May 21, 2001


Electronic Transmittal


Securities and Exchange Commission
450 Fifth Street, NW
Washington, DC 20549


                       Re:  Interneuron Pharmaceuticals, Inc.


Dear Sir or Madam:

     On behalf of J. Morton Davis and D.H.  Blair  Investment  Banking  Corp.,
transmitted  herewith  is an amended  Schedule  13D  reporting changes in
beneficial ownership of the securities of the above-mentioned company.




Very truly yours,

/s/ David Selengut


David Selengut

DS:dv








                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934

                          (Amendment No. 23)
                          --------------------



                        Interneuron Pharmaceuticals, Inc.
              -----------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.001 par value
            --------------------------------------------------------
                         (Title of Class of Securities)

                                  460573108
           ----------------------------------------------------------
                                 (CUSIP Number)

                David Selengut, Ellenoff, Grossman, Schole, & Cyruli, LLP
                370 Lexington Avenue, New York, NY  10017   (212) 370-1300
         ------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                 Authorized to Receive Notices and Communications)

                                May 21, 2001
          -----------------------------------------------------------
            (Date of Event which Requires FIling of this Statement)


If the filing  person has  previously  filed a statement on Schedule 13G to
report the acquisition  which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b) (3) or (4), check the following box [ ].


Check the following box if a fee is being paid with this statement [ ].(A fee
is not required only if the reporting person:  (1) has a previous  statement
on file reporting beneficial ownership of more than five percent of the class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are
to be sent.


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                             Page 1 of 4 pages





CUSIP No.  460573108                 13D                   Page 2 of 4 Pages



--------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       J. Morton Davis


--------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [  ]


--------------------------------------------------------------------------------
   3   SEC USE ONLY


-------------------------------------------------------------------------------
   4   Source of Funds

       See Item #3 herein.

-------------------------------------------------------------------------------
   5   Check Box if Disclosure of Legal Proceedings is required pursuant to
       Items 2(d) or 2(e)


-------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       United States

--------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            5,146,487
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH             0
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             5,146,487
                 --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                       0
--------------------------------------------------------------------------------
   11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      5,146,487
--------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


--------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                         12%
--------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*
                    IN

--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT




CUSIP No.  460573108                 13D           Page 3 of 4 Pages



--------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       D.H. Blair Investment Banking Corp.


--------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [  ]


--------------------------------------------------------------------------------
   3   SEC USE ONLY


-------------------------------------------------------------------------------
   4   Source of Funds

       See Item #3 herein.

-------------------------------------------------------------------------------
   5   Check Box if Disclosure of Legal Proceedings is required pursuant to
       Items 2(d) or 2(e)


-------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       Delaware

--------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            5,096,331
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH             0
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             5,096,331
                  --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                       0
--------------------------------------------------------------------------------
   11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      5,096,331
--------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


--------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                    11.9%
--------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*
                    BD

--------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT

                                                            Page 4 of 4 Pages

          J. Morton Davis and D.H. Blair Investment  Banking Corp.  ("Blair
          Investment"),  (together,  the "Reporting  Parties")  hereby amend the
          following  in their  statement  on Schedule 13D relating to the common
          stock, $.001 par value ("shares") of Interneuron Pharmaceuticals, Inc.
          (the "Issuer") as follows:

Item 5. (a) is hereby amended in its entirety as follows:

          As of May 21,  2001,  Mr.  Davis may be deemed to  beneficially  own
          5,146,487  shares or 12% of the Issuer's shares issued and outstanding
          as follows:  (i) 50,156  shares  owned  directly by Mr. Davis and (ii)
          5,096,331 shares owned by Blair Investment.

          As of May 21, 2001, Blair Investment may be deemed to beneficially
          own 5,096,331 sgares ir 11.9% of the Issuer's shares as indicated
          in (ii) above.

          This Amendment corrects certain information contained in Amendment
          #22.


Item 5. (b) is hereby amended in its entirety as follows:


          Mr.  Davis has the sole power to vote or to direct  the vote,  to
          dispose or to direct the disposition of those shares owned directly by
          him and those owned by Blair Investment.



                                   SIGNATURES

 After reasonable inquiry and to the best of my knowledge and belief, we
certify that the information set forth in this statement is true, complete
and correct.



                                              /s/ J. Morton Davis
Date:    May 21, 2001                   ____________________________
         New York, New York                  J. Morton Davis








                                       D.H. BLAIR INVESTMENT BANKING CORP.



                                              /s/ David Nachamie
Date:    May 21, 2001                  by_____________________________
         New York, New York                     David Nachamie
                                                Treasurer