................................  2.15(a)(vii)
Agreed Amount...........................................  6.2(c)
Buyer...................................................  Introduction
Buyer Average Stock Price...............................  7.1(g)(i)
Buyer Certificate.......................................  5.3(g)
Buyer Common Stock......................................  1.5
Buyer Disclosure Schedule...............................  3
Buyer ERISA Affiliate...................................  3.13(a)
Buyer Intellectual Property Rights......................  3.9(b)
Buyer Material Adverse Effect...........................  3.1
Buyer Ongoing Clinical Programs.........................  3.8
Buyer Options...........................................  3.2
Buyer Preferred Stock...................................  3.2
Buyer Reports...........................................  3.5
Buyer Stock.............................................  3.2
Buyer Third Party License...............................  3.9(a)
Buyer Warrants..........................................  3.2
CERCLA..................................................  2.21(a)
Certificates............................................  1.7(a)
Certificate of Merger...................................  1.1
Claim Notice............................................  6.2(b)
Claimed Amount..........................................  6.2(b)
Closing.................................................  1.2
Closing Date............................................  1.2
Code....................................................  1.9(a)
Common Conversion Ratio.................................  1.5(a)
Common Shares...........................................  1.5(a)
Company.................................................  Introduction
Company Certificate.....................................  5.2(g)
Company Common Warrants.................................  1.9(d)(i)
Company Disclosure Schedule.............................  Article II-Preamble
Company ERISA Affiliate.................................  2.20(a)(iii)
Company Intellectual Property Rights....................  2.14(b)
Company Material Adverse Effect.........................  2.1


                                      A-54




DEFINED TERM                                              SECTION
------------                                              -------
                                                       
Company Ongoing Clinical Programs.......................  2.13
Company Options.........................................  1.9(a)
Company Notes...........................................  1.9(f)
Company Series A Warrants...............................  1.9(d)(ii)
Company Series B Warrants...............................  1.9(d)(iii)
Company Series A Notes..................................  1.9(f)(i)
Company Series B Notes..................................  1.9(f)(ii)
Company Series C-1 Notes................................  1.9
Company Shares..........................................  1.5(g)
Company Stockholder.....................................  1.3(d)
Company Stockholders' Meeting...........................  7.1(g)
Company Stockholder Escrow Shares.......................  1.5(g)
Company Third Party Licenses............................  2.14(a)
Company Warrants........................................  1.9(d)
Controlling Party.......................................  6.2(a)
Damages.................................................  6.1
Dispute.................................................  6.2(c)
Dissenting Shares.......................................  1.6(a)
Effective Time..........................................  1.1
Employee Benefit Plan...................................  2.20(a)(i)
Environmental Law.......................................  2.21(a)
ERISA...................................................  2.20(a)(ii)
Escrow Agreement........................................  1.3(f)
Escrow Agent............................................  1.3(f)
Escrow Representatives..................................  1.3(f)
Escrow Shares...........................................  1.14
Expected Claim Notice...................................  6.3
Exchange Act............................................  2.15(a)(vii)
Financial Statements....................................  2.6
GAAP....................................................  2.6
Governmental Entity.....................................  2.4
Holders.................................................  6.1
Indemnification Escrow Shares...........................  1.10(a)
Indemnified Executives..................................  4.10
Indemnified Party.......................................  6.2(a)
Indemnifying Party......................................  6.2(a)
Initial Shares..........................................  1.5(g)
Intellectual Property Rights............................  2.14(b)
Legal Proceedings.......................................  2.18
Lock-up Agreement.......................................  4.11
Management Escrow Shares................................  1.14
Management Incentive Plan...............................  1.14
Management Incentive Shares.............................  1.14
Management Member.......................................  1.14
Materials of Environmental Concern......................  2.21(b)
Merger..................................................  1.1


                                      A-55




DEFINED TERM                                              SECTION
------------                                              -------
                                                       
Merger Shares...........................................  1.5(g)
Milestone Escrow Shares.................................  1.10(a)
Most Recent Balance Sheet...............................  2.8
Most Recent Balance Sheet Date..........................  2.6
Nasdaq..................................................  1.8
Nasdaq Notice...........................................  4.12
Non-controlling Party...................................  6.2(a)
Company Options.........................................  1.9(a)
Ordinary Course of Business.............................  2.4
Parties.................................................  Introduction
Permits.................................................  2.23
Preferred Shares........................................  1.5(f)
Prospectus/Proxy Statement..............................  4.3(a)
Reasonable Best Efforts.................................  4.1
Registration Statement..................................  4.3(a)
Response................................................  6.2(c)
Requisite Buyer Stockholder Approval....................  3.3
Requisite Company Stockholder Approval..................  2.3
SEC.....................................................  3.5
Securities Act..........................................  1.9(c)
Security Interest.......................................  2.4
Series A Preferred Shares...............................  1.5(b)
Series A Preferred Conversion Ratio.....................  1.5(b)
Series B Preferred Shares...............................  1.5(c)
Series B Preferred Conversion Ratio.....................  1.5(c)
Series C-1 Preferred Shares.............................  1.5(d)
Series C-1 Preferred Conversion Ratio...................  1.5(d)
Series C-2 Preferred Shares.............................  1.5(e)
Series C-2 Preferred Conversion Ratio...................  1.5(e)
Surviving Corporation...................................  1.1
Taxes...................................................  2.9(a)(i)
Tax Returns.............................................  2.9(a)(ii)
Total Consideration.....................................  1.5
Transitory Subsidiary...................................  Introduction
Value...................................................  6.2(c)


                                   ARTICLE IX
                                 MISCELLANEOUS

    9.1  PRESS RELEASES AND ANNOUNCEMENTS.  No Party shall issue any press
release or public announcement relating to the subject matter of this Agreement
without the prior written approval of the other Parties; PROVIDED, HOWEVER, that
any Party may make any public disclosure it believes in good faith is required
by applicable law, regulation or stock market rule (in which case the disclosing
Party shall use reasonable efforts to advise the other Parties and provide them
with a copy of the proposed disclosure prior to making the disclosure).

                                      A-56

    9.2  NO THIRD PARTY BENEFICIARIES.  This Agreement shall not confer any
rights or remedies upon any person other than the Parties and their respective
successors and permitted assigns; PROVIDED, HOWEVER, that (a) the provisions in
Article I concerning issuance of the Merger Shares and Management Inventive
Shares and Article VI concerning indemnification are intended for the benefit of
the Company Stockholders and Management Members and (b) the provisions in
Section 4.10 concerning indemnification are intended for the benefit of the
individuals specified therein and their successors and assigns.

    9.3  ENTIRE AGREEMENT.  This Agreement (including the documents referred to
herein) constitutes the entire agreement among the Parties and supersedes any
prior understandings, agreements or representations by or among the Parties,
written or oral, with respect to the subject matter hereof; provided that the
Confidentiality Agreement dated June 13, 2000 between the Buyer and the Company
shall remain in effect in accordance with its terms.

    9.4  SUCCESSION AND ASSIGNMENT.  This Agreement shall be binding upon and
inure to the benefit of the Parties named herein and their respective successors
and permitted assigns. No Party may assign either this Agreement or any of its
rights, interests or obligations hereunder without the prior written approval of
the other Parties; provided that the Transitory Subsidiary may assign its
rights, interests and obligations hereunder to an Affiliate of the Buyer.

    9.5  COUNTERPARTS AND FACSIMILE SIGNATURE.  This Agreement may be executed
in two or more counterparts, each of which shall be deemed an original but all
of which together shall constitute one and the same instrument. This Agreement
may be executed by facsimile signature.

    9.6  HEADINGS.  The section headings contained in this Agreement are
inserted for convenience only and shall not affect in any way the meaning or
interpretation of this Agreement.

    9.7  NOTICES.  All notices, requests, demands, claims, and other
communications hereunder shall be in writing. Any notice, request, demand, claim
or other communication hereunder shall be deemed duly delivered four business
days after it is sent by registered or certified mail, return receipt requested,
postage prepaid, or one business day after it is sent for next business day
delivery via a reputable nationwide overnight courier service, in each case to
the intended recipient as set forth below:




                             
       IF TO THE COMPANY:       Eligix, Inc.
                                200 Boston Avenue
                                Medford, MA 02155
                                Attention: President

                 Copy to:       Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
                                One Financial Center
                                Boston, MA 02111
                                Attn: William T. Whelan, Esq.


                                      A-57





                             
   IF TO THE BUYER OR THE       BioTransplant Incorporated
   TRANSITORY SUBSIDIARY:       Building 75
                                Third Avenue
                                Charlestown, MA 02129
                                Attention: Chief Executive Officer

                 Copy to:       Hale and Dorr LLP
                                60 State Street
                                Boston, MA 02109
                                Attn: Steven D. Singer, Esq.


    Any Party may give any notice, request, demand, claim or other communication
hereunder using any other means (including personal delivery, expedited courier,
messenger service, telecopy, telex, ordinary mail or electronic mail), but no
such notice, request, demand, claim or other communication shall be deemed to
have been duly given unless and until it actually is received by the party for
whom it is intended. Any Party may change the address to which notices,
requests, demands, claims, and other communications hereunder are to be
delivered by giving the other Parties notice in the manner herein set forth.

    9.8  GOVERNING LAW.  This Agreement shall be governed by and construed in
accordance with the internal laws of the State of Delaware without giving effect
to any choice or conflict of law provision or rule (whether of the State of
Delaware or any other jurisdiction) that would cause the application of laws of
any jurisdictions other than those of the State of Delaware.

    9.9  AMENDMENTS AND WAIVERS.  The Parties may mutually amend any provision
of this Agreement at any time prior to the Effective Time; PROVIDED, HOWEVER,
that any amendment effected subsequent to the Requisite Company Stockholder
Approval and or Requisite Buyer Stockholder Approval shall be subject to any
restrictions contained in the Delaware General Corporation Law. No amendment of
any provision of this Agreement shall be valid unless the same shall be in
writing and signed by all of the Parties. No waiver of any right or remedy
hereunder shall be valid unless the same shall be in writing and signed by the
Party giving such waiver. No waiver by any Party with respect to any default,
misrepresentation or breach of warranty or covenant hereunder shall be deemed to
extend to any prior or subsequent default, misrepresentation or breach of
warranty or covenant hereunder or affect in any way any rights arising by virtue
of any prior or subsequent such occurrence.

    9.10  SEVERABILITY.  Any term or provision of this Agreement that is invalid
or unenforceable in any situation in any jurisdiction shall not affect the
validity or enforceability of the remaining terms and provisions hereof or the
validity or enforceability of the offending term or provision in any other
situation or in any other jurisdiction. If the final judgment of a court of
competent jurisdiction declares that any term or provision hereof is invalid or
unenforceable, the Parties agree that the court making the determination of
invalidity or unenforceability shall have the power to limit the term or
provision, to delete specific words or phrases, or to replace any invalid or
unenforceable term or provision with a term or provision that is valid and
enforceable

                                      A-58

and that comes closest to expressing the intention of the invalid or
unenforceable term or provision, and this Agreement shall be enforceable as so
modified.

    9.11  SUBMISSION TO JURISDICTION.  Each of the Parties (a) submits to the
jurisdiction of any state or federal court sitting in the Commonwealth of
Massachusetts in any action or proceeding arising out of or relating to this
Agreement, (b) agrees that all claims in respect of such action or proceeding
may be heard and determined in any such court, and (c) agrees not to bring any
action or proceeding arising out of or relating to this Agreement in any other
court. Each of the Parties waives any defense of inconvenient forum to the
maintenance of any action or proceeding so brought and waives any bond, surety
or other security that might be required of any other Party with respect
thereto. Any Party may make service on another Party by sending or delivering a
copy of the process to the Party to be served at the address and in the manner
provided for the giving of notices in Section 9.7. Nothing in this
Section 9.11, however, shall affect the right of any Party to serve legal
process in any other manner permitted by law.

    9.12  CONSTRUCTION.

        (a) The language used in this Agreement shall be deemed to be the
    language chosen by the Parties to express their mutual intent, and no rule
    of strict construction shall be applied against any Party.

        (b) Any reference to any federal, state, local or foreign statute or law
    shall be deemed also to refer to all rules and regulations promulgated
    thereunder, unless the context requires otherwise.

                 [Remainder of page intentionally left blank.]

                                      A-59

    IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date
first above written.


                                                         
                                                       BIOTRANSPLANT INCORPORATED

                                                       By:                /s/ ELLIOT LEBOWITZ
                                                               ----------------------------------------

                                                       Title:              President and CEO
                                                               ----------------------------------------

                                                       BT/EL ACQUISITION CO.

                                                       By:                /s/ ELLIOT LEBOWITZ
                                                               ----------------------------------------

                                                       Title:                  President
                                                               ----------------------------------------

                                                       ELIGIX, INC.

                                                       By:                /s/ WALTER C. OGIER
                                                               ----------------------------------------

                                                       Title:              President and CEO
                                                               ----------------------------------------


                                      A-60

    The undersigned, being the duly elected Secretary of the Transitory
Subsidiary, hereby certifies that this Agreement has been adopted by a majority
of the votes represented by the outstanding shares of capital stock of the
Transitory Subsidiary entitled to vote on this Agreement.

                                          --------------------------------------
                                          Secretary

    The undersigned, being the duly elected Secretary of the Company, hereby
certifies that this Agreement has been adopted by a majority of the votes
represented by the outstanding Company Shares entitled to vote on this
Agreement.

                                          --------------------------------------
                                          Secretary

                                      A-61

                                   EXHIBIT A

                                ESCROW AGREEMENT

                                ESCROW AGREEMENT

    This Escrow Agreement is entered into as of       , by and among
BioTransplant Incorporated, a Delaware corporation (the "Buyer"), each of the
persons named on the signature pages hereto under the heading "Management
Members" (the "Management Members"), Robert Momsen and Pieter Schiller (the
"Escrow Representatives") and The American Stock Transfer and Trust Company (the
"Escrow Agent"). Capitalized terms used herein but not defined shall have the
meaning ascribed to them in the Merger Agreement (defined below).

    WHEREAS, the Buyer, BT/EL Acquisition Co., a wholly owned subsidiary of the
Buyer (the "Subsidiary"), and Eligix, Inc. (the "Company") have entered into an
Agreement and Plan of Merger dated December 8, 2000 (the "Merger Agreement")
pursuant to which the Subsidiary will be merged (the "Merger") with and into the
Company which, as the surviving corporation (the "Surviving Corporation"), will
become a wholly-owned subsidiary of the Buyer;

    WHEREAS, pursuant to the Merger Agreement, the Company Stockholders and the
Management Members will receive shares of Buyer Common Stock;

    WHEREAS, the Merger Agreement provides that an escrow account will be
established to secure (i) the indemnification obligations of the Company
Stockholders receiving consideration pursuant to Section 1.5 of the Merger
Agreement and the Management Members receiving consideration pursuant to
Section 1.14 of the Merger Agreement (collectively, the "Holders") to the Buyer
and (ii) the payment of fifty percent (50%) of the Escrow Shares (as defined
below) (the "Milestone Escrow Shares") to the Company Stockholders and the
Management Members, subject to the satisfaction of the conditions set forth in
Section 2(c) herein; and

    WHEREAS, the parties hereto desire to establish the terms and conditions
pursuant to which such escrow account will be established and maintained;

    NOW, THEREFORE, the parties hereto hereby agree as follows:

    1.  CONSENT OF HOLDERS.  The Holders have, either by virtue of their
approval of the Merger Agreement or through the execution of an instrument to
such effect or through their execution of this Agreement (in the case of the
Management Members), consented to: (a) the establishment of this escrow to
secure (i) the Holders' indemnification obligations under Article VI of the
Merger Agreement and (ii) the payment of the Milestone Escrow Shares to the
Company Stockholders and the Management Members, subject to the satisfaction of
the conditions set forth in Section 2(c) herein, in each case in the manner set
forth herein, (b) the appointment of the Escrow Representatives as their
representatives for purposes of this Agreement and as attorneys-in-fact and
agents for and on behalf of each Holder, and the taking by the Escrow
Representatives of any and all actions and the making of any decisions required
or permitted to be taken or made by them under this Agreement and (c) all of the
other terms, conditions and limitations in this Agreement.

    2.  ESCROW AND INDEMNIFICATION.

        (a) Escrow of Shares. Simultaneously with the execution of this
    Agreement, the Buyer shall deposit with the Escrow Agent a certificate for
          shares of Buyer Common Stock, as determined pursuant to Section 1.5 of
    the Merger Agreement, issued in the name of the Escrow Agent or its nominee.
    The Escrow Agent hereby acknowledges receipt of such stock certificate.
    Within seventy-five (75) days after the date of this Agreement, the Buyer
    shall deposit with the Escrow Agent a certificate for 198,000 shares of
    Buyer Common Stock, in accordance with Section 1.14 of the Merger Agreement,
    issued in the name of the Escrow Agent or its nominee. The Buyer may from
    time to time deposit with the Escrow Agent additional shares of Buyer Common
    Stock pursuant to the final sentence of Section 1.6(a) of the Merger
    Agreement. The aggregate shares deposited with the Escrow Agent pursuant to
    the first and second sentences of this Section 2(a), together with any
    further shares deposited by the Buyer pursuant to the immediately preceding
    sentence, are referred to herein as the "Escrow Shares." The Escrow Shares
    shall be held as a trust fund and shall not be subject to any lien,
    attachment, trustee

    process or any other judicial process of any creditor of any party hereto.
    The Escrow Agent agrees to hold the Escrow Shares in an escrow account (the
    "Escrow Account"), subject to the terms and conditions of this Agreement.

        (b) INDEMNIFICATION. The Holders have agreed to indemnify and hold
    harmless the Buyer from and against specified Damages (as defined in
    Section 6.1 of the Merger Agreement) in accordance with Article VI of the
    Merger Agreement. Fifty percent (50%) of the Escrow Shares (the
    "Indemnification Escrow Shares") shall be security for such indemnity
    obligation of the Holders, subject to the limitations, and in the manner
    provided, in this Agreement.

        (c) MILESTONE ESCROW SHARES. The Milestone Escrow Shares shall be held
    by the Escrow Agent for issuance solely upon the receipt by the Buyer, on or
    before December 31, 2001, of written authorization or other customary
    evidence of approval from a recognized Notified Body under the European
    Medical Device Directives (currently elected by the Company to be TUV
    Product Services) in the European Union to affix the CE mark, denoting
    conformity with European standards for safety, to the Company's TCell-HDM
    product (the "Milestone"). The Buyer shall provide the funding,
    authorizations and other resources reasonably necessary to meet the
    Milestone, as determined in good faith by its Board of Directors; provided
    that to the extent that any dispute arises with respect to whether the Buyer
    has allocated reasonably necessary resources, the good faith determination
    of the Buyer's Board of Directors with respect to the matter shall include
    the determination of the members of the Board of Directors who have been
    designated to serve on the Board of Directors in accordance with
    Section 4.13 of the Merger Agreement.

        (d) DIVIDENDS, ETC. Any securities distributed in respect of or in
    exchange for any of the Escrow Shares, whether by way of stock dividends,
    stock splits or otherwise, shall be issued in the name of the Escrow Agent
    or its nominee, and shall be delivered to the Escrow Agent, who shall hold
    such securities in the Escrow Account. Such securities shall be considered
    Escrow Shares for purposes hereof. Any cash dividends or property (other
    than securities) distributed in respect of the Escrow Shares shall promptly
    be distributed by the Escrow Agent to the Holders in accordance with
    Section 3(d).

        (e) VOTING OF SHARES. The Escrow Representatives shall have the right,
    in their sole discretion, on behalf of the Holders, to direct the Escrow
    Agent in writing as to the exercise of any voting rights pertaining to the
    Escrow Shares, and the Escrow Agent shall comply with any such written
    instructions. In the absence of such instructions, the Escrow Agent shall
    not vote any of the Escrow Shares. The Escrow Representatives shall have no
    obligation to solicit consents or proxies from the Holders for purposes of
    any such vote.

        (f) Transferability. The respective interests of the Holders in the
    Escrow Shares shall not be assignable or transferable, other than by
    operation of law. Notice of any such assignment or transfer by operation of
    law shall be given to the Escrow Agent and the Buyer, and no such assignment
    or transfer shall be valid until such notice is given.

    3.  DISTRIBUTION OF ESCROW SHARES.

        (a) The Escrow Agent shall distribute the Escrow Shares only in
    accordance with (i) a written instrument delivered to the Escrow Agent that
    is executed by both the Buyer and the Escrow Representatives and that
    instructs the Escrow Agent as to the distribution of some or all of the
    Escrow Shares, (ii) an order of a court of competent jurisdiction, a copy of
    which is delivered to the Escrow Agent by either the Buyer or the Escrow
    Representatives, that instructs the Escrow Agent as to the distribution of
    some or all of the Escrow Shares, (iii) the provisions of Section 3(b)
    hereof or (iv) the provisions of Section 3(c) hereof.

        (b) Upon delivery to the Escrow Agent of a written instrument of
    instruction that is executed by both the Buyer and the Escrow
    Representatives within five business days after the date which is

                                  Exhibit A-2

    the end of the fifteenth (15th) full month following the date of this
    Agreement (the "Termination Date"), the Escrow Agent shall distribute to the
    Holders all of the Indemnification Escrow Shares then held in escrow,
    registered in the name of the Holders. Notwithstanding the foregoing, if the
    Buyer has previously delivered to the Escrow Agent a copy of a Claim Notice
    (as defined in Section 6.2(b) of the Merger Agreement) and the Escrow Agent
    has not received written notice of the resolution of the claim covered
    thereby, or if the Buyer has previously delivered to the Escrow Agent a copy
    of an Expected Claim Notice (as defined in Section 6.3 of the Merger
    Agreement) and the Escrow Agent has not received written notice of the
    resolution of the anticipated claim covered thereby, the Escrow Agent shall
    retain in escrow after the Termination Date such number of Indemnification
    Escrow Shares as have a Value (as defined in Section 4 below) equal to the
    Claimed Amount covered by such Claim Notice or equal to the estimated amount
    of Damages set forth in such Expected Claim Notice, as the case may be. Any
    Indemnification Escrow Shares so retained in escrow shall be distributed
    only in accordance with the terms of clauses (i) or (ii) of Section 3(a)
    hereof.

        (c) In the event the Milestone is achieved, the Escrow Agent shall
    distribute to the Holders the Milestone Escrow Shares then held in escrow,
    registered in the name of the Holders. In the event the Milestone is not
    achieved, the Escrow Agent shall distribute to the Buyer the Milestone
    Escrow Shares then held in escrow, registered in the name of the Buyer. The
    Escrow Agent shall distribute the Milestone Escrow Shares in accordance with
    this Section 3(c) within five (5) business days after the date on which it
    has received a written instrument that is executed by both the Buyer and the
    Escrow Representatives and that instructs the Escrow Agent as to the proper
    distribution of the Milestone Escrow Shares. The Buyer and the Escrow
    Representatives agree in good faith to prepare written instructions to the
    Escrow Agent as promptly as practicable after achievement of the Milestone
    (or failure to achieve the Milestone).

        (d) Any distribution of all or a portion of the Escrow Shares (or cash
    or other property pursuant to Section 2(d)) to the Holders shall be made by
    delivery of stock certificates issued in the name of the Holders covering
    such percentage of the Escrow Shares being distributed as is calculated in
    accordance with the percentages set forth opposite such holders' respective
    names on ATTACHMENT A attached hereto; PROVIDED, HOWEVER, that the Escrow
    Agent shall withhold the distribution of the portion of the Escrow Shares
    otherwise distributable to a Holder who has not, according to a written
    notice provided by the Buyer to the Escrow Agent, prior to such
    distribution, surrendered pursuant to the terms of the Merger Agreement his,
    her or its stock certificates formerly representing shares of stock of the
    Company, if applicable, and PROVIDED FURTHER that such ATTACHMENT A shall be
    appropriately revised by the Buyer in the event the Buyer deposits
    additional Escrow Shares with the Escrow Agent pursuant to the final
    sentence of Section 1.6(a) of the Merger Agreement following the date of
    this Agreement. Any such withheld shares shall be delivered to the Buyer
    promptly after the Termination Date, and shall be delivered by the Buyer to
    the Holders to whom such shares would have otherwise been distributed upon
    surrender of their Company stock certificates. Distributions to the Holders
    shall be made by mailing stock certificates to such holders at their
    respective addresses shown on ATTACHMENT A (or such other address as may be
    provided in writing to the Escrow Agent by any such holder). No fractional
    Escrow Shares shall be distributed to Holders pursuant to this Agreement.
    Instead, the number of shares that each Holder shall receive shall be
    rounded up or down to the nearest whole number (provided that the Escrow
    Representatives shall have the authority to effect such rounding in such a
    manner that the total number of whole Escrow Shares to be distributed equals
    the number of Escrow Shares then held in the Escrow Account).

    4.  VALUATION OF INDEMNIFICATION ESCROW SHARES.  For purposes of this
Agreement, the "Value" of any Indemnification Escrow Shares delivered in
satisfaction of an indemnity claim shall be the average of the closing prices
for a share of Buyer Common Stock (as defined in the Merger Agreement) as

                                  Exhibit A-3

quoted on the Nasdaq National Market ("Nasdaq"), as reported by Nasdaq, for the
thirty (30) consecutive trading days immediately preceding the date which is
three (3) calendar days prior to the date of distribution of such
Indemnification Escrow Shares pursuant to this Agreement (subject to equitable
adjustment in the event of any stock split, stock dividend, reverse stock split
or similar event affecting the Buyer Common Stock since the beginning of such
thirty-day period), multiplied by the number of such Indemnification Escrow
Shares.

    5.  FEES AND EXPENSES OF ESCROW AGENT.  The Buyer shall pay the fees of the
Escrow Agent for the services to be rendered by the Escrow Agent hereunder.

    6.  LIMITATION OF ESCROW AGENT'S LIABILITY.

        (a) The Escrow Agent shall incur no liability with respect to any action
    taken or suffered by it in reliance upon any notice, direction, instruction,
    consent, statement or other documents believed by it to be genuine and duly
    authorized, nor for other action or inaction except its own willful
    misconduct or gross negligence. The Escrow Agent shall not be responsible
    for the validity or sufficiency of this Agreement. In all questions arising
    under the Escrow Agreement, the Escrow Agent may rely on the advice of
    counsel, and the Escrow Agent shall not be liable to anyone for anything
    done, omitted or suffered in good faith by the Escrow Agent based on such
    advice. The Escrow Agent shall not be required to take any action hereunder
    involving any expense unless the payment of such expense is made or provided
    for in a manner reasonably satisfactory to it. In no event shall the Escrow
    Agent be liable for indirect, punitive, special or consequential damages.

        (b) The Buyer and the Holders hereby, jointly and severally, agree to
    indemnify the Escrow Agent for, and hold it harmless against, any loss,
    liability or expense incurred without gross negligence or willful misconduct
    on the part of Escrow Agent, arising out of or in connection with its
    carrying out of its duties hereunder. The Buyer and the Holders agree, as
    between themselves, that with respect to their indemnification obligations
    under this Section 6(b), the Buyer, on the one hand, and the Holders, on the
    other hand, shall each be liable for one-half of such amounts.

    7.  LIABILITY AND AUTHORITY OF ESCROW REPRESENTATIVES; SUCCESSORS AND
ASSIGNEES.

        (a) The Escrow Representatives shall incur no liability to the Holders
    with respect to any action taken or suffered by them in reliance upon any
    note, direction, instruction, consent, statement or other documents believed
    by them to be genuinely and duly authorized, nor for other action or
    inaction except their own willful misconduct or gross negligence. The Escrow
    Representatives may, in all questions arising under the Escrow Agreement,
    rely on the advice of counsel and the Escrow Representatives shall not be
    liable to the Holders for anything done, omitted or suffered in good faith
    by the Escrow Representatives based on such advice.

        (b) In the event of the death or permanent disability of any Escrow
    Representative, or his or her resignation as an Escrow Representative, a
    successor Escrow Representative shall be appointed by the other Escrow
    Representative or, absent its appointment, a successor Escrow Representative
    shall be elected by a majority vote of the Holders based upon the total
    number of shares of the Buyer Common Stock issued in the Merger (including
    for purposes of this clause (b) the shares of Buyer Common Stock issued to
    the Management Members pursuant to Section 1.14 of the Merger Agreement),
    with each such Holder (or his, her or its successors or assigns) to be given
    a vote equal to the number of shares of the Buyer Common Stock issued to
    such Holder in the Merger. Each successor Escrow Representative shall have
    all of the power, authority, rights and privileges conferred by this
    Agreement upon the original Escrow Representatives, and the term "Escrow
    Representatives" as used herein shall be deemed to include successor Escrow
    Representatives.

        (c) The Escrow Representatives, acting jointly but not singly, shall
    have full power and authority to represent the Holders, and their
    successors, with respect to all matters arising under this Agreement and all
    actions taken by any Escrow Representative hereunder shall be binding

                                  Exhibit A-4

    upon the Holders, and their successors, as if expressly confirmed and
    ratified in writing by each of them. Without limiting the generality of the
    foregoing, the Escrow Representatives, acting by a majority thereof, shall
    have full power and authority to interpret all of the terms and provisions
    of this Agreement, to compromise any claims asserted hereunder and to
    authorize any release of the Escrow Shares to be made with respect thereto,
    on behalf of the Holders and their successors. All actions to be taken by
    the Escrow Representatives hereunder shall be evidenced by, and taken upon,
    the written direction of a majority thereof.

        (d) The Escrow Agent may rely on the Escrow Representatives as the
    exclusive agents of the Holders under this Agreement and shall incur no
    liability to any party with respect to any action taken or suffered by it in
    reliance thereon.

    8.  AMOUNTS PAYABLE BY HOLDERS.  The amounts payable by the Holders under
this Agreement (i.e., the indemnification obligations pursuant to Section 6(b))
shall be payable solely as follows. The Escrow Agent shall notify the Escrow
Representatives of any such amount payable by the Holders as soon as it becomes
aware that any such amount is payable, with a copy of such notice to the Buyer.
On the sixth business day after the delivery of such notice, the Escrow Agent
shall sell such number of Indemnification Escrow Shares (up to the number of
Indemnification Escrow Shares then available in the Escrow Account), subject to
compliance with all applicable securities laws, as is necessary to raise such
amount, and shall be entitled to apply the proceeds of such sale in satisfaction
of such indemnification obligations of the Holders; provided that if the Buyer
delivers to the Escrow Agent (with a copy to the Escrow Representatives), within
five business days after delivery of such notice by the Escrow Representatives,
a written notice contesting the legitimacy or reasonableness of such amount,
then the Escrow Agent shall not sell Indemnification Escrow Shares to raise the
disputed portion of such claimed amount except in accordance with the terms of
clauses (i) or (ii) of Section 3(a).

    9.  TERMINATION.  This Agreement shall terminate upon the distribution by
the Escrow Agent of all of the Escrow Shares in accordance with this Agreement;
provided that the provisions of Sections 6 and 7 shall survive such termination.

    10.  NOTICES.  All notices, instructions and other communications given
hereunder or in connection herewith shall be in writing. Any such notice,
instruction or communication shall be sent either (i) by registered or certified
mail, return receipt requested, postage prepaid, or (ii) via a reputable
nationwide overnight courier service, in each case to the address set forth
below. Any such notice, instruction or communication shall be deemed to have
been delivered two business days after it

                                  Exhibit A-5

is sent by registered or certified mail, return receipt requested, postage
prepaid, or one business day after it is sent via a reputable nationwide
overnight courier service.


                    
If to the Buyer:       BioTransplant Incorporated
                       Building 75
                       Third Avenue
                       Charlestown, MA 02129
                       Attention: Chief Executive Officer

If to the Escrow
Representatives:
                       ------------------------
                       ------------------------
                       ------------------------
If to the Escrow
Agent:                 The American Stock Transfer & Trust Company
                       6201 15th Avenue, 3rd Floor
                       Brooklyn, NY 11219
                       Attention: Herbert Lemmer, Esq.
                                General Counsel


    If to the Management Members, at his or her address set forth on the
signature pages hereto.

    Any party may give any notice, instruction or communication in connection
with this Agreement using any other means (including personal delivery, telecopy
or ordinary mail), but no such notice, instruction or communication shall be
deemed to have been delivered unless and until it is actually received by the
party to whom it was sent. Any party may change the address to which notices,
instructions or communications are to be delivered by giving the other parties
to this Agreement notice thereof in the manner set forth in this Section 10.

    11.  SUCCESSOR ESCROW AGENT.  In the event the Escrow Agent becomes
unavailable or unwilling to continue in its capacity herewith, the Escrow Agent
may resign and be discharged from its duties or obligations hereunder by
delivering a resignation to the parties to this Escrow Agreement, not less than
60 days prior to the date when such resignation shall take effect. The Buyer may
appoint a successor Escrow Agent without the consent of the Escrow
Representatives so long as such successor is a bank with assets of at least
$500 million, and may appoint any other successor Escrow Agent with the consent
of the Escrow Representatives, which shall not be unreasonably withheld. If,
within such notice period, the Buyer provides to the Escrow Agent written
instructions with respect to the appointment of a successor Escrow Agent and
directions for the transfer of any Escrow Shares then held by the Escrow Agent
to such successor, the Escrow Agent shall act in accordance with such
instructions and promptly transfer such Escrow Shares to such designated
successor. If no successor Escrow Agent is named as provided in this Section 11
prior to the date on which the resignation of the Escrow Agent is to properly
take effect, the Escrow Agent may apply to a court of competent jurisdiction for
appointment of a successor Escrow Agent.

    12.  GENERAL.

        (a) DISPUTE RESOLUTION; GOVERNING LAW; ASSIGNS. In the event of any
    unresolved dispute under this Agreement with respect to either the liability
    of a Holder for all or part of the Claimed Amount or with respect to the
    issuance of the Milestone Escrow Shares, the parties shall follow the
    procedures for alternative dispute resolution set forth in Section 6.2(d) of
    the Merger Agreement. This Agreement shall be governed by and construed in
    accordance with the internal

                                  Exhibit A-6

    laws of the State of Delaware without regard to conflict-of-law principles
    and shall be binding upon, and inure to the benefit of, the parties hereto
    and their respective successors and assigns.

        (b) COUNTERPARTS. This Agreement may be executed in two or more
    counterparts, each of which shall be deemed an original, but all of which
    together shall constitute one and the same instrument.

        (c) ENTIRE AGREEMENT. Except for those provisions of the Merger
    Agreement referenced herein, this Agreement constitutes the entire
    understanding and agreement of the parties with respect to the subject
    matter of this Agreement and supersedes all prior agreements or
    understandings, written or oral, between the parties with respect to the
    subject matter hereof.

        (d) WAIVERS. No waiver by any party hereto of any condition or of any
    breach of any provision of this Escrow Agreement shall be effective unless
    in writing. No waiver by any party of any such condition or breach, in any
    one instance, shall be deemed to be a further or continuing waiver of any
    such condition or breach or a waiver of any other condition or breach of any
    other provision contained herein.

        (e) AMENDMENT. This Agreement may be amended only with the written
    consent of the Buyer, the Escrow Agent and the Escrow Representatives.

        (f) CONSENT TO JURISDICTION AND SERVICE. The parties hereby absolutely
    and irrevocably consent and submit to the jurisdiction of the courts in the
    Commonwealth of Massachusetts and of any Federal court located in said
    Commonwealth in connection with any actions or proceedings brought against
    any party hereto by the Escrow Agent arising out of or relating to this
    Escrow Agreement. In any such action or proceeding, the parties hereby
    absolutely and irrevocably waive personal service of any summons, complaint,
    declaration or other process and hereby absolutely and irrevocably agree
    that the service thereof may be made by certified or registered first-class
    mail directed to such party, at their respective addresses in accordance
    with Section 10 hereof.

                 [Remainder of page intentionally left blank.]

                                  Exhibit A-7

    IN WITNESS WHEREOF, the parties have duly executed this Agreement as of the
day and year first above written.


                                            
                                               BIOTRANSPLANT INCORPORATED:

                                               By:
                                                    ----------------------------------------

                                               Name:
                                                       -------------------------------------

                                               Title:
                                                      --------------------------------------

                                               ESCROW REPRESENTATIVES:

                                               --------------------------------------------
                                               Robert Momsen

                                               --------------------------------------------
                                               Pieter Schiller

                                               THE AMERICAN STOCK TRANSFER AND TRUST
                                               COMPANY:

                                               By:
                                                    ----------------------------------------

                                               Name:
                                                       -------------------------------------

                                               Title:
                                                      --------------------------------------

                                               MANAGEMENT MEMBERS:

                                               Name:
                                                       -------------------------------------
                                                                Tara Clark

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------


                                  Exhibit A-8


                                            
                                               Name:
                                                       -------------------------------------
                                                                David Cook

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                               James Embree

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                               Joseph Fazio

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                         James R. Fitzgerald, Jr.

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                              Connie Garrison

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                               Michael Jarpe

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------


                                  Exhibit A-9


                                            
                                               Name:
                                                       -------------------------------------
                                                                Nancy Jones

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                              Cynthia Letizia

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                               Rodney Monroy

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                              Walter C. Ogier

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------

                                               Name:
                                                       -------------------------------------
                                                                Judith Snow

                                               Address:
                                                        ------------------------------------

                                                        ------------------------------------

                                                        ------------------------------------


                                  Exhibit A-10

                                  ATTACHMENT A

                      Holder                     Percentage

                                  Exhibit A-11

                                   EXHIBIT B

                           FORM OF LOCK-UP AGREEMENT

                          [FORM OF LOCK-UP AGREEMENT]

          , 2000

BioTransplant Incorporated
Building 75
Third Avenue
Charlestown, MA 02129

Ladies and Gentlemen:

    (a)  The undersigned stockholder of Eligix, Inc. (the "Company") understands
that BioTransplant Incorporated (the "Buyer"), and BT/EL Acquisition Co., a
wholly-owned subsidiary of the Buyer (the "Transitory Subsidiary"), have entered
into an Agreement and Plan of Merger (the "Merger Agreement") with the Company
pursuant to which the Transitory Subsidiary will merge (the "Merger") with and
into the Company and the outstanding shares of capital stock of the Company (the
"Company Shares") will be converted into shares of common stock of the Buyer
(the "Buyer Common Stock").

    (b)  In order to facilitate the transactions contemplated by the Merger
Agreement, the undersigned agrees that the undersigned will not, for the period
commencing on the Effective Time (as defined in the Merger Agreement) and
terminating on the date one year subsequent to the Effective Time, sell,
transfer, pledge, hypothecate or otherwise dispose of, or reduce the
undersigned's interest in or risk relating to, any shares of Buyer Common Stock:
(i) issued to the undersigned upon the conversion of the undersigned's Company
Shares (as defined in the Merger Agreement) in accordance with the terms of the
Merger Agreement; (ii) issued to the undersigned upon the exercise or conversion
of any Company Options, Company Warrants or Company Notes (as defined in the
Merger Agreement) assumed by the Buyer in accordance with the terms of the
Merger Agreement; (iii) issued to the undersigned in the form of Management
Incentive Shares in accordance with Section 1.14 of the Merger Agreement; or
(iv) otherwise acquired or beneficially owned by the undersigned as a result of
the transactions contemplated by the Merger Agreement (collectively the
"RESTRICTED SHARES"). The provisions of the preceding sentence shall not apply:
(a) during the period beginning after the date 90 days subsequent to the
Effective Time and ending on the date 180 days subsequent to the Effective Time,
with respect to 33 1/3% of the Restricted Shares; (b) during the period
beginning on the date 181 days subsequent to the Effective Time and ending on
the date 270 days subsequent to the Effective Time, with respect to 66 2/3% of
the Restricted Shares (including the 33 1/3% of the Restricted Shares set forth
in the preceding clause (a)); and (c) during the period beginning on the date
271 days subsequent to the Effective Time and ending on the date 365 days
subsequent to the Effective Time, with respect to 90% of the Restricted Shares
(including the 66 2/3% of the Restricted Shares set forth in the preceding
clause (b)). The Company shall cause stop transfer orders to be placed with its
transfer agent with respect to the securities of the Company restricted by this
Section 2.

    (c)  Notwithstanding the foregoing, the undersigned agrees that, if
requested by the Buyer and the managing underwriter of any registered public
offering by the Buyer of the Buyer Common Stock or other securities of the Buyer
pursuant to a registration statement filed with the U.S. Securities and Exchange
Commission under the Securities Act of 1933, as amended ("Registration
Statement"), at any time prior to 365 days subsequent to the Effective Time, the
undersigned shall not sell, transfer, pledge, hypothecate or otherwise dispose
of any Restricted Shares for a period of time not to exceed ninety (90) days
following the effective date of such Registration Statement; PROVIDED that the
officers and directors of the Buyer who own Buyer Common Stock or other
securities of Buyer also agree, and remain subject to, such restrictions.

    (d)  It is understood that, if the Closing Date (as defined in the Merger
Agreement) does not occur on or before April 30, 2001, or if the Merger
Agreement shall be terminated by either party in accordance with the provisions
thereof at any time prior to the Closing Date, then this Agreement shall
terminate.

    (e)  The Agreement shall be governed by and construed in accordance with the
laws of the State of Delaware. This agreement may not be amended, modified,
revoked or terminated in any respect without the written consent of the
undersigned, the Company and the Buyer. This Agreement shall be binding upon the
undersigned and its heirs, successors and assigns.

                                          Very truly yours,

                                          --------------------------------------

                                          Name of Stockholder

                                          By:
                                          --------------------------------------

                                          Title:

                                          Date: __________, 2000

                                  Exhibit B-2

                                   EXHIBIT C

                          FORM OF AFFILIATE AGREEMENT

                              AFFILIATE AGREEMENT

                                __________, 2000

BioTransplant Incorporated
Building 75
Third Avenue
Charlestown, MA 02129
Eligix, Inc.
200 Boston Avenue
Medford, MA 02155

Dear Sirs:

    An Agreement and Plan of Merger dated as of December 8, 2000 (the "Merger
Agreement") has been entered into by and among BioTransplant Incorporated, a
Delaware corporation (the "Buyer"), BT/EL Acquisition Co., a Delaware
corporation and a wholly-owned subsidiary of Buyer (the "Transitory
Subsidiary"), and Eligix, Inc., a Delaware corporation (the "Company"). The
Merger Agreement provides for the merger of the Transitory Subsidiary with and
into the Company (the "Merger"). In accordance with the Merger Agreement, the
shares of each class of capital stock of the Company (collectively, the "Company
Stock") shall be converted into shares of common stock, $0.01 par value per
share, of the Buyer (the "Buyer Common Stock"), as more fully described in the
Merger Agreement.

    The undersigned may be deemed to be an "affiliate" of the Company within the
meaning of the rules promulgated under the Securities Act of 1933, as amended
(the "Securities Act"). In consideration of the mutual agreements set forth in
the Merger Agreement and hereinafter in this agreement, the undersigned
represents and agrees as follows:

    1.  RULE 145.

        (a) The undersigned will not offer, sell, transfer, pledge, hypothecate
    or otherwise dispose of, or reduce the undersigned's interest in or risk
    relating to, any shares of Buyer Common Stock (other than Management
    Incentive Shares issued in accordance with Section 1.14 of the Merger
    Agreement) issued to the undersigned in the Merger unless at such time
    either: (i) such transaction shall be permitted pursuant to the provisions
    of Rule 145 under the Securities Act; (ii) the undersigned shall have
    furnished to the Buyer an opinion of counsel, satisfactory to the Buyer, to
    the effect that no registration under the Securities Act would be required
    in connection with the proposed offer, sale, transfer, pledge, hypothecation
    or other disposition; or (iii) a registration statement under the Securities
    Act covering the proposed offer, sale, transfer, pledge, hypothecation or
    other disposition shall be effective under the Securities Act.

        (b) The undersigned understands that all certificates representing
    shares of Buyer Common Stock (other than Management Incentive Shares)
    delivered to the undersigned pursuant to the Merger shall bear a legend
    substantially in the form set forth below, until the earliest to occur of
    (i) one of the events referred to in clauses (i), (ii) or (iii) of
    Section 1(a) above or (ii) the date on which the undersigned requests
    removal of such legend, provided that such request occurs at least two years
    from the Effective Time and that the undersigned is not at the time of such
    request, and has not been during the three-month period immediately
    preceding such request, an affiliate of the Buyer:

                "The shares represented by this certificate were issued in a
                transaction to which Rule 145 of the Securities Act of 1933
                applies and may only be transferred in accordance with the
                provisions of such rule. In addition, the shares represented by

                this certificate may only be transferred in accordance with the
                terms of an Affiliate Agreement dated as of December 8, 2000
                between the initial holder hereof and the corporation, a copy of
                which agreement may be inspected by the holder of this
                certificate at the principal offices of the corporation, or
                furnished by the corporation to the holder of this certificate
                upon written request without charge."

        (c) The Buyer, in its discretion, may cause stop transfer orders to be
    placed with its transfer agent with respect to the certificates for the
    shares of Buyer Common Stock which are required to bear the foregoing
    legend.

    2.  MISCELLANEOUS.

        (a) This agreement shall be governed by and construed in accordance with
    the laws of the State of Delaware.

        (b) This agreement shall be binding on the undersigned's successors and
    assigns, including his heirs, executors and administrators.

    The undersigned has carefully read this agreement and discussed its
requirements, to the extent the undersigned believed necessary, with its counsel
or counsel for the Company.

                                          Very truly yours,

                                          Signature

                                          --------------------------------------

                                          Print Name

Accepted:

BIOTRANSPLANT INCORPORATED

---------------------------------------------

(signature)

---------------------------------------------

(print name and title)

---------------------------------------------

(date)

ELIGIX, INC.

---------------------------------------------

(signature)

---------------------------------------------

(print name and title)

---------------------------------------------

(date)

                                  Exhibit C-2

                                   EXHIBIT D

         OPINION OF MINTZ, LEVIN, COHN, FERRIS, GLOVSKY AND POPEO, P.C.

                   FORM OF OPINION OF COUNSEL TO THE COMPANY

    1.  The Company is a corporation duly incorporated, validly existing and in
good standing under the laws of the State of Delaware. The Company has all
requisite corporate power and authority to carry on the businesses in which, to
our knowledge, it is engaged and to own and use the properties which, to our
knowledge, are owned and used by it.

    2.  As of the date hereof, the authorized capital stock of the Company
consists of (a) 66,000,000 Common Shares, of which 196,969 shares are of record
issued and outstanding and no shares were of record held in the treasury of the
Company and (b) 57,200,000 Preferred Shares, of which (i) 11,100,000 shares have
been designated as Series A Convertible Preferred Stock, of which 10,911,332
shares are of record issued and outstanding, (ii) 12,500,000 shares have been
designated as Series B Convertible Preferred Stock, of which 11,214,755 shares
are of record issued and outstanding, (iii) 10,000,000 shares have been
designated as Series C-1 Convertible Preferred Stock, of which no shares are of
record issued and outstanding, (iv) 11,100,000 shares have been designated as
Series C-2 Convertible Preferred Stock, of which no shares are of record issued
and outstanding, and (v) 12,500,000 shares have been designated as Series C-3
Convertible Preferred Stock, of which no shares are of record issued and
outstanding. To the best of such counsel's knowledge, all of the issued and
outstanding shares of capital stock of the Company are duly authorized, validly
issued, fully paid, nonassessable and free of all preemptive rights. Except as
set forth in the Company Disclosure Schedule, to such counsel's knowledge, there
are no outstanding or authorized options, warrants, rights, agreements or
commitments to which the Company is a party or which are binding upon the
Company providing for the issuance or redemption of any of its capital stock.

    3.  The Company has all requisite corporate power and authority to execute
and deliver the Agreement and to perform its obligations thereunder. The
execution and delivery by the Company of the Agreement and the consummation by
the Company of the transactions contemplated thereby have been duly and validly
authorized by all necessary corporate action (including the Requisite Company
Stockholder Approval) on the part of the Company. The Agreement has been duly
and validly executed and delivered by the Company. Assuming the due
authorization, execution and delivery by the Buyer, the Agreement constitutes a
valid and binding obligation of the Company, enforceable against the Company in
accordance with its terms, subject to bankruptcy, insolvency and similar laws
affecting the rights of creditors generally, general equitable principles and
other customary exceptions.

    4.  Except as set forth in Section 2.4 of the Agreement or Section 2.4 of
the Company Disclosure Schedule, neither the execution and delivery by the
Company of the Agreement, nor the consummation by the Company of the
transactions contemplated thereby, (i) conflicts with or violates any provision
of the Certificate of Incorporation or By-laws of the Company, (ii) requires on
the part of the Company or any Subsidiary any filing with, or permit,
authorization, consent or approval of, any Governmental Entity, (iii) conflicts
with, results in a breach of, constitutes (with or without due notice or lapse
of time or both) a default under, results in the acceleration of obligations
under, creates in any party the right to terminate, modify or cancel, or
requires any notice, consent or waiver under, any contract or instrument to
which the Company is a party set forth in Section 2.13 or Section 2.15 of the
Company Disclosure Schedule, (iv) to the best of such counsel's knowledge,
results in the imposition of any Security Interest upon any assets of the
Company, (v) violates any Massachusetts state statute, or United States federal
rule or regulation applicable to the Company, or (vi) violates any order, writ,
injunction or decree known to such counsel and specifically naming the Company
or any of its properties or assets, excluding from the foregoing clauses (iii),
(iv) and (v) any exceptions to the foregoing that, in the aggregate, would not
have a material adverse effect on the Company or on the ability of the Company
to consummate the transactions contemplated by the Agreement.

    5.  The Certificate of Amendment of Certificate of Incorporation has been
duly authorized by all necessary corporate action on the part of the Company.

    6.  To such counsel's knowledge, except as set forth in the Company
Disclosure Schedule, there are no actions, suits, investigations or claims or
legal, administrative or arbitration proceedings pending or threatened against
the Company.

    7.  Upon the filing and acceptance of the Certificate of Merger with the
Secretary of State of Delaware, the Merger will be effective under the Delaware
General Corporation Law statute.

                                   EXHIBIT E
               FORM OF VOTING AND TRANSFER RESTRICTION AGREEMENT

                   VOTING AND TRANSFER RESTRICTION AGREEMENT
                                DECEMBER , 2000

BioTransplant Incorporated
Building 75
Third Avenue
Charlestown, MA 02129

Eligix, Inc.
200 Boston Avenue
Medford, MA 02155

Ladies and Gentlemen:

    An Agreement and Plan of Merger dated as of December 8, 2000 (the "MERGER
AGREEMENT") is being or has been entered into by and among BioTransplant
Incorporated, a Delaware corporation (the "BUYER"), BT/EL Acquisition Co., a
Delaware corporation and a wholly owned subsidiary of the Buyer (the "TRANSITORY
SUBSIDIARY"), and Eligix, Inc., a Delaware corporation (the "COMPANY"). The
Merger Agreement provides for the merger of the Transitory Subsidiary with and
into the Company (the "MERGER"). In accordance with the Merger Agreement, the
shares of each class of capital stock of the Company (collectively, the "COMPANY
STOCK") shall be converted into shares of common stock, $0.01 par value per
share, of the Buyer (the "BUYER COMMON STOCK"), as more fully described in the
Merger Agreement.

    The undersigned is the record holder and beneficial owner of such number of
shares of Company Stock (the "SHARES") as is indicated on the final page of this
Voting and Transfer Restriction Agreement (this "AGREEMENT").

    The undersigned may be deemed to be an Affiliate (as defined in the Merger
Agreement) of the Company.

    In consideration of the mutual agreements set forth in the Merger Agreement
and hereinafter in this Agreement, the undersigned represents and agrees as
follows:

    1.  VOTING.

        (a) At every meeting of the stockholders of the Company called with
    respect to any of the matters set forth in clauses (i) or (ii) of this
    Section 1(a), and at every adjournment thereof, and on every action or
    approval by written consent of the stockholders of the Company with respect
    to any of the matters set forth in clauses (i) or (ii) of this
    Section 1(a), the undersigned shall (i) vote the Shares and any New Shares
    (as defined in Section 1(b) of this Agreement) in favor of the adoption of
    the Merger Agreement and the approval of the Merger and any matter that
    could reasonably be expected to facilitate the Merger, including without
    limitation approval of the proposed Certificate of Amendment to the
    Company's Amended and Restated Certificate of Incorporation in the form
    attached as Exhibit F to the Merger Agreement, and as specified by the Buyer
    with respect to any matter that would be inconsistent with or make it more
    difficult or less desirable for the Buyer to complete the transactions
    contemplated by the Merger Agreement and (ii) not vote the Shares nor any
    New Shares in favor of any other acquisition (whether by way of merger,
    consolidation, share exchange, stock purchase, asset purchase or otherwise)
    of all or a majority of the outstanding capital stock or assets of the
    Company (a "Competing Transaction"). The undersigned further agrees not to
    solicit, encourage or recommend to other stockholders of the Company that
    they (a) vote their shares of Company Stock or any other securities in any
    contrary manner, (b) do not vote their shares of Company Stock at all,
    (c) tender, exchange or otherwise dispose of their shares of Company Stock
    pursuant to a Competing Transaction or (d) attempt to exercise any statutory
    appraisal or other similar rights they may have.

        (b) The undersigned agrees that any shares of Company Stock that the
    undersigned purchases or with respect to which the undersigned otherwise
    acquires beneficial ownership after

    the execution of this Agreement and prior to the termination of this
    Agreement in accordance with Section 7 of this Agreement ("NEW SHARES")
    shall be subject to the terms and conditions of this Agreement to the same
    extent as if they constituted Shares.

        (c) Concurrently with the execution of this Agreement, the undersigned
    agrees to deliver to the Buyer a proxy in the form attached hereto as
    Appendix A (the "PROXY"), which shall be irrevocable, with respect to the
    Shares.

    2.  TRANSFER RESTRICTIONS.

        (a) During the term of this Agreement, except pursuant to the Merger,
    the undersigned agrees not to sell, transfer, pledge, hypothecate or
    otherwise dispose of, or reduce the undersigned's interest in or risk
    relating to, any securities of the Company; provided that the undersigned
    may sell or otherwise dispose of any of his or her shares of Company Stock
    provided that the transferee of such Shares of Company Stock agrees to be
    bound by and subject to the terms and conditions of this Agreement.

        (b) During the period commencing on the Effective Time (as defined in
    the Merger Agreement) and terminating on the date one year subsequent to the
    Effective Time, the undersigned agrees not to sell, transfer, pledge,
    hypothecate or otherwise dispose of, or reduce the undersigned's interest in
    or risk relating to, any shares of Buyer Common Stock: (i) issued to the
    undersigned upon the conversion of the undersigned's shares of Company Stock
    in accordance with the terms of the Merger Agreement; (ii) issued to the
    undersigned upon the exercise or conversion of any Company Options, Company
    Warrants or Company Notes (each as defined in the Merger Agreement) assumed
    by the Buyer in accordance with the terms of the Merger Agreement;
    (iii) issued to the undersigned in the form of Management Incentive Shares
    in accordance with Section 1.14 of the Merger Agreement; or (iv) otherwise
    acquired or beneficially owned by the undersigned as a result of the
    transactions contemplated by the Merger Agreement (collectively with the
    shares of Buyer Common Stock described in the preceding clauses (i),
    (ii) and (iii), the "RESTRICTED SHARES"). The provisions of the preceding
    sentence shall not apply: (a) during the period beginning after the date
    90 days subsequent to the Effective Time and ending on the date 180 days
    subsequent to the Effective Time, with respect to 33 1/3% of the Restricted
    Shares; (b) during the period beginning on the date 181 days subsequent to
    the Effective Time and ending on the date 270 days subsequent to the
    Effective Time, with respect to 66 2/3% of the Restricted Shares (including
    the 33 1/3% of the Restricted Shares set forth in the preceding
    clause (a)); and (c) during the period beginning on the date 271 days
    subsequent to the Effective Time and ending on the date 365 days subsequent
    to the Effective Time, with respect to 90% of the Restricted Shares
    (including the 66 2/3% of the Restricted Shares set forth in the preceding
    clause (b)). The Company shall cause stop transfer orders to be placed with
    its transfer agent with respect to the securities of the Company restricted
    by this Section 2.

        (c) Notwithstanding the foregoing, the undersigned agrees that, if
    requested by the Buyer and the managing underwriter of any registered public
    offering by the Buyer of Buyer Common Stock or other securities of the Buyer
    pursuant to a registration statement filed with the U.S. Securities and
    Exchange Commission under the Securities Act of 1933, as amended
    ("Registration Statement"), at any time prior to one year subsequent to the
    Effective Time, the undersigned shall not sell, transfer, pledge,
    hypothecate or otherwise dispose of any Restricted Shares for a period of
    time not to exceed ninety (90) days following the effective date of such
    Registration Statement; provided that the officers and directors of the
    Buyer who own Buyer Common Stock or other securities of Buyer also agree,
    and remain subject to, such restrictions.

                                  Exhibit E-2

    3.  RULE 145.

        (a) The undersigned will not offer, sell, transfer, pledge, hypothecate
    or otherwise dispose of, or reduce the undersigned's interest in or risk
    relating to, any shares of Buyer Common Stock (other than the Management
    Incentive Shares) issued to the undersigned in connection with the
    transaction contemplated by the Merger Agreement unless at such time either:
    (i) such transaction shall be permitted pursuant to the provisions of
    Rule 145 under the Securities Act of 1933, as amended (the "SECURITIES
    ACT"); (ii) the undersigned shall have furnished to the Buyer an opinion of
    counsel, satisfactory to the Buyer, to the effect that no registration under
    the Securities Act would be required in connection with the proposed offer,
    sale, transfer, pledge, hypothecation or other disposition; or (iii) a
    registration statement under the Securities Act covering the proposed offer,
    sale, transfer, pledge, hypothecation or other disposition shall be
    effective under the Securities Act.

        (b) The undersigned understands that all certificates representing
    shares of Buyer Common Stock (other than the Management Incentive Shares)
    delivered to the undersigned pursuant to the transactions contemplated by
    the Merger Agreement shall bear a legend substantially in the form set forth
    below, until the earliest to occur of (i) one of the events referred to in
    clauses (i), (ii) or (iii) of Section 3(a) or (ii) the date on which the
    undersigned requests removal of such legend, provided that such request
    occurs at least two years from the Effective Time and that the undersigned
    is not at the time of such request, and has not been during the three-month
    period immediately preceding such request, an affiliate of the Buyer:

       "The shares represented by this certificate were issued in a
       transaction to which Rule 145 of the Securities Act of 1933
       applies and may only be transferred in accordance with the
       provisions of such rule. In addition, the shares represented by
       this certificate may only be transferred in accordance with the
       terms of a Voting and Transfer Restriction Agreement dated as of
       December 8, 2000 between the initial holder hereof and the
       corporation, a copy of which agreement may be inspected by the
       holder of this certificate at the principal offices of the
       corporation, or furnished by the corporation to the holder of this
       certificate upon written request without charge."

    Notwithstanding the foregoing, in no event shall such legend be removed
prior to the expiration of the transfer restrictions set forth in Section 2 of
this Agreement.

        (c) The Buyer, in its discretion, may cause stop transfer orders to be
    placed with its transfer agent with respect to the certificates for the
    shares of Buyer Common Stock which are required to bear the foregoing
    legend.

    4.  REPRESENTATIONS AND WARRANTIES.  The undersigned represents and warrants
that he, she or it: (i) is the beneficial owner of the Shares, which at the date
hereof are free and clear of any liens, claims, options, charges, restrictions
on voting or other encumbrances; (ii) does not beneficially own any shares of
capital stock of the Company other than the Shares; and (iii) has full power and
authority to make, enter into and carry out the terms of this Agreement.

    5.  ADDITIONAL DOCUMENTS.  The undersigned hereby covenants and agrees to
execute and deliver any additional documents necessary or desirable, in the
reasonable opinion of the Buyer, to carry out the intent of this Agreement.

    6.  CONSENTS AND WAIVERS.  The undersigned hereby gives any consents or
waivers that are reasonably required for the consummation of the Merger under
the terms of any agreements to which the undersigned is a party or pursuant to
any rights the undersigned may have.

                                  Exhibit E-3

    7.  TERMINATION.  The provisions of Section 1 of this Agreement, including
the Proxy, shall terminate and shall have no further force or effect on the
earlier to occur of (i) the date and time the Merger Agreement is terminated in
accordance with its terms and (ii) the date and time on which the Merger shall
become effective in accordance with the terms and provisions of the Merger
Agreement. The provisions of Section 2 of this Agreement shall terminate if
either (i) the Closing Date (as defined in the Merger Agreement) does not occur
on or before April 30, 2001 or (ii) the Merger Agreement is terminated by either
party in accordance with the provisions thereof at any time prior to the Closing
Date.

    8.  GENERAL.

        (a) Entire Agreement. Except for the Merger Agreement and the Escrow
    Agreement (as defined in the Merger Agreement), this Agreement constitutes
    the entire agreement among the parties hereto and supersedes any prior
    understandings, agreements or representations by or among the parties
    hereto, written or oral, with respect to the subject matter hereof.

        (b) Succession and Assignment. This Agreement shall be binding upon and
    inure to the benefit of the parties hereto and their respective successors
    and permitted assigns.

        (c) Counterparts and Facsimile Signature. This Agreement may be executed
    in two or more counterparts, each of which shall be deemed an original but
    all of which together shall constitute one and the same instrument. This
    Agreement may be executed by facsimile signature.

        (d) Headings. The section headings contained in this Agreement are
    inserted for convenience only and shall not affect in any way the meaning or
    interpretation of this Agreement.

        (e) Notices. All notices, instructions and other communications
    hereunder shall be in writing. Any notice, instruction or other
    communication hereunder shall be deemed duly delivered four business days
    after it is sent by registered or certified mail, return receipt requested,
    postage prepaid, or one business day after it is sent for next business day
    delivery via a reputable nationwide overnight courier service, in each case
    to the intended recipient as set forth below:


                                    
IF TO THE BUYER:                       COPY TO:

BioTransplant Incorporated             Hale and Dorr LLP
Building 75                            60 State Street
Third Avenue                           Boston, Massachusetts 02109
Charlestown, MA 02129                  Attention: Steven D. Singer, Esq.


        Attention: Chief Executive Officer

        IF TO THE UNDERSIGNED:

        At the address set forth on the signature page to this Agreement.


                                    
IF TO THE COMPANY:                     COPY TO:

Eligix, Inc.                           Mintz, Levin, Cohn, Ferris, Glovsky
200 Boston Avenue                      and Popeo, P.C.
Medford, MA 02155                      One Financial Center
Attention: President                   Boston, MA 02111
                                       Attention: William T. Whelan, Esq.


    Any party hereto may give any notice, instruction or other communication
hereunder using any other means (including personal delivery, expedited courier,
messenger service, telecopy, telex, ordinary mail or electronic mail), but no
such notice, instruction or other communication shall be deemed to

                                  Exhibit E-4

have been duly given unless and until it actually is received by the party to
whom it is intended. Any party hereto may change the address to which notices,
instructions, or other communications hereunder are to be delivered by giving
the other parties hereto notice in the manner set forth in this Section 8(e).

        (f) Governing Law. This Agreement shall be governed by and construed in
    accordance with the internal laws of the Commonwealth of Massachusetts
    without giving effect to any choice or conflict of law provision or rule
    (whether of the Commonwealth of Massachusetts or any other jurisdiction)
    that would cause the application of laws of any jurisdiction other than
    those of the Commonwealth of Massachusetts.

        (g) Amendments and Waivers. This Agreement may be amended only with the
    written consent of the Buyer and the undersigned. No waiver of any right or
    remedy hereunder shall be valid unless the same shall be in writing and
    signed by the party giving such waiver. No waiver by any party hereto with
    respect to any condition, default or breach of covenant hereunder shall be
    deemed to extend to any prior or subsequent condition, default or breach of
    covenant hereunder or affect in any way any rights arising by virtue of any
    prior or subsequent such occurrence.

        (h) Submission to Jurisdiction. Each of the parties hereto (a) submits
    to the jurisdiction of any state or federal court sitting in the
    Commonwealth of Massachusetts in any action or proceeding arising out of or
    relating to this Agreement, (b) agrees that all claims in respect of such
    action or proceeding may be heard and determined in any such court, and
    (c) agrees not to bring any action or proceeding arising out of or relating
    to this Agreement in any other court. Each of the parties hereto waives any
    defense of inconvenient forum to the maintenance of any action or proceeding
    so brought and waives any bond, surety or other security that might be
    required of any other party with respect thereto. Any party hereto may make
    service on another party hereto by sending or delivering a copy of the
    process to the party hereto to be served at the address and in the manner
    provided for the giving of notices in Section 8(e). Nothing in this
    Section 8(h), however, shall affect the right of any party to serve legal
    process in any other manner permitted by law.

        (i) Severability. If any provisions of this Agreement is declared
    invalid or unenforceable by any tribunal, then such provision shall be
    deemed automatically adjusted to conform to the requirements for validity
    and enforceability as declared at such time and, as so adjusted, shall be
    deemed a provision of this Agreement as though originally included herein.
    If the provision that is declared invalid or unenforceable is of such a
    nature that it cannot be so adjusted, the provision shall be deleted from
    this Agreement as though the provision had never been included herein. In
    either case, all other provisions of this Agreement shall remain in full
    force and effect.

        (j) Specific Performance; Injunctive Relief. The parties hereto
    acknowledge that it will be impossible to measure in money the damage to the
    Buyer if the undersigned fails to comply with the obligations imposed by
    this Agreement and that the Buyer will be irreparably harmed and there will
    be no adequate remedy at law for a violation of any of the covenants or
    agreements of the undersigned set forth herein. Therefore, it is agreed
    that, in addition to any other remedies that may be available to the Buyer
    upon any such violation, the Buyer shall have the right to seek to enforce
    such covenants and agreements by specific performance, injunctive relief or
    by any other means available to the Buyer at law or in equity. The
    undersigned agrees not to seek, and agrees to waive any requirement for, the
    securing or posting of a bond in connection with the Buyer seeking or
    obtaining such equitable relief.

        (k) No Voting Trusts. The undersigned hereby revokes any and all proxies
    and voting instructions with respect to the Shares previously given by the
    undersigned, and the undersigned agrees that it will not grant or give any
    other proxies or voting instructions with respect to the voting of the
    Shares, enter into any voting trust or other arrangement or agreement with
    respect to

                                  Exhibit E-5

    the voting of the Shares (and, if given or executed, such proxies, voting
    instructions, voting trust or other arrangement or agreement shall not be
    effective) in matters which directly relate to the Merger.

                 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK.]

                                  Exhibit E-6

    The undersigned has carefully read this agreement and discussed its
requirements, to the extent the undersigned believed necessary, with its
counsel.


                                    
                                       Very truly yours,

                                       ------------------------------------
                                       Print Name:
                                       Number of Shares Beneficially
                                       Owned: ----------------------------

                                       Address: ---------------------------

                                                 ---------------------------

                                                 ---------------------------

Accepted:

BIOTRANSPLANT INCORPORATED

------------------------------------
(signature)

------------------------------------
(print name and title)

------------------------------------

(date)
ELIGIX, INC.

------------------------------------
(signature)

------------------------------------
(print name and title)

------------------------------------
(date)


                                  Exhibit E-7

                                                                      APPENDIX A

                               IRREVOCABLE PROXY

    The undersigned securityholder of Eligix, Inc., a Delaware corporation (the
"COMPANY"), hereby irrevocably appoints the members of the Board of Directors of
BioTransplant Incorporated, a Delaware corporation (the "BUYER"), and each of
them, as the sole and exclusive attorneys and proxies of the undersigned, with
full power of substitution and resubstitution, to the full extent of the
undersigned's rights with respect to the securities of the Company beneficially
owned by the undersigned, which securities are listed on the final page of this
Irrevocable Proxy, and any and all other securities of the Company that the
undersigned purchases or with respect to which the undersigned otherwise
acquires beneficial ownership on or after the date hereof and prior to the date
this proxy terminates (collectively, the "SHARES"), until the earlier to occur
of (i) the date and the time on which the Merger (as defined in the Agreement
and Plan of Merger dated as of December 8, 2000 (the "MERGER AGREEMENT") by and
among the Buyer, a wholly owned subsidiary of the Buyer and the Company) shall
become effective in accordance with the terms and provisions of the Merger
Agreement and (ii) the date that the Merger Agreement is terminated in
accordance with its terms (which such other securities shall be deemed Shares
for purposes of this proxy) (such earlier date, the "PROXY TERMINATION"). Upon
the execution hereof, all prior proxies given by the undersigned with respect to
the Shares are hereby revoked and no subsequent proxies will be given until such
time as this proxy shall be terminated in accordance with its terms.

    This proxy is irrevocable, is granted pursuant to the Voting and Transfer
Restriction Agreement dated as of December 8, 2000 between the Buyer and the
undersigned stockholder (the "VOTING AGREEMENT"), and is granted in
consideration of the Buyer entering into the Merger Agreement. The Buyer and the
undersigned stockholder agree and acknowledge that the grant of this irrevocable
proxy is a material inducement for the Buyer to enter into the Merger Agreement,
and is therefore coupled with an interest and irrevocable. The attorneys and
proxies named above will be empowered at any time prior to the Proxy Termination
to exercise all voting and other rights (including, without limitation, the
power to execute and deliver written consents with respect to the Shares) of the
undersigned (a) in favor of the adoption of the Merger Agreement and the
approval of the Merger (as defined in the Merger Agreement) and any matter that
could reasonably be expected to facilitate the Merger, including without
limitation approval of the proposed Certificate of Amendment of the Company's
Amended and Restated Certificate of Incorporation in the form attached as
EXHIBIT F to the Merger Agreement, (b) as such attorneys and proxies deem
appropriate with respect to any matter that would be inconsistent with or make
it more difficult or less desirable for the Buyer to complete the transactions
contemplated by the Merger Agreement and (c) against any other acquisition
(whether by way of merger, consolidation, share exchange, stock purchase, asset
purchase or otherwise) of all or a majority of the outstanding capital stock or
assets of the Company at every annual, special or adjourned meeting of the
Company stockholders, and in every written consent in lieu of such a meeting, or
otherwise. This proxy will terminate upon the Proxy Termination.

    The attorneys and proxies named above may only exercise this proxy to vote
the Shares at any time prior to the Proxy Termination at every annual, special
or adjourned meeting of the stockholders of the Company and in every written
consent in lieu of such meeting, (a) in favor of the adoption of the Merger
Agreement and the approval of the Merger and any matter than could reasonably be
expected to facilitate the Merger, (b) as such attorneys and proxies deem
appropriate with respect to any matter that would be inconsistent with or make
it more difficult or less desirable for the Buyer to complete the transactions
contemplated by the Merger Agreement and (c) against any other acquisition
(whether by way of merger, consolidation, share exchange, stock purchase, asset
purchase or otherwise) of all or a majority of the outstanding capital stock or
assets of the Company. The undersigned securityholder may vote the Shares on all
other matters.

    Any obligation of the undersigned hereunder shall be binding upon the
successors and assigns of the undersigned.

    Dated: December   , 2000

    Name of Stockholder:
-------------------------

    By:
-----------------------------------------

    Print Name of Signatory:
----------------------

    Title of Signatory:
----------------------------

    Number of Shares of Common Stock Beneficially Owned:
-------------------

    Number of Shares of Preferred Stock Beneficially Owned:
-------------------

                                   EXHIBIT F

                     AMENDMENT TO THE AMENDED AND RESTATED
                  CERTIFICATE OF INCORPORATION OF ELIGIX, INC.

                     AMENDMENT TO THE AMENDED AND RESTATED
                  CERTIFICATE OF INCORPORATION OF ELIGIX, INC.

    1.  Sections 3(e)(i)(A) and 3(e)(i)(B) of Article IV of the Amended and
Restated Certificate of Incorporation of Eligix, Inc. are hereby amended and
restated to read in their entirety as follows:

       "(A) If traded on a securities exchange or the Nasdaq National
       Market, the value shall be deemed to be the average of the closing
       sale prices for a share of the security to be delivered to the
       holders of the Series Preferred and/or Common Stock (the
       "Liquidation Security"), as quoted on the Nasdaq National Market
       ("Nasdaq"), as reported by Nasdaq, for the thirty (30) trading
       days immediately preceding the date which is three (3) calendar
       days prior to the date of the agreement relating to such
       Acquisition or Asset Transfer (subject to equitable adjustment in
       the event of any stock split, stock dividend, reverse stock split
       or similar event affecting the Liquidation Security since the
       beginning of such thirty-day period) (the "Thirty-Day Period");
       and

       (B) If actively traded over-the-counter, the value shall be deemed
       to be the average of the closing bid prices for a share of the
       Liquidation Security, as quoted in the over-the-counter market,
       for the Thirty-Day Period."

    2.  Section 3(f) of Article IV of the Amended and Restated Certificate of
Incorporation is hereby amended and restated to read in its entirety as follows:

       "(f) If, upon any liquidation, distribution or winding up, the
       assets of the Company shall be insufficient to make payment in
       full to all holders of Series Preferred, then such assets shall be
       distributed first among the holders of Senior Series C Preferred
       at the time outstanding, ratably in proportion to the full amounts
       to which they would otherwise be respectively entitled. If after
       payment in full to the holders of Senior Series C Preferred the
       remaining assets of the Company shall be insufficient to make
       payment in full to the holders of Junior Series Preferred, then
       such remaining assets shall be distributed to the holders of
       Junior Series Preferred at the time outstanding, ratably in
       proportion to the full amounts to which they would otherwise be
       entitled."

                                   EXHIBIT G

                        FORM OF EMPLOYMENT OFFER LETTER

                       [FORM OF EMPLOYMENT OFFER LETTER]

Date

XXXXXXXXX
XXXXXXXXX
XXXXXXXXX

Dear XXXXX:

    I am writing to confirm our offer to you for a position as       , reporting
to       . We are pleased to offer you a starting salary of $           per
month (equivalent to $               per year), to be paid semi-monthly and
reviewed annually. The monthly salary includes an allowance to help offset
contributions to certain benefits should you elect them. You are also eligible
for an annual cash bonus and to participate in our annual merit-based stock
option program, provided that any award of options will be subject to the
approval of our Board of Directors. You are also entitled to receive shares of
BTI common stock in accordance with the terms and conditions of the
Eligix, Inc. Management Equity Incentive Plan. In addition, you will receive
medical and dental insurance, 15% of the cost of which is contributed by the
employee. Term life insurance, equivalent to one times your annual salary, and
parking will be provided by the company without employee contribution. Long-term
disability insurance is provided, 100% of the cost is contributed by the
employee (your annual premium would be approximately $      ). You will also be
entitled to three weeks paid vacation accrued on an annual basis and 10 paid
holidays per year.

    Your employment is subject to your signing an Invention, Non-Disclosure and
Non-Compete Agreement with BioTransplant, in the form previously provided to
you, and review of any agreement you may have with others to insure that your
employment with BioTransplant is not in conflict with any such agreements.

    Also, this offer is contingent upon your ability to provide proof of your
legal right to work in the United States, as defined by Federal regulations.

    By signing this letter below, you acknowledge that the foregoing offered
terms of your employment with BioTransplant do not constitute (i) a significant
diminution of your duties, responsibilities, power, title or office in effect at
Eligix, Inc. immediately prior to your acceptance of this offer or (ii) a
material reduction in your compensation (including without limitation, salary,
bonuses, options and benefits) or material change in your manner of compensation
(including without limitation, the timing of any salary or bonus payments) in
effect for you at Eligix, Inc. immediately prior to your acceptance of this
offer.

    If you agree to the terms outlined above, please sign both copies of this
letter and return one copy using the enclosed, stamped envelope.

    We look forward to your joining BioTransplant. We are confident that you
will make a significant contribution to BioTransplant's future success.

Sincerely,

Elliot Lebowitz, Ph.D.
President and CEO

Accepted and Agreed to:


                                                                
------------------------------------------------------------              ------------------------
Name:                                                                                        Date:



                                   EXHIBIT H

             FORM OF NON-COMPETITION AND NON-SOLICITATION AGREEMENT

            INVENTION, NON-DISCLOSURE AND NON-COMPETITION AGREEMENT

    This Agreement is made between BioTransplant Incorporated, a Delaware
corporation (hereinafter referred to collectively with its subsidiaries as the
"Company"), and             (the "Employee").

    In consideration of the employment or continued employment of the Employee
by the Company, the Employee and the Company agree as follows:

    1.  PROPRIETARY INFORMATION.

        (a) The Employee agrees that all information, whether or not in writing,
    of a private, secret or confidential nature concerning the Company's
    business, business relationships, technology or financial affairs
    (collectively, "Proprietary Information") is and shall be the exclusive
    property of the Company. By way of illustration, but not limitation,
    Proprietary Information may include inventions, products, processes,
    methods, techniques, formulas, compositions, compounds, projects,
    developments, plans, research data, clinical data, financial data, personnel
    data, computer programs, customer and supplier lists, and contacts at or
    knowledge of customers or prospective customers of the Company. The Employee
    will not disclose any Proprietary Information to any person or entity other
    than employees of the Company or use the same for any purposes (other than
    in the performance of his/her duties as an employee of the Company) without
    written approval by an officer of the Company, either during or after his/
    her employment with the Company, unless and until such Proprietary
    Information has become public knowledge without fault by the Employee.

        (b) The Employee agrees that all files, letters, memoranda, reports,
    records, data, sketches, drawings, laboratory notebooks, program listings,
    or other written, photographic, or other tangible material containing
    Proprietary Information, whether created by the Employee or others, which
    shall come into his/her custody or possession, shall be and are the
    exclusive property of the Company to be used by the Employee only in the
    performance of his/her duties for the Company. All such materials or copies
    thereof and all tangible property of the Company in the custody or
    possession of the Employee shall be delivered to the Company, upon the
    earlier of (i) a request by the Company or (ii) termination of his/her
    employment. After such delivery, the Employee shall not retain any such
    materials or copies thereof or any such tangible property.

        (c) The Employee agrees that his/her obligation not to disclose or to
    use information and materials of the types set forth in paragraphs (a) and
    (b) above, and his/her obligation to return materials and tangible property,
    set forth in paragraph (b) above, also extends to such types of information,
    materials and tangible property of customers of the Company or suppliers to
    the Company or other third parties who may have disclosed or entrusted the
    same to the Company or to the Employee.

    2.  DEVELOPMENTS.

        (a) The Employee will make full and prompt disclosure to the Company of
    all inventions, improvements, discoveries, methods, developments, software,
    and works of authorship, whether patentable or not, which are created, made,
    conceived or reduced to practice by him/her or under his/her direction or
    jointly with others during his/her employment by the Company, whether or not
    during normal working hours or on the premises of the Company (all of which
    are collectively referred to in this Agreement as "Developments").

        (b) The Employee agrees to assign and does hereby assign to the Company
    (or any person or entity designated by the Company) all his/her right, title
    and interest in and to all Developments and all related patents, patent
    applications, copyrights and copyright applications. However, this
    paragraph 2(b) shall not apply to Developments which do not relate to the
    present or planned business or research and development of the Company and
    which are made and conceived by the Employee not during normal working
    hours, not on the Company's premises and not using the Company's tools,
    devices, equipment or Proprietary Information. The Employee understands
    that, to the extent this Agreement shall be construed in accordance with the
    laws of any state which

    precludes a requirement in an employee agreement to assign certain classes
    of inventions made by an employee, this paragraph 2(b) shall be interpreted
    not to apply to any invention which a court rules and/or the Company agrees
    falls within such classes. The Employee also hereby waives all claims to
    moral rights in any Developments.

        (c) The Employee agrees to cooperate fully with the Company, both during
    and after his/her employment with the Company, with respect to the
    procurement, maintenance and enforcement of copyrights, patents and other
    intellectual property rights (both in the United States and foreign
    countries) relating to Developments. The Employee shall sign all papers,
    including, without limitation, copyright applications, patent applications,
    declarations, oaths, formal assignments, assignments of priority rights, and
    powers of attorney, which the Company may deem necessary or desirable in
    order to protect its rights and interests in any Development. The Employee
    further agrees that if the Company is unable, after reasonable effort, to
    secure the signature of the Employee on any such papers, any executive
    officer of the Company shall be entitled to execute any such papers as the
    agent and the attorney-in-fact of the Employee, and the Employee hereby
    irrevocably designates and appoints each executive officer of the Company as
    his/her agent and attorney-in-fact to execute any such papers on his/her
    behalf, and to take any and all actions as the Company may deem necessary or
    desirable in order to protect its rights and interests in any Development,
    under the conditions described in this sentence.

    3.  NON-COMPETITION.

        (a) While the Employee is employed by the Company and for a period of
    two (2) years after the termination or cessation of such employment for any
    reason, the Employee will not directly or indirectly:

           (i) as an individual proprietor, partner, stockholder, officer,
       employee, director, joint venturer, investor, lender, consultant, or in
       any other capacity whatsoever (other than as the holder of not more than
       one percent of the combined voting power of the outstanding stock of a
       publicly held company), develop, design, produce, market, sell or render
       (or assist any other person in developing, designing, producing,
       marketing, selling or rendering) products or services competitive with
       those being developed, designed, produced, marketed, sold or rendered by
       the Company while the Employee was employed by the Company; or

           (ii) solicit, divert or take away, or attempt to divert or to take
       away, the business or patronage of any of the clients, customers or
       accounts, or prospective clients, customers or accounts, of the Company
       which were contacted, solicited or served by the Employee while employed
       by the Company.

        (b) If the Employee violates the provisions of Section 3(a), the
    Employee shall continue to be bound by the restrictions set forth in
    Section 3(a) until a period of two (2) years has expired without any
    violation of such provisions.

    4.  NON-SOLICITATION.

        (a) While the Employee is employed by the Company and for a period of
    two (2) years after the termination or cessation of such employment for any
    reason, the Employee will not directly or indirectly recruit, solicit or
    hire any employee of the Company, or induce or attempt to induce any
    employee of the Company to terminate his/her employment with, or otherwise
    cease his/her relationship with, the Company.

        (b) If the Employee violates the provisions of Section 4(a), the
    Employee shall continue to be bound by the restrictions set forth in
    Section 4(a) until a period of two (2) years has expired without any
    violation of such provisions.

                                  Exhibit H-2

    5.  OTHER AGREEMENTS.

    The Employee hereby represents that, except as the Employee has disclosed in
writing to the Company, the Employee is not bound by the terms of any agreement
with any previous employer or other party to refrain from using or disclosing
any trade secret or confidential or proprietary information in the course of
his/her employment with the Company or to refrain from competing, directly or
indirectly, with the business of such previous employer or any other party. The
Employee further represents that his/her performance of all the terms of this
Agreement and as an employee of the Company does not and will not breach any
agreement to keep in confidence proprietary information, knowledge or data
acquired by the Employee in confidence or in trust prior to his/her employment
with the Company, and the Employee will not disclose to the Company or induce
the Company to use any confidential or proprietary information or material
belonging to any previous employer or others.

    6.  UNITED STATES GOVERNMENT OBLIGATIONS.

    The Employee acknowledges that the Company from time to time may have
agreements with other persons or with the United States Government, or agencies
thereof, which impose obligations or restrictions on the Company regarding
inventions made during the course of work under such agreements or regarding the
confidential nature of such work. The Employee agrees to be bound by all such
obligations and restrictions, which are made known to the Employee and to, take
all action necessary to discharge the obligations of the Company under such
agreements.

    7.  OTHER ACKNOWLEDGEMENTS.

    The Employee recognizes that his or her willingness to enter into the
restrictive covenants contained in this Agreement was a critical condition
precedent to the Company's willingness to enter into and perform under this
Agreement and the Agreement and Plan of Merger, dated December 8, 2000, among
the Company, BT/EL Acquisition Co., a wholly-owned subsidiary of the Company,
and Eligix, Inc. The Employee also acknowledges that the restrictions contained
in this Agreement will not materially or unreasonably interfere with the
Employee's ability to earn a living.

    8.  MISCELLANEOUS.

        (a) NO CONFLICT. The Employee represents that the execution and
    performance by him/her of this Agreement does not and will not conflict with
    or breach the terms of any other agreement by which the Employee is bound.

        (b) NOT EMPLOYMENT CONTRACT. The Employee acknowledges that this
    Agreement does not constitute a contract of employment and does not imply
    that the Company will continue his/her employment for any period of time.

        (c) INTERPRETATION. If any restriction set forth in Sections 3 or 4 is
    found by any court of competent jurisdiction to be unenforceable because it
    extends for too long a period of time or over too great a range of
    activities or in too broad a geographic area, it shall be interpreted to
    extend only over the maximum period of time, range of activities or
    geographic area as to which it may be enforceable.

        (d) SEVERABILITY. The invalidity or unenforceability of any provision of
    this Agreement shall not affect the validity or enforceability of any other
    provision of this Agreement.

        (e) WAIVER OF RIGHTS. No delay or omission by the Company in exercising
    any right under this Agreement will operate as a waiver of that or any other
    right. A waiver or consent given by the Company on any one occasion is
    effective only in that instance and will not be construed as a bar to or
    waiver of any right on any other occasion.

                                  Exhibit H-3

        (f) EQUITABLE REMEDIES. The restrictions contained in this Agreement are
    necessary for the protection of the business and goodwill of the Company and
    are considered by the Employee to be reasonable for such purpose. The
    Employee agrees that any breach of this Agreement is likely to cause the
    Company substantial and irrevocable damage and therefore, in the event of
    any such breach, the Employee agrees that the Company, in addition to such
    other remedies which may be available, shall be entitled to specific
    performance and other injunctive relief.

        (g) PRIOR AGREEMENTS. This Agreement supersedes all prior agreements,
    written or oral, between the Employee and the Company relating to the
    subject matter of this Agreement. This Agreement may not be modified,
    changed or discharged in whole or in part, except by an agreement in writing
    signed by the Employee and the Company. The Employee agrees that any change
    or changes in his/ her duties, salary or compensation after the signing of
    this Agreement shall not affect the validity or scope of this Agreement.

        (h) ASSIGNABILITY. The Company may assign this Agreement to any other
    corporation or entity which acquires (whether by purchase, merger,
    consolidation or otherwise) all or substantially all of the business and/or
    assets of the Company. Sections 1 and 2 of this Agreement will be binding
    upon the Employee's heirs, executors and administrators and the entire
    Agreement will inure to the benefit of the Company and its successors and
    assigns.

        (i) GOVERNING LAW. This Agreement shall be governed by and construed in
    accordance with the laws of the Commonwealth of Massachusetts. Any action,
    suit, or other legal proceeding which is commenced to resolve any matter
    arising under or relating to any provision of this Agreement shall be
    commenced only in a court of the Commonwealth of Massachusetts (or, if
    appropriate, a federal court located within Massachusetts), and the Company
    and the Employee each consents to the jurisdiction of such a court.

                                  Exhibit H-4

    THE EMPLOYEE ACKNOWLEDGES THAT HE/SHE HAS CAREFULLY READ THIS AGREEMENT AND
UNDERSTANDS AND AGREES TO ALL OF THE PROVISIONS IN THIS AGREEMENT.

    EXECUTED as a sealed instrument as of the dates indicated below.


                                            
                                               BIOTRANSPLANT INCORPORATED

Date: ------------------------                 By: ----------------------------------------

Date: ------------------------                 By: ----------------------------------------
                                               Employee Name


                                  Exhibit H-5

                                   EXHIBIT I

                          OPINION OF HALE AND DORR LLP

     FORM OF OPINION OF COUNSEL TO THE BUYER AND THE TRANSITORY SUBSIDIARY

    1.  Each of the Buyer and the Transitory Subsidiary is a corporation duly
incorporated, validly existing and in good standing under the laws of the state
of its incorporation. The Buyer has all requisite corporate power and authority
to carry on the business in which it, to our knowledge, is engaged and to own
and use the properties which, to our knowledge, are owned and used by it.

    2.  The authorized capital stock of the Buyer consists of (a) 50,000,000
shares of Buyer Common Stock, of which 11,710,793 shares were of record issued
and outstanding as of September 30, 2000, and (b) 2,000,000 shares of Preferred
Stock, $0.01 par value per share, of which no shares are issued or outstanding.
All of the Merger Shares and Management Incentive Shares will be, when issued in
accordance with the Agreement, duly authorized, validly issued, fully paid and
nonassessable.

    3.  Each of the Buyer and the Transitory Subsidiary has all requisite
corporate power and authority to execute and deliver the Agreement and (in the
case of the Buyer) the Escrow Agreement and to perform its obligations
thereunder. The execution and delivery by the Buyer and the Transitory
Subsidiary of the Agreement and (in the case of the Buyer) the Escrow Agreement
and the consummation by the Buyer and the Transitory Subsidiary of the
transactions contemplated thereby have been duly and validly authorized by all
necessary corporate action on the part of the Buyer and the Transitory
Subsidiary, respectively. The Agreement and (in the case of the Buyer) the
Escrow Agreement have been duly and validly executed and delivered by the Buyer
and the Transitory Subsidiary and constitute the valid and binding obligations
of the Buyer and the Transitory Subsidiary, enforceable against the Buyer and
the Transitory Subsidiary in accordance with their respective terms, subject to
bankruptcy, insolvency and similar laws affecting the rights of creditors
generally, general equitable principles and other customary exceptions.

    4.  Except as set forth in Section 3.4 of the Agreement, neither the
execution and delivery by the Buyer or the Transitory Subsidiary of the
Agreement, nor the consummation by the Buyer or the Transitory Subsidiary of the
transactions contemplated thereby, (i) conflicts with or violates any provision
of the charter or by-laws of the Buyer or the Transitory Subsidiary,
(ii) requires on the part of the Buyer or the Transitory Subsidiary any filing
with, or permit, authorization, consent or approval of, any Governmental Entity,
(iii) conflicts with, results in a breach of, constitutes (with or without due
notice or lapse of time or both) a default under, results in the acceleration of
obligations under, creates in any party the right to terminate, modify or
cancel, or requires any notice, consent or waiver under, any contract or
instrument to which the Buyer is a party which is filed as an Exhibit to any of
the Buyer Reports, (iv) violates any Massachusetts state statute or United
States federal rule or regulation applicable to the Buyer or the Transitory
Subsidiary, or (v) violates any order, writ, injunction or decree known to such
counsel and specifically naming the Buyer or the Transitory Subsidiary or any of
their respective properties or assets, excluding from the foregoing clauses
(iii) or (iv) any exceptions to the foregoing that, in the aggregate, would not
have a material adverse effect on the Buyer or on the ability of the Buyer to
consummate the transactions contemplated by the Agreement.

    5.  Upon the filing and acceptance of the Certificate of Merger with the
Secretary of State of Delaware, the Merger will be effective under the Delaware
General Corporation Law statute.

    6.  The Registration Statement has become effective under the Securities Act
and, to our knowledge, no stop order suspending the effectiveness of the
Registration Statement or preventing the use of the Prospectus/Proxy Statement
has been issued and no proceedings for that purpose have been instituted or are
pending or threatened.

    7.  The Merger Shares and the Management Incentive Shares to be issued to
the Company Stockholders pursuant to the Agreement have been registered under
the Securities Act pursuant to the Registration Statement.

    8.  To our knowledge, except as disclosed in the Registration Statement or
the Buyer Reports, there are no actions, suits, investigations or claims or
legal, administrative or arbitration proceedings pending or threatened against
the Buyer.

                                                                         ANNEX B

     AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF
                                  ELIGIX, INC.

    1.  Sections 3(e)(i)(A) and 3(e)(i)(B) of Article IV of the Amended and
Restated Certificate of Incorporation of Eligix, Inc. are hereby amended and
restated to read in their entirety as follows:

       "(A) If traded on a securities exchange or the Nasdaq National
       Market, the value shall be deemed to be the average of the closing
       sale prices for a share of the security to be delivered to the
       holders of the Series Preferred and/or Common Stock (the
       "Liquidation Security"), as quoted on the Nasdaq National Market
       ("Nasdaq"), as reported by Nasdaq, for the thirty (30) trading
       days immediately preceding the date which is three (3) calendar
       days prior to the date of the agreement relating to such
       Acquisition or Asset Transfer (subject to equitable adjustment in
       the event of any stock split, stock dividend, reverse stock split
       or similar event affecting the Liquidation Security since the
       beginning of such thirty-day period) (the "Thirty-Day Period");
       and

       (B) If actively traded over-the-counter, the value shall be deemed
       to be the average of the closing bid prices for a share of the
       Liquidation Security, as quoted in the over-the-counter market,
       for the Thirty-Day Period."

    2.  Section 3(f) of Article IV of the Amended and Restated Certificate of
Incorporation is hereby amended and restated to read in its entirety as follows:

       "(f) If, upon any liquidation, distribution or winding up, the
       assets of the Company shall be insufficient to make payment in
       full to all holders of Series Preferred, then such assets shall be
       distributed first among the holders of Senior Series C Preferred
       at the time outstanding, ratably in proportion to the full amounts
       to which they would otherwise be respectively entitled. If after
       payment in full to the holders of Senior Series C Preferred the
       remaining assets of the Company shall be insufficient to make
       payment in full to the holders of Junior Series Preferred, then
       such remaining assets shall be distributed to the holders of
       Junior Series Preferred at the time outstanding, ratably in
       proportion to the full amounts to which they would otherwise be
       entitled."

                                      B-1


                                                                         ANNEX C


                                     [LOGO]

The Board of Directors
BioTransplant Incorporated
Charlestown Navy Yard
(Building 75)
Third Avenue
Charlestown, MA 02129

Dear Members of the Board:

    We understand that BioTransplant Incorporated (the "Company"), Eligix, Inc.
(the "Subject Company") and a wholly owned subsidiary of the Company ("Sub")
have entered into an Agreement and Plan of Merger dated as of December 8, 2000
(the "Merger Agreement"), pursuant to which Sub will merge with and into the
Subject Company (the "Merger") with the Subject Company being the surviving
corporation of the Merger. Pursuant to the Merger Agreement, the Company has
agreed to issue an aggregate of 6.60 million shares (the "Total Consideration")
of its common stock, par value $0.01 per share (the "Company Common Stock"),
(i) in exchange for all of the shares of (a) common stock, par value $0.001 per
share, of the Subject Company (the "Subject Company Common Stock") issued and
outstanding immediately prior to the effective time of the Merger (the
"Effective Time"), other than shares of Subject Company Common Stock that are
owned beneficially by the Company and Sub, held in the treasury of the Subject
Company and Dissenting Shares (as defined in the Merger Agreement),
(b) Series A preferred stock, par value $0.001 per share, of the Subject Company
(the "Series A Preferred Stock") issued and outstanding immediately prior to the
Effective Time, other than shares of Series A Preferred Stock that are owned
beneficially by the Company and Sub, held in the treasury of the Subject Company
and Dissenting Shares, (c) Series B preferred stock, par value $0.001 per share,
of the Subject Company (the "Series B Preferred Stock") issued and outstanding
immediately prior to the Effective Time, other than shares of Series B Preferred
Stock that are owned beneficially by the Company and Sub, held in the treasury
of the Subject Company and Dissenting Shares, (d) Series C-1 preferred stock,
par value $0.001 per share, of the Subject Company (the "Series C-1 Preferred
Stock") issued and outstanding immediately prior to the Effective Time, other
than shares of Series C-1 Preferred Stock that are owned beneficially by the
Company and Sub, held in the treasury of the Subject Company and Dissenting
Shares, (e) Series C-2 preferred stock, par value $0.001 per share, of the
Subject Company (the "Series C-2 Preferred Stock") issued and outstanding
immediately prior to the Effective Time, other than shares of Series C-2
Preferred Stock that are owned beneficially by the Company and Sub, held in the
treasury of the Subject Company and Dissenting Shares, and (f) Series C-3
preferred stock, par value $0.001 per share, of the Subject Company (the
"Series C-3 Preferred Stock") issued and outstanding immediately prior to the
Effective Time, other than shares of Series C-3 Preferred Stock that are owned
beneficially by the Company and Sub, held in the treasury of the Subject Company
and Dissenting Shares; (ii) in satisfaction of the Subject Company's management
incentive liability as set forth in the Merger Agreement and (iii) upon exercise
or conversion, as the case may be, of all the Subject Company's options,
warrants and notes, whether vested or unvested, outstanding immediately prior to
the Effective Time.

                                     [LOGO]

                                      C-1

    You have requested our opinion as to the fairness, from a financial point of
view, to the Company of the Total Consideration to be paid in the Merger. In
connection with this opinion, we have:

     (i) Reviewed the financial terms and conditions contained in the Merger
         Agreement and the form of escrow agreement appended thereto;

     (ii) Analyzed certain historical business and financial information
          relating to the Company and the Subject Company;

    (iii) Reviewed various financial forecasts and other data provided to us by
          the Company and the Subject Company relating to their respective
          businesses;

     (iv) Held discussions with members of the senior managements of the Company
          and the Subject Company with respect to the businesses and prospects
          of the Company and the Subject Company, respectively, the strategic
          objectives of each, and possible benefits which might be realized
          following the Merger;

     (v) Reviewed public information with respect to certain other companies in
         lines of businesses we believe to be generally comparable to the
         businesses of the Company and the Subject Company;

     (vi) Reviewed the financial terms of certain business combinations
          involving companies in lines of businesses we believe to be generally
          comparable to those of the Company and the Subject Company;

    (vii) Reviewed the historical stock prices and trading volumes of the
          Company Common Stock; and

   (viii) Conducted such other financial studies, analyses and investigations as
          we deemed appropriate.

    We have relied upon the accuracy and completeness of the foregoing
information, and have not assumed any responsibility for any independent
verification of such information or any independent valuation or appraisal of
any of the assets or liabilities of the Company or the Subject Company, or
concerning the solvency or fair value of either of the foregoing entities. With
respect to financial forecasts, we have assumed that they have been reasonably
prepared on bases reflecting the best current available estimates and judgments
of the managements of the Company and the Subject Company as to the future
financial performance of the Company and the Subject Company, respectively. We
assume no responsibility for and express no view as to such forecasts or the
assumptions on which they are based.

    Further, our opinion is necessarily based on economic, monetary, market and
other conditions as in effect on, and the information made available to us, as
of the date hereof.

    In rendering our opinion, we have assumed that the Merger will be
consummated on the terms described in the Merger Agreement, without any waiver
of any material terms or conditions by the Company and that obtaining the
necessary regulatory approvals, if any, for the Merger will not have an adverse
effect on the Company. We have further assumed that the Merger will be accounted
for as a purchase under U.S. generally accepted accounting principles and that
it will qualify as a tax-free reorganization for U.S. federal income tax
purposes.

    Lazard Freres & Co. LLC is acting as investment banker to the Company in
connection with the Merger and will receive a fee for our services, a
substantial portion of which is contingent upon the consummation of the Merger.
In addition, in the ordinary course of business, we may actively trade shares of
Company Common Stock and other securities of the Company for our own account and
for the accounts of our customers and, accordingly, may at any time hold a long
or short position in such securities.

                                      C-2


    Our engagement and the opinion expressed herein are solely for the benefit
of the Company's Board of Directors, and such opinion is rendered to the
Company's Board of Directors in its consideration of the Merger. Our opinion
does not address the merits of the underlying decision by the Company to engage
in the Merger and does not constitute a recommendation to any stockholder of the
Company as to how such stockholder should vote on the Merger. In addition, we
express no opinion as to the price at which the Company Common Stock will trade
following the announcement or the consummation of the Merger, as the case may
be. It is understood that this letter may not be disclosed or otherwise referred
to without our prior consent, except as may otherwise be required by law or by a
court of competent jurisdiction.


    Based on and subject to the foregoing, we are of the opinion that the Total
Consideration to be paid in the Merger is fair to the Company from a financial
point of view.

                                          Very truly yours,

                                          LAZARD FRERES & CO. LLC

                                          By: /s/ STEPHEN H. SANDS
                                          --------------------------------------
                                          Stephen H. Sands
                                          Managing Director

                                      C-3

                                                                         ANNEX D

                        DELAWARE GENERAL CORPORATION LAW

SEC. 262 APPRAISAL RIGHTS.

    (a) Any stockholder of a corporation of this State who holds shares of stock
on the date of the making of a demand pursuant to subsection (d) of this section
with respect to such shares, who continuously holds such shares through the
effective date of the merger or consolidation, who has otherwise complied with
subsection (d) of this section and who has neither voted in favor of the merger
or consolidation nor consented thereto in writing pursuant to sec. 228 of this
title shall be entitled to an appraisal by the Court of Chancery of the fair
value of the stockholder's shares of stock under the circumstances described in
subsections (b) and (c) of this section. As used in this section, the work
"stockholder" means a holder of record of stock in a stock corporation and also
a member of record of a nonstock corporation; the words "stock" and "share" mean
and include what is ordinarily meant by those words and also membership or
membership interest of a member of a nonstock corporation; and the words
"depository receipt" mean a receipt or other instrument issued by a depository
representing an interest in one or more shares, or fractions thereof, solely of
stock of a corporation, which stock is deposited with the depository.

    (b) Appraisal rights shall be available for the shares of any class or
series of stock of a constituent corporation in a merger or consolidation to be
effected pursuant to Section 251 (other than a merger effected pursuant to
Section 251(g) of this title), Section 252, Section 254, Section 257,
Section 258, Section 263 or Section 264 of this title:

        (1) Provided, however, that no appraisal rights under this section shall
    be available for the shares of any class or series of stock, which stock, or
    depository receipts in respect thereof, at the record date fixed to
    determine the stockholders entitled to receive notice of and to vote at the
    meeting of stockholders to act upon the agreement of merger or
    consolidation, were either (i) listed on a national securities exchange or
    designated as a national market system security on an interdealer quotation
    system by the National Association of Securities Dealers, Inc. or (ii) held
    of record by more than 2,000 holders; and further provided that no appraisal
    rights shall be available for any shares of stock of the constituent
    corporation surviving a merger if the merger did not require for its
    approval the vote of the stockholders of the surviving corporation as
    provided in subsection (f) of Section 251 of this title.

        (2) Notwithstanding paragraph (1) of this subsection, appraisal rights
    under this section shall be available for the shares of any class or series
    of stock of a constituent corporation if the holders thereof are required by
    the terms of an agreement of merger or consolidation pursuant to
    SectionSection 251, 252, 254, 257, 258, 263 and 264 of this title to accept
    for such stock anything except:

           a.  Shares of stock of the corporation surviving or resulting from
       such merger or consolidation, or depository receipts in respect thereof;

           b.  Shares of stock of any other corporation, or depository receipts
       in respect thereof, which shares of stock (or depository receipts in
       respect thereof) or depository receipts at the effective date of the
       merger or consolidation will be either listed on a national securities
       exchange or designated as a national market system security on an
       interdealer quotation system by the National Association of Securities
       Dealers, Inc. or held of record by more than 2,000 holders;

           c.  Cash in lieu of fractional shares or fractional depository
       receipts described in the foregoing subparagraphs a. and b. of this
       paragraph; or

                                      D-1

           d.  Any combination of the shares of stock, depository receipts and
       cash in lieu of fractional shares or fractional depository receipts
       described in the foregoing subparagraphs a., b. and c. of this paragraph.

        (3) In the event all of the stock of a subsidiary Delaware corporation
    party to a merger effected under Section 253 of this title is not owned by
    the parent corporation immediately prior to the merger, appraisal rights
    shall be available for the shares of the subsidiary Delaware corporation.

    (c) Any corporation may provide in its certificate of incorporation that
appraisal rights under this section shall be available for the shares of any
class or series of its stock as a result of an amendment to its certificate of
incorporation, any merger or consolidation in which the corporation is a
constituent corporation or the sale of all or substantially all of the assets of
the corporation. If the certificate of incorporation contains such a provision,
the procedures of this section, including those set forth in subsections
(d) and (e) of this section, shall apply as nearly as is practicable.

    (d) Appraisal rights shall be perfected as follows:

        (1) If a proposed merger or consolidation for which appraisal rights are
    provided under this section is to be submitted for approval at a meeting of
    stockholders, the corporation, not less than 20 days prior to the meeting,
    shall notify each of its stockholders who was such on the record date for
    such meeting with respect to shares for which appraisal rights are available
    pursuant to subsection (b) or (c) hereof that appraisal rights are available
    for any or all of the shares of the constituent corporations, and shall
    include in such notice a copy of this section. Each stockholder electing to
    demand the appraisal of such stockholder's shares shall deliver to the
    corporation, before the taking of the vote on the merger or consolidation, a
    written demand for appraisal of such stockholder's shares. Such demand will
    be sufficient if it reasonably informs the corporation of the identity of
    the stockholder and that the stockholder intends thereby to demand the
    appraisal of such stockholder's shares. A proxy or vote against the merger
    or consolidation shall not constitute such a demand. A stockholder electing
    to take such action must do so by a separate written demand as herein
    provided. Within 10 days after the effective date of such merger or
    consolidation, the surviving or resulting corporation shall notify each
    stockholder of each constituent corporation who has complied with this
    subsection and has not voted in favor of or consented to the merger or
    consolidation of the date that the merger or consolidation has become
    effective; or

        (2) If the merger or consolidation was approved pursuant to Section 228
    or Section 253 of this title, each constituent corporation, either before
    the effective date of the merger or consolidation or within ten days
    thereafter, shall notify each of the holders of any class or series of stock
    of such constituent corporation who are entitled to appraisal rights of the
    approval of the merger or consolidation and that appraisal rights are
    available for any or all shares of such class or series of stock of such
    constituent corporation, and shall include in such notice a copy of this
    section; provided that, if the notice is given on or after the effective
    date of the merger or consolidation, such notice shall be given by the
    surviving or resulting corporation to all such holders of any class or
    series of stock of a constituent corporation that are entitled to appraisal
    rights. Such notice may, and, if given on or after the effective date of the
    merger or consolidation, shall, also notify such stockholders of the
    effective date of the merger or consolidation. Any stockholder entitled to
    appraisal rights may, within 20 days after the date of mailing of such
    notice, demand in writing from the surviving or resulting corporation the
    appraisal of such holder's shares. Such demand will be sufficient if it
    reasonably informs the corporation of the identity of the stockholder and
    that the stockholder intends thereby to demand the appraisal of such
    holder's shares. If such notice did not notify stockholders of the effective
    date of the merger or consolidation, either (i) each such constituent
    corporation shall send a second notice before the effective date of the
    merger or consolidation notifying each of the holders of any class or series
    of stock of such constituent

                                      D-2

    corporation that are entitled to appraisal rights of the effective date of
    the merger or consolidation or (ii) the surviving or resulting corporation
    shall send such a second notice to all such holders on or within 10 days
    after such effective date; provided, however, that if such second notice is
    sent more than 20 days following the sending of the first notice, such
    second notice need only be sent to each stockholder who is entitled to
    appraisal rights and who has demanded appraisal of such holder's shares in
    accordance with this subsection. An affidavit of the secretary or assistant
    secretary or of the transfer agent of the corporation that is required to
    give either notice that such notice has been given shall, in the absence of
    fraud, be prima facie evidence of the facts stated therein. For purposes of
    determining the stockholders entitled to receive either notice, each
    constituent corporation may fix, in advance, a record date that shall be not
    more than 10 days prior to the date the notice is given, provided, that if
    the notice is given on or after the effective date of the merger or
    consolidation, the record date shall be such effective date. If no record
    date is fixed and the notice is given prior to the effective date, the
    record date shall be the close of business on the day next preceding the day
    on which the notice is given.

    (e) Within 120 days after the effective date of the merger or consolidation,
the surviving or resulting corporation or any stockholder who has complied with
subsections (a) and (d) hereof and who is otherwise entitled to appraisal
rights, may file a petition in the Court of Chancery demanding a determination
of the value of the stock of all such stockholders. Notwithstanding the
foregoing, at any time within 60 days after the effective date of the merger or
consolidation, any stockholder shall have the right to withdraw such
stockholder's demand for appraisal and to accept the terms offered upon the
merger or consolidation. Within 120 days after the effective date of the merger
or consolidation, any stockholder who has complied with the requirements of
subsections (a) and (d) hereof, upon written request, shall be entitled to
receive from the corporation surviving the merger or resulting from the
consolidation a statement setting forth the aggregate number of shares not voted
in favor of the merger or consolidation and with respect to which demands for
appraisal have been received and the aggregate number of holders of such shares.
Such written statement shall be mailed to the stockholder within 10 days after
such stockholder's written request for such a statement is received by the
surviving or resulting corporation or within 10 days after expiration of the
period for delivery of demands for appraisal under subsection (d) hereof,
whichever is later.

    (f) Upon the filing of any such petition by a stockholder, service of a copy
thereof shall be made upon the surviving or resulting corporation, which shall
within 20 days after such service file in the office of the Register in Chancery
in which the petition was filed a duly verified list containing the names and
addresses of all stockholders who have demanded payment for their shares and
with whom agreements as to the value of their shares have not been reached by
the surviving or resulting corporation. If the petition shall be filed by the
surviving or resulting corporation, the petition shall be accompanied by such a
duly verified list. The Register in Chancery, if so ordered by the Court, shall
give notice of the time and place fixed for the hearing of such petition by
registered or certified mail to the surviving or resulting corporation and to
the stockholders shown on the list at the addresses therein stated. Such notice
shall also be given by 1 or more publications at least 1 week before the day of
the hearing, in a newspaper of general circulation published in the City of
Wilmington, Delaware or such publication as the Court deems advisable. The forms
of the notices by mail and by publication shall be approved by the Court, and
the costs thereof shall be borne by the surviving or resulting corporation.

    (g) At the hearing on such petition, the Court shall determine the
stockholders who have complied with this section and who have become entitled to
appraisal rights. The Court may require the stockholders who have demanded an
appraisal for their shares and who hold stock represented by certificates to
submit their certificates of stock to the Register in Chancery for notation
thereon of the pendency of the appraisal proceedings; and if any stockholder
fails to comply with such direction, the Court may dismiss the proceedings as to
such stockholder.

                                      D-3

    (h) After determining the stockholders entitled to an appraisal, the Court
shall appraise the shares, determining their fair value exclusive of any element
of value arising from the accomplishment or expectation of the merger or
consolidation, together with a fair rate of interest, if any, to be paid upon
the amount determined to be the fair value. In determining such fair value, the
Court shall take into account all relevant factors. In determining the fair rate
of interest, the Court may consider all relevant factors, including the rate of
interest which the surviving or resulting corporation would have had to pay to
borrow money during the pendency of the proceeding. Upon application by the
surviving or resulting corporation or by any stockholder entitled to participate
in the appraisal proceeding, the Court may, in its discretion, permit discovery
or other pretrial proceedings and may proceed to trial upon the appraisal prior
to the final determination of the stockholder entitled to an appraisal. Any
stockholder whose name appears on the list filed by the surviving or resulting
corporation pursuant to subsection (f) of this section and who has submitted
such stockholder's certificates of stock to the Register in Chancery, if such is
required, may participate fully in all proceedings until it is finally
determined that such stockholder not entitled to appraisal rights under this
section.

    (i) The Court shall direct the payment of the fair value of the shares,
together with interest, if any, by the surviving or resulting corporation to the
stockholders entitled thereto. Interest may be simple or compound, as the Court
may direct. Payment shall be so made to each such stockholder, in the case of
holders of uncertificated stock forthwith, and the case of holders of shares
represented by certificates upon the surrender to the corporation of the
certificates representing such stock. The Court's decree may be enforced as
other decrees in the Court of Chancery may be enforced, whether such surviving
or resulting corporation be a corporation of this State or of any state.

    (j) The costs of the proceeding may be determined by the Court and taxed
upon the parties as the Court deems equitable in the circumstances. Upon
application of a stockholder, the Court may order all or a portion of the
expenses incurred by any stockholder in connection with the appraisal
proceeding, including, without limitation, reasonable attorney's fees and the
fees and expenses of experts, to be charged pro rata against the value of all
the shares entitled to an appraisal.

    (k) From and after the effective date of the merger or consolidation, no
stockholder who has demanded appraisal rights as provided in subsection (d) of
this section shall be entitled to vote such stock for any purpose or to receive
payment of dividends or other distributions on the stock (except dividends or
other distributions payable to stockholders of record at a date which is prior
to the effective date of the merger or consolidation); provided, however, that
if no petition for an appraisal shall be filed within the time provided in
subsection (e) of this section, or if such stockholder shall deliver to the
surviving or resulting corporation a written withdrawal of such stockholder's
demand for an appraisal and an acceptance of the merger or consolidation, either
within 60 days after the effective date of the merger or consolidation as
provided in subsection (e) of this section or thereafter with the written
approval of the corporation, then the right of such stockholder to an appraisal
shall cease. Notwithstanding the foregoing, no appraisal proceeding in the Court
of Chancery shall be dismissed as to any stockholder without the approval of the
Court, and such approval may be conditioned upon such terms as the Court deems
just.

    (l) The shares of the surviving or resulting corporation to which the shares
of such objecting stockholders would have been converted had they assented to
the merger or consolidation shall have the status of authorized and unissued
shares of the surviving or resulting corporation.

                                      D-4

                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 20. INDEMNIFICATION OF DIRECTORS AND OFFICERS

    Article IX of our Restated Certificate of Incorporation provides that no
director of our company shall be personally liable for any monetary damages for
any breach of fiduciary duty as a director, except to the extent that the
Delaware General Corporation Law prohibits the elimination or limitation of
liability of directors for breach of fiduciary duty.

    Article X of our Restated Certificate of Incorporation provides that a
director or officer of our company (a) shall be indemnified by us against all
expenses (including attorneys' fees), judgments, fines, and amounts paid in
settlement incurred in connection with any litigation or other legal proceeding
(other than an action by or in the right of our company) brought against him by
virtue of his position as a director or officer of our company if he acted in
good faith and in a manner he reasonably believed to be in, or not opposed to,
the best interests of our company, and, with respect to any criminal action or
proceeding, had no reasonable cause to believe his conduct was unlawful and
(b) shall be indemnified by us against all expenses (including attorneys' fees)
and amounts paid in settlement incurred in connection with any action by or in
the right of our company brought against him by virtue of his position as a
director or officer of our company if he acted in good faith and in a manner he
reasonably believed to be in, or not opposed to, the best interests of our
company, except that no indemnification shall be made with respect to any matter
as to which such person shall have been adjudged to be liable to us, unless a
court determines that, despite such adjudication but in view of all of the
circumstances, he is entitled to indemnification of such expenses.
Notwithstanding the foregoing, to the extent that a director or officer has been
successful, on the merits or otherwise, he will be indemnified by us against all
expenses (including attorneys' fees) incurred in connection therewith. Expenses
shall be advanced to a director or officer at his request, provided that he
undertakes to repay the amount advanced if it is ultimately determined that he
is not entitled to indemnification for such expenses.

    Indemnification is required to be made unless we determine that the
applicable standard of conduct required for indemnification has not been met. In
the event of a determination by us that the director or officer did not meet the
applicable standard of conduct required for indemnification, or if we fail to
make an indemnification payment within 60 days after such payment is claimed by
such person, such person is permitted to petition the court to make an
independent determination as to whether such person is entitled to
indemnification. As a condition precedent to the right of indemnification, the
director or officer must give us notice of the action for which indemnity is
sought and we have the right to participate in such action or assume the defense
thereof.

    Article X of our Restated Certificate of Incorporation further provides that
the indemnification provided therein is not exclusive, and provides that in the
event that the Delaware General Corporation Law is amended to expand the
indemnification permitted to directors or officers we must indemnify those
persons to the fullest extent permitted by such law as so amended.

    Section 145 of the Delaware General Corporation Law provides that a
corporation has the power to indemnify a director, officer, employee, or agent
of the corporation and certain other persons serving at the request of the
corporation in related capacities against amounts paid and expenses incurred in
connection with an action or proceeding to which he is or is threatened to be
made a party by reason of such position, if such person shall have acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests of the corporation, and, in any criminal proceeding, if such person
had no reasonable cause to believe his conduct was unlawful; provided that, in
the case of actions brought by or in the right of the corporation, no
indemnification shall be made with respect to any matter as to which such person
shall have been adjudged to be liable to the

                                      II-1

corporation unless and only to the extent that the adjudicating court determines
that such indemnification is proper under the circumstances.

    We maintain a general liability insurance policy which covers certain
liabilities of directors and officers of our company arising out of claims based
on acts or omissions in their capacities as directors or officers.

ITEM 21. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES



                                                                                
       (A)              EXHIBITS

       *2.1(1)          Agreement and Plan of Merger, dated as of December 8, 2000,
                        by and among the Registrant, BT/EL Acquisition Co. and
                        Eligix, Inc.

        3.1(2)          Amended and Restated Certificate of Incorporation of the
                        Registrant, as amended to date.

        3.2(3)          Amended and Restated By-laws of the Registrant, as amended
                        to date.

        4.1(3)          Specimen certificate for shares of common stock, $.01 par
                        value per share, of the Registrant.

        5.1             Opinion of Hale and Dorr LLP.

        8.1             Form of Opinion of Hale and Dorr LLP as to tax matters.

        8.2             Form of Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and
                        Popeo, P.C. as to tax matters.

      +10.1(3)          Research and License Agreement between the Registrant and
                        The General Hospital Corporation, dated January 1, 1991 as
                        amended by Agreements dated November 10, 1993, June 28, 1995
                        and January 31, 1996 (the "1991 MGH Agreement").

     ++10.2(3)          Research and License Agreement between the Registrant and
                        The General Hospital Corporation dated December 8, 1992.

     ++10.3(3)          Research and License Agreement between the Registrant and
                        The General Hospital Corporation dated August 1, 1994.

     ++10.4(3)          Alliance Agreement between the Registrant and MedImmune,
                        Inc. dated October 2, 1995.

     ++10.5(3)          Research and Supply Agreement between the Registrant and
                        Charles River Laboratories, Inc., dated March 1, 1991, as
                        supplemented by letter dated April 10, 1992.

      +10.6             An extension to the Research and License Agreement between
                        The General Hospital Corporation and the Registrant, having
                        an effective date of January 1, 1991, as amended.

       10.7             Shareholders' Agreement by and among the Registrant,
                        Castella Research, Secure Sciences and Stem Cell Sciences
                        Pty. Ltd. dated April 5, 1994, as amended.

       10.8             Research and License Agreement between the Registrant and
                        Stem Cell Sciences Pty. Ltd. dated April 5, 1994.

       10.9(3)          Form of Common Stock Warrant issued to affiliates of
                        BioLease, Inc., in June 1994 and Schedule of Warrantholders.

       10.10(3)         Common Stock Warrant issued to Aberlyn Capital Management
                        dated June 16, 1993.

       10.11(3)         Common Stock Warrant issued to Aberlyn Capital Management
                        Limited Partnership dated November 18, 1994.

       10.12(3)         Form of Common Stock Warrant issued to certain investors in
                        August 1994 and Schedule of Warrantholders.



                                      II-2



                                                                                
       10.13(3)         Form of Common Stock Warrant issued to certain investors in
                        October 1994 and Schedule of Warrantholders.

       10.14(3)         Form of Common Stock Warrant issued to certain investors in
                        August 1995 and Schedule of Warrantholders.

       10.15(3)         Convertible Promissory Note and Warrant Purchase Agreement
                        by and among the Registrant, HealthCare Ventures II, L.P.
                        and Everest Trust dated December 20, 1991.

       10.16(3)         Preferred Stock Warrant Agreement between the Registrant and
                        Comdisco, Inc., dated December 12, 1991, as clarified by a
                        Letter Agreement dated May 15, 1992.

       10.17(3)         Convertible Promissory Note and Warrant Purchase Agreement
                        by and among the Registrant and the parties signatory
                        thereto dated October 31, 1994.

       10.18(3)         Third Amended and Restated Stockholders Agreement by and
                        among the Registrant and the parties signatory thereto, as
                        amended by a Consent, Waiver and Amendment dated January 23,
                        1996.

       10.19(3)         Form of Consent, Waiver and Amendment Agreement to the Third
                        Amended and Restated Stockholders' Agreement by and among
                        the Registrant and the parties signatory thereto.

       10.20(3)         Amended 1991 Stock Option Plan.

       10.21(4)         1994 Directors' Equity Plan, as amended.

       10.22            1997 Stock Incentive Plan, as amended.

       10.23(3)         Consulting Agreement between the Registrant and Dr. David H.
                        Sachs dated January 1, 1991.

       10.24(5)         Amendments to Consulting Agreement between the Registrant
                        and Dr. David H. Sachs dated December 1, 1998 and January 5,
                        2000.

       10.25(3)         Master Lease Agreement between the Registrant and Aberlyn
                        Capital Management Limited Partnership dated May 12, 1993.

       10.26(3)         Master Lease Agreement between the Registrant and Comdisco,
                        Inc. dated December 12, 1991.

       10.27(3)         Lease between the Registrant and BioLease, Inc. dated March
                        17, 1994.

       10.28(5)         First Amendment to Lease between the Registrant and
                        BioLease, Inc. dated November 17, 1998.

     ++10.29(6)         Development and Supply Agreement between the Registrant and
                        Dendreon Corporation (formerly, Activated Cell Therapy),
                        dated August 22, 1996.

       10.30            Agreement to further vary Shareholders' Agreement among the
                        Registrant and Castella Research, Secure Sciences and Stem
                        Cell Sciences Pty., Ltd., dated December 20, 1996.

       10.31            Agreement to further vary Shareholders' Agreement among the
                        Registrant and Castella Research, Secure Sciences and Stem
                        Cell Sciences Pty., Ltd., dated March 16, 1997, as amended.

       10.32(7)         Letter Agreement, Security Agreement and Promissory Note
                        between the Registrant and Fleet National Bank, dated August
                        10, 1999.

     ++10.33(8)         Miniature Swine Transfer and Maintenance Agreement dated
                        January 1, 1998 by and between Charles River Laboratories,
                        Inc., Wilmington Partners, L.P. and the Registrant.

     ++10.34(9)         Shareholder Agreement dated September 24, 2000 by and
                        between the Registrant, Novartis AG and Immerge
                        BioTherapeutics AG (formerly known as Loxo AG), together
                        with exhibits.




                                      II-3




                                                                                
     ++10.35(10)        Patent License Agreement (MEDI-507), dated July 17, 1997 by
                        and between Protein Design Labs and MedImmune, Inc.

       10.36(11)        Promissory Note made by Eligix, Inc. in favor of the
                        Registrant.

       21               Subsidiaries of the Registrant.

       23.1             Consent of Hale and Dorr LLP (included in Exhibits 5.1 and
                        8.1).

       23.2             Consent of Arthur Andersen LLP.

       23.3             Consent of PricewaterhouseCoopers LLP.

       23.4             Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
                        P.C. (included in Exhibit 8.2).

       23.5             Consent of Lazard Freres & Co. LLC.

     **24.1             Power of Attorney with respect to the Registrant.

       99.1(12)         Fairness Opinion of Lazard Freres & Co. LLC.

       99.2(13)         Form of Escrow Agreement to be entered into by and among the
                        Registrant, the Management Members and Robert Momsen and
                        Pieter Schiller, as representatives of the security holders
                        of Eligix, Inc., and The American Stock Transfer and Trust
                        Company.

       99.3             Form of Proxy Card of the Registrant.

     **99.4             Form of Proxy Card of Eligix, Inc.



------------------------


+   Confidential treatment requested as to certain portions.



++  Confidential treatment granted as to certain portions.


*   The Registrant agrees to furnish supplementally a copy of any omitted
    schedules to this agreement to the Securities and Exchange Commission upon
    its request.


**  Previously filed.


(1) Attached as Annex A to the Joint Proxy Statement/Prospectus.


(2) Incorporated herein by reference from the Registrant's Form 8-K dated
    July 18, 2000.



(3) Incorporated herein by reference to the Registrant's Registration Statement
    on Form S-1, as amended (File No. 333-02144).



(4) Incorporated herein by reference to the Registrant's Definitive Proxy
    Statement for the 1999 Annual Meeting of Stockholders filed on
    Schedule 14A.



(5) Incorporated herein by reference to the Registrant's Form 10-K for the year
    ended December 31, 1999.



(6) Incorporated herein by reference to the Registrant's Form 10-Q for the
    quarter ended September 30, 1996.



(7) Incorporated herein by reference to the Registrant's Form 10-Q for the
    quarter ended June 30, 1998.



(8) Incorporated herein by reference to the Registrant's Form 10-Q for the
    quarter ended September 30, 1999.



(9) Incorporated herein by reference to the Registrant's Form 10-Q for the
    quarter ended September 30, 2000.



(10) Incorporated herein by reference to the exhibit filed with MedImmune,
    Inc.'s Quarterly Report on Form 10-Q for the quarter ended September 30,
    1997.



(11) Incorporated herein by reference to the Registrant's Current Report on
    Form 8-K dated March 9, 2001.



(12) Attached as Annex C to the Joint Proxy Statement/Prospectus.



(13) Attached as Exhibit A to Annex A to the Joint Proxy Statement/Prospectus.


                                      II-4

    (B) FINANCIAL STATEMENT SCHEDULES

    All schedules for which provision is made in the applicable accounting
regulations of the Securities and Exchange Commission are not required under the
related instructions or are not applicable, and, therefore, have been omitted.

ITEM 22. UNDERTAKINGS

    A. The undersigned registrant hereby undertakes:

        (1) To file, during any period in which offers or sales are being made,
    a post-effective amendment to this registration statement:

           (i) To include any prospectus required by Section 10(a)(3) of the
       Securities Act;

           (ii) To reflect in the prospectus any facts or events arising after
       the effective date of the registration statement (or the most recent
       post-effective amendment thereof) which, individually or in the
       aggregate, represents a fundamental change in the information set forth
       in the Registration Statements. Notwithstanding the foregoing, any
       increase or decrease in volume of securities offered (if the total dollar
       value of securities offered would not exceed that which was registered)
       and any deviation from the low or high end of the estimated maximum
       offering range may be reflected in the form of prospectus filed with the
       Commission pursuant to Rule 424(b), if, in the aggregate, the changes in
       volume and price represent no more than 20 percent change in the maximum
       aggregate offering price set forth in the "Calculation of Registration
       Fee" table in the effective registration statement.

           (iii) To include any material information with respect to the plan of
       distribution not previously disclosed in the registration statement or
       any material change to such information in the registration statement;

        (2) That, for the purpose of determining liability under the Securities
    Act of 1933, each such post-effective amendment shall be deemed to be a new
    registration statement relating to the securities offered therein, and the
    offering of such securities at that time shall be deemed to be the initial
    BONA FIDE offering thereof.

        (3) To remove from registration by means of a post-effective amendment
    any of the securities being registered which remain unsold at the
    termination of the offering.

    B. The registrant hereby undertakes as follows:

        (1) That prior to any public reoffering of the securities registered
    hereunder through use of a prospectus which is a part of this registration
    statement, by any person or party who is deemed to be an underwriter within
    the meaning of Rule 145(c), the issuer undertakes that such reoffering
    prospectus will contain the information called for by the applicable
    registration form with respect to reofferings by persons who may be deemed
    underwriters, in addition to the information called for by the other items
    of the applicable form.

        (2) That every prospectus (i) that is filed pursuant to paragraph (1)
    immediately preceding, or (ii) that purports to meet the requirements of
    Section 10(a)(3) of the Securities Act and is used in connection with an
    offering of securities subject to Rule 415, will be filed as a part of an
    amendment to this registration statement and will not be used until such
    amendment is effective, and that, for purposes of determining any liability
    under the Securities Act, each such post-effective amendment shall be deemed
    to be a new registration statement relating to the securities offered
    therein, and the offering of such securities at that time shall be deemed to
    be the initial BONA FIDE offering thereof.

    C. Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the Securities and Exchange

                                      II-5

Commission such indemnification is against public policy as expressed in the
Securities Act and is therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.

    D. The registrant hereby undertakes to respond to requests for information
that is incorporated by reference into the prospectus pursuant to Items 4,
10(b), 11 or 13 of this Form, within one business day of receipt of such
request, and to send the incorporated documents by first class mail or other
equally prompt means. This includes information contained in documents filed
subsequent to the effective date of this registration statement through the date
of responding to the request.

    E. The registrant hereby undertakes to supply by means of a post-effective
amendment all information concerning a transaction, and the company being
acquired involved therein, that was not the subject of and included in the
registration statement when it became effective.

                                      II-6

                                   SIGNATURES


    Pursuant to the requirements of the Securities Act of 1933, the Registrant
has duly caused this Amendment No. 1 to the Registration Statement to be signed
on its behalf by the undersigned, thereunto duly authorized, in the City of
Charlestown, Commonwealth of Massachusetts on the 12th day of March 2001.




                                                      
                                                       BIOTRANSPLANT INCORPORATED

                                                       By:             /s/ ELLIOT LEBOWITZ
                                                            -----------------------------------------
                                                                         Elliot Lebowitz
                                                              PRESIDENT AND CHIEF EXECUTIVE OFFICER




    Pursuant to the requirements of the Securities Act of 1933, as amended, this
Amendment No. 1 to the Registration Statement has been signed by the following
persons in the capacities and on the date indicated.





                      SIGNATURE                                    TITLE                    DATE
                      ---------                                    -----                    ----
                                                                                 
                 /s/ ELLIOT LEBOWITZ
     -------------------------------------------       President, Chief Executive      March 12, 2001
                   Elliot Lebowitz                       Officer and Director

                                                       Vice President, Finance and
               /s/ RICHARD V. CAPASSO                    Treasurer (Principal
     -------------------------------------------         Financial Officer and         March 12, 2001
                 Richard V. Capasso                      Principal Accounting
                                                         Officer)

                 DONALD R. CONKLIN*
     -------------------------------------------       Director
                  Donald R. Conklin

                 WILLIAM W. CROUSE*
     -------------------------------------------       Director                        March 12, 2001
                  William W. Crouse

                  JAMES C. FOSTER*
     -------------------------------------------       Director                        March 12, 2001
                   James C. Foster

                  DANIEL O. HAUSER*
     -------------------------------------------       Director                        March 12, 2001
                  Daniel O. Hauser

                  MICHAEL S. PERRY*
     -------------------------------------------       Director                        March 12, 2001
                  Michael S. Perry





                                                                                    
*By:                   /s/ ELLIOT LEBOWITZ
             --------------------------------------
                         Elliot Lebowitz                                                     March 12, 2000
                        ATTORNEY-IN-FACT



                                      II-7

                                 EXHIBIT INDEX



                                                                                
       (A)              EXHIBITS

       *2.1(1)          Agreement and Plan of Merger, dated as of December 8, 2000,
                        by and among the Registrant, BT/EL Acquisition Co. and
                        Eligix, Inc.

        3.1(2)          Amended and Restated Certificate of Incorporation of the
                        Registrant, as amended to date.

        3.2(3)          Amended and Restated By-laws of the Registrant, as amended
                        to date.

        4.1(3)          Specimen certificate for shares of common stock, $.01 par
                        value per share, of the Registrant.

        5.1             Opinion of Hale and Dorr LLP.

        8.1             Form of Opinion of Hale and Dorr LLP as to tax matters.

        8.2             Form of Opinion of Mintz, Levin, Cohn, Ferris, Glovsky and
                        Popeo, P.C. as to tax matters.

      +10.1(3)          Research and License Agreement between the Registrant and
                        The General Hospital Corporation, dated January 1, 1991 as
                        amended by Agreements dated November 10, 1993, June 28, 1995
                        and January 31, 1996 (the "1991 MGH Agreement").

     ++10.2(3)          Research and License Agreement between the Registrant and
                        The General Hospital Corporation dated December 8, 1992.

     ++10.3(3)          Research and License Agreement between the Registrant and
                        The General Hospital Corporation dated August 1, 1994.

     ++10.4(3)          Alliance Agreement between the Registrant and MedImmune,
                        Inc. dated October 2, 1995.

     ++10.5(3)          Research and Supply Agreement between the Registrant and
                        Charles River Laboratories, Inc., dated March 1, 1991, as
                        supplemented by letter dated April 10, 1992.

      +10.6             An extension to the Research and License Agreement between
                        The General Hospital Corporation and the Registrant, having
                        an effective date of January 1, 1991, as amended.

       10.7             Shareholders' Agreement by and among the Registrant,
                        Castella Research, Secure Sciences and Stem Cell Sciences
                        Pty. Ltd. dated April 5, 1994, as amended.

       10.8             Research and License Agreement between the Registrant and
                        Stem Cell Sciences Pty. Ltd. dated April 5, 1994.

       10.9(3)          Form of Common Stock Warrant issued to affiliates of
                        BioLease, Inc., in June 1994 and Schedule of Warrantholders.

       10.10(3)         Common Stock Warrant issued to Aberlyn Capital Management
                        dated June 16, 1993.

       10.11(3)         Common Stock Warrant issued to Aberlyn Capital Management
                        Limited Partnership dated November 18, 1994.

       10.12(3)         Form of Common Stock Warrant issued to certain investors in
                        August 1994 and Schedule of Warrantholders.

       10.13(3)         Form of Common Stock Warrant issued to certain investors in
                        October 1994 and Schedule of Warrantholders.

       10.14(3)         Form of Common Stock Warrant issued to certain investors in
                        August 1995 and Schedule of Warrantholders.






                                                                                
       10.15(3)         Convertible Promissory Note and Warrant Purchase Agreement
                        by and among the Registrant, HealthCare Ventures II, L.P.
                        and Everest Trust dated December 20, 1991.

       10.16(3)         Preferred Stock Warrant Agreement between the Registrant and
                        Comdisco, Inc., dated December 12, 1991, as clarified by a
                        Letter Agreement dated May 15, 1992.

       10.17(3)         Convertible Promissory Note and Warrant Purchase Agreement
                        by and among the Registrant and the parties signatory
                        thereto dated October 31, 1994.

       10.18(3)         Third Amended and Restated Stockholders Agreement by and
                        among the Registrant and the parties signatory thereto, as
                        amended by a Consent, Waiver and Amendment dated January 23,
                        1996.

       10.19(3)         Form of Consent, Waiver and Amendment Agreement to the Third
                        Amended and Restated Stockholders' Agreement by and among
                        the Registrant and the parties signatory thereto.

       10.20(3)         Amended 1991 Stock Option Plan.

       10.21(4)         1994 Directors' Equity Plan, as amended.

       10.22            1997 Stock Incentive Plan, as amended

       10.23(3)         Consulting Agreement between the Registrant and Dr. David H.
                        Sachs dated January 1, 1991.

       10.24(5)         Amendments to Consulting Agreement between the Registrant
                        and Dr. David H. Sachs dated December 1, 1998 and January 5,
                        2000.

       10.25(3)         Master Lease Agreement between the Registrant and Aberlyn
                        Capital Management Limited Partnership dated May 12, 1993.

       10.26(3)         Master Lease Agreement between the Registrant and Comdisco,
                        Inc. dated December 12, 1991.

       10.27(3)         Lease between the Registrant and BioLease, Inc. dated March
                        17, 1994.

       10.28(5)         First Amendment to Lease between the Registrant and
                        BioLease, Inc. dated November 17, 1998.

     ++10.29(6)         Development and Supply Agreement between the Registrant and
                        Dendreon Corporation (formerly, Activated Cell Therapy),
                        dated August 22, 1996.

       10.30            Agreement to further vary Shareholders' Agreement among the
                        Registrant and Castella Research, Secure Sciences and Stem
                        Cell Sciences Pty., Ltd., dated December 20, 1996.

       10.31            Agreement to further vary Shareholders' Agreement among the
                        Registrant and Castella Research, Secure Sciences and Stem
                        Cell Sciences Pty., Ltd., dated March 16, 1997, as amended.

       10.32(7)         Letter Agreement, Security Agreement and Promissory Note
                        between the Registrant and Fleet National Bank, dated August
                        10, 1999.

     ++10.33(8)         Miniature Swine Transfer and Maintenance Agreement dated
                        January 1, 1998 by and between Charles River Laboratories,
                        Inc., Wilmington Partners, L.P. and the Registrant.

     ++10.34(9)         Shareholder Agreement dated September 24, 2000 by and
                        between the Registrant, Novartis AG and Immerge
                        BioTherapeutics AG (formerly known as Loxo AG), together
                        with exhibits.

     ++10.35(10)        Patent License Agreement (MEDI-507), dated July 17, 1997 by
                        and between Protein Design Labs and MedImmune, Inc.

       10.36(11)        Promissory Note made by Eligix, Inc. in favor of the
                        Registrant.






                                                                                
       21               Subsidiaries of the Registrant.

       23.1             Consent of Hale and Dorr LLP (included in Exhibits 5.1 and
                        8.1).

       23.2             Consent of Arthur Andersen LLP.

       23.3             Consent of PricewaterhouseCoopers LLP.

       23.4             Consent of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo,
                        P.C. (included in Exhibit 8.2).

       23.5             Consent of Lazard Freres & Co. LLC.

     **24.1             Power of Attorney with respect to the Registrant.

       99.1(12)         Fairness Opinion of Lazard Freres & Co. LLC.

       99.2(13)         Form of Escrow Agreement to be entered into by and among the
                        Registrant, the Management Members and Robert Momsen and
                        Pieter Schiller, as representatives of the security holders
                        of Eligix, Inc., and The American Stock Transfer and Trust
                        Company.

       99.3             Form of Proxy Card of the Registrant.

     **99.4             Form of Proxy Card of Eligix, Inc.



------------------------


+   Confidential treatment requested as to certain portions.



++  Confidential treatment granted as to certain portions.


*   The Registrant agrees to furnish supplementally a copy of any omitted
    schedules to this agreement to the Securities and Exchange Commission upon
    its request.


**  Previously filed.


(1) Attached as Annex A to the Joint Proxy Statement/Prospectus.


(2) Incorporated herein by reference from the Registrant's Form 8-K dated
    July 18, 2000.



(3) Incorporated herein by reference to the Registrant's Registration Statement
    on Form S-1, as amended (File No. 333-02144).



(4) Incorporated herein by reference to the Registrant's Definitive Proxy
    Statement for the 1999 Annual Meeting of Stockholders filed on
    Schedule 14A.



(5) Incorporated herein by reference to the Registrant's Form 10-K for the year
    ended December 31, 1999.



(6) Incorporated herein by reference to the Registrant's Form 10-Q for the
    quarter ended September 30, 1996.



(7) Incorporated herein by reference to the Registrant's Form 10-Q for the
    quarter ended June 30, 1998.



(8) Incorporated herein by reference to the Registrant's Form 10-Q for the
    quarter ended September 30, 1999.



(9) Incorporated herein by reference to the Registrant's Form 10-Q for the
    quarter ended September 30, 2000.



(10) Incorporated herein by reference to the exhibit filed with MedImmune,
    Inc.'s Quarterly Report on Form 10-Q for the quarter ended September 30,
    1997.



(11) Incorporated herein by reference to the Registrant's Current Report on
    Form 8-K dated March 9, 2001.



(12) Attached as Annex C to the Joint Proxy Statement/Prospectus.



(13) Attached as Exhibit A to Annex A to the Joint Proxy Statement/Prospectus.