SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF
THE SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of Earliest Event Reported) April 25, 2006

E. I. du Pont de Nemours and Company
(Exact Name of Registrant as Specified in Its Charter)

1007 Market Street
Wilmington, Delaware 19898
(Address of principal executive offices)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

[    ]      Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

[    ]      Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

[    ]      Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

[    ]      Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

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Section 2 - Financial Information

Item 2.02     Results of Operations and Financial Condition

                  On April 25, 2006, the Registrant announced its consolidated financial results for the quarter ended March 31, 2006. A copy of the Registrant's earnings news release is furnished on Form 8-K. The information contained in Item 2.02 of this report on Form 8-K shall not be deemed "filed" for purposes of Section 18 of the Exchange Act, or otherwise subject to the liability of that section, nor incorporated by reference in any registration statement filed by the Registrant under the Securities Act of 1933, as amended.

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SIGNATURE

          Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

April 25, 2006

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            "We knew it would be a difficult operating environment in the first quarter, and I am very encouraged by the better than expected performance of our company," said Charles O. Holliday, Jr., DuPont chairman and chief executive officer. "I am especially pleased with how our people delivered these results. We are fully committed to growing revenue, controlling costs and improving return on assets across all of our businesses."

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Global Consolidated Net Income and Sales
            Consolidated net income for the first quarter was $817 million, or $.88 per share, including a previously announced Coatings & Color Technologies restructuring charge of $.10 per share, partly offset by a favorable tax audit settlement of $.05 per share. First quarter net income reflects higher local selling prices across all regions which were more than offset by the impact of higher raw material costs and the adverse effect of the stronger dollar. First quarter 2005 net income was $967 million, or $.96 per share.
            Consolidated net sales for the first quarter were $7.4 billion, essentially equal to the first quarter 2005, and up 2 percent on a comparable business basis. For the quarter, volume increased 2 percent, reflecting increases in all regions except Europe, which had a modest decline. U.S. volume was up 1 percent in spite of reduced production for most of the quarter at the DeLisle, Miss., titanium dioxide (TiO₂) plant, resulting from Hurricane Katrina.

Earnings Per Share
            The table below shows the variances in first quarter 2006 earnings per share (EPS) versus first quarter 2005, by major element:

Improved local pricing and higher volumes offset much of the impact of higher raw material costs. While total fixed costs were lower than last year, and fixed cost productivity (measured as percent of sales) improved 40 basis points versus last year, total fixed costs, excluding a currency translation benefit and portfolio changes, were slightly higher.

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Business Segment Performance
            Segment pretax operating income (PTOI) for first quarter 2006 was $1.3 billion, including a restructuring charge of $135 million for the Coatings & Color Technologies segment. Segment PTOI, sales, and percentage changes versus first quarter 2005 are shown in the tables below.

            Following are summaries of first quarter 2006 performance for the business segments. Additional information on segment performance is available on the DuPont Investor Center at www.dupont.com.
Agriculture & Nutrition

• PTOI decreased $169 million with current quarter earnings of $588 million versus $757 million in the prior year. The decline reflects negative currency impact, higher cost of goods sold and slightly lower volumes, partly offset by a $28 million gain on the sale of a technology license.
  

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• First quarter sales of $2.2 billion were down 5 percent, in line with expectations, reflecting negative currency impact and lower seed volumes.
  
• Cost of goods sold increased as a result of higher raw material and seed production costs.
  
• Important recent pipeline advances include the U.S. launch of corn hybrids with the new HerculexÒ Root Worm trait and licensing agreements for the company's proprietary herbicide tolerance trait -- OptimumÔ GATÔ -- and a new high efficacy insecticide, RynaxypyrÔ .. DuPont also announced the formation of a joint venture with Syngenta, GreenLeaf Genetics, to out-license genetics and biotech traits.
  

• PTOI of $15 million was reduced by a $135 million charge associated with the transformation program in performance coatings. Prior year PTOI was $161 million.
  
• First quarter sales were $1.5 billion, down 1 percent. U.S. dollar (USD) prices increased 2 percent, while volumes were 3 percent lower, primarily the result of reduced production earlier in the quarter at the DeLisle TiO₂ plant due to hurricane damage. Full production at the plant was restored in March.
  
• Higher USD selling prices largely reflect local price improvements for titanium dioxide and refinish products, partly offset by a negative currency impact.
  
• The transformation program for the coatings unit focuses the business on higher growth market segments, and is expected to reduce segment costs by $165 million per year.
  

• PTOI was $163 million versus $110 million in the prior year, up 48 percent. Higher sales and lower fixed costs more than offset higher ingredients costs.
  
• First quarter sales were $0.9 billion, up 6 percent, with 1 percent higher USD selling prices.
  
• Revenue growth principally reflects higher sales volumes and precious metal prices for electronic materials and higher prices and volumes for fluoroproducts. Key growth applications included photovoltaics, semiconductor fabrication, cell phones, and wire and cable.
  

• PTOI was $137 million versus $211 million in 2005, a decline of 35 percent, primarily resulting from significantly higher raw material costs, raw material supply disruptions, and an asset impairment charge of $27 million.
  
• First quarter sales of $1.7 billion increased 6 percent on a comparable business basis, reflecting higher selling prices and volumes that more than overcame a negative currency impact.
  
• Revenue growth in engineering polymers and elastomers occurred in all major product lines and across all regions.
  

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• PTOI was $269 million versus $231 million in the prior year, largely as a result of sales growth in aramids, nonwovens and solid surfaces. PTOI margins increased moderately as a result of effective manufacturing operations and fixed costs leverage.
  
• First quarter sales of $1.4 billion reflected double-digit growth before currency impacts. USD prices increased 5 percent despite negative currency impact, and more than offset higher raw materials costs. Volumes grew in almost all businesses.
  
• Demand remained firm across major markets such as personal protection, construction and industrial.
  

Outlook
            On January 25, the company provided its full-year earnings outlook of $2.60 per share, up 11 percent from $2.34 per share in 2005 before significant items. On March 15, this outlook was increased to $2.70 per share, excluding significant items, because of improved operating performance by many of the company's businesses. Today, the company increased its full-year 2006 outlook to about $2.80 per share, including first quarter significant items totaling a net charge of $.05 per share. Excluding significant items, the company expects to earn about $2.85 per share, 22 percent higher than 2005 earnings per share of $2.34.
            For the second quarter, the company expects to earn about $.90 per share, anticipating that continued pricing strength, volume and fixed cost control will offset higher energy and ingredient costs and competitive pressures in its production agriculture businesses.
            "We are raising our full-year earnings outlook in light of first quarter performance and the progress we have made in successfully implementing initiatives to accelerate shareholder value," Holliday said. "We are building on the positive momentum achieved in the first quarter, taking the necessary measures in underperforming businesses, and accelerating execution to deliver on our commitments."

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Use of Non-GAAP Measures
            Management believes that measures of income excluding significant items ("non-GAAP" information) are meaningful to investors because they provide insight with respect to ongoing operating results of the company. Such measurements are not recognized in accordance with generally accepted accounting principles (GAAP) and should not be viewed as an alternative to GAAP measures of performance. Reconciliations of non-GAAP measures to GAAP are provided in Schedule E.
            DuPont is a science company. Founded in 1802, DuPont puts science to work by creating sustainable solutions essential to a better, safer, healthier life for people everywhere. Operating in more than 70 countries, DuPont offers a wide range of innovative products and services for markets including agriculture, nutrition, electronics, communications, safety and protection, home and construction, transportation and protective apparel.

Forward-Looking Statements: This news release contains forward-looking statements based on management's current expectations, estimates and projections. All statements that address expectations or projections about the future, including statements about the company's strategy for growth, product development, market position, expected expenditures and financial results are forward-looking statements. Some of the forward-looking statements may be identified by words like "expects," "anticipates," "plans," "intends," "projects," "indicates," and similar expressions. These statements are not guarantees of future performance and involve a number of risks, uncertainties and assumptions. Many factors, including those discussed more fully elsewhere in this release and in documents filed with the Securities and Exchange Commission by DuPont, particularly its latest annual report on Form 10-K and quarterly report on Form 10-Q, as well as others, could cause results to differ materially from those stated. These factors include, but are not limited to changes in the laws, regulations, policies and economic conditions, including inflation, interest and foreign currency exchange rates, of countries in which the company does business; competitive pressures; successful integration of structural changes, including restructuring plans, acquisitions, divestitures and alliances; cost of raw materials, research and development of new products, including regulatory approval and market acceptance; seasonality of sales of agricultural products; and severe weather events that cause business interruptions, including plant and power outages, or disruptions in supplier and customer operations.

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4/25/06

Ò Herculex is a registered trademark of Dow AgroSciences LLC.

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E. I. DU PONT DE NEMOURS AND COMPANY AND CONSOLIDATED SUBSIDIARIES

SCHEDULE A

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E. I. DU PONT DE NEMOURS AND COMPANY AND CONSOLIDATED SUBSIDIARIES

SIGNIFICANT ITEMS
(Dollars in millions, except per share)

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E. I. DU PONT DE NEMOURS AND COMPANY AND CONSOLIDATED SUBSIDIARIES

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E. I. DU PONT DE NEMOURS AND COMPANY AND CONSOLIDATED SUBSIDIARIES

SELECTED INCOME STATEMENT DATA
(Dollars in millions, except per share)

RECONCILIATION OF NON-GAAP MEASURES
(Dollars in millions)

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