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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14A
                                 (RULE 14a-101)

                            SCHEDULE 14A INFORMATION
                    INFORMATION REQUIRED IN PROXY STATEMENT

          Proxy Statement Pursuant to Section 14(a) of the Securities
                        Exchange Act of 1934, as amended

Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[X]  Preliminary Proxy Statement.
[ ]  CONFIDENTIAL, FOR USE OF THE COMMISSION ONLY (AS PERMITTED BY
     RULE 14a-6(e)(2)).
[ ]  Definitive Proxy Statement.
[ ]  Definitive Additional Materials.
[ ]  Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12

                              DOR BIOPHARMA, INC.
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                (Name of Registrant as Specified In Its Charter)

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    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (check the appropriate box):

[X]  No fee required.

[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

     1) Title of each class of securities to which transaction applies:

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[ ]  Fee paid previously with preliminary materials.

[ ]  Check box if any part of the fee is offset as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
     paid previously. Identify the previous filing by registration statement
     number, or the Form or Schedule and the date of its filing.

     1) Amount Previously Paid:

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     2) Form, Schedule or Registration Statement No.:

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SEC 1913 (02-02)



                              DOR BIOPHARMA, INC.
                           28101 BALLARD DR., SUITE F
                           LAKE FOREST, ILLINOIS 60045

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                                  JULY 14, 2003

TO THE STOCKHOLDERS:

         The annual meeting of stockholders of DOR BioPharma, Inc., will be held
at [  ], Palm Beach, Florida, on July 14, 2003, at 10:00 a.m., Eastern, for the
following purposes, each as more fully described herein:

                  1.       To elect eight directors to serve until the next
                           annual meeting of stockholders or until their
                           respective successors have been duly elected and
                           qualified;

                  2.       To consider and approve an amendment to our Amended
                           and Restated Certificate of Incorporation to increase
                           the number of authorized shares of Common Stock from
                           50,000,000 to 100,000,000;

                  3.       To consider and approve an amendment to our Amended
                           and Restated 1995 Stock Incentive Plan to increase
                           the number of shares of Common Stock available for
                           issuance under the 1995 Plan from 4,708,257 to
                           10,000,000 shares of Common Stock and increase from
                           750,000 to 2,500,000 the maximum number of shares of
                           Common Stock for which any participant may receive
                           options or separately exercisable stock appreciation
                           rights in the aggregate per calendar year;

                  4.       To ratify the appointment of Ernst and Young LLP as
                           our independent auditors for the year ending December
                           31, 2003; and

                  5.       To transact such other business as may properly come
                           before the Annual Meeting or any adjournment or
                           postponement thereof.

         Only stockholders of record at the close of business on June 23, 2003
are entitled to notice of and to vote at the Annual Meeting. A list of
stockholders eligible to vote at the meeting will be available for inspection at
the meeting and for a period of 10 days prior to the meeting, during regular
business hours, at our corporate headquarters at the address set forth above.

         Information concerning the matters to be acted upon at the Annual
Meeting is included in the accompanying proxy statement. Whether or not you
expect to attend the Annual Meeting, your vote is important. To assure your
shares are represented at the Annual Meeting, please sign and date the enclosed
proxy card and return it promptly in the enclosed envelope, which requires no
additional postage if mailed in the United States.

                                          By Order of the Board of Directors


                                          Ralph M. Ellison
                                          President and Chief Executive Officer

Lake Forest, Illinois
June 16, 2003



                               DOR BIOPHARMA, INC.
                               28101 BALLARD DRIVE
                              LAKE FOREST, IL 60045
                               PHONE: 847-573-8990

               PROXY STATEMENT FOR ANNUAL MEETING OF STOCKHOLDERS

         We are furnishing this Proxy Statement to stockholders of record as of
the close of business on June 23, 2003 in connection with the solicitation of
proxies by our Board of Directors for use at the Annual Meeting of Stockholders
to be held on July 14, 2003. This Proxy Statement and the accompanying form of
proxy are being mailed to the stockholders on or about June 26, 2003. Our Annual
Report on Form 10-KSB for the year ended December 31, 2002 (which does not form
a part of the proxy solicitation materials) is being distributed concurrently
herewith to stockholders.

VOTING SECURITIES; PROXIES; REQUIRED VOTE

VOTING SECURITIES

         We have two classes of voting securities: Common Stock and Series B
Convertible Preferred Stock. The Common Stock and Series B Convertible Preferred
Stock vote together as a single class. At the annual meeting, each holder of
record of Common Stock at the close of business on June 23, 2003 will be
entitled to one vote for each share of Common Stock owned on that date as to
each matter presented at the Annual Meeting. In addition, the Series B
Convertible Preferred Stock votes on an as converted to Common Stock basis.
Accordingly, each stockholder of record on June 23, 2003 of Series B Convertible
Preferred Stock will be entitled to 13.55 votes for each share of Series B
Convertible Preferred Stock owned as to each matter presented at the Annual
Meeting however, fractional votes will not be permitted, and any fractional
votes on an as-converted basis will be rounded to the nearest whole number of
votes. On June 16, 2003, 27,393,182 shares of Common Stock and 117,118 shares of
Series B Convertible Preferred Stock, representing a total of 1,586,987 votes,
were outstanding.

PROXIES

         You cannot vote your shares at the meeting unless you are present in
person or represented by proxy. All properly executed and unrevoked proxies in
the accompanying form that are received in time for the meeting will be voted at
the meeting or any adjournment or postponement thereof in accordance with
instructions thereon, or if no instructions are given, will be voted "FOR" the
election of the named nominees as Directors, "FOR" the amendment to our Restated
Certificate of Incorporation to increase the number of authorized shares of
Common Stock, "FOR" the amendment to our Amended and Restated 1995 Stock
Incentive Plan, "FOR" the ratification of Ernst and Young LLP as our independent
auditors, and in accordance with the judgment of the persons appointed as
proxies with respect to other matters which properly come before the Annual
Meeting. You may revoke proxy by written notice to us at any time prior to
exercise of the proxy. In addition, although mere attendance at the Annual
Meeting will not revoke a proxy, you may withdraw your proxy by voting in
person.

REQUIRED VOTE

         At the Annual Meeting, (1) a plurality of the votes cast in person or
by proxy is required to elect Directors and (2) the affirmative vote of holders
of at least a majority of the voting power of the Common Stock and the Series B
Preferred Stock, voting together as a single class, is required to approve the
amendment our Certificate of Incorporation, approve the amendment to our Amended
and Restated 1995 Stock Incentive Plan and ratify the appointment of Ernst and
Young LLP as the independent auditors of our financial statements for the year
ending December 31, 2003. In addition, the affirmative vote of holders of at
least a majority of the voting power of the Common Stock, voting as a single
class, is



                                     - 1 -


required to approve the amendment to our Certificate of Incorporation.
Stockholders are not allowed to cumulate their votes in the election of
directors. With respect to the proposal to amend our Certificate of
Incorporation, the proposal to amend our Amended and Restated 1995 Stock
Incentive Plan and the appointment of Ernst and Young LLP, abstentions and
broker non-votes will have the same effect as votes against such proposal.
Neither abstentions nor broker non-votes will have any effect on the voting to
elect directors.

QUORUM

         The required quorum for the transaction of business at the Annual
Meeting will be a majority of the voting power of shares of Common Stock and
Series B Convertible Preferred Stock issued and outstanding on the record date,
voting together as a single class. Abstentions and broker non-votes will be
included in determining the presence of a quorum.

                                   PROPOSAL 1
                              ELECTION OF DIRECTORS

         Unless otherwise directed, the persons appointed in the accompanying
form of proxy intend to vote at the Annual Meeting for the election of the eight
nominees named below as directors to serve until our next annual meeting of
stockholders or until their successors have been duly elected and qualified. If
any nominee is unable to be a candidate when the election takes place, the
shares represented by valid proxies will be voted in favor of such substitute
nominee as the Board of Directors recommends or to allow the vacancy to remain
open until filled by the Board of Directors, as the Board of Directors
recommends. The Board of Directors does not currently anticipate that any
nominee will be unable to be a candidate for election. The eight nominees who
receive the greatest number of "FOR" votes of our outstanding Common Stock and
Series B Convertible Preferred Stock, voting together as a single class, cast at
the Annual Meeting will be elected as directors. Stockholders are not permitted
to cumulate their votes in the election of directors.

         The Board of Directors currently has eight members, all of whom are
nominees for re-election. Each Director will serve until the next annual meeting
of stockholders or until his successor has been duly elected and qualified,
unless he dies, resigns or is removed from office prior to that time. Two of the
eight nominees were appointed to the Board of Directors since the last election
of directors at the 2002 annual stockholders meeting on May 23rd, 2002:
Alexander M. Haig Jr. was appointed on December 23, 2002, Evan Myrianthopoulos
was appointed on October 13, 2002, and Ralph M. Ellison was appointed March 17,
2003.

            ELECTION OF DIRECTORS--NOMINEES FOR ELECTION AS DIRECTORS



                                                                                                      SERVED AS
NAME                                          AGE    POSITION(S) WITH COMPANY                      DIRECTOR SINCE
------------------------------------------   -----   ---------------------------------------      -----------------
                                                                                         
Alexander M. Haig                             76     Chairman of the Board                        2002
Steve H. Kanzer (1)                           39     Vice Chairman of the Board                   1996
Ralph M. Ellison M.D.                         41     President, Chief Executive
                                                     Officer and Director                         2003
Larry Kessel M.D. (2)                         48     Director                                     2002
Arthur Asher Kornbluth M.D.                   42     Director                                     2002
Paul D. Rubin, M.D.                           49     Director                                     1997
Evan Myrianthopoulos (1)                      38     Director                                     2002
Peter Salomon (2)                             43     Director                                     2002

(1) Member of Audit Committee.
(2) Member of Compensation Committee.

         ALEXANDER M. HAIG, JR., 76, currently serves as our non-employee
Chairman of the Board. Since 1984, Mr. Haig has been Chairman and President of
Worldwide Associates, Inc., a Washington


                                     - 2 -


D.C. based international advisory firm. He served as Secretary of State
(1981-82), President and Chief Operating Officer of United Technologies Company
(1978-81), and Supreme Allied Commander in Europe (1974-79). Before that, he was
White House Chief of Staff, Vice Chief of Staff, Vice Chief of Staff of the U.S.
Army, and Deputy National Security Advisor. Mr. Haig currently serves on the
Board of Directors of MGM Mirage, Inc.; Indevus Pharmaceuticals, Inc.; SDC
International, Inc.; and Metro-Goldwyn-Mayer, Inc. He is also the host of his
own weekly television program, "World Business Review."

         STEVE H. KANZER, C.P.A., ESQ., 39, currently serves as our non-employee
Vice Chairman after having served as our Interim President from June 30, 2002
through January 4, 2003 and as a member of the Board of Directors since 1996.
Since December 2000, he has served as Chairman of Accredited Ventures Inc. and
Accredited Equities Inc., a venture capital and NASD member investment banking
firm respectively specializing in the biotechnology industries. He also serves
as President of several private biotechnology companies, including, CD4
Biosciences, Inc., Developmental Therapeutics, Inc. and Solovax, Inc. He was a
co-founder of Paramount Capital, Inc. in 1991 and served as Senior Managing
Director-- Head of Venture Capital of Paramount Capital until December 2000.
While at Paramount Capital, Mr. Kanzer was involved in the formation and
financing of numerous biotechnology companies, including Corporate Technology
Development, Inc. (CTD) Mr. Kanzer was Chief Executive Officer of CTD from 1997
until its acquisition by us in November 2001. From 1993 until 2003, he was a
member of the board of directors of Atlantic Technology Ventures, Inc. a public
biotechnology company. From 1995 until June 1999, Mr. Kanzer was a founder and
Chairman of the Board of Discovery Laboratories, Inc., a public biotechnology
company. From 1997 until December 2000, Mr. Kanzer was President of PolaRx
Biopharmaceuticals, Inc., a private pharmaceutical company developing arsenic
trioxide as a treatment for acute leukemia. PolaRx was subsequently acquired by
Cell Therapeutics, Inc., a public biotechnology company, which currently markets
arsenic trioxide under the name Trisenox(R).

         Prior to joining Paramount Capital in 1991, Mr. Kanzer was an attorney
at the law firm of Skadden, Arps, Slate, Meagher & Flom in New York, where he
specialized in mergers and acquisitions. Mr. Kanzer is a member of the Licensing
Executive Society and has served as the Co-Chair of its New York Chapter. Mr.
Kanzer received his J.D. from New York University School of Law and B.B.A. in
Accounting from Baruch College.

         RALPH M. ELLISON, M.D., M.B.A., 41, became our Chief Executive Officer
and President in March 2003. He was a co-founder, Chief Executive Officer and
Director of PolaRx Biopharmaceuticals, Inc., an oncology focused drug
development company that developed Trisenox(R) (arsenic trioxide) for the
treatment of cancer. Following the successful completion of PolaRx's pivotal
phase III clinical trial, PolaRx was acquired by Cell Therapeutics, Inc., a
public biopharmaceutical company based in Seattle, Washington. During his tenure
as the Chief Executive Officer of PolaRx, Dr. Ellison was responsible for all
aspects of PolaRx's drug development program from IND filing through the end of
phase III testing. Trisenox(R) currently holds the record as the fastest drug
developed and approved by the FDA. Dr. Ellison then worked closely with Cell
Therapeutics during the preparation and filing of the new drug application for
Trisenox(R), which was ultimately approved by the FDA for the treatment of
relapsed acute promyelocytic leukemia, a life-threatening cancer of the blood.
Trisenox(R) is currently in clinical trials to treat more than 10 types of
cancer, including multiple myeloma, myelodysplasia and chronic myeloid leukemia.
Prior to founding PolaRx, Dr. Ellison started and ran a contract research
organization, which was a division of RTL, Inc., a drug testing facility based
in New York. At RTL he spent five years designing, implementing and completing
clinical trials for both large and small pharmaceutical companies. Dr. Ellison's
experience includes the development of anticancer compounds, antifungals,
analgesics, anti-inflammatories, antibiotics and drug delivery systems Dr.
Ellison holds a degree of Doctor of Medicine from the University of the
Witwatersrand in South Africa and a Masters of Business Administration from the
University of Cape Town South Africa.

         LARRY J. KESSEL, M.D., 48, is president of a five physician practice
specializing in Internal Medicine and Geriatrics since 1984. He graduated Magna
Cum Laude with a B.S. degree from the University of Pittsburgh as an honors
major in Biology and subsequently graduated with an MD degree from Temple
Medical School. He completed a formal residency in Internal Medicine at Abington
Memorial Hospital, and is board certified in Internal Medicine, with added
qualifications as a diplomat in Geriatric Medicine. He is an active staff
attending and Clinical Instructor at Chestnut Hill Hospital (University of
Pennsylvania affiliate) and Roxborough Memorial Hospital in Philadelphia
Pennsylvania. Dr Kessel is a Board Reviewer for the American Board of Internal
Medicine, as well as a fellow of the American College of Physicians. He also
serves on the advisory board of Independence Blue Cross. Dr. Kessel Presently
serves as a director to Cypress Biosciences, Inc of San Diego, California and
NovaDel Pharma Inc. of Flemington, New Jersey. He previously served on the Board
of Genta Inc.

         ARTHUR ASHER KORNBLUTH, 42, is a Board Certified Gastroenterologist and
Associate Clinical Professor of Medicine at Mount Sinai Medical Center and
School of Medicine in New York City, an internationally recognized leading
center in the clinical research and management of inflammatory bowel disease.
Dr. Kornbluth is an active clinical investigator and practicing clinician, with
a large practice specializing in the management of patients with complex
inflammatory bowel disease. He has published extensively in peer-reviewed
journals regarding the pharmacologic and biologic treatments of inflammatory
bowel disease. He is the author of several book chapters regarding the diagnosis
and management of inflammatory bowel disease. He is the principal author of the
American College of Gastroenterology's "Ulcerative Colitis Practice Guidelines
in Adults." He has taught and lectured



                                     - 3 -


extensively throughout the United States and has received numerous awards as a
medical educator. Dr. Kornbluth received his undergraduate degree from Brooklyn
College and his medical degree from Downstate Medical Center. He completed his
postgraduate training in internal medicine at the Albert Einstein College of
Medicine, where he was chosen as chief medical resident. He performed his
gastroenterology fellowship at the Mount Sinai Medical Center in New York City.
He is a member of the American Gastroenterology Association, the American
College of Gastroenterology and the Alpha Omega Alpha Honor Medical Society, for
which he was selected as both an educator and clinician at the Mount Sinai
School of Medicine. He is a member of the Crohn's and Colitis Foundation of
America and that foundation's Clinical Research Alliance, has served on their
Clinical Trials Protocol Review Committee and currently serves on the Clinical
Research Agenda Task Force.

         EVAN MYRIANTHOPOULOS, 38, is currently the President of CVL Advisors,
LLC, a financial consulting firm he founded that specializes in the
biotechnology sector. Before founding CVL Advisors, Mr. Myrianthopoulos was a
co-founder of Discovery Laboratories, Inc., a public specialty pharmaceutical
company developing respiratory therapies. While at Discovery, Mr.
Myrianthopoulos held the positions of Chief Financial Officer and Vice President
of Finance. Before co-founding Discovery, Mr. Myrianthopoulos was a Technology
Associate at Paramount Capital Investments, L.L.C., a New York City based
biotechnology venture capital and investment banking firm.

         PAUL D. RUBIN, M.D., 49, has served as a member of the Board of
Directors since November 1997. Dr. Rubin is currently the Chief Executive
Officer and President of Critical Therapeutics, Inc., a private pharmaceuticals
company. Prior to joining Critical Therapeutics in 2002, Dr. Rubin served as
Executive Vice President for Drug Development at Sepracor, Inc., having
previously been Senior Vice President of Sepracor since 1996. He is responsible
for managing research and development programs for Sepracor's improved chemical
entities portfolio, which includes the management of discovery research,
regulatory, clinical, preclinical and project management teams. Dr. Rubin has
also played a key role in the evaluation of external technology and licensing
opportunities. From 1993 to 1996, Dr. Rubin was the Vice President and Worldwide
Director of Early Clinical Development and Clinical Pharmacology at Glaxo
Wellcome. Prior to joining Glaxo, Dr. Rubin held various executive research
positions at Abbott Laboratories. Dr. Rubin received his M.D. from Rush Medical
College in Chicago and completed his residency in Internal Medicine at the
University of Wisconsin Hospitals and clinics in Madison, Wisconsin.

         PETER SALOMON, M.D., F.A.C.G., 43, is a Board Certified
gastroenterologist and has been in private practice with Gastroenterology
Associates of South Florida for the last 11 years. An active clinical researcher
in the treatment of Crohn's disease, Dr. Salomon has treated several thousand
patients suffering from inflammatory bowel disease. Dr. Salomon has authored
numerous peer-reviewed publications on the subject of Crohn's disease and is
co-author of the chapter of a leading gastroenterology textbook, Sleisinger &
Fordtran's Gastrointestinal & Liver Diseases. Dr. Salomon received his
undergraduate degree from New York University in 1981 and his Medical Degree
from New York University in 1985. Dr. Salomon received his training in Internal
Medicine and Gastroenterology at The Mount Sinai Hospital in New York, where he
also held a grant from the Crohn's and Colitis Foundation to perform research in
inflammatory bowel disease. Dr. Salomon has previously been a member of the
Board of Directors of Genta Inc. and PolaRx and has been a scientific advisor to
Cypress Biosciences Inc.

RECOMMENDATION OF THE BOARD OF DIRECTORS

         The Board of Directors recommends that you vote "FOR" the election of
all of the nominees listed above.



                                     - 4 -


SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         We are required to identify each person who was an officer, director or
beneficial owner of more than 10% of our Common Stock during our most recent
fiscal year and who failed to file on a timely basis reports required by Section
16(a) of the Securities Exchange Act of 1934. Based solely on our review of the
copies of such reports received by us, and representatives from certain
reporting persons, we believe that, during the year ended December 31, 2002, our
directors, executive officers and beneficial owners of more than 10% of our
Common Stock complied with all such filing requirements applicable to them,
except that (a) William Milling filed one late Form 3 and one late Form 4
reporting one transaction; (b) Steve Kanzer filed one late Form 4 reporting one
transaction; (c) Peter Salomon filed one late Form 4 reporting one transaction;
(d) Paul Rubin filed one late Form 4 reporting one transaction; (e) Larry Kessel
filed one late Form 4 reporting one transaction and (f) Arthur Asher Kornbluth
filed one late Form 4 reporting one transaction.

BOARD And COMMITTEE MEETINGS

         During the year ended December 31, 2002, the Board of Directors held 12
meetings. During 2002, each of the current members of the Board of Directors
attended at least 75 percent of all of the Board meetings, while a director, and
meetings of the committees on which he served, while a member of those
committees. In addition to formal meetings, the Board of Directors and the
members of the Audit and Compensation Committees conferred frequently on an
informal basis.

         The Compensation Committee of the Board of Directors determines the
salaries and incentive compensation of our officers and provides recommendations
for the salaries and incentive compensation of our other employees and
consultants. The Compensation Committee also administers various incentive
compensation, stock and benefit plans. Dr. Salomon and Dr. Kessel are
currently the Compensation Committee members, with Dr. Salomon serving as
Chairman. The Compensation Committee held two meetings during 2002.

         The Audit Committee of the Board of Directors reviews, acts on and
reports to the Board of Directors with respect to various auditing and
accounting matters, including the selection of our independent auditors, the
scope of the annual audits, fees to be paid to the auditors, the performance of
auditors and our accounting practices. Messrs. Kanzer and Myrianthopoulos were
for the fiscal year ended December 31, 2002, and currently are, the Audit
Committee members, with Mr. Myrianthopoulos serving as Chairman.  Messrs. Kanzer
and Myrianthopoulos are independent as defined by Section 121(A) of the American
Stock Exchange's listing standards; and the Board of Directors believes that
each of these individuals has the requisite financial skills and experience to
discharge his obligations as a member of the Audit Committee. The Audit
Committee held four meetings during 2002

REPORT OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS

         The Audit Committee exercises oversight responsibilities regarding the
quality and integrity of our accounting, auditing and financial reporting
practices. In discharging its oversight responsibilities regarding the audit
process for the year ended December 31, 2002, the Audit Committee:


         o        reviewed and discussed the audited financial statements with
                  management and with Ernst and Young LLP, our independent
                  auditors;

         o        discussed with the independent auditors the matters required
                  to be discussed by Statement on Auditing Standards No. 61 as
                  amended;



                                     - 5 -


         o        reviewed the selection, application and disclosure of our
                  critical accounting policies pursuant to SEC Financial Release
                  No. 60, "Cautionary Advice Regarding Disclosure About Critical
                  Accounting Policies;" and

         o        reviewed the written disclosures and the letter from the
                  independent auditors required by the Independence Standards
                  Board's Standard No. 1, and discussed with the independent
                  auditors any relationships that may impact their objectivity
                  and independence.

         Based upon the review and discussions referred to above, the Audit
Committee recommended to the Board of Directors that the audited financial
statements be included in our Annual Report on Form 10-KSB for the fiscal year
ended December 31, 2002, as filed with the SEC.

         The Audit Committee has considered and determined that the level of
fees of Ernst and Young LLP for provision of services other than the audit
services is compatible with maintaining the auditor's independence. The Audit
Committee has approved the appointment of Ernst and Young LLP as our auditors of
our financial statements for the year ending December 31, 2003.

The Audit Committee Members

Steve H. Kanzer
Evan Myrianthopoulos

EXECUTIVE COMPENSATION

         The following table contains information concerning the compensation
paid during the fiscal years ended December 31, 2000, 2001 and 2002 to the two
persons who served as our Chief Executive Officers during 2002, and the other
two other most highly compensated (based on combined salary and bonus) persons
who served as executive officers during the year (who we collectively refer to
as the Named Executive Officers).

                           SUMMARY COMPENSATION TABLE



                                                                ANNUAL                    LONG-TERM
                                                             COMPENSATION                COMPENSATION
                                                                                            AWARDS
                                                    -------------------------------     ---------------
 NAME AND PRINCIPAL                                                                       SECURITIES
 POSITION                      YEAR                   SALARY($)           BONUS           UNDERLYING          ALL OTHER
                                                                                          OPTIONS (#)       COMPENSATION($)
-------------------------      ----                 -------------     -------------     ---------------    -----------------
                                                                                             
 Steve H Kanzer                2002                         --               --             250,000                 --
    Interim President (1)
 Dr. Colin Bier                2002                    103,124           47,948                  --            152,066
    Chairman and Chief         2001                     24,863               --             700,000                 --
    Executive Officer(2)

 Michael S. Rosen              2002                    116,691               --             160,000            266,050
    President, Chief           2001                    254,600               --                  --                 --
    Operating Officer(3)       2000                    249,600               --                  --                 --

Panos Constantinides           2002                     90,099               --              60,000            114,646
   Vice President of           2001                    163,000               --                  --                 --
   Research and
   Development(4)




                                     - 6 -


(1)      Mr. Kanzer assumed the role of Interim President from June 31, 2002
         through January 4, 2003 without salary. Mr. Kanzer received options to
         purchase 250,000 shares of Common Stock in connection with his role as
         a director.

(2)      Dr. Bier joined our company in November 2001 and resigned on June 15,
         2002.

(3)      Mr. Rosen resigned from our company on June 14, 2002.

(4)      Mr. Constantinides joined our company in February of 2001, and resigned
         in July 2002.

         The following table contains information concerning options granted to
our Named Executive Officers during the year ended December 31, 2002. No SARs
were granted during 2002.

                        OPTION GRANTS IN LAST FISCAL YEAR



                                                              PERCENTAGE OF TOTAL
                                          NUMBER OF            OPTIONS GRANTED TO       EXERCISE
                                    SECURITIES UNDERLYING          EMPLOYEES              PRICE        EXPIRATION
                                     OPTIONS GRANTED (#)       IN FISCAL YEAR(1)      ($/SHARE)(2)        DATE
                                   -----------------------   ----------------------  --------------   ------------
                                                                                          
Steve Kanzer(3)                                  250,000                  30.5%           0.20           10/23/12
Colin Bier                                            --                    --              --              --
Michael S. Rosen                                      --                    --              --              --
Panos P. Constantinides(4)                        30,000                   0.8%           1.29           10/31/02


(1)      Based on options to purchase an aggregate of 821,000 shares of our
         Common Stock granted to employees in the year ended December 31, 2002,
         including all options granted to our named executive officers in all
         capacities.

(2)      The exercise price of each grant is equal to the fair market value of
         our Common Stock on the date of the grant.

(3)      Mr. Kanzer's options were fully vested on the date of the grant.

(4)      Mr. Constantinides' options were granted as compensation for his
         services to us in all capacities and expired on October 31, 2002, 90
         days after the termination of his employment.

         The following table sets forth information concerning stock options
held as of December 31, 2002 by each of the Named Executive Officers. None of
the Named Executive Officers exercised any options during 2002. There were no
SARs exercised in, or outstanding at the end of, 2002.

                          FISCAL YEAR-END OPTION VALUES



                                                              NUMBER OF SECURITIES         VALUE OF UNEXERCISED
                                                             UNDERLYING UNEXERCISED        IN-THE-MONEY OPTIONS
                                                             OPTIONS AT 12/31/02 (#)        AT 12/31/02 ($)(1)
                                                           ---------------------------  ----------------------------

NAME                                                        EXERCISABLE/UNEXERCISABLE    EXERCISABLE/UNEXERCISABLE

--------------------------------------------------------   ---------------------------  ----------------------------
                                                                                  
Steve Kanzer                                                                666,800/--                    50,000/--
Colin Bier                                                                  213,572/--                        --/--
Michael S. Rosen                                                            835,000/--                        --/--
Panos P. Constantinides                                                          --/--                        --/--




                                     - 7 -


(1)      Based on the difference between the closing price for our Common Stock
         on December 31, 2002 of $0.47, as reported on the American Stock
         Exchange, and the exercise prices of outstanding options.

EMPLOYMENT AND SEVERANCE AGREEMENTS

         Following the implementation of our restructuring plan, we entered into
Separation and General Release Agreements with Dr. Colin Bier, our former
Chairman and Chief Executive Officer, and Michael S. Rosen, our former President
and Chief Operating Officer. Under these agreements, our former executives
immediately received six month's severance pay, and any options to purchase our
Common Stock held by these executives which were not vested at the time of
termination immediately became vested, and the options remained exercisable for
one year following the execution of the separation agreements. Each of the
terminated executives were also entitled to receive six additional months of
severance pay beginning six months after termination, however this severance was
offset by any earnings the executives received from other sources.

         On September 20, 2002, we entered into a letter agreement with William
Milling, CPA, our Controller, Corporate Secretary and Treasurer. Under this
agreement, we agreed to pay Mr. Milling a base salary of $95,000 per year and we
granted Mr. Milling options to purchase 200,000 shares of our Common Stock
vesting over three years.

         On October 7, 2002, we entered into a letter agreement with Robin
Simuncak, our Director of Clinical Affairs. Under the this agreement, we agreed
to pay Ms. Simuncak a base salary of $90,000 per year and we granted Ms.
Simuncek options to purchase 100,000 shares of our Common Stock, vesting over
three years.

         On December 10, 2002, we entered into a letter agreement with Robert N.
Brey, Ph.D., our Vice President of Research and Development. Under this
agreement, we agreed to pay Dr. Brey a base salary of $155,000 per year and we
granted Dr. Brey options to purchase 100,000 shares of our Common Stock, vesting
over three years.

         During March 2003, we entered into a three year employment agreement
with Ralph M. Ellison M.D., M.B.A. Pursuant to this Employment Agreement we
agreed to pay Mr. Ellison a base salary of $200,000 per year as well as a bonus
of 30% of his base salary. Upon the completion of an equity financing of at
least $1,000,000, Dr. Ellison would receive an increase in base salary to
$300,000 per year. In addition, we agreed to issue options to purchase 2,000,000
shares of our Common Stock, with one third immediately vesting and the remainder
vesting over three years. Upon termination without "just cause" as defined by
this agreement, we would pay Dr. Ellison six months severance, as well as any
unpaid bonuses and all unvested options would immediately become vested.

AGREEMENT WITH DIRECTOR

         On December 23, 2002, we entered into a letter agreement with Alexander
M. Haig, Jr. to serve as the Chairman of our Board of Directors. We agreed to
pay Mr. Haig a retainer of $50,000 per year for consulting services, and issue
him options to purchase 2,000,000 shares of our common stock.

DIRECTOR COMPENSATION

         Directors who are compensated as full-time employees receive no
additional compensation for service on our Board of Directors or its committees.
During 2002, each director who was not a full-time employee was paid $1,000 for
each board or committee meeting attended ($500 if attended telephonically). This
rate applied until the October 23, 2002 Board meeting. At that meeting, the rate
was changed to $2,000 per meeting for each meeting attended ($1,000 if attended
telephonically).



                                     - 8 -


         We maintain a stock option grant program pursuant to the nonqualified
stock option plan, whereby members of our Board of Directors who are not
full-time employees receive an initial grant of fully vested options to purchase
50,000 shares of Common Stock, and subsequent yearly grants of fully vested
options to purchase 50,000 shares of Common Stock after re-election to our Board
of Directors. In addition, each member of the Board of Directors received a
one-time grant of fully vested options to purchase 100,000 shares of Common
Stock on October 23, 2002.

         In 2002, Mr. Haig received, instead of the regular initial grant,
options to purchase an aggregate of 2,000,000 shares of our Common Stock, of
which options to purchase 900,000 shares of Common Stock are subject to
stockholder approval of the amendment to our option plan at the Annual Meeting,
in connection with our retention of him as Chairman of the Board. In addition,
Mr. Kanzer also received additional options to purchase 100,000 shares of Common
Stock in consideration for his service as our interim President during 2002,
and Mr. Haig will receive an additional $50,000 a year for consulting services
outside of his service as Chairman of the Board. (See "Proposal 3.  Proposal to
Amend the 1995 Stock Incentive Plan.")

RELATED PARTY TRANSACTIONS

         In December 2002, we completed a private placement of 3,093,569 shares
of our Common Stock and warrants to purchase 1,546,789 shares of our Common
Stock. In this private placement we received total proceeds of $1,082,750.
Purchasers in this private placement included David M. Kent, our former Chief
Executive Officer and President, Ralph M. Ellison our current President Chief
Executive Officer and a member of our Board of Directors, and Steve H. Kanzer,
Lawrence Kessel and Peter Salomon, each of whom is a member of our Board of
Directors. In addition, we issued warrants to purchase 463,073 shares of our
Common Stock to certain individuals and entities, including warrants to purchase
80,913 shares of our Common Stock to Mr. Kanzer, in consideration for placement
services he rendered in connection with this private placement.

         In connection with our 2002 private placement, Evan Myrianthopoulos, a
member of or Board of Directors, acted as a placement agent, introducing certain
investors to us. For these services, we paid Mr. Myrianthopoulos $15,375 in cash
compensation and issued to him warrants to purchase 65,454 shares of Common
Stock.

SECURITY OWNERSHIP OF PRINCIPAL STOCKHOLDERS AND MANAGEMENT

         The table below provides information regarding the beneficial ownership
of the Common Stock and Series B Convertible Preferred Stock as of June 14,
2003. The table reflects ownership by: (1) each person or entity who owns
beneficially 5% or more of the shares of our outstanding Common Stock or Series
B Convertible Preferred Stock; (2) each of our directors, (3) each of the Named
Executive Officers, and (4) our directors and officers as a group. Except as
otherwise indicated, and subject to applicable community property laws, we
believe the persons named in the table have sole voting and investment power
with respect to all shares of Common Stock held by them. Except as otherwise
indicated, each stockholder's percentage ownership of our Common Stock in the
following table is based on 27,251,877 shares of Common Stock outstanding as of
June 14, 2003.



                                                                                 SHARES OF SERIES B
                                                                                 ------------------
                                             SHARES OF                              CONVERTIBLE
                                             ---------                              -----------
                                            COMMON STOCK                          PREFERRED STOCK
                                            ------------                          ---------------
NAME OF BENEFICIAL OWNER                 BENEFICIALLY OWNED   PERCENT OF CLASS   BENEFICIALLY OWNED    PERCENT OF CLASS
------------------------                 ------------------   ----------------   ------------------    ----------------
                                                                                           
Aries Select, Ltd.(1)                        2,326,652              8.53%                -                    -
Nomura Bank (2)                              1,390,358              5.10%                -                    -
TVM Techno Venture Management (3)            1,310,663              4.81%                -                    -
Aries Select I LLC (4)                       1,052,747              3.86%                -                    -




                                     - 9 -


                                                                                           
Elan International Services, Ltd.(5)         3,347,750             12.28%             117,118                100%
Lindsay A. Rosenwald, M.D.(6)                5,882,680             21.59%                -                    -
Paramount Capital Asset
Management, Inc.(7)                          3,399,684             12.48%                -                    -
Steve H. Kanzer (8)                           747,713               2.74%                -                    -
Henry Schwartz (17)                           831,666               3.05%
Alexander M. Haig, Jr. (9)                   1,100,000              4.04%                -                    -
Ralph M. Ellison, M.D., M.B.A. (10)           142,857                   *                -                    -
Paul Rubin M.D. (11)                          204,000                   *                -                    -
Arthur Asher Kornbluth, M.D. (12)             150,000                   *                -                    -
Evan Myrianthopoulos (13)                     215,454                   *                -                    -
Peter Salomon, M.D.(14)                       165,000                   *                -                    -
Larry Kessel, M.D.(15)                        214,286                   *                -                    -
Colin Bier (16)                                  -                      *                -                    -
Michael S. Rosen (16)                            -                      *                -                    -
Panos P. Constantinides(16)                      -                      *                -                    -
All directors and executive officers as
a group (10 persons)                         3,968,476             14.56%                -                    -


*Less than 1%.

(1)      Number of shares beneficially owned includes 112,159 shares of Common
         Stock immediately issuable upon exercise of warrants until April 16,
         2008. The address of Aries Select, Ltd. is 787 Seventh Avenue, New
         York, NY 10019


(2)      The address of Nomura Book is Kasamari Strasse I, CH 8021, Zurich,
         Switzerland.


(3)      As reported on a Schedule 13G filed with the SEC on February 14, 2003
         by TVM Medical Ventures GmbH & Co. KG. According to the Schedule 13G,
         TVM Medical Ventures GmbH & Co. KG has sole voting and dispositive
         power with respect to 1,310,663 shares. The address of TVM Medical
         Ventures GmbH & Co. KG is 101 Arch Street, Suite 1950, Boston, MA
         02110.


(4)      Number of shares beneficially owned includes 56,533 shares of Common
         Stock immediately issuable upon exercise of warrants until April 16,
         2008. The address of Aries Select I LLC is 787 Seventh Avenue, New
         York, NY 10019.


(5)      Number of shares beneficially owned includes 1,564,101 shares of Common
         Stock immediately issuable upon conversion of Series B Convertible
         Preferred Stock, and 230,770 shares of Common Stock immediately
         issuable upon exercise of warrants until January 21, 2004. The Address
         of Elan International is 102 St. James Court, Fletts Smith, SC, 04
         Bermuda.


(6)      Lindsay A. Rosenwald, M.D., is the Chairman and Chief Executive Officer
         of Paramount Capital Asset Management, Inc. ("PCAM"). PCAM is the
         investment manager of Aries Select, Ltd and is the managing member of
         Aries Select I LLC. Dr. Rosenwald and PCAM share the power to vote
         and/or dispose of the shares held by Aries Select, Ltd. and Aries
         Select I LLC. The securities beneficially owned by Dr. Rosenwald
         include 1,392,783 shares of Common Stock immediately issuable upon
         exercise of warrants exercisable until April 16, 2008, 66,931 shares of
         Common Stock immediately issuable upon exercise of warrants
         exercisable until October 2007, 2,326,652 shares beneficially owned by
         Aries Select I LLC, 1,052,747 shares beneficially owned by Aries
         Select, Ltd. and 20,284 shares beneficially owned by Aries Select II
         LLC. The securities beneficially owned by Dr. Rosenwald also include
         682,774 shares of Common Stock owned by Paramount Capital Drug
         Development Holdings, LLC and 13,572 shares of Common Stock owned by
         each of June Street Company and Huntington Street Company. The address
         of Dr. Ronsenwald is 787 Seventh Avenue, New York, NY 10019.


(7)      Includes the 2,326,652 shares of Common Stock beneficially owned by
         Aries Select, Ltd. and the 1,52,748 shares of Common Stock beneficially
         owned by Aries Select I LLC and 20,284 shares of Common Stock
         beneficially owned by Aries Select II, LLC. The address of Paramount
         Capitol Asset Management, Inc. is 787 Seventh Avenue, New York, NY
         10019.


(8)      The number of shares beneficially owned by Mr. Kanzer includes 747,713
         shares of Common Stock immediately issuable upon exercise of options
         and warrants. The number of shares beneficially owned by Mr. Kanzer
         does not include 688,809 shares of Common Stock and 142,857 shares of
         Common Stock issuable upon the exercise of warrants held by
         Pharmainvestors, L.L.C. See footnote (18). The address of Mr. Kanzer is
         28101 N. Ballard Drive, Suite F, Lake Forest, IL 60045.


(9)      Includes 1,100,000 shares of Common Stock immediately issuable upon the
         exercise of options. Excludes 900,000 shares of Common Stock issuable
         upon the exercise of options issued pending stockholder approval of the
         amendment to the 1995 omnibus option plan at the annual meeting. The
         address of Mr. Haig is c/o Worldwide Associates, Inc., 1155 15 Street,
         N.W. Suite 800, Washington, D.C. 20005.


                                     - 10 -

(10)     Includes 142,857 shares of Common Stock owned by Ralph M. Ellison,
         M.D., MBA, 71,429 shares of Common Stock immediately issuable upon the
         exercise of warrants until December 31, 2007. Excludes 833,750 shares
         of Common Stock issuable upon the exercise of option within 60 days of
         June 14, 2003 issued pending stockholder approval of the amendment to
         the 1995 Omnibus Incentive Plan at the Annual Meeting. The address of
         Mr. Ellison is 28101 N. Ballard Drive, Suite F, Lake Forest, IL 60045.


(11)     Includes 204,000 shares of Common Stock immediately issuable upon the
         exercise of option within 60 days of June 14, 2003. The address of Mr.
         Rubin is c/o Critical TheraPeudics, 675 Massachusetts Ave., 14th Floor,
         Cambridge, MD 02139.


(12)     Includes 150,000 shares of Common Stock immediately issuable upon the
         exercise of option within 60 days of June 14, 2003. The address of Mr.
         Kornbluth is c/o Mt. Sinai Medical Center, 1751 York Avenue, New York,
         NY 10178.


(13)     Includes 150,000 shares of Common Stock immediately issuable upon the
         exercise of option within 60 days of June 14, 2003 and 65,454 shares of
         Common Stock immediately issuable upon the exercise of warrants until
         December 31, 2007. The address of Mr. Myrianthopoulos is c/o CVL
         Advisors 305 Fifth Aenue, Suite 5411, New York, NY 10018.


(14)     Includes 150,000 shares of Common Stock immediately issuable upon the
         exercise of option within 60 days of June 14, 2003 and 5,000 shares
         immediately issuable upon the exercise of warrants exercisable until
         December 31, 2007. Excludes 150,000 shares of Common Stock issuable
         upon exercise options issued pending stockholder approval of the
         amendment to the 1995 Omnibus Incentive Plan at the Annual Meeting. The
         address of Peter Salomon is c/o Gastroenterology Consultants, 951 N.W.
         13th St., Boca Raton, FL 33486.


(15)     Includes 150,000 shares of Common Stock immediately issuable upon the
         exercise of option within 60 days of June 14, 2003 and 21,429 shares
         immediately issuable upon the exercise of warrants exercisable until
         December 31, 2007. Excludes 150,000 shares of Common Stock issuable
         upon exercise options issued pending stockholder approval of the
         amendment to the 1995 Omnibus Incentive Plan at the Annual Meeting. The
         address of Mr. Kessel is 4114 Hain Drive, Lafayette Hill, PA
         19444-1514.


(16)     Mr. Bier, Mr. Rosen, and Mr. Constantinides no longer work for us, and
         have no beneficial ownership of any shares of common stock or options
         exercisable within 60 days.


(17)     Pharmainvestors, LLC, is a limited liability company incorporated under
         the laws of Nevis, the sole member of which is an irrevocable trust of
         which Steve H. Kanzer is a beneficiary, but over which he has no
         control. Henry Schwartz is the sole trustee of the irrevocable trust.
         The shares beneficially owned by Pharmainvestors, LLC consist of
         688,809 shares of Common Stock and 142,857 shares of Common Stock
         immediately issuable upon the exercise of warrants. Mr. Kanzer
         disclaims beneficial ownership of all such shares.


EQUITY COMPENSATION PLAN INFORMATION

         As of December 31, 2002, we maintained our 1995 Amended and Restated
Omnibus Incentive Plan, which was approved by our stockholders. In December
2002, our Board of Directors approved an amendment to our 1995 Plan to increase
the number of shares available for issuance under the 1995 Plan to 11,000,000
and increase the maximum number of shares for which any participant may receive
options or separately exercisable stock appreciation rights in the aggregate per
calendar year under the 1995 Plan to 2,500,000, subject to stockholder approval.
In June 2003, our Board of Directors modified the amendment to the 1995 Plan, to
reduce the maximum number of shares available for issuance under the 1995 Plan
to 10,000,000, subject to stockholder approval of the amendment at the Annual
Meeting. Because this amendment, and options issued based upon that amendment,
are subject to stockholder approval, the additional shares and those options are
included in the category "Equity Compensation Plans Not Approved by Security
Holders."



                                          (a)                          (b)                          (c)
                                                                                          Number of securities
                                                                                          remaining available for
                                Number of securities to be   Weighted--average            future issuance under
                                issued upon exercise of      exercise price of            equity compensation plans
                                outstanding options,         outstanding options,         (excluding securities
Plan Category                   warrants and rights          warrants and rights          reflected in column (a))
-------------                   -------------------          -------------------          ------------------------
                                                                                 
Equity compensation plans                4,708,257                      $0.95                          0
approved by security holders
Equity compensation plans not            1,355,580                      $0.35                      5,600,000
approved by security





                                     - 11 -



                                                                                 
holders
Total                                    6,063,837                      $0.82                      5,600,000


         For further information regarding the 1995 Plan, see "Proposal 3.
Proposal to Amend the 1995 Stock Incentive Plan."

                                   PROPOSAL 2
         PROPOSAL TO AMEND THE RESTATED CERTIFICATE OF INCORPORATION TO
                    INCREASE THE NUMBER OF AUTHORIZED SHARES

GENERAL

         Our Amended and Restated Certificate of Incorporation currently
authorize the issuance of 50,000,000 shares of Common Stock. In June 2003, the
Board of Directors adopted a resolution proposing that the Amended and Restated
Certificate of Incorporation be amended to increase the authorized number of
shares of Common Stock to 100,00,000 shares, subject to stockholder approval of
the amendment. No changes will be made to the number of authorized shares of our
preferred stock.

         The proposed Charter Amendment to the Restated Certificate of
Incorporation will be effected by amending paragraph A. of Article FOURTH
thereof to read in full as follows:

"A. Authorization

         The total number of shares of all classes of stock which we shall have
authority to issue is 105,000,000 consisting of 100,000,000 shares of Common
Stock, par value $.001 per share (the "Common Stock"), and 5,000,000 shares of
Preferred Stock, par value $.001 per share (the "Preferred Stock").

         The Board may divide the Preferred Stock into any number of series, fix
the designation and number of shares of each such series, and determine or
change the designation, relative rights, preferences, and limitations of any
series of Preferred Stock. The Board (within the limits and restrictions of any
resolutions adopted by it originally fixing the number of any shares of any
series of Preferred Stock) may increase or decrease the number of shares
initially fixed for any series, but no such decrease shall reduce the number
below the number of shares then outstanding and shares duly reserved for
issuance."

PURPOSE OF THE CHARTER AMENDMENT

         As of June 16, 2003 we had 27,393,182 shares of Common Stock
outstanding. In addition, as of such date, 764,961 shares reserved for future
option grants and 7,143,326 shares reserved for issuance upon exercise of
presently outstanding options under the Amended and Restated 1995 Stock
Incentive Plan. Based upon the foregoing number of outstanding and reserved
shares of Common Stock, we have 7,942,067 shares remaining available for other
purposes.

         The proposed increase in the number of shares available for issuance
under the Certificate is intended to provide the Board of Directors with
authority, without further action of the stockholders, to issue the additional
shares of Common Stock, from time to time in such amounts as the Board of
Directors deems necessary. While we believe our current cash position will be
sufficient to meet our anticipated cash needs for working capital and capital
expenditures for at least the near future, we may decide to seek additional
capital through the sale of Common Stock and/or securities convertible into or
exercisable for Common Stock in the private and/or public equity markets to
support a higher level of growth, to respond to competitive pressures, develop
new products and services and support new strategic partnership expenditures.
Without limitation of the foregoing, the additional shares may be issued in


                                     - 12 -


connection with (1) private financings that we may seek to effect pursuant to
exemptions from the registration requirements of the Securities Act and (2)
strategic partnering transactions involving the issuance of securities pursuant
to exemptions from the registration requirements of the Securities Act.

         In the absence of a proportionate increase in our earnings and book
value, an increase in the aggregate number of outstanding shares of Common Stock
caused by the issuance of the additional shares would dilute the earnings per
share (including projected future earnings per share) and book value per share
of all outstanding shares of our Common Stock. If such factors were reflected in
the price per share of the Common Stock, the potential realizable value of a
stockholder's investment could be adversely affected. An issuance of additional
shares of Common Stock, could therefore have an adverse effect on the potential
realizable value of a stockholder's investment. The holders of outstanding
shares of Common Stock have no preemptive rights to purchase additional shares.

         The proposed increase in the authorized number of shares of Common
Stock could have other effects on our stockholders, depending upon the exact
nature and circumstances of any actual issuances of authorized but unissued
shares. The increase could deter takeovers, in that additional shares could be
issued (within the limits imposed by applicable law) in one or more transactions
that could make a change in control or takeover of us more difficult. For
example, additional shares could be issued by us so as to dilute the stock
ownership or voting rights of persons seeking to obtain control. Similarly, the
issuance of additional shares to certain persons allied with our management
could have the effect of making it more difficult to remove our current
management by diluting the stock ownership or voting rights of persons seeking
to cause such removal.

RECOMMENDATION OF THE BOARD OF DIRECTORS

         The Board of Directors recommends that you vote "FOR" the approval of
the Charter Amendment.

                                   PROPOSAL 3
         PROPOSAL TO AMEND THE 1995 STOCK INCENTIVE PLAN TO INCREASE THE
                          NUMBER OF AUTHORIZED SHARES

         Subject to the approval of stockholders at the Annual Meeting, in June
2002 the Board of Directors adopted an amendment to the DOR BioPharma, Inc.
Amended and Restated 1995 Omnibus Incentive Plan, or 1995 Plan, which will have
the following effects:

         (1) increase the number of shares of Common Stock issuable under the
1995 Plan by an additional 5,291,743 shares to an aggregate of 10,000,000
shares; and

         (2) To consider and approve an amendment to our Amended and Restated
1995 Stock Incentive Plan to increase the number of shares of Common Stock
available for issuance under the 1995 Plan from 4,708,257 to 10,000,000 shares
of Common Stock and increase from 750,000 to 2,500,000 the maximum number of
shares of Common Stock for which any participant may receive options or
separately exercisable stock appreciation rights in the aggregate per calendar
year.

         Stockholder approval of this amendment is sought to (a) meet the
requirements of the American Stock Exchange, (b) qualify awards under the
1995 Plan as performance-based compensation that is tax deductible without
limitation under Section 162(m) of the Code, and (c) qualify certain stock
options granted under the 1995 Plan as incentive stock options.

         As of June 16 2003, options to purchase a total of 3,943,326 shares of
Common Stock were either (1) outstanding (excluding options granted subject to
stockholder approval of the amendment to the Amended and Restated 1995 Omnibus
Incentive Plan) or (2) already been exercised under the 1995 Plan. As a result,
764,931 shares remained available for issuance under the 1995 Plan.
Consequently, in June 2003, the Board of Directors adopted the Amendment to
authorize



                                     - 13 -


an additional 5,291,743 shares of Common Stock, representing approximately 16%
of the shares of Common Stock outstanding as of June 16, 2003, for awards under
the 1995 Plan. Since December 2002, we have granted (i) Mr. Haig options to
purchase 900,000 shares of our Common Stock; (ii) Mr. Ellison options to
purchase 2,000,000 shares of our Common Stock; (iii) Mr. Salomon options to
purchase 150,000 shares of our Common Stock and (iv) Mr. Kessel options to
purchase 150,000 shares of our Common Stock, each subject to stockholder
approval of the amendment to the 1995 Plan. If stockholders do not approve this
proposal, the grants to Mr. Haig, Mr. Ellison, Mr. Salomon, and Mr. Kessel will
terminate.

         The 1995 Plan provides the Compensation Committee, which currently
administers the Employee Plan, with the flexibility to award stock-based and
performance-related incentives to our executive officers and other employees, as
the Compensation Committee deems appropriate. We believe the amendment to
increase the share reserve and increase the maximum aggregate annual award size
per participant is necessary to assure that a sufficient reserve of Common Stock
remains available for issuance under the 1995 Plan in order to allow us continue
to utilize equity incentives to attract and retain the services of key
individuals essential to our long-term growth and financial success. The
increase the number of shares of Common Stock issuable under the 1995 Plan in
any calendar year to one person in order to allow us continue to utilize equity
incentives to attract and retain the services of key individuals essential to
our long-term growth and financial success. We rely significantly on equity
incentives in the form of stock option grants in order to attract and retain key
employees and believe that such equity incentives are necessary for it to remain
competitive in the marketplace for executive talent and other key employees.
Option grants made to newly-hired or continuing employees will be based on both
competitive market conditions and individual performance.

         The following is a summary of the principal features of the 1995 Plan,
as most recently amended. Any stockholder who wishes to obtain a copy of the
actual plan document may do so upon written request to us at 28101 Ballard
Drive, Suite F, Lake Forest, Illinois 60045.

EQUITY INCENTIVE PROGRAMS

         The 1995 Plan consists of four separate equity incentive programs: (1)
the Discretionary Option Grant Program, (2) the Salary Investment Option Grant
Program, (3) the Automatic Option Grant Program for non-employee board members
and (4) the Director Fee Option Grant Program for non-employee board members.
The principal features of each program are described below. The Compensation
Committee of the Board of Directors administers the Discretionary Option Grant
Program, determines the calendar year or years in which the Salary Investment
Option Grant Program will be in effect and selects the individuals who are to
participate in such program. The Board of Directors may at any time appoint a
secondary committee of one or more board members to have separate but concurrent
authority with the Compensation Committee to make option grants under the
Discretionary Option Grant Program to individuals other than our executive
officers and non-employee Board members. All grants under the Salary Investment
Option Grant, the Automatic Option Grant and the Director Fee Option Grant
Programs are made in strict compliance with the express provisions of each such
program. Neither the Compensation Committee nor any secondary committee
exercises any administrative discretion under those programs.

         The term plan administrator, as used in this summary, means the
Compensation Committee and any secondary committee, to the extent each such
entity is acting within the scope of its administrative jurisdiction under the
1995 Plan.

SHARE RESERVE

         An aggregate of 10,000,000 shares of Common Stock has been reserved for
issuance over the term of the 1995 Plan, including the increase of 5,291,743
shares of Common Stock that forms part of this



                                     - 14 -


proposal. In addition, on the first trading day of each calendar year during the
term of the 1995 Plan, the number of shares of Common Stock available for
issuance under the 1995 Plan will automatically increase by an amount equal to
one percent (1%) of the total number of shares of our Common Stock outstanding
on the last trading day of the immediately preceding fiscal year. In no event
will any such annual increase exceed 500,000 shares of Common Stock.

         As of June 16, 2003, 3,943,326 shares of Common Stock were either (i)
subject to outstanding options under the 1995 Plan or (ii) shares of Common
Stock that have been issued pursuant to the exercise of options granted under
the 1995 Plan, and 764,931 shares of Common Stock remained available for future
issuance, under the 1995 Plan.

         Subject to stockholder approval of the amendment, no participant in the
1995 Plan may receive option grants or separately exercisable stock appreciation
rights for more than 2,500,000 shares of Common Stock in the aggregate per
calendar year.

         The shares of Common Stock issuable under the 1995 Plan may be drawn
from shares of our authorized but unissued shares of Common Stock or shares of
Common Stock reacquired by us, including shares repurchased on the open market.

         In the event any change is made to the outstanding shares of Common
Stock by reason of any recapitalization, stock dividend, stock split,
combination of shares, exchange of shares or other change in corporate structure
effected without the receipt of consideration by us, appropriate adjustments
will be made to: (1) the maximum number and/or class of securities issuable
under the 1995 Plan, (2) the maximum number and/or class of securities by which
the share reserve may increase annually under the automatic share increase
reserve provisions, (3) the number and/or class of securities for which any one
person may be granted options or separately exercisable stock appreciation
rights per calendar year, (4) the number and/or class of securities for which
automatic option grants are to be subsequently granted to eligible directors,
and (5) the number and/or class of securities and the exercise price per share
in effect under each outstanding option (including any options incorporated from
the predecessor 1994 Non-Employee Stock Option Plan and Incentive Stock Option
Plan which were incorporated into the 1995 Plan).

ELIGIBILITY

         Employees, non-employee board members and independent consultants in
our service or it's the service of our parent and subsidiaries (whether now
existing or subsequently established) are eligible to participate in the
Discretionary Option Grant Program. Executive officers and other highly paid
employees are also eligible to participate in the Salary Investment Option Grant
Program. Participation in the Automatic Option Grant and Director Fee Option
Grant Programs is limited to non-employee members of the board.

         As of June 16, 2003 three executive officers, seven non-employee board
members and approximately 11 other employees and consultants were eligible to
participate in the Discretionary Option Grant Program. The seven non-employee
board members were also eligible to participate in the Automatic Option Grant
and Director Fee Option Grant Programs.

VALUATION

         The fair market value per share of Common Stock on any relevant date
under the 1995 Plan is deemed to be equal to the closing selling price per share
on that date on a stock exchange where shares of our Common Stock are traded. On
June 12, 2003, the fair market value per share determined on that basis was
$1.03.



                                     - 15 -


DISCRETIONARY OPTION GRANT PROGRAM

         The plan administrator has complete discretion under the Discretionary
Option Grant Program to determine which eligible individuals are to receive
option grants, the time or times when those grants are to be made, the number of
shares subject to each such grant, the status of any granted option as either an
incentive stock option or a non-statutory option under the federal tax laws, the
vesting schedule (if any) to be in effect for the option grant and the maximum
term for which any granted option is to remain outstanding.

         Each granted option must have an exercise price per share no less than
85% of the fair market value of the shares on the grant date unless otherwise
determined by the plan administrator. No granted option may have a term in
excess of 10 years, and the option will generally become exercisable in one or
more installments over a specified period of service measured from the grant
date. However, one or more options may be structured so that they will be
immediately exercisable for any or all of the option shares. The shares acquired
under immediately exercisable options will be subject to repurchase by us, at
the exercise price paid per share, if the optionee ceases service with us prior
to any required vesting in those shares.

         Upon cessation of service, the optionee will have a limited period of
time in which to exercise any outstanding option to the extent exercisable for
vested shares. The plan administrator will have complete discretion to extend
the period following the optionee's cessation of service during which his or her
outstanding options may be exercised and/or to accelerate the exercisability or
vesting of such options in whole or in part. Such discretion may be exercised at
any time while the options remain outstanding, whether before or after the
optionee's actual cessation of service.

         The plan administrator is authorized to issue two types of stock
appreciation rights in connection with option grants made under the
Discretionary Option Grant Program:

              o   Tandem Stock Appreciation Rights, which provide the holders
                  with the right to surrender their options for an appreciation
                  distribution from us equal in amount to the excess of (a) the
                  fair market value of the vested shares of Common Stock subject
                  to the surrendered option over (b) the aggregate exercise
                  price payable for such shares (which appreciation distribution
                  may, at the discretion of the plan administrator, be made in
                  cash or in shares of Common Stock); and

              o   Limited Stock Appreciation Rights, which may be granted to our
                  officers as part of their option grants. Any option with such
                  a limited stock appreciation right in effect may be
                  surrendered to us upon the successful completion of a hostile
                  takeover of us. In return for the surrendered option, the
                  officer will be entitled to a cash distribution from us in an
                  amount per surrendered option share equal to the excess of (a)
                  the take-over price per share over (b) the exercise price
                  payable for such share.

         The plan administrator also has the authority to effect the
cancellation of outstanding options under the Discretionary Option Grant Program
(and outstanding options incorporated from the predecessor 1994 Non-Employee
Stock Option Plan and Incentive Stock Option Plan which were incorporated into
the 1995 Plan) that have exercise prices in excess of the then-current market
price of our Common Stock and to issue replacement options with an exercise
priced on the market price of our Common Stock at the time of the new grant.

SALARY INVESTMENT OPTION GRANT PROGRAM

         The Compensation Committee has complete discretion to implement the
Salary Investment Option Grant Program for one or more calendar years and in
selecting the executive officers and other



                                     - 16 -


eligible individuals who are to participate in the program. As a condition to
such participation, each selected individual must, prior to the start of the
calendar year of participation, file with the Compensation Committee an
irrevocable authorization directing us to reduce his or her base salary for the
upcoming calendar year by a specified dollar amount not less than $10,000 nor
more than $75,000 and to apply that amount to the acquisition of a special
option grant under the program. Each selected individual who files such a timely
election will automatically be granted a non-statutory option on or before the
last trading day in January of the calendar year for which that salary reduction
is to be in effect.

         The number of shares subject to each option will be determined by
dividing the salary reduction amount by two-thirds of the fair market value per
share of our Common Stock on the grant date. The exercise price will be equal to
one-third of the fair market value of our Common Stock per share on the grant
date. As a result, the total spread on the option shares at the time of grant
(the fair market value of the option shares on the grant date less the aggregate
exercise price payable for those shares) will be equal to the amount by which
the optionee's salary is to be reduced for the calendar year. In effect, the
salary reduction serves as an immediate prepayment, as of the time of the option
grant, of two thirds of the then-current market price of the shares of Common
Stock subject to the option.

         The option will become exercisable in a series of 12 equal monthly
installments upon the optionee's completion of each month of service in the
calendar year for which such salary reduction is in effect and will become
immediately exercisable for all the option shares on an accelerated basis should
we experience certain changes in ownership or control. Each option will remain
exercisable for any vested shares until the earlier of (1) the expiration of the
ten-year option term or (2) the end of the three-year period measured from the
date of the optionee's cessation of service.

         We have not yet implemented the Salary Investment Option Grant Program.

AUTOMATIC OPTION GRANT PROGRAM

         Under the Automatic Option Grant Program, eligible non-employee board
members receive a series of option grants over their period of board service.
Each non-employee board member, at the time of his or her initial election or
appointment to the board on or after this annual stockholders meeting, receives
a non-statutory stock option grant for 50,000 shares of Common Stock. In
addition, on the date of each annual stockholders meeting including this
annual Meeting, each individual who is re-elected to serve as a non-employee
board member is automatically granted an option to purchase 50,000 shares of
Common Stock (provided such individual has served as a non-employee board member
for at least six months). There is no limit on the number of such 50,000-share
option grants any one eligible non-employee board member may receive over his or
her period of continued board service.

         Each automatic grant has an exercise price per share equal to the
fair market value per share of Common Stock on the grant date and has a
maximum term of 10 years, subject to earlier termination following the
optionee's cessation of board service.

         The shares subject to each initial 50,000 share automatic grant
vest immediately. Each 50,000 share option is immediately exercisable for the
option shares, and the shares acquired under the option are subject to
repurchase by us at the option exercise price paid per share, upon the
optionee's cessation of board service prior to vesting in those shares. The
shares subject to each annual 50,000 share grant vest upon the completion of one
year of board service measured from the option grant date.



                                     - 17 -


         Each outstanding automatic option grant will automatically accelerate
and become immediately exercisable for any or all of the option shares as
fully-vested shares upon certain changes in control or ownership of our Company
or upon the optionee's death or disability while a member of the Board of
Directors. Following the optionee's cessation of board service for any reason,
each option will remain exercisable for a 12-month period and may be exercised
during that time for any or all shares in which the optionee is vested at the
time of such cessation of board service.

DIRECTOR FEE OPTION GRANT PROGRAM

         The Compensation Committee has complete discretion to implement the
Director Fee Option Grant Program for one or more calendar years in which
non-employee board members may participate. As a condition to such
participation, each non-employee board member must, prior to the start of the
calendar year of participation, file with our Treasurer an irrevocable
authorization directing us to apply all or a portion of his or her cash retainer
fee for the upcoming calendar year to the acquisition of a special option grant
under the program.

         Each non-employee board member who files such a timely election will
automatically be granted a non-statutory option on the first trading day in
January of the calendar year for which that retainer fee election is to be in
effect.

         The number of shares subject to each such option will be determined by
dividing the amount of the retainer fee for the calendar year to be applied to
the program by two-thirds of the fair market value per share of our Common Stock
on the grant date. The exercise price will be equal to one-third of the fair
market value of our Common Stock per share on the grant date. As a result, the
total spread on the option shares at the time of grant (the fair market value of
the option shares on the grant date less the aggregate exercise price payable
for those shares) will be equal to the portion of the retainer fee that optionee
has elected to be applied to the program. In effect, the portion of the annual
retainer fee otherwise payable in cash serves as an immediate prepayment, as of
the time of the option grant, of two thirds of the then-current market price of
the shares of Common Stock subject to the option.

         The option will become exercisable for 50% of the option shares upon
the optionee's completion of six months of service in the calendar year for
which such retainer fee election is in effect and the balance will become
exercisable in a series of six equal monthly installments upon the optionee's
completion of each additional month of service during that calendar year. The
option will become immediately exercisable for all the option shares on an
accelerated basis should we experience certain changes in ownership or control.
Each option will remain exercisable for any vested shares until the earlier of
(1) the expiration of the ten-year option term or (2) the end of the three-year
period measured from the date of the optionee's cessation of service.

         We have not yet implemented the Director Fee Option Grant Program.

GENERAL PROVISIONS

ACCELERATION

         In the event that we are acquired by merger or asset sale, each
outstanding option under the Discretionary Option Grant Program that is not to
be assumed or replaced by the successor corporation will automatically
accelerate in full, and all unvested shares outstanding under the Discretionary
Option Grant Program will immediately vest, except to the extent our repurchase
rights with respect to those shares are to be assigned to the successor
corporation.

         The plan administrator will have the authority under the Discretionary
Option Grant Program to provide that options granted under such program will
automatically vest in full (1) upon an acquisition of



                                     - 18 -


DOR, whether or not those options are assumed or replaced, (2) upon a hostile
change in control of DOR effected through a tender offer for more than 50% of
our outstanding voting stock or by proxy contest for the election of board
members, or (3) in the event the individual's service is terminated, whether
involuntarily or through a resignation for good reason, within a designated
period (not to exceed 18 months) following an acquisition in which those options
are assumed or replaced or a hostile change in control. The options granted
under the Salary Investment Option Grant Program, the Automatic Option Grant
Program and the Director Fee Option Grant Program will automatically accelerate
and become exercisable in full upon an acquisition or change in control
transaction.

         The acceleration of vesting in the event of a change in the ownership
or control may be seen as an anti-takeover provision and may have the effect of
discouraging a merger proposal, a takeover attempt or other efforts to gain
control of our Company.

LIMITED STOCK APPRECIATION RIGHTS

         Each option granted under the Automatic Option Grant and Director Fee
Option Grant Programs includes a limited stock appreciation right so that upon
the successful completion of a hostile tender offer for more than 50% of our
outstanding voting securities, the option may be surrendered to us in return for
a cash distribution from us. The amount of the distribution per surrendered
option share will be equal to the excess of (1) the fair market value per share
at the time the option is surrendered or, if greater, the tender offer price
paid per share in the hostile takeover over (2) the exercise price payable per
share under such option. In addition, the plan administrator may grant such
rights to our officers as part of their option grants under the Discretionary
Option Grant Program.

FINANCIAL ASSISTANCE

         The plan administrator may institute a loan program to assist one or
more participants in financing the exercise of outstanding options under the
Discretionary Option Grant Program through full-recourse interest-bearing
promissory notes. However, the maximum amount of financing provided any
participant may not exceed the cash consideration payable for the issued shares
plus all applicable withholding taxes incurred in connection with the
acquisition of those shares.

SPECIAL TAX ELECTION

         The plan administrator may provide one or more holders of non-statutory
options under the 1995 Plan with the right to have us withhold a portion of the
shares otherwise issuable to such individuals in satisfaction of the withholding
taxes to which such individuals become subject in connection with the exercise
of those options or the vesting of those shares. Alternatively, the plan
administrator may allow such individuals to deliver previously acquired shares
of Common Stock in payment of such withholding tax liability.

AMENDMENT AND TERMINATION

         The board may amend or modify the 1995 Plan at any time, subject to any
required stockholder approval pursuant to applicable laws and regulations.
Unless sooner terminated by the board, the 1995 Plan will terminate on the
earliest of (1) April 23, 2005, (2) the date on which all shares available for
issuance under the 1995 Plan have been issued as fully-vested shares or (3) the
termination of all outstanding options in connection with certain changes in
control or ownership of DOR



                                     - 19 -


FEDERAL INCOME TAX CONSEQUENCES

OPTION GRANTS
         Options granted under the 1995 Plan may be either incentive stock
options which satisfy the requirements of Section 422 of the Internal Revenue
Code or non-statutory options which are not intended to meet such requirements.
The Federal income tax treatment for the two types of options differs as
follows:

Incentive Options. No taxable income is recognized by the optionee at the time
of the option grant, and no taxable income is generally recognized at the time
the option is exercised. The optionee will, however, recognize taxable income in
the year in which the purchased shares are sold or otherwise disposed. For
Federal income tax purposes, dispositions are divided into two categories:(1)
qualifying and (2) disqualifying. A qualifying disposition occurs if the sale or
other disposition is made after the optionee has held the shares for more than
two years after the option grant date and more than one year after the exercise
date. If either of these two holding periods is not satisfied, then a
disqualifying disposition will result.

         If the optionee makes a disqualifying disposition of the purchased
shares, we will be entitled to an income tax deduction, for the taxable year in
which such disposition occurs, equal to the excess of (1) the fair market value
of such shares on the option exercise date over (2) the exercise price paid for
the shares. If the optionee makes a qualifying disposition, we will not be
entitled to any income tax deduction.

         Non-Statutory Options. No taxable income is recognized by an optionee
upon the grant of a non-statutory option. The optionee will in general recognize
ordinary income in the year in which the option is exercised equal to the excess
of the fair market value of the purchased shares on the exercise date over the
exercise price paid for the shares, and the optionee will be required to satisfy
the tax withholding requirements applicable to such income.

         If the shares acquired upon exercise of the non-statutory option are
unvested and subject to repurchase by us in the event of the optionee's
termination of service prior to vesting in those shares, then the optionee will
not recognize any taxable income at the time of exercise but will have to report
as ordinary income, as and when our repurchase right lapses, an amount equal to
the excess of (1) the fair market value of the shares on the date the repurchase
right lapses over (2) the exercise price paid for the shares. The optionee may,
however, elect under Section 83(b) of the Internal Revenue Code to include as
ordinary income in the year of exercise of the option an amount equal to the
excess of (1) the fair market value of the purchased shares on the exercise date
over (2) the exercise price paid for such shares. If the Section 83(b) election
is made, the optionee will not recognize any additional income as and when the
repurchase right lapses.

         We will be entitled to an income tax deduction equal to the amount of
ordinary income recognized by the optionee with respect to the exercised
non-statutory option. The deduction will in general be allowed for the taxable
year in which such ordinary income is recognized by the optionee.

STOCK APPRECIATION RIGHTS

         No taxable income is recognized upon receipt of a stock appreciation
right. The holder will recognize ordinary income, in the year in which the stock
appreciation right is exercised, in an amount equal to the appreciation
distribution. We will be entitled to an income tax deduction equal to the
appreciation distribution in the taxable year in which such ordinary income is
recognized by the optionee.



                                     - 20 -


DEDUCTIBILITY OF EXECUTIVE COMPENSATION

         We anticipate that any compensation deemed paid by us in connection
with the disqualifying dispositions of incentive stock option shares or the
exercise of non-statutory options with exercise prices equal to the fair market
value of the option shares on the grant date will qualify as performance-based
compensation for purposes of Internal Revenue Code Section 162(m) and will not
have to be taken into account for purposes of the $1 million limitation per
covered individual on the deductibility of the compensation paid to certain of
our executive officers. Accordingly, all compensation deemed paid with respect
to those options will remain deductible by us without limitation under Code
Section 162(m).

ACCOUNTING TREATMENT

         Option grants made to employees and directors under the 1995 Plan with
exercise prices equal to the fair market value of the option shares on the grant
date will not result in any direct charge to our reported earnings. However, the
fair value of those options is required to be disclosed in the notes to our
annual and quarterly financial statements, and we must also disclose, in
footnotes to our financial statements, the pro forma impact those options would
have upon our reported earnings were the fair value of those options at the time
of grant treated as a compensation expense. In addition, the number of
outstanding options may be a factor in determining our earnings per share on a
fully diluted basis.

         For any options issued pending approval of the amendment of the Amended
and restated 1995 Omnibus Incentive Plan, we will be required to record
compensation expense as the options vest if the market price of our common stock
exceeds the option price on the date stockholder approval is obtained.

         Option grants made to employees and directors under the 1995 Plan with
exercise or issue prices less than the fair market value of the shares on the
grant or issue date will result in a direct compensation expense in an amount
equal to the excess of such fair market value over the exercise or issue price.
The expense must be amortized against our earnings over the period that the
option shares or issued shares are to vest.

         Option grants made to consultants (but not non-employee board members)
will result in a direct charge to our reported earnings based upon the fair
value of the option measured initially as of the grant date and then
subsequently on the vesting date of each installment of the underlying option
shares. Such charge will accordingly include the appreciation in the value of
the option shares over the period between the grant date of the option and the
vesting date of each installment of the option shares.

         Should one or more individuals be granted tandem stock appreciation
rights under the 1995 Plan, then such rights would result in a compensation
expense to be charged against our reported earnings. Accordingly, at the end of
each fiscal quarter, the amount (if any) by which the fair market value of the
shares of Common Stock subject to such outstanding stock appreciation rights has
increased from the prior quarter-end would be accrued as compensation expense,
to the extent such fair market value is in excess of the aggregate exercise
price in effect for those rights.



                                     - 21 -


NEW PLAN BENEFITS

         The table below presents the number of shares of Common Stock
underlying options that have been previously granted under the 1995 Plan to our
current executive officers, other employees and non-executive directors,
including (i) the 2,000,000 shares of Common Stock issuable upon exercise of
options granted to Ralph M. Ellison and (ii) 1,200,000 shares of Common Stock
issuable upon exercise options granted to non-executive members of our Board of
Directors, pending stockholder approval of the amendment to the 1995 Plan at the
Annual Meeting.



                                                                    NUMBER OF
                                                              SHARES OF COMMON STOCK
                                                                   UNDERLYING
                                                                OPTIONS GRANTED (#)
                                                             ------------------------
                                                          
Ralph M. Ellison (1)                                                2,000,000
Chief Executive Officer and President
Robert Brey                                                           190,000
Vice President Research and Development
William Milling                                                       200,000
Controller/Treasurer/Corporate Secretary
Executive Group (1)                                                 2,390,000
Non-Executive Director Group (2)                                    4,070,800
Non-Executive Officer Employee Group                                  241,000


(1)      Number of securities underlying options granted includes 2,000,000
         shares of Common Stock issuable upon exercise options issued to Ralph
         M. Ellison pending stockholder approval.

(2)      Number of securities underlying options granted includes 1,200,000
         shares of Common Stock issuable upon exercise options issued to
         non-executive members of our Board of Directors pending stockholder
         approval.


RECOMMENDATION OF THE BOARD OF DIRECTORS

         The Board of Directors recommends that you vote "FOR" the approval of
the amendments to the 1995 Plan.

                                   PROPOSAL 4
                      RATIFICATION OF INDEPENDENT AUDITORS

         The Audit Committee, of the Board of Directors appointed Ernst & Young
LLP, independent public accountants, as auditors of our financial statements for
the fiscal year ending December 31, 2003, subject to the ratification of such
appointment by stockholders at the Annual Meeting.

         A representative of Ernst & Young LLP is expected to be available at
the annual meeting, will have the opportunity to make a statement if he or she
desires to do so, and will be available to respond to appropriate questions.

RECOMMENDATION OF THE BOARD OF DIRECTORS

         The Board of Directors recommends that you vote "FOR" ratification of
Ernst & Young LLP as our independent auditors for the year ending December 31,
2003.

AUDIT FEES

         The aggregate fees for professional services rendered by Ernst & Young
LLP and Price Waterhouse Coopers (Price Waterhouse Coopers acted as our
accountants through 1999, until December 31, 2002 we required approval to
incorporate their opinions) in connection with their audit of our consolidated
financial statements included in our Annual Report on Form 10-KSB and review of
our financial statements included in our Quarterly Reports on Form 10-QSB for
the year ended December 31, 2002 were $192,894 and $15,750, respectively.



                                     - 22 -


FINANCIAL INFORMATION SYSTEMS DESIGN AND IMPLEMENTATION FEES

         There were no professional services rendered by Ernst & Young LLP or
Price Waterhouse Coopers in the year ended December 31, 2002 relating to
financial information systems design and implementation.

ALL OTHER FEES

         There were no other professional services rendered by E&Y or
PriceWaterhouseCoopers in the fiscal year ended December 31, 2002.

STOCKHOLDER PROPOSALS

         Under SEC Rule 14a-8, stockholder proposals for the annual meeting of
stockholders to be held in 2004 will not be included in the Proxy Statement for
that meeting unless the proposal is proper for inclusion in the Proxy Statement
and for consideration at the next annual meeting of stockholders, and is
received by our Secretary at our executive offices, no later than [__________],
2004. Stockholders must also follow the other procedures prescribed in SEC Rule
14a-8 under the Exchange Act, as well as our By-Laws, which contain requirements
that are separate and apart from the SEC requirements of Rule 14a-8. Our By-Laws
provide that stockholders desiring to bring business before the 2004 annual
meeting, including nomination of a person for election to our Board of
Directors, must provide written notice to the our Secretary at our executive
offices no earlier than 75 days before, and no later than 45 days before, the
one year anniversary of the mailing of this Proxy Statement. The written notice
must include the information required by Section 2.4 of the By-Laws.

OTHER MATTERS

         Management knows of no matters that are to be presented for action at
the meeting other than those set forth above. If any other matters properly come
before the meeting, the persons named in the enclosed form of proxy will vote
the shares represented by proxies in accordance with their judgment on such
matters.

         The cost of this proxy solicitation will be borne by us. In addition to
the solicitation of proxies by mail, our directors, officers and employees may
also solicit proxies by telephone, facsimile, e-mail or other forms of
communication, without special compensation for such activities. We will also
request banks, brokers, fiduciaries, custodians, nominees and certain other
record holders to send proxies, proxy statements and other materials to their
principals at our expense. We will reimburse such banks, brokers, fiduciaries,
custodians, nominees and other record holders for their reasonable out-of-pocket
expenses of solicitation. We do not anticipate that costs and expenses incurred
in connection with this proxy solicitation will exceed those normally expended
for a proxy solicitation for an election of directors in the absence of a
contest.


                                     - 23 -


By Order of the Board of

                               DOR BIOPHARMA, INC.
             28101 BALLARD DR., SUITE F, LAKE FOREST, ILLINOIS 60045
                 ANNUAL MEETING OF STOCKHOLDERS -- JULY 14, 2003
         THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS OF
                               DOR BIOPHARMA, INC.

         The undersigned hereby appoints Dr. Ralph M. Ellison, the Chief
Executive Officer and President of DOR BioPharma, Inc, Steve H. Kanzer Vice
Chairman of DOR BioPharma, and William D. Milling, the Secretary and Treasurer
of DOR BioPharma, Inc., or any of them, each with the power of substitution, and
hereby authorizes each of them to represent and to vote as designated on the
reverse side of this proxy card, all of the shares of Common Stock and Series B
Preferred Stock of DOR BioPharma, Inc. that the undersigned is entitled to vote
at the annual meeting of stockholders to be held at 10:00 a.m., Eastern Daylight
Time, on July 14, 2003 at [], Palm Beach, Florida, or any adjournment or
postponement thereof.

         THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED AS DIRECTED BY THE
UNDERSIGNED STOCKHOLDER. IF NO SUCH DIRECTIONS ARE MADE, THIS PROXY WILL BE
VOTED FOR THE ELECTION OF THE NOMINEES LISTED ON THE REVERSE SIDE OF THIS PROXY
CARD FOR THE BOARD OF DIRECTORS AND FOR EACH OF THE OTHER PROPOSALS SET FORTH ON
THE REVERSE SIDE.

         The Board of Directors recommends you vote `FOR' the nominees listed on
the reverse side of this proxy card for the Board of Directors and `FOR' each of
the other proposals set forth on the reverse side.

                   CONTINUED AND TO BE SIGNED ON REVERSE SIDE

                         Please date, sign and mail your
                      proxy card back as soon as possible!
                         Annual Meeting of Stockholders
                               DOR BIOPHARMA, INC.

                                  July 14, 2003

               / Please Detach and Mail in the Envelope Provided /