SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                               -----------------

                                  SCHEDULE 13G
                                 (Rule 13d-102)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b),(c) AND (d) AND AMENDMENTS THERETO FILED
                           PURSUANT TO RULE 13d-2(b)
                               (Amendment No. 1)1


                          ESSENTIAL THERAPEUTICS, INC.
                    (f/k/a Microcide Pharmaceuticals, Inc.)
 ------------------------------------------------------------------------------
                                (Name of Issuer)


                    Common Stock, $0.001 par value per share
 ------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                  595018 10 2
 ------------------------------------------------------------------------------
                                 (CUSIP Number)


                               December 31, 2001
 -----------------------------------------------------------------------------
            (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

         [ ] Rule 13d-1(b)

         [ ] Rule 13d-1(c)

         [X] Rule 13d-1(d)



--------
         1 The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page. The information required on
the remainder of this cover page shall not be deemed to be "filed" for the
purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise
subject to the liabilities of that section of the Act but shall be subject to
all other provisions of the Act.




CUSIP No. 595018 10 2                                          Page 2 of 5 Pages


-----------------------------------------------------------------------------
1.   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                  Johnson & Johnson
                  22-1024240
-----------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                   (a) [  ]
                                                   (b) [  ]
-----------------------------------------------------------------------------
3.   SEC USE ONLY
-----------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

         New Jersey
-----------------------------------------------------------------------------
   NUMBER OF                        5.   SOLE VOTING POWER
    SHARES
 BENEFICIALLY                                         -0-
   OWNED BY
     EACH                           ----------------------------------------
   REPORTING                        6.   SHARED VOTING POWER
    PERSON
     WITH                                571,429 shares of Common Stock

                                    ----------------------------------------
                                    7.   SOLE DISPOSITIVE POWER

                                                      -0-
                                    ----------------------------------------
                                    8.   SHARED DISPOSITIVE POWER

                                         571,429 shares of Common Stock
-----------------------------------------------------------------------------
9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                  571,429 shares of Common Stock

-----------------------------------------------------------------------------
10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                          [  ]
-----------------------------------------------------------------------------
11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                  3.4%
-----------------------------------------------------------------------------
12.      TYPE OF REPORTING PERSON

                  CO
-----------------------------------------------------------------------------




CUSIP No. 595018 10 2                                          Page 3 of 5 Pages


-----------------------------------------------------------------------------
1.   NAMES OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

                  Johnson & Johnson Development Corporation
                  22-2007137
-----------------------------------------------------------------------------
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                   (a) [  ]
                                                   (b) [  ]
-----------------------------------------------------------------------------
3.   SEC USE ONLY
-----------------------------------------------------------------------------
4.   CITIZENSHIP OR PLACE OF ORGANIZATION

         New Jersey
-----------------------------------------------------------------------------
   NUMBER OF                        5.   SOLE VOTING POWER
    SHARES
 BENEFICIALLY                                         -0-
   OWNED BY
     EACH                           ----------------------------------------
   REPORTING                        6.   SHARED VOTING POWER
    PERSON
     WITH                                 571,429 shares of Common Stock
                                    ----------------------------------------
                                    7.   SOLE DISPOSITIVE POWER

                                                      -0-
                                    ----------------------------------------
                                    8.   SHARED DISPOSITIVE POWER

                                          571,429 shares of Common Stock
-----------------------------------------------------------------------------
9.       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                  571,429 shares of Common Stock

-----------------------------------------------------------------------------
10.      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

                                                          [  ]
-----------------------------------------------------------------------------
11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                  3.4%
-----------------------------------------------------------------------------
12.      TYPE OF REPORTING PERSON

                  CO
-----------------------------------------------------------------------------





CUSIP No. 595018 10 2                                          Page 4 of 5 Pages



               Amendment No. 1 to Schedule 13G (Final Amendment)
               -------------------------------------------------

     Reference is hereby made to the statement on Schedule 13G filed with the
Securities and Exchange Commission on February 10, 1997 (the "Schedule 13G").
Terms defined in the Schedule 13G are used herein as so defined.

     The following items of the Schedule 13G are hereby amended and restated as
follows:

ITEM 4.   OWNERSHIP.

              (a) Amount Beneficially Owned:

                       J&J: 571,429 shares of Common Stock
                       JJDC: 571,429 shares of Common Stock


              (b) Percent of Class:

                       J&J: 3.4%
                       JJDC: 3.4%


              (c) Number of shares as to which such person has:

                  (i)   sole power to vote or to direct the vote: -0-

                  (ii)  shared power to vote or to direct the vote:

                        J&J: 571,429 shares of Common Stock
                        JJDC: 571,429 shares of Common Stock

                  (iii) sole power to dispose or to direct
                        the disposition of:      -0-

                  (iv)  shared power to dispose or to direct the disposition of:

                        J&J: 571,429 shares of Common Stock
                        JJDC: 571,429 shares of Common Stock


ITEM 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

     If this statement is being filed to report the fact that as of the date
hereof the reporting persons have ceased to be the beneficial owners of more
than five percent of the Common Stock, check the following [X].








CUSIP No. 595018 10 2                                          Page 5 of 5 Pages

                                   SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                  JOHNSON & JOHNSON


                                  By    /s/ MICHAEL H. ULLMAN
                                    --------------------------------------
                                  Name: Michael H. Ullman
                                  Title: Secretary

Dated: February 13, 2002

                                  JOHNSON & JOHNSON DEVELOPMENT CORPORATION


                                  By   /s/ ERIC B. JUNG
                                    ---------------------------------------
                                  Name: Eric B. Jung
                                  Title: Secretary

Dated: February 13, 2002