SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D
                                 (Rule 13d-101)

INFORMATION  TO BE  INCLUDED  IN  STATEMENTS  FILED  PURSUANT  TO  13d-1(a)  AND
                 AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a)

                              (Amendment # __1___)1


                              Orphan Medical, Inc.
                              --------------------
                                (Name of Issuer)

                          Common Stock, $0.01 par value
                          -----------------------------
                         (Title of Class of Securities)

                                    687303107
                                    ---------
                                 (CUSIP Number)

                                  Hilary Strain
                       One Embarcadero Center, Suite 4050
                             San Francisco, CA 94111
                                 (415) 362-4022
                          -----------------------------
           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)

                                 April 18, 2005
                         -----------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box: [ ]

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.


                        (Continued on following page(s))


---------------------------
1 The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The  information  required  on the  remainder  of this  cover page shall note be
deemed to be "filed"  for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 or otherwise  subject to the  liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




CUSIP No. 687303107              13D                          Page 2 of 15 Pages


--------------------------------------------------------------------------------

  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

       Alta Partners II, Inc.
--------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                 (a):
                                                                       (b) )X
--------------------------------------------------------------------------------
  (3) SEC Use Only

--------------------------------------------------------------------------------
  (4) Source Of Funds*

       WC
--------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

--------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

               California
--------------------------------------------------------------------------------
                       (7)    Sole Voting Power              -0-
Number Of Shares
Beneficially Owned     ---------------------------------------------------------
By Each Reporting      (8)    Shared Voting Power          6,216,825
Person With
                       ---------------------------------------------------------
                       (9)    Sole Dispositive Power         -0-

                       ---------------------------------------------------------
                       (10)   Shared Dispositive Power     6,216,825


--------------------------------------------------------------------------------
  (11) Aggregate Amount Beneficially Owned By Each Reporting Person

        6,216,825 2
--------------------------------------------------------------------------------
  (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

--------------------------------------------------------------------------------
  (13) Percent Of Class Represented By Amount In Row (11)

          44.2%
--------------------------------------------------------------------------------
  (14) Type Of Reporting Person

          IA
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

--------------------------
2  Includes  2,632,104  shares  subject to  outstanding  options,  warrants  and
convertible preferred stock. See Item 5 on page 12.


CUSIP No. 687303107              13D                          Page 3 of 15 Pages


--------------------------------------------------------------------------------

  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

       Alta BioPharma Partners II, L.P.
--------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                 (a):
                                                                       (b) )X
--------------------------------------------------------------------------------
  (3) SEC Use Only

--------------------------------------------------------------------------------
  (4) Source Of Funds*

       WC
--------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

--------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

         Delaware
--------------------------------------------------------------------------------
                       (7)    Sole Voting Power              -0-
Number Of Shares
Beneficially Owned     ---------------------------------------------------------
By Each Reporting      (8)    Shared Voting Power          6,216,825
Person With
                       ---------------------------------------------------------
                       (9)    Sole Dispositive Power         -0-

                       ---------------------------------------------------------
                       (10)   Shared Dispositive Power     6,216,825


--------------------------------------------------------------------------------
  (11) Aggregate Amount Beneficially Owned By Each Reporting Person

        6,216,825 3
--------------------------------------------------------------------------------
  (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

--------------------------------------------------------------------------------
  (13) Percent Of Class Represented By Amount In Row (11)

          44.2%
--------------------------------------------------------------------------------
  (14) Type Of Reporting Person

          PN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

--------------------------
3  Includes  2,632,104  shares  subject to  outstanding  options,  warrants  and
convertible preferred stock. See Item 5 on page 12.





CUSIP No. 687303107              13D                          Page 4 of 15 Pages


--------------------------------------------------------------------------------

  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

       Alta Embarcadero BioPharma II, LLC
--------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                 (a):
                                                                       (b) )X
--------------------------------------------------------------------------------
  (3) SEC Use Only

--------------------------------------------------------------------------------
  (4) Source Of Funds*

       WC
--------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

--------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

         California
--------------------------------------------------------------------------------
                       (7)    Sole Voting Power              -0-
Number Of Shares
Beneficially Owned     ---------------------------------------------------------
By Each Reporting      (8)    Shared Voting Power          6,216,825
Person With
                       ---------------------------------------------------------
                       (9)    Sole Dispositive Power         -0-

                       ---------------------------------------------------------
                       (10)   Shared Dispositive Power     6,216,825


--------------------------------------------------------------------------------
  (11) Aggregate Amount Beneficially Owned By Each Reporting Person

        6,216,825 4
--------------------------------------------------------------------------------
  (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

--------------------------------------------------------------------------------
  (13) Percent Of Class Represented By Amount In Row (11)

          44.2%
--------------------------------------------------------------------------------
  (14) Type Of Reporting Person

          CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

----------------------------
4  Includes  2,632,104  shares  subject to  outstanding  options,  warrants  and
convertible preferred stock. See Item 5 on page 12.



CUSIP No. 687303107              13D                          Page 5 of 15 Pages


--------------------------------------------------------------------------------

  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

       Alta BioPharma Management II, LLC
--------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                 (a):
                                                                       (b) )X
--------------------------------------------------------------------------------
  (3) SEC Use Only

--------------------------------------------------------------------------------
  (4) Source Of Funds*

       WC
--------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

--------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

         Delaware
--------------------------------------------------------------------------------
                       (7)    Sole Voting Power              -0-
Number Of Shares
Beneficially Owned     ---------------------------------------------------------
By Each Reporting      (8)    Shared Voting Power          6,216,825
Person With
                       ---------------------------------------------------------
                       (9)    Sole Dispositive Power         -0-

                       ---------------------------------------------------------
                       (10)   Shared Dispositive Power     6,216,825


--------------------------------------------------------------------------------
  (11) Aggregate Amount Beneficially Owned By Each Reporting Person

        6,216,825 5
--------------------------------------------------------------------------------
  (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

--------------------------------------------------------------------------------
  (13) Percent Of Class Represented By Amount In Row (11)

          44.2%
--------------------------------------------------------------------------------
  (14) Type Of Reporting Person

          CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

----------------------------
5  Includes  2,632,104  shares  subject to  outstanding  options,  warrants  and
convertible preferred stock. See Item 5 on page 12.




CUSIP No. 687303107              13D                          Page 6 of 15 Pages


--------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

       Jean Deleage
--------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                 (a):
                                                                       (b) X
--------------------------------------------------------------------------------
  (3) SEC Use Only

--------------------------------------------------------------------------------
  (4) Source Of Funds*

       AF
--------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

--------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

         U.S.A.
--------------------------------------------------------------------------------
                       (7)    Sole Voting Power              -0-
Number Of Shares
Beneficially Owned     ---------------------------------------------------------
By Each Reporting      (8)    Shared Voting Power          6,216,825
Person With
                       ---------------------------------------------------------
                       (9)    Sole Dispositive Power         -0-

                       ---------------------------------------------------------
                       (10)   Shared Dispositive Power     6,216,825


--------------------------------------------------------------------------------
  (11) Aggregate Amount Beneficially Owned By Each Reporting Person

        6,216,825 6
--------------------------------------------------------------------------------
  (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

--------------------------------------------------------------------------------
  (13) Percent Of Class Represented By Amount In Row (11)

          44.2%
--------------------------------------------------------------------------------
  (14) Type Of Reporting Person

          IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

-----------------------------
6  Includes  2,632,104  shares  subject to  outstanding  options,  warrants  and
convertible preferred stock. See Item 5 on page 12.



CUSIP No. 687303107              13D                          Page 7 of 15 Pages


--------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

       Alix Marduel
--------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                 (a):
                                                                       (b) X
--------------------------------------------------------------------------------
  (3) SEC Use Only

--------------------------------------------------------------------------------
  (4) Source Of Funds*

       AF
--------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

--------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

         U.S.A.
--------------------------------------------------------------------------------
                       (7)    Sole Voting Power              -0-
Number Of Shares
Beneficially Owned     ---------------------------------------------------------
By Each Reporting      (8)    Shared Voting Power          6,216,825
Person With
                       ---------------------------------------------------------
                       (9)    Sole Dispositive Power         -0-

                       ---------------------------------------------------------
                       (10)   Shared Dispositive Power     6,216,825


--------------------------------------------------------------------------------
  (11) Aggregate Amount Beneficially Owned By Each Reporting Person

        6,216,825 7
--------------------------------------------------------------------------------
  (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

--------------------------------------------------------------------------------
  (13) Percent Of Class Represented By Amount In Row (11)

          44.2%
--------------------------------------------------------------------------------
  (14) Type Of Reporting Person

          IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

---------------------------
7  Includes  2,632,104  shares  subject to  outstanding  options,  warrants  and
convertible preferred stock. See Item 5 on page 12.





CUSIP No. 687303107              13D                          Page 8 of 15 Pages


--------------------------------------------------------------------------------
  (1) Names of  Reporting  Persons.  SS or I.R.S.  Identification  Nos. of Above
      Persons

       Farah Champsi
--------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                 (a):
                                                                       (b) X
--------------------------------------------------------------------------------
  (3) SEC Use Only

--------------------------------------------------------------------------------
  (4) Source Of Funds*

       AF
--------------------------------------------------------------------------------
  (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items
      2(d) Or 2(e):

--------------------------------------------------------------------------------
  (6) Citizenship Or Place Of Organization

         U.S.A.
--------------------------------------------------------------------------------
                       (7)    Sole Voting Power              -0-
Number Of Shares
Beneficially Owned     ---------------------------------------------------------
By Each Reporting      (8)    Shared Voting Power          6,216,825
Person With
                       ---------------------------------------------------------
                       (9)    Sole Dispositive Power         -0-

                       ---------------------------------------------------------
                       (10)   Shared Dispositive Power     6,216,825


--------------------------------------------------------------------------------
  (11) Aggregate Amount Beneficially Owned By Each Reporting Person

        6,216,825 8
--------------------------------------------------------------------------------
  (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

--------------------------------------------------------------------------------
  (13) Percent Of Class Represented By Amount In Row (11)

          44.2%
--------------------------------------------------------------------------------
  (14) Type Of Reporting Person

          IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

--------------------------
8  Includes  2,632,104  shares  subject to  outstanding  options,  warrants  and
convertible preferred stock. See Item 5 on page 12.



Item 1. Security and Issuer.

This  statement  relates  to the  common  stock,  $0.01 par value per share (the
"Common Stock"), of Orphan Medical, Inc., a Delaware corporation (the "Issuer").
The  principal  executive  offices of the Issuer are located at 13911  Ridgedale
Drive, Minnetonka, MN 55305.

Item 2. Identity and Background.

(a) This Schedule 13-D is being filed by (i) Alta BioPharma Partners II, L.P., a
Delaware limited partnership ("Alta BioPharma"): (ii) Alta Embarcadero BioPharma
Partners II, LLC, a California  limited liability company  ("Embarcadero  LLC"):
(iii) Alta BioPharma  Management II, LLC, a Delaware limited  liability  company
("Alta  Management"),  by  virtue  of being  the sole  general  partner  of Alta
BioPharma;  (iv)  Alta  Partners  II,  Inc.,  a  California  corporation  ("Alta
Partners"),  by  virtue  of  being  the  management  advisory  company  of  Alta
BioPharma,  Embarcadero  LLC and Alta  Management;  and (v) Jean  Deleage,  Alix
Marduel  and  Farah   Champsi   (collectively   referred  to  as  the  "Managing
Directors"),  by virtue of being the managing  directors of Alta  Management and
officers or employees of Alta Partners.  Alta BioPharma,  Embarcadero  LLC, Alta
Management,  Alta Partners and the Managing Directors are sometimes  hereinafter
collectively   referred  to  as  the  "Reporting  Persons".  By  virtue  of  the
relationships  described  above and their roles with Alta Partners,  each of the
Managing  Directors may be deemed to control Alta Partners and Alta  Management,
and therefore,  may be deemed to possess indirect beneficial ownership of shares
of Common Stock held by Alta BioPharma and Embarcadero LLC. However, none of the
Managing Directors, acting alone, has voting or investment power with respect to
the shares of the Common Stock directly beneficially held by Embarcadero LLC and
Alta  BioPharma and, as a result,  the Managing  Directors  disclaim  beneficial
ownership  of the shares of Common  Stock  directly  beneficially  owned by Alta
BioPharma and Embarcadero LLC, except to the extent of their pecuniary  interest
therein.  Embarcadero  LLC is a side company that makes all investments pro rata
to the capital of Alta BioPharma with all allocations  made to its members based
on paid-in capital.  The Managing  Directors are managers of Embarcadero LLC and
the managers of Embarcadero LLC are affiliates of Alta Partners.

(b) The principal  executive  offices of Alta BioPharma,  Embarcadero  LLC, Alta
Management,  and  Alta  Partners,  and the  business  address  of each  Managing
Director,  are located at One  Embarcadero  Center,  Suite 4050,  San Francisco,
California 94111.

(c) Alta  Partners  provides  investment  advisory  services to venture  capital
firms.  Alta BioPharma and  Embarcadero  LLC's  principal  business is acting as
venture capital  investment  vehicles.  Alta Management's  principal business is
acting as managing director of Alta BioPharma.  Each of the Managing  Directors'
principal business is acting as a managing director of Alta Management and as an
officer or employee of Alta  Partners.  (d) During the past five years,  none of
the Reporting Persons has been convicted in a criminal proceeding .

(e) During the past five years,  none of the Reporting  Persons was a party to a
civil proceeding of a judicial or administrative body of competent  jurisdiction
as a result of which such  person was or is  subject  to a  judgment,  decree or
final  order  enjoining  future  violations  of,  or  prohibiting  or  mandating
activities subject to, federal or state securities laws of finding any violation
with respect to such laws.


                               Page 9 of 15 Pages



(f) Alta  Partners is a  California  corporation.  Alta  BioPharma is a Delaware
limited   partnership.   Embarcadero  LLC  is  a  California  limited  liability
corporation.  Alta Management is a Delaware limited liability  company.  Each of
the Managing Directors is a citizen of the United States.

Item 3. Source and Amount of Funds or Other Consideration.

To facilitate the consummation of the Merger (as defined in Item 4 below) and to
induce Jazz Pharmaceuticals, Inc., a Delaware corporation ("Jazz:) to enter into
the Merger  Agreement  (as defined in Item 4 below),  Alta  Partners has entered
into a Voting Agreement with Jazz, Twist Merger Sub Inc., a Delaware corporation
and a  wholly-owned  subsidiary of Jazz ("Merger  Sub"),  Orphan  Medical,  Inc.
("Orphan") and certain  stockholders of Orphan.  Alta Partners has not been paid
additional  consideration  in connection  with the execution and delivery of the
Voting Agreement.

Item 4. Purpose of Transaction.

         (a) - (b) Orphan has entered  into that certain  Agreement  and Plan of
         Merger,  dated April 18, 2005 (the  "Merger  Agreement")  with Jazz and
         Merger Sub . Upon the terms and subject to the conditions of the Merger
         Agreement  (including,  but  not  limited  to the  approval  of  Orphan
         stockholders of the Merger Agreement),  Merger Sub shall be merged with
         and into Orphan (the "Merger") in accordance with the Delaware  General
         Corporation Law. Following the Merger, the separate corporate existence
         of Merger Sub shall cease and Orphan  shall  continue as the  surviving
         corporation  and a wholly owned  subsidiary of Orphan.  Pursuant to the
         Merger  Agreement,  each issued and outstanding  share of Common Stock,
         par value $0.01 per share of the Merger Sub shall be converted into one
         validly issued,  fully paid and nonassessable  share of common stock of
         the  Surviving  Corporation  and shall  constitute  the only  shares of
         capital  stock of the  Surviving  Corporation  outstanding  immediately
         after the  Effective  Time (see  section 1.3 of  Agreement  and Plan of
         Merger)  in  accordance  with  the  Merger  Agreement  and  subject  to
         adjustment as provided in the Merger Agreement.

         Concurrently with, and as a condition to, the execution and delivery of
         the  Merger  Agreement  by  Orphan,   Jazz,   Merger  Sub  and  certain
         stockholders  of Orphan who have  entered  into the  Voting  Agreement,
         dated April 18, 2005 (the "Voting  Agreement")  with Orphan  concerning
         all shares of Orphan Common Stock held by the certain  stockholders  of
         Orphan,  whose  names  appear on  Schedule 1 of the  Voting  Agreement.
         Pursuant to the Voting Agreement,  Certain Orphan stockholders agree to
         vote,  or  cause  to be  voted,  to the  extent  not  voted by Buyer as
         appointed  by the Proxy  all of such  stockholder's  Subject  Share (as
         defined  in the Voting  Agreement):  (i) in favor of the  approval  and
         adoption of the Merger Agreement and the approval of the Merger and the
         transactions   contemplated  by  the  Merger  Agreement,  (ii)  against
         approval of any proposal made in opposition to, or in competition with,
         the Merger and the transactions  contemplated by the Merger  Agreement;
         and (iii) against  actions (other than those actions that relate to the
         Merger and the  transactions  contemplated by the Merger Agreement that
         are intended to, or could be reasonably expected to, impair the ability
         of Orphan to consummate the Merger or otherwise impede, interfere with,
         delay, postpone, discourage or adversely affect the consummation of the
         Merger  in  accordance  with the  terms  of the  Merger  Agreement.  In
         addition,  the  stockholders  irrevocably  granted and  appointed  Jazz
         acting through each of Matt Fust and Carol Gamble, each with full power
         to act alone and with full power of substitution and resubstitution, at
         any time during the Term as its true and lawful  attorneys-in-fact  and
         proxies,   for  and  in  its  name,  place  and  stead,  to  vote  such
         stockholder's Subject Shares as its Proxy, at every

                               Page 10 of 15 Pages


         annual, special,  adjourned or postponed meeting of the stockholders of
         Orphan called for purposes of considering whether to approve the Merger
         Agreement or any of the other transactions or matters  contemplated by,
         or directly or indirectly affecting,  the Merger Agreement or execute a
         written  consent  of  stockholders  in lieu of any  such  meeting  (see
         section 2.2 of Voting  Agreement  for full text).  The proxy so granted
         will  terminate  upon  any  termination  of  the  Voting  Agreement  in
         accordance  with its terms.  The  Voting  Agreement  terminates  on the
         earlier of the  consummation  of the Merger or the  termination  of the
         Merger Agreement.

         References to, and descriptions of the Merger, the Merger Agreement and
         the  Voting  Agreement  as set  forth  herein  are  qualified  in their
         entirety by reference to the copies of the Merger  Agreement and Voting
         Agreement,  included as Exhibits 1 and 2 respectively, to this Schedule
         13D,  which  are  incorporated  herein  in their  entirety  where  such
         references and descriptions appear.

         (c) Not applicable.

         (d) On  consummation  of the Merger,  the  directors  of the Merger Sub
         immediately  prior to the effective  time of the Merger will become the
         directors  of the  Surviving  Corporation  (as  defined  in the  Merger
         Agreement)  until  their  respective  successors  are duly  elected  or
         appointed or qualified.  On consummation of the Merger, the officers of
         the Merger Sub  immediately  prior to the effective  time of the Merger
         will become the initial  officers of the Surviving  Corporation,  until
         their  respective   successors  are  duly  appointed.   Jazz,  as  sole
         stockholder of the Merger Sub, will appoint,  or cause the  appointment
         of, each of the directors and officers of the Merger Sub.

         (e) Other than as a result of the Merger described in Item 3 and Item 4
         above, not applicable.

         (f) Not applicable

         (g) On consummation of the Merger,  the Certificate of Incorporation of
         the Surviving Corporation in effect at the effective time of the Merger
         will be the Certificate of Incorporation  of the Surviving  Corporation
         until  thereafter  amended  in  accordance  with the  Delaware  General
         Corporation  Law  and  such  Certificate  of   Incorporation.   On  the
         consummation of the Merger, the By-laws of Merger Sub, as in effect, at
         the effective time of the Merger,  will be the By-laws of the Surviving
         Corporation  until  thereafter   amended  as  provided  therein  or  by
         applicable law.

         (h) - (i) On consummation  of the Merger,  the Orphan Common Stock will
         be deregistered under the Securities  Exchange Act of 1934, as amended,
         and delisted from the Nasdaq National Market,  as Orphan will then be a
         wholly owned subsidiary of Jazz.

         (j) Other than as described above, Alta Partners  currently has no plan
         or  proposal  which  relates  to, or may  result in any of the  matters
         listed in Items 4(a) - (i) of the Schedule 13D

                               Page 11 of 15 Pages



Item 5. Interest in Securities of the Issuer.

         (a) - (b) As a result  of the  Voting  Agreement,  Alta  BioPharma  and
         Embarcadero  LLC may be deemed to have shared  voting  power,  together
         with the  other  Parties  to the  Voting  Agreement,  with  respect  to
         6,216,825  shares9 of Common Stock,  as of April 18, 2005.  Such Orphan
         Common  Stock  constitutes   approximately  44.2%  of  the  issued  and
         outstanding shares of Orphan Common Stock.  However, Alta BioPharma and
         Embarcadero,  LLC (a) are entitled to all other rights as  stockholders
         of Orphan only with respect to 1,169,113  shares of and 43,008  shares,
         respectively,  of the foregoing  share of Orphan Common Stock,  and (b)
         each  of  Alta  BioPharma  and  Embarcadero  LLC  disclaims  beneficial
         ownership  of the  remaining  shares of Orphan  Common  Stock which are
         covered by the Voting  Agreement.  On consummation of the Merger,  each
         issued and  outstanding  share of Common  Stock,  par value  $0.01,  of
         Merger Sub shall be  converted  into one validly  issued and fully paid
         and nonassessable  share of Common Stock of the Surviving  Corporation.
         At the  Effective  Time,  each issued and  outstanding  share of Orphan
         Common  Stock  shall  immediately   cease  to  be  outstanding,   shall
         automatically be cancelled and retired, shall cease to exist, and shall
         be converted into the right to receive $10.75 in cash to be distributed
         in accordance  with the Merger  Agreement.  As of April 18, 2005,  Alta
         BioPharma is the record  owner of  1,169,113  shares of Common Stock of
         Orphan,  or  approximately  10.2% of the  outstanding  shares of Common
         Stock of Orphan.  Embarcadero  LLC is the record owner of 43,008 shares
         of Common Stock of Orphan,  or  approximately  0.4% of the  outstanding
         shares of Common  Stock of Orphan.  The  shares  held of record by Alta
         BioPharma and  Embarcadero  LLC are referred to herein  collectively as
         the "Record Shares". By virtue of its relationship with Alta BioPharma,
         Alta Management may be deemed to own  beneficially  1,169,113 shares of
         Common Stock of Orphan or approximately 10.2% of the outstanding shares
         of Common Stock of Orphan.  By virtue of their affiliate  relationships
         with  Alta  BioPharma  and  Embarcadero  LLC,  Alta  Partners  and each
         Managing  Director may be deemed to own  beneficially all of the Record
         Shares or approximately 10.6% of the outstanding shares of Common Stock
         of Orphan. Each of the Reporting Persons expressly disclaims beneficial
         ownership of any shares of Common  Stock of Orphan,  except in the case
         of Alta  BioPharma for the 1,169,113  shares of Common Stock,  which it
         holds of record,  and in the case of Embarcadero  LLC for 43,008 shares
         of Common Stock, which it holds of record.

The foregoing percentages are calculated based upon the 11,430,066 shares (as of
March 10, 2005) of the  Orphan's  Common Stock  reported to be  outstanding,  as
disclosed in Orphan's  Annual Report on Form 10-K, for the period ended December
31, 2004.

         (c)  Except as set  forth  above,  none of the  Reporting  Persons  has
         effected any transactions in shares of the Issuer's Common Stock during
         the last 60 days.

         (d) No other  person is known to have the right to receive or the power
         to direct the receipt of dividends  from, or any proceeds from the sale
         of,  the  shares  of  Common  Stock  beneficially  owned  by any of the
         Reporting Persons.

         (e) Not applicable.


                               Page 12 of 15 Pages


-------------------------
9  Includes  2,632,104  shares  subject to  outstanding  options,  warrants  and
convertible preferred stock.



Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
        Securities of the Issuer.

Other than as described in Item 4 above, to the best knowledge of Alta Partners,
there are no contracts, understandings, arrangements, or relationships (legal or
otherwise)  giving the persons  named in Item 2 and between such persons and any
other  person  with  respect to the  securities  of Orphan,  including,  but not
limited to  transfer  or voting of any of Orphan's  securities,  finder's  fees,
joint  ventures,  loan or  option  arrangements,  puts or calls,  guarantees  of
profit, division of profits or loss, or the giving or withholding of proxies.


Item 7. Material to be Filed as Exhibits.

        Exhibit A: Joint Filing Statement.

        Exhibit 1:  Agreement  and Plan of Merger  Among  Jazz  Pharmaceuticals,
        Inc.,  Twist Merger Sub, Inc. and Orphan  Medical,  Inc. dated April 18,
        2005  (incorporated  by  reference to Exhibit 2.1 filed with the Current
        Report on Form 8-K of Orphan Medical, Inc. on April 20, 2005)

        Exhibit 2:  Voting  Agreement  dated  April 18,  2005  (incorporated  by
        reference to Exhibit  10.1 filed with the Current  Report on Form 8-K of
        Orphan Medical Inc. filed on April 20, 2005)




                               Page 13 of 15 Pages



Signature


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


Date:  April 27, 2005

Alta Partners II, Inc.                     Alta BioPharma Partners II, L.P.

By:    /s/ /Jean Deleage                   By: Alta BioPharma Management II, LLC
    ---------------------------
       Jean Deleage, President


Alta BioPharma Management II, LLC          By:   /s/ Farah Champsi
                                              --------------------------
                                                Farah Champsi,
                                                 Managing Director

By:    /s/ Farah Champsi
    ---------------------------
       Farah Champsi, Member


Alta Embarcadero BioPharma Partners II, LLC


By:    /s/ Farah Champsi
    ---------------------------
       Farah Champsi, Manager


         /s/ Jean Deleage                       /s/ Alix Marduel
---------------------------------          -----------------------------
         Jean Deleage                             Alix Marduel

         /s/ Farah Champsi
---------------------------------
         Farah Champsi



                                    EXHIBIT A

                             Joint Filing Statement

         We, the  undersigned,  hereby  express our agreement  that the attached
Schedule 13D is filed on behalf of each of us.

Date:  April 27, 2005

Alta Partners II, Inc.                     Alta BioPharma Partners II, L.P.

By:    /s/ /Jean Deleage                   By: Alta BioPharma Management II, LLC
    ---------------------------
       Jean Deleage, President


Alta BioPharma Management II, LLC          By:   /s/ Farah Champsi
                                              --------------------------
                                                Farah Champsi,
                                                 Managing Director

By:    /s/ Farah Champsi
    ---------------------------
       Farah Champsi, Member


Alta Embarcadero BioPharma Partners II, LLC


By:    /s/ Farah Champsi
    ---------------------------
       Farah Champsi, Manager


         /s/ Jean Deleage                       /s/ Alix Marduel
---------------------------------          -----------------------------
         Jean Deleage                             Alix Marduel

         /s/ Farah Champsi
---------------------------------
         Farah Champsi