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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington D.C. 20549

                                   FORM 10-QSB



[ X ]    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended:             September 30, 2004
                                 -----------------------------------------------


                                       OR

[    ]   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                       to
                               -------------------------------------------------

Commission file number:             0-22319
                         -------------------------------------------------------

                            PATIENT INFOSYSTEMS, INC.
                            -------------------------
        (Exact name of small business issuer as specified in its charter)

          Delaware                                   16-1476509
          --------                                   ----------
(State or other jurisdiction of            (I.R.S. Employer Identification No.)
incorporation or organization)

                      46 Prince Street, Rochester, NY 14607
                    (Address of principal executive offices)

                                 (585) 242-7200
                (Issuer's telephone number, including area code)

Check  whether the issuer (1) filed all reports  required to be filed by Section
13 or 15 (d) of the  Exchange Act during the past 12 months (or for such shorter
period that the registrant was required to file such reports),  and (2) has been
subject to such filing requirements for the last 90 days. Yes [X] No [ ]

State the number of shares outstanding of each of the issuer's classes of common
equity, as of the latest  practicable  date: As of November 15, 2004,  9,638,076
shares  of  the  Company's  common  stock,  par  value  $0.01  per  share,  were
outstanding.

Transitional Small Business Disclosure Format (check one) Yes [ ] No [X]

--------------------------------------------------------------------------------



PART I. FINANCIAL INFORMATION
Item 1. Financial Statements



                   PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES
                 CONSOLIDATED BALANCE SHEETS (UNAUDITED) AS OF

ASSETS                                                                          September 30, 2004      December 31, 2003
                                                                                ------------------      -----------------
CURRENT ASSETS:
                                                                                                               
  Cash and cash equivalents                                                             $ 954,408              $ 397,851
  Accounts receivable                                                                   1,078,465                771,258
  Prepaid expenses and other current assets                                               265,674                156,729
                                                                                ------------------ ----------------------
        Total current assets                                                            2,298,547              1,325,838

Property and equipment, net                                                               605,913                305,551

OTHER ASSETS:
  Intangible assets                                                                       642,700                497,893
  Goodwill                                                                             13,866,989              6,981,876
                                                                                ------------------ ----------------------
TOTAL ASSETS                                                                         $ 17,414,149            $ 9,111,158
                                                                                ================== ======================
LIABILITIES AND STOCKHOLDERS' EQUITY

CURRENT LIABILITIES:
  Bank overdraft                                                                     $       -               $   189,608
  Accounts payable                                                                      1,283,197              1,337,862
  Accrued salaries and wages                                                              667,956                442,299
  Accrued expenses                                                                        256,049              1,043,247
  Accrued dividends                                                                     1,111,593                490,756
  Current maturities of long-term debt                                                     25,518                294,117
  Deferred revenue                                                                        293,761                336,598
                                                                                ------------------ ----------------------
        Total current liabilities                                                       3,638,074              4,134,487
                                                                                ------------------ ----------------------
LINE OF CREDIT                                                                          7,000,000              3,000,000
LONG-TERM DEBT                                                                             23,172                 40,295

STOCKHOLDERS' EQUITY:
  Preferred stock - $.01 par value:  shares authorized: 20,000,000
    Series C, 9% cumulative, convertible, issued and outstanding - 75,000
       as of September 30, 2004, 100,000 as of December 31, 2003                              750                  1,000
    Series D, 9% cumulative, convertible, issued and outstanding - 840,118
       as of September 30, 2004, 830,100 as of December 31, 2003                            8,401                  8,301
  Common stock - $.01 par value:  shares authorized:
     80,000,000; issued and outstanding - 9,638,067 as of September  30, 2004,
        4,960,354 as of December 31, 2003                                                  96,381                 49,604
  Additional paid-in capital                                                           54,541,419             45,596,684
  Unearned debt issuance cost                                                         (1,955,967)                      -
  Accumulated deficit                                                                (45,938,081)           (43,719,213)
                                                                                ------------------ ----------------------
        Total stockholders' equity                                                      6,752,903              1,936,376
                                                                                ------------------ ----------------------
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY                                           $ 17,414,149            $ 9,111,158
                                                                                ================== ======================


See notes to unaudited consolidated financial statements.





                   PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES
                CONSOLIDATED STATEMENTS OF OPERATION (UNAUDITED)

                                              Three Months Ended              Nine Months Ended
                                                September 30,                   September 30,
                                           2004              2003            2004             2003
                                           ----              ----            ----             ----

REVENUES
                                                                                       
  Disease and demand management fees    $ 1,967,444      $ 1,429,692      $ 5,991,597      $ 3,957,408
  Ancillary benefits management fees      1,406,376             -           4,476,082             -
                                      -------------- ---------------- ---------------- ----------------
       Total revenues                     3,373,820        1,429,692       10,467,679        3,957,408
                                      -------------- ---------------- ---------------- ----------------
COSTS AND EXPENSES
  Cost of sales                           2,801,762        1,107,776        8,578,400        3,054,233
  Sales and marketing                       363,123          230,606        1,060,756          675,667
  General and administrative                611,089          341,526        2,256,920          913,837
  Research and development                   31,451           35,060           89,685          100,288
                                      -------------- ---------------- ---------------- ----------------
        Total costs and expenses          3,807,425        1,714,968       11,985,761        4,744,025
                                      -------------- ---------------- ---------------- ----------------
OPERATING LOSS                             (433,605)        (285,276)      (1,518,082)        (786,617)

OTHER EXPENSE
  Financing cost                           (203,158)        (754,101)        (545,908)      (1,467,947)
  Interest expense, net                     (21,552)        (151,262)         (76,698)        (447,479)
                                      -------------- ---------------- ---------------- ----------------
NET LOSS                                   (658,315)      (1,190,639)      (2,140,688)      (2,702,043)

CONVERTIBLE PREFERRED STOCK DIVIDENDS      (205,902)        (667,924)        (699,018)      (2,180,242)
                                      -------------- ---------------- ---------------- ----------------
NET LOSS ATTRIBUTABLE TO
  COMMON STOCKHOLDERS                   $  (864,217)   $  (1,858,563)   $  (2,839,706)   $  (4,882,285)
                                      ============== ================ ================ ================
NET LOSS PER SHARE - BASIC
   AND DILUTED                             $  (0.09)         $ (2.04)         $ (0.39)         $ (5.35)
                                      ============== ================ ================ ================
WEIGHTED AVERAGE COMMON  SHARES           9,638,067          913,035        7,202,947          913,015
                                      ============== ================ ================ ================


See notes to unaudited consolidated financial statements.





                   PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES
               CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)

                                                                            Nine Months          Nine Months
                                                                               Ended                Ended
                                                                         September 30, 2004  September 30, 2003

OPERATING ACTIVITIES:
                                                                                                      
  Net loss                                                                 $  (2,140,688)        $  (2,702,042)
  Adjustments to reconcile net loss to net cash used in
    operating activities net of acquisition:
      Depreciation and amortization                                              788,203             1,704,499
      Compensation expense related to warrants                                   245,463                  -
      (Increase) decrease in accounts receivable                                (226,869)              284,440
      (Decrease) Increase in prepaid expenses and other current assets            38,904               (80,672)
      (Increase) decrease in accounts payable                                   (153,586)              265,087
      Increase in accrued salaries and wages                                      86,651               180,737
      (Decrease) increase in accrued expenses                                   (791,330)              403,365
      Decrease in deferred revenue                                               (42,837)              (10,314)
                                                                         ---------------- ---------------------
            Net cash (used in) provided by operating activities               (2,196,089)               45,100
                                                                         ---------------- ---------------------
INVESTING ACTIVITIES:
  Property and equipment additions                                              (259,820)              (27,744)
  Property and equipment disposals and retirements                                 4,206                  -
  Acquisition of CBCA Care Management, net                                    (7,235,000)                 -
  Additional expenses related to ACS acquisition                                 (45,343)                 -
                                                                         ---------------- ---------------------
  Increase in notes receivable                                                      -               (2,900,000)
                                                                         ---------------- ---------------------
          Net cash used in investing activities                               (7,535,957)           (2,927,744)
                                                                         ---------------- ---------------------
FINANCING ACTIVITIES:
  Borrowing from directors, net                                                     -                1,500,000
  Borrowing from stockholders                                                       -                2,125,002
  Borrowing from line of credit                                                4,000,000                  -
  Decrease in bank overdraft                                                    (189,608)                 -
  Payment of debt                                                               (285,722)                 -
  Proceeds from the sale of capital stock                                      7,343,039                    36
  Expenses related to the sale of capital stock                                 (579,106)                 -
                                                                         ---------------- ---------------------
            Net cash provided by financing activities                         10,288,603             3,625,038
                                                                         ---------------- ---------------------
NET INCREASE IN CASH AND CASH  EQUIVALENTS                                       556,557               742,394

CASH AND CASH EQUIVALENTS AT  BEGINNING OF PERIOD                                397,851                 5,011
                                                                         ---------------- ---------------------

CASH AND CASH EQUIVALENTS AT  END OF PERIOD                                   $  954,408             $ 747,405
                                                                              ===========            =========

Supplemental disclosures of non-cash information
  Dividend declared on Convertible Preferred Stock                            $  620,837           $   155,887
                                                                              ===========          ===========
  Beneficial conversion feature of Convertible Preferred Stock                $   78,180           $ 2,024,354
                                                                              ===========          ===========
  Portion of Finance Cost recorded as debt discount                                                $ 2,024,354
                                                                                                   ===========
  Fair market value of:
    Warrants issued for debt guarantee                                      $  2,501,875
                                                                            ============


See notes to unaudited consolidated financial statements.



PATIENT INFOSYSTEMS, INC. AND SUBSIDIARIES

Notes to  Unaudited  Consolidated  Financial  Statements  for the  period  ended
September 30, 2004

1.   The consolidated  financial  statements include the accounts of the Company
     and its wholly owned subsidiaries,  Patient Infosystems Canada, Inc., which
     ceased  operations  in January 2001;  American  Caresource  Holdings,  Inc.
     ("ACS"),  which was created in December 2003 and CBCA Care  Management Inc.
     ("CM"),  which the Company  purchased  on September  22, 2004.  Significant
     intercompany   transactions   and   balances   have  been   eliminated   in
     consolidation.

     The accompanying  consolidated  financial statements for the three and nine
     month periods ended September 30, 2004 and September 30, 2003 are unaudited
     and  reflect  all  adjustments   (consisting   only  of  normal   recurring
     adjustments) which are, in the opinion of management,  necessary for a fair
     presentation  of the  financial  position  and  operating  results  for the
     interim periods.  These unaudited  consolidated financial statements should
     be read in conjunction with the audited  consolidated  financial statements
     and notes thereto,  together with  management's  discussion and analysis of
     financial  condition and results of  operations  contained in the Company's
     Annual Report on Form 10-KSB for the year ended December 31, 2003.  Certain
     reclassifications  of  2003  amounts  have  been  made to  conform  to 2004
     presentations.  The  results of  operations  for the three and nine  months
     ended September 30, 2004 are not necessarily  indicative of the results for
     the entire year ending December 31, 2004.

     All share and per share information  contained herein gives effect to the 1
     for 12 reverse stock split which was effective as of January 9, 2004.

     Acquisitions - On December 31, 2003, the Company acquired substantially all
     the assets and liabilities of American  Caresource  Corporation for a total
     purchase price of $5,754,866.  The Company recorded the American Caresource
     Corporation  acquisition  using  the  purchase  method  of  accounting  and
     therefore,  the  operations  of ACS are included only since the date of the
     acquisition.

     On September 22, 2004, the Company  acquired all the outstanding  equity of
     CBCA Care  Management,  Inc. for a total purchase price of $7,235,000 which
     included  (1)  $7,100,000  in cash and (2)  estimated  direct  expenses  of
     $135,000.  The Company recorded the CBCA Care Management,  Inc. acquisition
     using the purchase method of accounting.

     Information related to the CBCA Care Management acquisition is as follows:

     Purchase price:                           $           7,235,000
                                              ========================
     Purchase allocation:
     Property and equipment                                  181,852
     Identifiable intangible assets                          250,000
     Current liabilities                                    (242,059)
     Current assets                                          228,187
     Goodwill                                              6,817,020
                                              ------------------------
                                               $           7,235,000
                                              ========================

     The  acquisition  has been  accounted  for  using  the  purchase  method of
     accounting  and  accordingly,  the results of  operations  of the  acquired
     entity  for the  eight  day  period  ending  September  30,  2004 have been
     included in the consolidated financial statements.

     The allocation of the identifiable  intangible assets and goodwill have not
     been finalized and any required  adjustments  will be recorded as necessary
     when the information becomes available.

     The  following  unaudited  pro forma  presents the  Company's  consolidated
     results of operations for the three and nine month periods ended  September
     30, 2003 and 2004 as if the acquisition of CM and ACS had been  consummated
     at January 1, 2003. The pro forma results of operations  including  certain
     pro  forma   adjustments,   including  the   amortization  of  identifiable
     intangible assets and interest on certain debt.



                                                  Pro forma for the               Pro forma for the
                                                  Three months ended              Nine months ended
                                                    September 30,                   September 30,
                                                 2004            2003           2004             2003
                                                 ----            ----           ----             ----
                                                                                          
     Revenue                                   5,058,649      5,407,656      15,903,688       15,756,866
                                            ------------- -------------- --------------- ----------------
     Net loss attributable to common share
     holders                                  (1,099,213)    (2,597,885)     (2,842,830)      (8,028,146)
                                            ============= ============== =============== ================
     Earnings per share                            (0.11)         (1.29)          (0.39)           (3.99)
                                            ============= ============== =============== ================
     Weighted average common shares            9,638,067      2,013,035       7,202,947        2,013,015


     Earnings  per share - The  calculations  for the basic and diluted loss per
     share for the three and nine month  periods  ended  September  30, 2004 and
     2003 did not  include  options to  purchase,  respectively,  1,419,827  and
     92,827 shares of common stock,  nor the common  equivalent  shares issuable
     upon  conversion of 75,000 and 840,118  shares,  respectively,  of Series C
     Preferred  Stock and Series D Preferred Stock because the effect would have
     been antidilutive due to the net loss in those periods.  The computation of
     basic and diluted net loss per share is as follows:



                                                  Three Months Ended                Nine Months Ended
                                                    September 30,                     September 30,
                                                2004              2003           2004            2003
                                                ----              ----           ----            ----
                                                                                           
     Net loss                               $    (658,315)   $ (1,190,639)   $ (2,140,688)   $ (2,702,043)
     Convertible preferred stock dividends       (205,902)       (667,924)       (699,018)     (2,180,242)
                                                ----------       ---------       ---------     -----------
     Net loss attributable to
          Common Stockholders               $    (864,217)   $ (1,858,563)   $ (2,839,706)   $ (4,882,285)
                                            =============== =============== =============== ==============
     Weighted average common shares             9,638,067         913,035       7,202,947         913,015
                                            --------------- --------------- --------------- --------------
     Net loss per share - Basic and diluted $       (0.09)   $      (2.04)   $      (0.39)   $      (5.35)
                                            =============== =============== =============== ==============


     Stock-Based  Compensation  - In 2002,  the  Company  adopted  Statement  of
     Financial   Accounting   Standards   ("SFAS")  No.  148,   "Accounting  for
     Stock-Based  Compensation  -  Transition  and  Disclosure."  This  standard
     provides alternative methods of transition for voluntary change to the fair
     value based method of accounting  for  stock-based  employee  compensation.
     Additionally,  the standard  also  requires  prominent  disclosures  in the
     Company's  financial  statements  about the method of  accounting  used for
     stock-based employee  compensation,  and the effect of the method used when
     reporting financial statements.



     The Company  accounts for stock-based  compensation in accordance with SFAS
     No. 123,  "Accounting for Stock-Based  Compensation".  As permitted by SFAS
     No. 123, the Company continues to measure compensation for such plans using
     the intrinsic  value based method of  accounting,  prescribed by Accounting
     Principles Board ("APB"),  Opinion No. 25,  "Accounting for Stock Issued to
     Employees."   Had   compensation   cost  for  the   Company's   stock-based
     compensation  plans been determined  based on the fair value at the date of
     grant for  awards  consistent  with the  provisions  of SFAS No.  123,  the
     Company's net loss and net loss per share would have been  increased to the
     pro forma amounts indicated below:



                                            Three Months Ended                Nine Months Ended
                                               September 30,                    September 30,
                                           2004            2003             2004            2003
                                           ----            ----             ----            ----
     Net loss attributable to common
                                                                                       
     shareholders - as reported           ($864,217)     ($1,858,563)    ($2,839,706)     ($4,882,285)

     Stock compensation expense             (90,150)         (30,961)     (1,347,952)         (88,123)
                                      --------------- ---------------- --------------- ----------------
     Net loss - pro forma                  (954,367)      (1,889,524)     (4,187,658)      (4,970,408)
                                      --------------- ---------------- --------------- ----------------
     Net loss per share - basic
       and diluted - as reported             ($0.09)          ($2.04)         ($0.39)          ($5.35)
                                      =============== ================ =============== ================
     Net loss per share - basic
       and diluted - pro forma               ($0.10)          ($2.07)         ($0.58)          ($5.44)
                                      =============== ================ =============== ================
     Weighted average common shares       9,638,067          913,035       7,202,947          913,015


     The fair value of each option grant is estimated on the date of grant using
     the  Black-Scholes  option-pricing  model using an expected life of 7 years
     and assumed risk-free  interest rates of 3.75% as of September 30, 2004 and
     3.79% as of December 31, 2003.  The assumed  dividend  yield was zero.  The
     Company has used a volatility  factor of 119% as of September  30, 2004 and
     98% as of December 31,  2003.  For  purposes of pro forma  disclosure,  the
     estimated  fair value of each  option is  amortized  to  expense  over such
     option's  vesting period and only the  compensation  expense related to the
     three and nine month periods ended September 30, 2003 and 2004 were used to
     adjust the net loss on a pro forma basis.

2.   On December 31, 2003,  the Company  entered into the Third  Addendum to the
     Second  Amended and Restated  Credit  Agreement  with Well Fargo Bank Iowa,
     N.A., which extended the term of the $3,000,000 credit facility to July 31,
     2005. Dr. Schaffer and Mr. Pappajohn,  directors of the Company, guaranteed
     this extension. In consideration of their guarantees, in February 2004, the
     Company granted to Dr. Schaffer and Mr.  Pappajohn  warrants to purchase an
     aggregate of 47,500 shares of Series D Convertible  Preferred Stock,  which
     are convertible into an aggregate of 475,000 shares of the Company's common
     stock for $10.00 per preferred  share. The Company valued these warrants at
     $1,085,375 using the Black-Scholes  method. The value of these warrants was
     recorded as unearned debt issuance costs and will be amortized as financing
     costs over the nineteen month period of the loan guarantee.

     On September 21, 2004, the Company  entered into the Fourth Addendum to the
     Second  Amended and Restated  Credit  Agreement  with Well Fargo Bank Iowa,
     N.A.,  which  increased the amount of the credit facility to $7,000,000 and
     extended the term of the facility to July 31,  2006.  Dr.  Schaffer and Mr.
     Pappajohn,  directors  of the  Company,  guaranteed  these  extensions.  In
     consideration of their guarantees, in September 2004 the Company granted to
     Dr.  Schaffer  and Mr.  Pappajohn  warrants  to purchase  an  aggregate  of
     1,000,000 shares of the Company's common stock for $1.68 per share expiring
     September 21, 2009. The Company  valued these warrants at $1,416,500  using
     the  Black-Scholes  method.  The value of these  warrants  was  recorded as
     unearned debt issuance costs and will be amortized as financing  costs over
     the 23 month period of the loan guarantee. During the three and nine months
     ended September 30, 2004, the Company recorded a financing cost of $203,158
     and $545,908, respectively.

3.   On March 28, 2004, Mr.  Pappajohn and Dr.  Schaffer  signed a letter to the
     Company in which they made a commitment to obtain the operating  funds that
     the Company  believes  would be sufficient to fund its  operations  through
     January 1, 2005. There can be no assurances given that Mr. Pappajohn or Dr.
     Schaffer can raise either the required  working capital through the sale of
     the  Company's  securities  or that the Company  can borrow the  additional
     amounts needed.

4.   During the nine month period ended  September 30, 2004,  the Company issued
     4,427,713  shares of its  common  stock and  10,018  shares of its Series D
     Convertible  Preferred  Stock to certain  investors for  $7,471,289,  which
     consisted  of  $7,263,200  of working  capital,  forgiveness  of $53,180 of
     accrued  interest  payable,  forgiveness  of $26,659 of debt and payment of
     $128,250 of  services.  The  Company  incurred  $579,106 of costs  directly
     attributable to the sale of its common stock.

     During the nine month period ended  September 30, 2004,  the Company issued
     72,125  shares of its  common  stock as  payment of  $128,250  in  expenses
     related to the sale of common stock and issued warrants to placement agents
     to purchase  118,450 shares of its common stock at exercise  prices between
     $1.68 and $2.75 per share.  These  warrants were assigned an aggregate fair
     market value of $311,663 using a Black-Scholes valuation method.

     Of the warrants to purchase  118,450 shares of the Company's  common stock,
     the  issuance of warrants to purchase  12,500  shares,  assigned a value of
     $22,750,  resulted  in an  additional  expense  related to the  purchase of
     substantially all the assets of and assumption of liabilities from American
     Caresource Corporation on December 31, 2003. Accordingly,  goodwill related
     to this acquisition was increased by $22,750.



5.   During the three months ended  September 30, 2004, the Company  operated in
     two segments:  (i) Patient  Infoystems,  which includes disease management,
     demand  management,  provider  improvement  as well as case  management and
     utilization  review  services  which were  acquired on  September  22, 2004
     through the  acquisition of CM, whose  operations  since September 22, 2004
     are  insignificant;   and  (ii)  ACS,  which  includes  ancillary  benefits
     management  services.  Selected  financial  information  on  the  Company's
     segments for the three and nine month periods ended  September 30, 2004 and
     2003 and pro forma  combined as if the ACS  acquisition  had occurred as of
     January 1, 2003 are presented as follows:



                                            Three Months ended September 30,              Nine Months ended September 30,
                                          2004            2003           2003           2004            2003           2003
Revenues                                                             Pro Forma                                     Pro Forma
                                                                                                           
  Patient Infosystems, Inc.             $ 1,967,444     $ 1,429,692    $ 1,429,692    $ 5,991,597     $ 3,957,408    $ 3,957,408
  American Caresource Holdings, Inc.      1,406,376            -         2,183,344      4,476,082            -         6,963,475
                                      -------------- --------------- -------------- -------------- --------------- --------------
Total revenue                             3,373,820       1,429,692      3,613,036     10,467,679       3,957,408     10,920,883
Cost of goods
  Patient Infosystems, Inc.               1,354,896       1,107,776      1,107,776      4,145,574       3,054,233      3,054,233
  American Caresource Holdings, Inc.      1,446,866            -         2,360,031      4,432,826            -         7,920,539
Selling, General and Administrative
  Patient Infosystems, Inc.                 632,353         607,192        607,192      1,771,486       1,689,792      1,689,792
  American Caresource Holdings, Inc.        373,310            -           610,963      1,635,875            -         1,848,093
Other
  Patient Infosystems, Inc.                 222,541         905,363        905,363        609,971       1,915,426      1,915,426
  American Caresource Holdings, Inc.          2,169            -            53,992         12,635            -           102,719
                                      -------------- --------------- -------------- -------------- --------------- --------------
Net loss
  Patient Infosystems, Inc.                (242,346)     (1,190,639)    (1,190,639)      (535,434)     (2,702,043)    (2,702,043)
  American Caresource Holdings, Inc.       (415,969)           -          (841,642)    (1,605,254)           -        (2,907,876)
                                      -------------- --------------- -------------- -------------- --------------- --------------
Total net loss                             (658,315)     (1,190,639)    (2,032,281)    (2,140,688)     (2,702,043)    (5,609,919)
Preferred Stock dividends                  (205,902)       (667,924)      (767,621)      (699,018)     (2,180,242)    (2,537,230)
                                      -------------- --------------- -------------- -------------- --------------- --------------
Net loss attributable to
  common shareholders                      (864,217)     (1,858,563)    (2,799,902)    (2,839,706)     (4,882,285)    (8,147,149)
                                      ============== =============== ============== ============== =============== ==============
Net loss per share basic and diluted      $   (0.09)       $  (2.04)     $   (1.39)     $   (0.39)      $   (5.35)     $   (4.05)
                                      ============== =============== ============== ============== =============== ==============
Weighted average common shares            9,638,067         913,035      2,013,035      7,202,947         913,015      2,013,015


6.   The  accompanying  unaudited  consolidated  financial  statements have been
     prepared on a going concern basis,  which  contemplates  the realization of
     assets  and  the  satisfaction  of  liabilities  in the  normal  course  of
     business.  As shown in the accompanying  unaudited  consolidated  financial
     statements, the Company incurred a net loss for the nine month period ended
     September  30,  2004 of  $2,140,688  and had a working  capital  deficit of
     $1,339,527 at September 30, 2004. These factors, among others, may indicate
     that the  Company  will be  unable to  continue  as a going  concern  for a
     reasonable period of time.

     The  unaudited   consolidated  financial  statements  do  not  include  any
     adjustments  relating to the recoverability of assets and classification of
     liabilities  that  might be  necessary  should  the  Company  be  unable to
     continue as a going concern.  The Company's  ability to continue as a going
     concern is dependant upon its ability to generate  sufficient  cash flow to
     meet its  obligations.  Management  is currently  assessing  the  Company's
     operating   structure  for  the  purpose  of  reducing  ongoing   expenses,
     increasing  sources of revenue and is  negotiating  the terms of additional
     debt or equity financing.



Item 2.  Management's Discussion and Analysis or Plan of Operations.

     Management's  discussion  and analysis  provides a review of the  Company's
operating  results for the three and nine month periods ended September 30, 2004
as compared to the three and nine month periods  ended  September 30, 2003 and a
review of the Company's financial condition at September 30, 2004 as compared to
September  30, 2003 and December  31,  2003.  The focus of this review is on the
underlying  reasons for significant  changes and trends  affecting the revenues,
net earnings and financial condition of the Company.  This review should be read
in  conjunction  with  the   accompanying   unaudited   consolidated   financial
statements.

     In an effort to give investors a well-rounded  forward-looking  view of the
Company's current condition and future  opportunities,  this Quarterly Report on
Form 10-QSB  includes  information  from the Company's  management  about future
performance  and results.  Because they are  forward-looking,  this  information
involves  uncertainties.  These  uncertainties  include the Company's ability to
continue its operations as a result of, among other things,  continuing  losses,
working capital short falls,  uncertainties  with respect to sources of capital,
risks of market  acceptance  of or  preference  for the  Company's  systems  and
services,  competitive forces, the impact of changes in government  regulations,
general economic factors in the healthcare  industry and other factors discussed
in the Company's filings with the Securities and Exchange  Commission  including
the Company's Annual Report on Form 10-KSB for the year ended December 31, 2003.

Results of Operations

     It is anticipated  that  operations of CBCA Care  Management,  Inc. will be
consolidated with Patient Infosystems in future periods.

     To assist the reader's understanding of the results of operations,  each of
the  Company's  segments,  Patient  Infosystems,  Inc. and  American  Caresource
Holdings,  Inc.,  will be presented  separately  using the  following  segmented
statement of operations, which includes pro forma results of American Caresource
Holdings, Inc. for the three and nine month periods ended September 30, 2003 for
comparative purposes. The results of operation during the 8 days ended September
30,  2004 of CBCA Care  Management,  Inc.  have been  included  with  results of
operations of the Patient Infosystems Segment.



                                                  Three Months ended September 30,
                                       Patient Infosystems               American Caresource
                                      2004            2003              2004            2003
                                      ----            ----              ----            ----
                                                                                      pro forma
                                                                                 
Revenues                           $ 1,967444      $ 1,429,692      $ 1,406,376      $ 2,183,344
Costs and expenses
      Cost of goods                 1,354,896        1,107,776        1,446,866        2,410,583
      Sales and marketing             264,180          230,606           98,943          102,636
      General and administrative      336,722          341,526          274,367          457,775
      Research & development           31,451           35,060             -                -
                                 ------------- ---------------- ---------------- ----------------
        Total costs and expenses    1,987,249        1,714,968        1,820,176        2,970,994
                                 ------------- ---------------- ---------------- ----------------
Operating loss                        (19,805)        (285,276)        (413,800)        (787,650)
Other                                (222,541)        (905,363)          (2,169)         (53,992)
                                 ------------- ---------------- ---------------- ----------------
Net loss                             (242,346)      (1,190,639)        (415,969)        (841,642)
                                 ============= ================ ================ ================






                                                  Nine Months ended September 30,
                                      Patient Infosystems               American Caresource
                                     2004            2003              2004            2003
                                     ----            ----              ----            ----
                                                                                     pro forma
                                                                                
Revenues                         $ 5,991,597      $ 3,957,408      $ 4,476,082      $ 6,963,475
Costs and expenses
      Cost of goods                4,145,574        3,054,233        4,432,826        7,920,539
      Sales and marketing            711,698          675,667          349,058          339,898
      General and administrative     970,103          913,837        1,286,817        1,508,195
      Research & development          89,685          100,288             -                -
                                ------------- ---------------- ---------------- ----------------
        Total costs and expenses   5,917,060        4,744,025        6,068,701        9,768,632
                                ------------- ---------------- ---------------- ----------------
Operating profit (loss)               74,537         (786,617)      (1,592,619)      (2,805,157)
Other                               (609,971)      (1,915,426)         (12,635)        (102,719)
                                ------------- ---------------- ---------------- ----------------
Net loss                            (535,434)      (2,702,043)      (1,605,254)      (2,907,876)
                                ============= ================ ================ ================


PATIENT INFOSYSTEMS SEGMENT INFORMATION

     Revenues

     Revenues  consist of revenues  from  operations  and other  fees.  Revenues
increased 38% to $1,967,444 for the three months ended  September 30, 2004, from
$1,429,692 for the three months ended September 30, 2003. Revenues increased 51%
from  $3,957,408 for the nine months ended  September 30, 2003 to $5,991,597 for
the nine months ended September 30, 2004.



                                           Three Months Ended                    Nine Months Ended
                                              September 30,                        September 30,
Revenues                                 2004               2003              2004              2003
--------                                 ----               ----              ----              ----
Operations fees
                                                                                         
  Provider improvement                $ 1,058,000       $   928,306       $ 4,082,019        $ 2,226,157
  Case and utilization management         180,762              -              180,762               -
  Disease and demand management           726,723           492,427         1,715,786          1,684,807
                                   --------------- ----------------- ----------------- ------------------
Total operations fees                   1,965,485         1,420,733         5,978,567          3,910,964
Other fees                                  1,959             8,959            13,030             46,444
                                   --------------- ----------------- ----------------- ------------------
Total revenues                        $ 1,967,444       $ 1,429,692       $ 5,991,597        $ 3,957,408
                                   --------------- ----------------- ----------------- ------------------


     Provider   innovations   and   improvement   fee  revenues  are   primarily
attributable  to  assistance  provided to  organizations  for the  management of
patients  with  chronic  disease,   including  information  technology  support,
learning organization services and data analysis and reporting. More than 95% of
the provider innovation and improvement revenue is related to a subcontract with
the Institute for Healthcare Improvement.  Provider improvement fee revenues for
the  three  and nine  month  periods  ended  September  30,  2004  increased  to
$1,058,000 and $4,082,019,  respectively, as compared to $928,306 and $2,226,157
for the same  respective  periods of 2003. The Company does not have a long term
agreement with the Institute for Healthcare Improvement and no assurances can be
given that Patient  Infosystems  will continue to provide these  services at the
current levels,  or at all. Revenue  recognized  during the three and nine month
periods ended September 30, 2004 are not  necessarily  indicative of the results
to be expected for the entire year ending  December 31, 2004.  The contracts for
substantially all the provider  improvement  services are annual in nature,  the
largest of which ended as of September 30, 2004. Patient Infosystems anticipates
renewing  this contract and is therefore  continuing  to provide these  services
during the renewal process.  No assurance can be given that the contract will be
renewed.

     Case and utilization  management fee revenues are primarily attributable to
the operation of the Company's  wholly owned  subsidiary,  CBCA Care Management,
Inc. The Company  acquired CBCA Care  Management,  Inc. on September 22, 2004. ,
The $180,762 of revenue  attributable to CBCA Care  Management,  Inc. during the
eight days of operation  following the  acquisition  during three and nine month
periods ended September 30, 2004.  Revenue  recognized during the three and nine
month periods ended  September  30, 2004 are not  necessarily  indicative of the
results to be expected for the entire year ending December 31, 2004.

     Disease and demand  management fee revenues are primarily  attributable  to
the operation of Patient  Infosystems' call center and the delivery of Care Team
Connect for Health  directly to  patients.  Disease  and demand  management  fee
revenues for the three and nine month periods ended September 30, 2004 increased
to $726,723 and $1,715,786, respectively, as compared to $492,427 and $1,684,807
for the same respective periods of 2003. The increase in these fees is primarily
attributable  to the new  sales of Care Team  Connect.  Patient  Infosystems  is
actively  marketing its disease and demand  management  services and anticipates
continuing  to sell  its  services.  No  assurances  can be given  that  Patient
Infosystems will be able to sell its demand and disease management services, or,
to the extent there are sales,  that any such sales will have a material  effect
on the financial condition of Patient Infosystems.

     Other fee revenues for the three and nine month periods ended September 30,
2004 were $1,959 and  $13,030,  respectively,  as compared to $8,959 and $46,444
for the same  respective  periods of 2003.  Patient  Infosystems  received other
revenues for (i)  development  fees from a variety of customers for creation of,
or modification to, specific programs and (ii) license fees. Patient Infosystems
has completed substantially all services under these agreements. Development fee
revenues include clinical,  technical and operational  design or modification of
Patient Infosystems'  primary disease management  programs.  Patient Infosystems
anticipates  that revenue from  development  fees will continue to be low unless
Patient Infosystems enters into new development agreements.  Patient Infosystems
has not  entered  into any new  licensing  agreements  and the  revenue  for the
current  period  reflects  revenue  generated   exclusively  from  the  existing
agreements.

     Costs and Expenses

     Cost of sales includes salaries and related benefits,  services provided by
third  parties,  and  other  expenses  associated  with the  implementation  and
delivery of Patient  Infosystems'  provider  improvement,  case and  utilization
management  and demand and disease  management  programs.  Cost of sales for the
three and nine month  periods  ended  September  30,  2004 were  $1,354,896  and
$4,145,574,  respectively, as compared to $1,107,776 and $3,054,233 for the same
respective periods of 2003. The increase in these costs was primarily the result
of increased  operational  activity.  Patient  Infosystems' gross margin,  being
total  revenues  over cost of sales,  was  positive for the three and nine month
periods ended September 30, 2004 and 2003. Patient Infosystems  anticipates that
revenue must increase for it to recognize economies of scale adequate to improve
its margins.  No assurance  can be given that revenues will increase or that, if
they do, they will continue to exceed costs and expenses.

     Sales  and  marketing  expenses  consist  primarily  of  salaries,  related
benefits,  travel costs,  sales materials and other marketing  related expenses.
Sales and marketing  expenses for the three and nine months ended  September 30,
2004 were  $264,180  and  $711,698,  respectively,  as compared to $230,606  and
$675,667  for  the  same  respective  periods  of  2003.   Patient   Infosystems
anticipates  expansion of Patient  Infosystems'  sales and  marketing  staff and
expects it will continue to invest in the sales and marketing process,  and that
such expenses related to sales and marketing may increase in future periods.

     General  and  administrative   expenses  include  the  costs  of  corporate
operations,  finance and accounting, human resources and other general operating
expenses of Patient  Infosystems.  General and  administrative  expenses for the
three  and nine  month  periods  ended  September  30,  2004 were  $336,722  and
$970,103,  respectively,  as  compared  to $341,526  and  $913,837  for the same
respective  periods of 2003. These  expenditures  have been incurred to maintain
the  corporate   infrastructure   necessary  to  support   anticipated   program
operations.  General and administrative  expenses may increase in future periods
as it continues to establish the resources  needed to comply with Section 404 of
the Sarbanes-Oxley Act of 2002.

     Research and development expenses consist primarily of salaries and related
benefits and  administrative  costs  associated  with the development of certain
components of Patient Infosystems'  integrated  information capture and delivery
system,  as well as development  of Patient  Infosystems'  standardized  disease
management programs and Patient Infosystems' Internet based technology products.
Research and  development  expenses for the three and nine month  periods  ended
September  30,  2004 were  $31,451  and  $89,685,  respectively,  as compared to
$35,060 and $100,288 for the same respective periods of 2003.

     Patient  Infosystems  recorded  other expenses for the three and nine month
periods  ended  September 30, 2004 of $222,541 and  $609,971,  respectively,  as
compared to $905,363 and  $1,915,426 for the same  respective  periods of, 2003.
This change was  principally due to the interest  expense and related  financing
cost on debt.

     Patient  Infosystems  had a net loss for the three and nine  month  periods
ended September 30, 2004 of $242,346 and $535,434,  respectively, as compared to
$1,190,639 and $2,702,043 for the same respective periods of 2003.

AMERICAN CARESOURCE SEGMENT INFORMATION

     Revenues

     Revenues of American  CareSource  Holdings,  Inc.  ("ACS") are comprised of
revenues  from  ancillary  service  claims and  processing  of  patient  claims.
Revenues  decreased to $1.4  million  from $2.2 million  during the three months
ended September 30, 2004 and 2003,  respectively,  or 36%. Revenues decreased to
$4.5 million from $7.0 million  during the nine months ended  September 30, 2004
and 2003, respectively, or 36%.



                         Three Months Ended                Nine Months Ended
                             September 30                     September 30
Revenues                2004             2003            2004             2003
--------                ----             ----            ----             ----
                                      Pro forma                        Pro forma
                                                                   
Ancillary Health     $ 1,267,981      $ 2,058,439     $ 4,079,460      $ 6,632,511
Patient Claims           138,395          124,905         396,622          330,964
                  ---------------- ---------------- --------------- --------------
Total Revenues       $ 1,406,376       $2,183,344     $ 4,476,082       $6,963,475


     Ancillary  health claims revenue for the three and nine month periods ended
September 30, 2004  decreased to $1,267,981  and  $4,079,460,  respectively,  as
compared to $2,058,439 and $6,632,511 for the same  respective  periods of 2003.
This decrease is attributable to the  cancellation of contracts by major clients
and to the reduction of revenue from certain  providers in ACS' ancillary health
provider  network,  partially  offset by the addition of new  clients.  Pinnacol
Assurance  ("Pinnacol")  notified  ACS on  December  19,  2003 of its  intent to
terminate its contract with ACS effective  March 18, 2004,  and was winding down
through  the first  quarter  and into the second  quarter of 2004.  There was no
revenue from Pinnacol in the third quarter of 2004. Revenue from Pinnacol in the
third quarter of 2003 was $1,097,322. Revenue from Pinnacol decreased 81.4% from
$3,034,121  for the nine month period ended  September  30, 2003 to $563,042 for
the same  period in 2004.  Plan  Vista,  from which ACS  received  $110,577  and
$554,746 of revenue for the three and nine month  periods  ended  September  30,
2003,  respectively,  notified  ACS of its  intent  to  terminate  its  contract
effective  October 13, 2004 and did not  generate any revenue for ACS during the
nine month period ended  September 30, 2004.  The  decreased  revenue due to the
termination  of clients was  partially  offset by $271,512 of new business  from
three new clients in the nine months ended September 30, 2004, of which $207,342
was generated in the third quarter.  ACS has experienced improved relations with
providers in its network as a result of the acquisition by Patient  Infosystems,
due to better funding.  ACS also has been able to expand its provider network by
seeking to restore  relationships  with providers  previously in the network and
adding new providers as ACS obtained new client payor contracts.  ACS expects to
see  growth in the  number of client and payor  relationships  due to  increased
emphasis on sales.  No assurances can be given that ACS will be able to continue
to expand its provider or payor relationships,  nor that any such expansion will
result in an improvement in the results of operations of ACS.

     The  processing  of patient  claims  revenues  for the three and nine month
periods ended September 30, 2004 increased 10.8% to $138,395 and increased 19.8%
to  $396,622,  respectively,  as compared to $124,905  and $330,964 for the same
respective periods of 2003. The Company does not expect to increase its revenues
from claims processing in future periods.

     Costs and Expenses

     Cost of revenues includes provider  payments,  direct expenses incurred for
providing  services and the related  direct labor and overhead of providing such
services.  ACS is not  liable for costs  incurred  by its  contracted  providers
unless and until these providers obtain approval from the appropriate payors and
provide the contracted services and ACS receives payment from the payors.  Costs
of revenues also include direct expenses to administer claims,  including direct
labor  associated  with  recruitment and  contracting  with providers,  database
maintenance,  data entry of claims,  claims repricing,  fulfillment and overhead
costs.  Costs of revenues for the three and nine month periods  ended  September
30, 2004 decreased to $1,446,866 and  $4,433,826,  respectively,  as compared to
$2,410,583 and $7,920,539 for the same respective periods of 2003. This decrease
was due to a decrease in provider payments, the renegotiation of management fees
payable  to  one  client,  and a  reduction  in  direct  expenses  and  overhead
associated  with the  decrease in claims  volume  related to  revenue.  Provider
payments  related to  revenues  during the three and nine  month  periods  ended
September 30, 2004 decreased  $687,576 and $2,262,675,  respectively as compared
to the same respective periods of 2003.  Management fees from ppoNEXT during the
three and nine month periods ended  September  30, 2004  decreased  $107,949 and
$320,987,  respectively,  as compared to the same respective periods of 2003, as
contract changes negotiated in July 2003 took effect upon the acquisition of ACS
by  Patient  Infosystems.  Direct  expenses  and  overhead  associated  with ACS
services  provided  during the three and nine month periods ended  September 30,
2004  decreased  $212,481 and  $889,197,  respectively,  as compared to the same
respective periods of 2003, as reductions were made to personnel and other costs
to align ACS' cost structure with its claims volume.

     Sales and marketing  expenses  include the salaries and related benefits of
ACS' account development employees,  travel and other costs for those employees,
and sales  materials and other  marketing or sales expenses of ACS.  Commissions
paid to  independent  outside  salespeople  are based directly on net margin per
client.  Payments to providers and all billing and processing of claims expenses
are included in cost of revenues. Sales and marketing expenses for the three and
nine month  periods  ended  September  30, 2004 were  $98,943 and  $349,058,  as
compared to $102,636 and $339,898 for the same  respective  periods of 2003. ACS
anticipates  continued  investment in the sales and marketing process,  and that
expenses  related to sales and  marketing  may  continue  to  increase in future
periods.

     General  and  administrative  expenses  include  the  salaries  and related
benefits  of ACS'  executive  employees,  systems  development  and  finance and
accounting  employees,  travel and other costs for those employees.  General and
administrative expenses for the three and nine month periods ended September 30,
2004 were  $274,367 and  $1,286,817,  respectively,  as compared to $457,775 and
$1,508,195 for the same respective periods of 2003.  Compared to the prior year,
legal fees  decreased  $39,868  and  $216,652  and  administrative  and  finance
compensation  expense  decreased  $100,786  and  $210,343 for the three and nine
month  periods  ended  September  30, 2004,  respectively.  The  personnel  cost
reductions   were  due  to   consolidation   of  these  functions  with  Patient
Infosystems,  as well as  efficiencies  and  reductions  in  payment  processing
volume.  The cost  reductions  were  offset by a one-time  warrant  compensation
expense of $211,900 charged in the first quarter of 2004.

     The Company  recorded  other  expense for the three and nine month  periods
ended  September  30, 2004 of $2,169 and $12,635,  respectively,  as compared to
$53,992 and $102,719 for the same respective  periods of 2003. Any new financing
arrangements will be made by Patient  Infosystems.  Consequently,  ACS' interest
expense is expected to be minimal in future periods.

     ACS had a net loss for the three and nine month periods ended September 30,
2004 of $415,969  and  $1,605,254,  respectively,  as  compared to $841,642  and
$2,907,876 for the same respective periods of 2003.

INCOME (LOSS)

     The Company reported a net loss attributable to common shareholders for the
three  and  nine  month  periods  ended  September  30,  2004  of  $864,576  and
$2,839,706,  respectively, as compared to $1,858,563 and $4,882,285 for the same
respective  periods of 2003. This represents a loss per share of $0.09 and $0.39
for the same  respective  periods or 2004 as compared to $2.04 and $5.35 for the
same respective  periods of 2003. The pro forma earnings per share assuming that
the  acquisition  of  substantially  all the assets and  liabilities of American
Caresource  Corporation  had  occurred  on  January 1, 2003 was $1.39 and $4.05,
respectively,  as  compared  to $0.09  and  $0.39  loss per  share  for the same
respective  period of 2004. During the nine months ended September 30, 2004, the
Company  recorded a  beneficial  conversion  feature  of $78,180  related to the
issuance of 10,018 shares of the Company's Series D Preferred  Stock,  which was
recorded as a dividend,  and declared  $620,837 of dividends on the  outstanding
preferred stock.

LIQUIDITY AND CAPITAL RESOURCES

     At  September  30,  2004,  the  Company  had a working  capital  deficit of
$1,339,527 as compared to a deficit of $2,808,649 at December 31, 2003.  Through
September  30,  2004,  these  amounts  reflect  the  effects  of  the  Company's
continuing  losses and borrowings as well as the recent  borrowing  necessary to
complete the acquisition of CBCA Care Management, partially offset by its recent
sale of capital stock. Since its inception, the Company has primarily funded its
operations,  working  capital  needs and capital  expenditures  from the sale of
equity securities or the incurrence of debt.

     On March 28, 2003, the Company  entered into an Amended and Restated Credit
Agreement  with Wells  Fargo Bank Iowa,  N.A.,  which  extended  the term of the
Company's $3,000,000 credit facility to January 2, 2004, under substantially the
same terms. Mr. Pappajohn and Dr. Schaffer, directors of the Company, guaranteed
this extension.

     On December 31, 2003,  the Company  entered into the Third  Addendum to the
Second Amended and Restated  Credit  Agreement with Well Fargo Bank Iowa,  N.A.,
which extended the term of the $3,000,000  credit facility to July 31, 2005. Mr.
Pappajohn and Dr. Schaffer guaranteed this extension. In consideration for their
guarantees,  in  February  2004 the  Company  granted  to Dr.  Schaffer  and Mr.
Pappajohn  warrants  to  purchase  an  aggregate  of  47,500  shares of Series D
Convertible  Preferred  Stock,  which are convertible into 475,000 shares of the
Company's  common stock for $10.00 per preferred share. The Company valued these
warrants  at  $1,085,375  using  the  Black-Scholes  method.  The value of these
warrants was recorded as unearned  debt  issuance  cost and will be amortized as
financing costs over the nineteen month period of the loan guarantee.

     In January 2004, the Company borrowed $200,000 for working capital from Mr.
Pappajohn  which was repaid in March 2004 using the  proceeds of the sale of the
Company's common stock.  During the three month period ended September 30, 2004,
the Company  borrowed  $570,000 of working capital from Mr.  Pappajohn which was
repaid in September 2004 using the proceeds of the sale of the Company's  common
stock.

     On March 28, 2004, Mr.  Pappajohn and Dr.  Schaffer  signed a letter to the
Company in which they made a commitment to obtain the  operating  funds that the
Company  believes would be sufficient to fund its operations  through January 1,
2005.  There can be no assurances  given that Mr.  Pappajohn or Dr. Schaffer can
raise  either the required  working  capital  through the sale of the  Company's
securities or that the Company can borrow the additional amounts needed.

     On September 21, 2004, the Company  entered into the Fourth Addendum to the
Second Amended and Restated  Credit  Agreement with Well Fargo Bank Iowa,  N.A.,
which increased the amount of the credit facility to $7,000,000 and extended the
term to July 31, 2006. Dr. Schaffer and Mr. Pappajohn, directors of the Company,
guaranteed these extensions.  In consideration of their guarantees, in September
2004 the Company granted to Dr. Schaffer and Mr. Pappajohn  warrants to purchase
an  aggregate of 1,000,000  shares of the  Company's  common stock for $1.68 per
share. The Company valued these warrants at $1,416,500  using the  Black-Scholes
method. The value of these warrants was recorded as unearned debt issuance costs
and will be amortized  as  financing  costs over the 23 month period of the loan
guarantee.  During the three and nine  months  ended  September  30,  2004,  the
Company recorded a financing cost of $203,158 and $545,908, respectively.

     During the nine month period ended  September 30, 2004,  the Company issued
4,427,713  shares  of its  common  stock  and  10,018  shares  of its  Series  D
Convertible  Preferred  Stock  to  certain  investors  in  for an  aggregate  of
$7,471,289  which  consisted of $7,263,200 of working  capital,  forgiveness  of
$53,180 of accrued interest payable,  forgiveness of $26,659 of debt and payment
of  $128,250  of  services.  The Company  incurred  $533,658  of costs  directly
attributable to the sale of its common stock.

     During the nine month period ended  September 30, 2004,  the Company issued
72,125 shares of its common stock as payment of $128,250 in expenses  related to
the sale of common  stock and issued  warrants to  placement  agents to purchase
118,450  shares of its common stock at exercise  prices  between $1.68 and $2.75
per share.  These  warrants  were  assigned an  aggregate  fair market  value of
$311,663 using a Black-Scholes valuation method.

     Of the warrants to purchase  118,450 shares of the Company's  common stock,
the issuance of warrants to purchase 12,500 shares, assigned a value of $22,750,
resulted in an additional  expense related to the purchase of substantially  all
of the assets and assumption of liabilities from American Caresource Corporation
on December 31, 2003.  Accordingly,  goodwill  related to this  acquisition  was
increased by $22,750.

     The  Company has  expended  significant  amounts to expand its  operational
capabilities, including increasing its administrative and technical costs. While
Patient  Infosystems  has both  curtailed its spending  levels and increased its
revenue,  to the extent that ACS,  revenues do not increase  substantially,  the
Company's losses will continue and its available  capital will diminish further.
The Company's  operations are currently  being funded by borrowings and the sale
of equity  securities.  There can be no  assurances  given that the  Company can
raise either the required  working capital through the sale of its securities or
that Patient  Infosystems  can borrow the  additional  amounts  needed.  In such
instance,  if Patient  Infosystems is unable to identify  additional  sources of
capital, it will likely be forced to curtail or cease operations. As a result of
the above, the Independent Auditors' Report on Patient Infosystems' consolidated
financial  statements  for the year ended December 31, 2003 includes an emphasis
paragraph indicating that Patient Infosystems'  recurring losses from operations
raise  substantial  doubt about  Patient  Infosystems'  ability to continue as a
going concern. The accompanying consolidated financial statements do not include
any adjustments that might result from the outcome of this uncertainty.

INFLATION

     Inflation did not have a significant  impact on the Company's  costs during
the three and nine month  periods  ended  September  30, 2004 and  September 30,
2003.  The  Company  continues  to monitor the impact of  inflation  in order to
minimize its effects through pricing strategies,  productivity  improvements and
cost reductions.

FORWARD LOOKING STATEMENTS

     When used in this and in future  filings of the Company with the Securities
and Exchange  Commission  ("SEC"),  in the Company's  press releases and in oral
statements  made with the  approval of an  authorized  executive  officer of the
Company,  the words or phrases "will likely result,"  "expects,"  "plans," "will
continue,"  "is  anticipated,"  "estimated,"  "project," or "outlook" or similar
expressions  (including  confirmations by an authorized executive officer of the
Company  of any such  expressions  made by a third  party  with  respect  to the
Company)  are  intended  to  identify  "forward-looking  statements"  within the
meaning of the Private  Securities  Litigation  Reform Act of 1995.  The Company
wishes  to  caution   readers   not  to  place   undue   reliance  on  any  such
forward-looking  statements,  each of which speak only as of the date made. Such
statements,  including those made with respect to future sources of revenue, new
customers  and control of costs and  expenses,  are subject to certain risks and
uncertainties  that  could  cause  actual  results  to  differ  materially  from
historical  earnings  and  those  presently  anticipated  or  projected.   These
uncertainties  include the  Company's  ability to continue its  operations  as a
result of, among other things,  continuing losses,  working capital short falls,
uncertainties with respect to sources of capital,  risks of market acceptance of
or preference for the Company's systems and services,  competitive  forces,  the
impact of changes in government  regulations,  general  economic  factors in the
healthcare  industry and other factors  discussed in the Company's  filings with
the SEC including the Company's  Annual Report on Form 10-KSB for the year ended
December 31, 2003. The Company has no obligation to publicly  release the result
of any revisions, which may be made to any forward-looking statements to reflect
anticipated or unanticipated events or circumstances occurring after the date of
such statements.

Item 3. Controls and Procedures.

     Our management,  with the  participation of our Chief Executive Officer and
Vice  President,  Financial  Planning,  has evaluated the  effectiveness  of our
disclosure  controls and  procedure as of  September  30, 2004.  Based upon this
evaluation,  our Chief Executive Officer and Vice President,  Financial Planning
concluded  that  our  disclosure  controls  and  procedures  are  effective  for
recording, processing, summarizing and reporting the information we are required
to disclose in the reports we file under the  Securities  Exchange  Act of 1934,
within the time periods  specified in the SEC's rules and forms. Such evaluation
did not  identify any change in our internal  control over  financial  reporting
that occurred  during the quarter ended  September 30, 2004 that has  materially
affected, or is reasonably likely to affect, our internal control over financial
reporting.

PART II - OTHER INFORMATION

Item 1.  Legal Proceedings

     A former  employee of American  Caresource  Corporation  filed a lawsuit on
June 16,  2004  entitled  Schrier  v.  American  Caresource  Corporation,  (Ind.
Superior  Ct.),  alleging  that  she  was  terminated  on  February  5,  2003 in
retaliation for refusing to engage in illegal conduct. She alleges that American
Caresource Corporation engaged in various activities that would have constituted
violations of agreements with customers, various laws, rules and regulations and
would have resulted in inaccurate  financial  information  being provided to the
Company in  connection  with the  acquisition  transaction.  The  plaintiff  has
demanded damages of $123,000. We have conducted a preliminary investigation into
the  allegations  and ACS and the  Company  intends to contest  the  plaintiff's
claims vigorously.

Item 6. Exhibits


Exhibit #     Description of Exhibits

3.1 --    Certificate of Amendment to the Certificate of Incorporation

3.2 *     By-Laws

4.1 --    Patient Infosystems, Inc. Amended and Restated Stock Option Plan

4.2 ***   Certificate  of  Designations,   Powers,   Preferences  and  Relative,
          Participating,   Optional   or   Other   Special   Rights,   and   the
          Qualifications, Limitations Thereof of the Series C Preferred Stock of
          Patient InfoSystems, Inc.

4.3 ***   Certificate  of  Designations,   Powers,   Preferences  and  Relative,
          Participating,   Optional   or   Other   Special   Rights,   and   the
          Qualifications, Limitations Thereof of the Series D Preferred Stock of
          Patient InfoSystems, Inc.

10.20 +   Lease  Agreement  dated  as  of  February  22,  1995  between  Patient
          Infosystems and Conifer Prince Street Associates.

10.21 +   First Addendum to Lease  Agreement dated as of August 22, 1995 between
          Patient Infosystems and Conifer Prince Street Associates.

10.22 +   Second  Addendum  to Lease  Agreement  dated as of  November  17, 1995
          between Patient Infosystems and Conifer Prince Street Associates.

10.23 +   Third Addendum to Lease  Agreement  dated as of March 28, 1996 between
          Patient Infosystems and Conifer Prince Street Associates.

10.24 +   Fourth  Addendum  to Lease  Agreement  dated as of  October  29,  1996
          between Patient Infosystems and Conifer Prince Street Associates.

10.25 +   Fifth  Addendum  to Lease  Agreement  dated as of  November  30,  1996
          between Patient Infosystems and Conifer Prince Street Associates.

10.26 +   Sixth  Addendum  to Lease  Agreement  dated as of  November  24,  1997
          between Patient Infosystems and Conifer Prince Street Associates.

10.30 ++  Seventh  Addendum to Lease Agreement dated as of June 16, 1999 between
          Patient Infosystems and Conifer Prince Street Associates.

10.33 ++  Revolving  Note  dated  as  of  December  23,  1999  between   Patient
          Infosystems and Norwest Bank Iowa, National Association.

10.34 ++  Credit  Agreement  dated  as of  December  23,  1999  between  Patient
          Infosystems and Norwest Bank Iowa, National Association.

10.35 ++  Security  Agreement  dated as of  December  23, 1999  between  Patient
          Infosystems and Norwest Bank Iowa, National Association.

10.36 ++  Arbitration  Agreement  dated as of December 23, 1999 between  Patient
          Infosystems and Norwest Bank Iowa, National Association.

10.37 ++  Financing  Statement executed by Patient  Infosystems and Norwest Bank
          Iowa, National Association.

10.38 ++  First Amendment to Credit Agreement dated as of March 21, 2000 between
          Patient Infosystems and Norwest Bank Iowa, National Association.

10.39 ++  Note Modification Agreement dated as of March 21, 2000 between Patient
          Infosystems and Norwest Bank Iowa, National Association.

10.41 *** Form of  Subscription  Agreement  dated on or  about  March  31,  2000
          between  Patient  Infosystems  and John  Pappajohn,  Derace  Schaffer,
          Gerald  Kirke  and  Michael   Richards  for  Series  C  9%  Cumulative
          Convertible Preferred Stock.

10.42 *** Form of Registration Rights Agreement dated on or about March 31, 2000
          between  Patient  Infosystems  and John  Pappajohn,  Derace  Schaffer,
          Gerald  Kirke  and  Michael   Richards  for  Series  C  9%  Cumulative
          Convertible Preferred Stock.

10.43 *** Eighth  Addendum  to Lease  Agreement  dated as of  December  8,  2000
          between Patient Infosystems and Conifer Prince Street Associates.

10.45 *** Amended  and  Restated  Credit  Agreement  dated as of March 28,  2001
          between  Patient  Infosystems  and Wells  Fargo  Bank  Iowa,  National
          Association.

10.46 *** Revolving Note dated as of March 28, 2001 between Patient  Infosystems
          and Wells Fargo Bank Iowa, National Association.

10.47 *** Form of Promissory Notes payable to Dr. Schaffer and Mr. Pappajohn.

10.48 *** Form of Security Agreements with Dr. Schaffer and Mr. Pappajohn.

10.49 *** Ninth Addendum to Lease  Agreement dated as of January 7, 2002 between
          Patient Infosystems and Conifer Prince Street Associates.

10.50 #   Letter  of  Agreement  dated  as of March  25,  2002  between  Patient
          Infosystems, John Pappajohn and Derace Schaffer.

10.51 #   Second  Amended and Restated  Credit  Agreement  dated as of March 28,
          2002 between Patient  Infosystems and Wells Fargo Bank Iowa,  National
          Association.

10.52 #   Revolving Note dated as of March 28, 2002 between Patient  Infosystems
          and Wells Fargo Bank Iowa, National Association.

10.53 #   Security  Agreement  dated  as  of  March  28,  2002  between  Patient
          Infosystems and Wells Fargo Bank Iowa, National Association.

10.54 ##  Addendum to Amended and Restated Credit Agreement dated as of June 28,
          2002 between Patient  Infosystems and Wells Fargo Bank Iowa,  National
          Association.

10.55 ##  Agreement  for Purchase  and Sale of Assets dated as of September  23,
          2002 between Patient Infosystems and American CareSource Corporation.

10.56 ### Tenth  Addendum to Lease  Agreement  dated as of June 24, 2002 between
          Patient Infosystems and Conifer Prince Street Associates.

10.57 ### Eleventh  Addendum to Lease  Agreement  dated as of December  30, 2002
          between Patient Infosystems and Conifer Prince Street Associates.

10.58 ### Letter  of  Agreement  dated  as of March  28,  2003  between  Patient
          Infosystems, John Pappajohn and Derace Schaffer.

10.59 ### Second Addendum to Second Amended and Restated Credit  Agreement dated
          as of March 28, 2003 between Patient Infosystems and Wells Fargo Bank,
          National Association.

10.60 ### Modification  Agreement  dated as of March 28,  2003  between  Patient
          Infosystems and Wells Fargo Bank, National Association.

10.61 ^   Amended and  Restated  Agreement  for the  Purchase and Sale of Assets
          among Patient  Infosystems,  Inc.,  American  Caresource  Corporation,
          formerly  known  as  Health  Data  Solutions,   and  the  Stockholders
          Signatory hereto, dated April 10, 2003.

10.62 ^   Note and Stock Purchase  Agreement between Patient  Infosystems,  Inc.
          and a group of investors, dated April 10, 2003.

10.63 ^   Patient  Infosystems,   Inc.  Series  D  Convertible  Preferred  Stock
          Registration Right Agreement dated April 10, 2003.

10.64 ^   Credit Agreement between American  Caresource  Corporation and Patient
          Infosystems, Inc. dated April 10, 2003.

10.65 ^^  Twelfth Addendum to Lease Agreement dated as of April 28, 2003 between
          Patient Infosystems and Conifer Prince Street Associates.

10.66 ^^  Thirteenth  Addendum  to Lease  Agreement  dated  as of June 27,  2003
          between Patient Infosystems and Conifer Prince Street Associates.

10.67 ^^^ Amendment No. 1 to the Amended and Restated Agreement for the Purchase
          and  Sale  of  Assets  dated  as of  July  30,  2003  between  Patient
          Infosystems and American Caresource Corporation.

10.68 ^^^ Amendment No. 1 to the Note and Stock Purchase  Agreement  dated as of
          September  11,  2003  between  Patient  Infosystems  and  a  group  of
          investors.

10.69 ^^^ Amendment  No. 1 to the  Credit  Agreement  dated as of July 30,  2003
          between Patient Infosystems and American Caresource Corporation.

10.70 ^^^ Amendment No. 2 to the Amended and Restated Agreement for the Purchase
          and Sale of  Assets  dated  as of  October  8,  2003  between  Patient
          Infosystems and American Caresource Corporation.

10.71 --  Third Addendum to Second Amended and Restated  Credit  Agreement dated
          as of December 31, 2003 between  Patient  Infosystems  and Wells Fargo
          Bank, National Association.

10.72 --  Form of Securities Purchase Agreement.

10.73 +++ Fourteenth  Addendum  to  Lease  Agreement  dated  as of May 18,  2004
          between Patient Infosystems and Conifer Prince Street Associates.

10.74 +++ Form of Securities Purchase Agreement.

10.75     Agreement  of  Purchase  and Sale dated as of August  26,  2004 by and
          among  the  Registrant,  CBCA Care  Management,  Inc.  and CBCA,  Inc.
          previously  filed with the  Securities  and Exchange  Commission as an
          Exhibit to the Current  Report on Form 8-K filed on  September 1, 2004
          and incorporated herein by reference.

10.76     Fourth Addendum to Second Amended and Restated Credit  Agreement dated
          as of September 21, 2004 between  Patient  Infosystems and Wells Fargo
          Bank, National Association.

10.77     Modification  Agreement dated as of September 22, 2004 between Patient
          Infosystems and Wells Fargo Bank, National Association.

31.1      Certification  of the Chief Executive  Officer pursuant to Section 302
          of the Sarbanes-Oxley Act of 2002.

31.2      Certification of the Principal  Accounting Officer pursuant to Section
          302 of the Sarbanes-Oxley Act of 2002.

32.1      Certification  pursuant  to Section 906 of the  Sarbanes-Oxley  Act of
          2002.


--   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 30, 2004 and  incorporated
     herein by reference.

*    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Registration  Statement  on Form  S-1  filed  on July 3,  1996  and
     incorporated herein by reference.

**   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Registration  Statement  on  Form  S-8  filed  on May 3,  2000  and
     incorporated herein by reference.

***  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual  Report on Form 10-K filed on April 2, 2001 and  incorporated
     herein by reference.

+    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on April 13, 1999 and  incorporated
     herein by reference.

++   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 30, 2000 and  incorporated
     herein by reference.

+++  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on Form  10-QSB  filed on  August  16,  2004 and
     incorporated herein by reference.

#    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on April 10, 2002 and  incorporated
     herein by reference.

##   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on Form  10-Q  filed on  November  14,  2002 and
     incorporated herein by reference.

###  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the Annual Report on Form 10-K filed on March 31, 2003 and  incorporated
     herein by reference.

^    Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on  Form  10-QSB  filed  on  May  15,  2003  and
     incorporated herein by reference.

^^   Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report  on Form  10-QSB  filed on  August  15,  2003 and
     incorporated herein by reference.

^^^  Previously filed with the Securities and Exchange  Commission as an Exhibit
     to the  Quarterly  Report on Form  10-QSB  filed on  November  14, 2003 and
     incorporated herein by reference.



SIGNATURES

In accordance with the requirements of the Securities Exchange Act of 1934, the
registrant caused this report to be signed on its behalf by the undersigned,
thereunto duly authorized.

                                                  PATIENT INFOSYSTEMS, INC.


Date: November 15, 2004         By:            /s/Kent A. Tapper
      ---------------------              -----------------------------------
                                         Name:    Kent A. Tapper
                                         Title:   Senior Vice President
                                                  (Principal Financial Officer)


Date: November 15, 2004         By:            /s/Roger L. Chaufournier
      ---------------------              -----------------------------------
                                         Name:    Roger L. Chaufournier
                                         Title:   Director, President and
                                                  Chief Executive Officer
                                                  (Authorized Officer and
                                                  Principal Executive Officer)