Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0104
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
  HIGHBRIDGE CAPITAL MANAGEMENT LLC
2. Date of Event Requiring Statement (Month/Day/Year)
04/26/2007
3. Issuer Name and Ticker or Trading Symbol
OSCIENT PHARMACEUTICALS CORP [OSCI]
(Last)
(First)
(Middle)
9 WEST 57TH STREET, 27TH FLOOR
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

NEW YORK, NY 10019
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Shares of Common Stock, par value $0.10 7,421
I (1) (2)
See footnotes (1) (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
3.50% Convertible Senior Notes 05/01/2007 04/14/2011 Common Stock 1,710,889 (2) (3) $ 13.5 I (2) (3) See footnotes (2) (3)
Warrants 03/05/2002 06/04/2008 Common Stock 58,891 (4) (5) $ 24.53 I (4) (5) See footnotes (4) (5)
Warrants 04/14/2004 10/15/2008 Common Stock 25,000 (5) (6) $ 27.84 I (5) (6) See footnotes (5) (6)
Warrants 04/05/2006 11/04/2011 Common Stock 161,917 (2) (7) $ 17.76 I (2) (7) See footnotes (2) (7)

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
HIGHBRIDGE CAPITAL MANAGEMENT LLC
9 WEST 57TH STREET
27TH FLOOR
NEW YORK, NY 10019
    X    
Highbridge International LLC
THE CAYMAN CORPORATE CENTER, 4TH FLOOR
27 HOSPITAL ROAD
GRAND CAYMAN, CAYMAN ISLANDS, E9 00000
    X    
SMITHFIELD FIDUCIARY LLC
THE CAYMAN CORPORATE CENTER, 4TH FLOOR
27 HOSPITAL ROAD
GRAND CAYMAN, CAYMAN ISLANDS, E9 00000
    X    
Dubin Glenn
C/O HIGHBRIDGE CAPITAL MANAGEMENT, LLC
9 WEST 57TH STREET, 27TH FLOOR
NEW YORK, NY 10019
    X    
Swieca Henry
C/O HIGHBRIDGE CAPITAL MANAGEMENT, LLC
9 WEST 57TH STREET, 27TH FLOOR
NEW YORK, NY 10019
    X    

Signatures

By: /s/ Carolyn Rubin, Managing Director 05/15/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) 7,421 shares of Common Stock are held by Highbridge International LLC.
(2) Highbridge Capital Management, LLC is the trading manager of Highbridge International LLC. Glenn Dubin is a Co-Chief Executive Officer of Highbridge Capital Management, LLC. Henry Swieca is a Co-Chief Executive Officer of Highbridge Capital Management, LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares of Common Stock owned by another Reporting Person to the extent such beneficial ownership exceeds such Reporting Person's pecuniary interest.
(3) 1,710,889 shares of Common Stock are issuable to Highbridge International LLC upon conversion of the 3.50% Convertible Senior Notes.
(4) 58,891 shares of Common Stock are issuable to Smithfield Fiduciary LLC upon exercise of the Warrants.
(5) Smithfield Fiduciary LLC is a wholly-owned subsidiary of Highbridge International LLC. Highbridge Capital Management, LLC is the trading manager of Highbridge International LLC and Smithfield Fiduciary LLC. Glenn Dubin is a Co-Chief Executive Officer of Highbridge Capital Management, LLC. Henry Swieca is a Co-Chief Executive Officer of Highbridge Capital Management, LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares of Common Stock owned by another Reporting Person to the extent such beneficial ownership exceeds such Reporting Person's pecuniary interest.
(6) 25,000 shares of Common Stock are issuable to Smithfield Fiduciary LLC upon exercise of the Warrants.
(7) 161,917 shares of Common Stock are issuable to Highbridge International LLC upon exercise of the Warrants.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.