H&Q HEALTHCARE INVESTORS -------------------------------------------------------------------------------- [GRAPHIC] SEMIANNUAL REPORT MARCH 31, 2001 To our Shareholders: At quarter-end on March 31, 2001, the net asset value of your Fund was $26.34 per share. Performance data for the fiscal year and the quarter ended March 31 compared to the indices is as follows: FISCAL YEAR TO DATE QUARTER ENDED 9/30/00 - 3/31/01 3/31/01 ----------------- ------- Net Asset Value -35.2% -20.7% Dow Jones Industrial Average -7.3% -8.4% NASDAQ Industrials -39.9% -17.1% Russell 2000 -13.6% -6.8% The collateral damage to other over-the-counter stocks from the declines in electronic and e-trade equities in the quarter ended March 31 is reflected in these performance data. Of some encouragement is the somewhat improved performance of healthcare stocks relative to the NASDAQ index toward the end of the quarter. The overall state of the economy and the levels of common stock valuation seem to us to still be fragile. For example, consumer sentiment polls seem to present a positive outlook. That seems inconsistent with the fact that almost every announcement of corporate earning disappointment is coupled with a layoff announcement. Under such conditions, how long are consumers going to continue to spend beyond their incomes? Corporate and consumer debt are at record levels. The Federal Reserve Board appears convinced that the wealth effect of the level of the stock market has to be sustained by lower interest rates to assure continued consumer confidence. While consumers are roughly two-thirds of the economy, it is troubling that the capital expenditure portion of the economy (and electronic equipment, computers, communications equipment, semi-conductors etc. are cyclically sensitive capital items) is in apparent recession. Perhaps we, as a country, have over the last several years added all the productivity that we can utilize until the next major technology product cycles come along. We are, therefore, concerned about the general valuation levels of the market and, from our experience, believe that there is no way even a specialized portfolio such as your Fund's can be totally immune to the effects of any future general decline in the 1 overall market. Accordingly, we are maintaining a larger than historic liquid asset position in anticipation of future opportunities to purchase good companies at depressed valuations in this sector. We believe the portfolio companies currently held already represent value at the current price levels of their stocks, especially in view of our expectations of their fundamental outlook. We continue to believe that it is important to keep in mind the differences in the long-term business models of the companies meeting the investment objectives of your Fund as compared to other types of "technology". While the development risks are high and attainment of FDA market approvals are a challenge, patent positions are generally more enforceable and product life cycles, especially in therapeutic products, are much longer. Market demand for approved products that improve the human condition usually is very responsive soon after introduction. In the quarter, our venture investment activity included follow-on commitments in Ceres, CytoLogix, KVM Technologies and Sontra Medical. The Fund also made new private investments in two public companies, ENDOCARDIAL SOLUTIONS and ORTHOVITA, at discounts to their public market prices and in one new private company, Novacept. NOVACEPT has an innovative minimally invasive catheter system to treat excessive menstrual bleeding that appears to be a dramatic improvement over currently available therapies for a large patient population. In no way are our expectations diminished that the future value creation from the inventions in biotechnology and genomics, instrumentation and devices and the growth of the healthcare sector will lead to vast improvements in the span and quality of life and present significant investment opportunities in the future. /s/ Alan G. Carr Alan G. Carr President 2 H&Q HEALTHCARE INVESTORS ------------------------ PRIVACY NOTICE If you are a registered shareholder of the Fund, the Fund and Hambrecht & Quist Capital Management, the Funds' investment adviser, may receive nonpublic personal information about you from the information collected by the transfer agent from your transactions in Fund shares. Any nonpublic personal information is not disclosed to third parties, except as permitted or required by law. In connection with servicing your account and effecting transactions, the information received may be shared with the investment adviser and non-affiliates, including transfer agents, custodians or other service companies. Access to your nonpublic personal information is restricted to employees who need to know that information to provide products or services to you. To maintain the security of your nonpublic personal information, physical, electronic, and procedural safeguards are in place that comply with federal standards. The policies and practices described above apply to both current and former shareholders. If your Fund shares are held in "street name" at a bank or brokerage, we do not have access to your personal information and you should refer to your bank's or broker's privacy policies for a statement of the treatment of your personal information. [CHART] H&Q HEALTHCARE INVESTORS ------------------------ PORTFOLIO AS OF MARCH 31, 2001 AGRI/ENVIRONMENTAL 1.46% 2.00% BIOTECHNOLOGY 9.61% 48.50% CROs 0.00% 0.60% DIAGNOSTICS 2.07% 5.90% INFORMATION SERVICES 0.56% 0.60% MANAGED CARE 0.85% 0.90% MEDICAL SPECIALTY 5.20% 10.50% MEDICAL SUPPLIES 1.15% 2.00% PHARMACEUTICALS 2.24% 16.00% LIQUID ASSETS 0.00% 13.30% 3 H&Q HEALTHCARE INVESTORS ------------------------ LARGEST HOLDINGS AS OF MARCH 31, 2001 % OF NET ASSETS --------------- Biovail 6.70% Cubist Pharmaceuticals 5.76% Gilead Sciences 4.48% ImClone Systems 3.68% Genzyme 3.51% CV Therapeutics 3.44% Celgene 3.42% Molecular Devices 2.65% Scios 2.57% MedImmune 2.51% H&Q HEALTHCARE INVESTORS ------------------------ SIGNIFICANT PORTFOLIO TRANSACTIONS QUARTER ENDED MARCH 31, 2001 UNITS HELD UNITS HELD PURCHASES 12/31/00 3/31/01 --------- -------- ------- Ceres (Restricted) Promissory Note $0 $108,000 Ceres (Restricted) Series D 0 277,967 Endocardial Solutions (Restricted) 0 1,000,000 KVM Technologies (Restricted) Cvt. Note $915,000 $1,050,000 Novacept (Restricted) 0 631,580 Orthovita (Restricted) 0 1,020,000 Sontra Medical (Restricted) Promissory Note $0 $180,000 Transkaryotic Therapies 169,812 264,912 SALES -------- Amgen 100,000 0 Cytyc 592,830 324,330 Gene Logic 135,000 0 Genzyme Biosurgery 104,470 55,841 Interpore Cross 180,000 178,300 4 H&Q HEALTHCARE INVESTORS ------------------------ SCHEDULE OF INVESTMENTS March 31, 2001 (UNAUDITED) CONVERTIBLE SECURITIES - 17.2% OF NET ASSETS SHARES CONVERTIBLE PREFERRED - 15.1% VALUE --------- ---------- AGRICULTURAL/ENVIRONMENTAL TECHNOLOGIES - 1.4% 375,000 Ceres (Restricted) Series C* $ 2,250,000 277,967 Ceres (Restricted) Series D* 1,667,802 222,222 EPR (Restricted) Series A* 333,333 BIOTECHNOLOGY - 5.9% 400,000 ACADIA Pharmaceuticals (Restricted) Series E* 3,000,000 1,818,182 Raven biotechnologies (Restricted) Series B* 3,000,000 47,407 Therion Biologics (Restricted) Series A* 177,776 36,092 Therion Biologics (Restricted) Sinking Fund* 135,345 1,750,000 Triad Therapeutics (Restricted) Series A* 3,500,000 825,000 Triad Therapeutics (Restricted) Series B* 1,650,000 923,077 Zyomyx (Restricted) Series B* 3,692,308 600,000 Zyomyx (Restricted) Series C* 2,400,000 DIAGNOSTICS - 1.9% 484,829 CytoLogix (Restricted) Series A* 2,448,386 227,130 CytoLogix (Restricted) Series B* 1,147,007 160,000 Masimo (Restricted) Series D* 1,760,000 1,724,138 Sontra Medical (Restricted) Series A* 465,517 MANAGED CARE - 0.5% 338,983 KVM Technologies (Restricted) Series B* 1,500,000 MEDICAL SPECIALTY - 2.0% 636,364 AbTox (Restricted) Series F* 6,364 1,066,667 Novatrix (Restricted) Series D* 10,667 639,659 Songbird Hearing (Restricted) Series B* 3,000,001 652,173 TherOx (Restricted) Series H* 2,999,996 MEDICAL SUPPLIES - 1.2% 400,000 InterVentional Technologies (Restricted) Series E* 200,000 87,500 InterVentional Technologies (Restricted) Series F* 218,750 15,000 InterVentional Technologies (Restricted) Series G* 37,500 343,750 LocalMed (Restricted) Series D* 3,438 631,580 Novacept (Restricted) Series D* 3,000,005 PHARMACEUTICALS/DRUG DELIVERY - 2.2% 211,765 Advanced Medicine (Restricted) Series C* 1,905,885 200,000 Advanced Medicine (Restricted) Series D-1* 1,800,000 1,398,732 Galileo Laboratories (Restricted) Series F* 3,000,000 ----------- $45,310,080 ----------- The accompanying notes are an integral part of these financial statements. 5 H&Q HEALTHCARE INVESTORS ------------------------ SCHEDULE OF INVESTMENTS March 31, 2001 (CONTINUED) PRINCIPAL AMOUNT CONVERTIBLE BONDS AND NOTES - 2.1% VALUE --------- --------- AGRICULTURAL/ENVIRONMENTAL TECHNOLOGY - 0.0% $108,000 Ceres (Restricted) 7% Prom. Note due 2001 $108,000 BIOTECHNOLOGY - 1.6% 6,800,000 CuraGen (Restricted) 6% Cvt. Deb. due 2007 4,658,000 DIAGNOSTICS - 0.1% 180,000 Sontra (Restricted) 8% Prom. Note due 2002 180,000 INFORMATION SERVICES - 0.0% 1,577,366 FitForAll.com (Restricted) 10% Prom. Note due 2003 158 MANAGED CARE - 0.4% 1,050,000 KVM Technologies (Restricted) Adj. Cvt. Note due 2001 1,050,000 MEDICAL SPECIALTY - 0.1% 180,000 AbTox (Restricted) 12% Prom. Note due 2001 180,000 ---------- $6,176,158 ---------- TOTAL CONVERTIBLE SECURITIES (Cost $55,383,443) $51,486,238 ----------- SHARES COMMON STOCKS - 69.6% ------ AGRICULTURAL/ENVIRONMENTAL TECHNOLOGY - 0.5% 71,483 Catalytica Energy Systems* $1,496,675 ---------- $1,496,675 ---------- BIOTECHNOLOGY - 41.1% BIOPHARMACEUTICALS - 35.5% 429,898 BioTransplant* $2,283,833 1,150 BioTransplant (Restricted) Warrants* 3,638 2,760 BioTransplant (Restricted) Warrants* 2,174 6,300 BioTransplant (Restricted) Warrants* 4,961 410,400 Celgene* 10,260,000 193,400 Cor Therapeutics* 4,351,500 246,389 Corixa* 1,971,112 550,556 Cubist Pharmaceuticals* 13,488,622 200,001 Cubist Pharmaceuticals (Restricted) Warrants* 3,782,519 312,823 CV Therapeutics* 10,323,159 116,500 Genzyme* 10,523,445 413,318 Gilead Sciences* 13,432,835 333,000 ImClone Systems* 11,051,438 210,000 MedImmune* 7,533,750 161,253 Pharming Group* 1,204,571 226,760 Therion Biologics (Restricted)* 850,350 240,000 Therion Biologics (Restricted) Units* 900,000 The accompanying notes are an integral part of these financial statements. 6 H&Q HEALTHCARE INVESTORS ------------------------ SCHEDULE OF INVESTMENTS March 31, 2001 (CONTINUED) SHARES BIOTECHNOLOGY - CONTINUED VALUE ------ ------------- 264,912 Transkaryotic Therapies* 4,652,517 270,270 Tularik* 5,135,130 450,000 Versicor* 3,628,125 178,165 Versicor (Restricted)* 1,077,346 GENOMICS/DRUG DISCOVERY - 5.6% 60,000 Affymetrix* 1,668,750 299,302 Dyax* 2,394,416 98,000 Exelixis* 851,375 225,000 Lynx Therapeutics* 1,894,922 174,461 Molecular Devices* 7,937,976 370,237 Telik* 1,920,604 ------------ $123,129,068 ------------ CONTRACT RESEARCH ORGANIZATIONS - 0.6% 91,400 Quintiles Transnational* $1,725,175 ------------ $1,725,175 ------------ DIAGNOSTICS - 3.9% 522,517 Biofield* $193,331 600,000 Biofield (Restricted)* 177,600 657,576 Calypte Biomedical* 420,849 324,330 Cytyc* 5,354,216 140,000 Digene* 2,135,000 152,000 IDEXX Laboratories* 3,334,500 160,000 Masimo Labs (Restricted)* 1,600 ------------ $11,617,096 ------------ INFORMATION SERVICES - 0.5% 4,366,920 Codman Group (Restricted)* $436,692 306,208 Physician WebLink (Restricted)* 1,200,473 188,096 Physician WebLink (Restricted) Warrants* 18,810 ------------ $1,655,975 ------------ MEDICAL SPECIALTY - 8.4% 381,818 ATS Medical* $3,674,998 130,900 Bioject Medical Technologies* 1,431,719 101,848 Biopure* 1,355,852 8,333 Biopure (Restricted) Warrants* 9,844 205,310 Curis* 760,289 1,000,000 Endocardial Solutions (Restricted)* 3,375,000 153,386 Focal* 95,866 55,841 Genzyme Biosurgery* 307,126 178,300 Interpore Cross* 746,631 441,409 Martek Biosciences* 6,841,840 The accompanying notes are an integral part of these financial statements. 7 H&Q HEALTHCARE INVESTORS ------------------------ SCHEDULE OF INVESTMENTS March 31, 2001 (CONTINUED) SHARES MEDICAL SPECIALTY - CONTINUED VALUE --------- ----------- 1,020,000 Orthovita (Restricted)* 6,024,426 198,000 Radiance Medical Systems* 711,563 ------------ $25,335,154 ------------ MEDICAL SUPPLIES - 0.9% 645,000 EP MedSystems* $1,451,250 137,457 KeraVision* 7,560 311,449 Landec* 1,129,003 ------------ $2,587,813 ------------ PHARMACEUTICALS/DRUG DELIVERY - 13.7% 225,000 Aradigm* $1,293,750 555,924 Biovail* 20,085,534 91,500 Emisphere Technologies* 1,309,594 334,500 Scios* 7,693,500 217,138 Sepracor* 6,948,416 70,000 Teva Pharmaceutical Industries 3,823,750 ------------ $41,154,544 ------------ TOTAL COMMON STOCKS (Cost $101,283,279) $208,701,500 ------------ TOTAL INVESTMENTS IN SECURITIES (Cost $156,666,722) $260,187,738 ============ PRINCIPAL AMOUNT TEMPORARY CASH INVESTMENTS - 14.8% VALUE --------- ----------- $5,500,000 American Express Credit, 5.17%, due 4/6/01 $5,496,050 2,000,000 American Express Credit, 5.09%, due 4/11/01 1,997,172 3,000,000 American Express Credit, 4.90%, due 4/23/01 2,991,017 13,000,000 Ford Motor Credit Corp., 4.84%, due 4/18/01 12,970,288 3,000,000 Ford Motor Credit Corp., 4.83%, due 4/25/01 2,990,340 5,000,000 General Electric Capital Corp., 4.94%, due 4/2/01 4,999,314 13,000,000 General Motors Acceptance Corp., 4.80%, due 4/16/01 12,974,000 ------------ TOTAL TEMPORARY CASH INVESTMENTS $44,418,181 ============ ----------- * Non income-producing security (see Notes 1 and 5). The accompanying notes are an integral part of these financial statements. 8 H&Q HEALTHCARE INVESTORS ------------------------ BALANCE SHEET March 31, 2001 (UNAUDITED) ASSETS: Investments in securities, at value (identified cost $156,666,722; see Schedule of Investments) (Notes 1, 3 and 5) $260,187,738 Temporary cash investments, at amortized cost which approximates value (see Schedule of Investments) (Note 1) 44,418,181 ------------ Total investments $304,605,919 Cash 776,473 Dividends and interest receivable 71,345 Prepaid expenses and other assets 168,869 ------------ Total assets $305,622,606 ------------ LIABILITIES: Capital gains distribution payable $5,233,003 Accrued advisory fees (Note 4) 379,472 Other accrued expenses 95,480 ------------ Total liabilities $5,707,955 ------------ NET ASSETS: Shares of beneficial interest, par value $.01 per share, unlimited number of shares authorized, amount paid in on 11,385,069 shares issued and outstanding (Note 1) $177,296,535 Accumulated undistributed net investment (loss) (747,635) Accumulated net realized gain on investments 19,844,735 Net unrealized gain on investments (Note 3) 103,521,016 ------------ Total net assets (equivalent to $26.34 per share based on 11,385,069 shares outstanding) $299,914,651 ============ The accompanying notes are an integral part of these financial statements. 9 H&Q HEALTHCARE INVESTORS ------------------------ STATEMENT OF OPERATIONS For the Six Months Ended March 31, 2001 (UNAUDITED) INVESTMENT INCOME (Note 1): Dividend income $8,251 Interest income 1,544,752 ---------- Total investment income $1,553,003 EXPENSES: Advisory fees (Note 4) $2,150,649 Trustees' fees and expenses 36,315 Shareholder reporting 29,532 Custodian fees 19,458 Legal fees 18,067 Transfer agent fees 11,688 Accounting and auditing fees 8,357 Other 26,572 ---------- Total expenses 2,300,638 ------------- Net investment (loss) ($747,635) ------------- NET REALIZED AND UNREALIZED GAIN ON INVESTMENTS: Net realized gain on investments (Note 1) $47,460,750 Net (decrease) in unrealized gain on investments (215,278,729) ------------- Net (loss) on investments ($167,817,979) ------------- Net (decrease) in net assets resulting from operations ($168,565,614) ============= The accompanying notes are an integral part of these financial statements. 10 H&Q HEALTHCARE INVESTORS ------------------------ STATEMENTS OF CHANGES IN NET ASSETS For the six For the months ended year ended March 31, 2001 September 30, (Unaudited) 2000 ------------- ------------ NET INCREASE (DECREASE) IN NET ASSETS FROM OPERATIONS: Net investment (loss) ($747,635) ($3,056,159) Net realized gain on investments 47,460,750 35,694,901 Net increase (decrease) in unrealized gain on investments (215,278,729) 253,975,089 ------------- ------------ Net increase (decrease) in net assets resulting from operations ($168,565,614) $286,613,831 ------------- ------------ DISTRIBUTIONS TO SHAREHOLDERS FROM: Net realized capital gains ($38,327,331) ($34,646,099) ------------- ------------ CAPITAL SHARE TRANSACTIONS: Value of shares issued in reinvestment of distributions $21,225,026 $24,095,211 ------------- ------------ Net increase (decrease) in net assets ($185,667,919) $276,062,943 NET ASSETS: Beginning of period 485,582,570 209,519,627 ------------- ------------ End of period $299,914,651 $485,582,570 ============= ============ The accompanying notes are an integral part of these financial statements. 11 H&Q HEALTHCARE INVESTORS ------------------------ STATEMENT OF CASH FLOWS For the Six Months Ended March 31, 2001 (UNAUDITED) CASH FLOWS FROM OPERATING ACTIVITIES: Interest received $1,597,023 Dividends received 8,251 Operating expenses paid (2,780,999) ------------ Net cash used for operating activities ($1,175,725) ------------ CASH FLOWS FROM INVESTING ACTIVITIES: Sales and maturities of portfolio securities $595,696,337 Purchases of portfolio securities (582,129,451) ------------ Net cash provided by investing activities $13,566,886 ------------ CASH FLOWS FROM FINANCING ACTIVITIES: Cash distributions paid, net ($11,869,302) ------------ Net cash used for financing activities ($11,869,302) NET INCREASE IN CASH $521,859 CASH AT BEGINNING OF PERIOD 254,614 ------------ CASH AT END OF PERIOD $776,473 ============ RECONCILIATION OF NET (DECREASE) IN NET ASSETS RESULTING FROM OPERATIONS TO NET CASH USED FOR OPERATING ACTIVITIES: Net (decrease) in net assets resulting from operations ($168,565,614) Net realized (gain) on investments (47,460,750) Net decrease in unrealized gain on investments 215,278,729 Net decrease in interest and dividends receivable 52,271 Net (decrease) in accrued advisory fees and accrued other expenses (369,482) Net (increase) in prepaid expenses and other assets (110,879) ------------ Net cash used for operating activities ($1,175,725) ============ The accompanying notes are an integral part of these financial statements. 12 H&Q HEALTHCARE INVESTORS ------------------------ FINANCIAL HIGHLIGHTS (SELECTED DATA FOR EACH SHARE OF BENEFICIAL INTEREST OUTSTANDING THROUGHOUT THE PERIOD INDICATED) For the six months ended For the years ended September 30, March 31, 2001 ------------------------------------------------------------------ (Unaudited) 2000 1999 1998 1997 1996 ----------- ---- ---- ---- ---- ---- Net asset value per share: Beginning of period $46.147 $21.771 $16.711 $23.106 $25.754 $21.818 ------- ------- ------- ------- ------- ------- Net investment (loss) ($0.066) ($0.290) ($0.176) ($0.217) ($0.224) ($0.331) Net realized and unrealized gain (loss) on investments (16.150) 28.131 5.596 (5.108) 4.524 5.487 Total increase (decrease) from investment operations ($16.216) $27.841 $5.420 ($5.325) $4.300 $5.156 ------- ------- ------- ------- ------- ------- Dilutive effect of sale of common stock and related expenses from rights offering -- -- -- -- (2.458) -- Long-term capital gains distribution to shareholders ($3.589) ($3.465) ($0.360) ($1.070) ($4.490) ($1.220) ------- ------- ------- ------- ------- ------- Net asset value per share: End of period $26.342 $46.147 $21.771 $16.711 $23.106 $25.754 ======= ======= ======= ======= ======= ======= Per share market value: End of period $20.790 $36.188 $16.313 $13.125 $19.000 $20.875 Total investment return (33.67%) 151.66% 27.39% (26.05%) 14.01% 22.03% Net assets: End of period $299,914,651 $485,582,570 $209,519,627 $157,976,073 $207,728,666 $147,552,505 RATIOS AND SUPPLEMENTAL DATA: Ratio of operating expenses to average net assets 1.21%* 1.45% 1.46% 1.46% 1.57% 1.62% Ratio of net investment (loss) to average net assets (0.39%)* (0.86%) (0.91%) (1.11%) (1.13%) (1.44%) Portfolio turnover rate 8.06% 12.90% 24.88% 7.15% 17.47% 22.41% Number of shares outstanding at end of period 11,385,069 10,522,490 9,623,524 9,453,317 8,990,179 5,729,160 *Annualized The accompanying notes are an integral part of these financial statements. 13 H&Q HEALTHCARE INVESTORS ------------------------ NOTES TO FINANCIAL STATEMENTS March 31, 2001 (UNAUDITED) (1) ORGANIZATION H&Q Healthcare Investors (the Fund) is a Massachusetts business trust registered under the Investment Company Act of 1940 as a diversified closed-end management investment company. The Fund's investment objective is long-term capital appreciation through investment in securities of companies in the healthcare industries. The Fund invests primarily in securities of public and private companies that are believed to have significant potential for above-average growth. The Fund was organized on October 31, 1986 and commenced operations on April 22, 1987. The preparation of these financial statements requires the use of certain estimates by management in determining the entity's assets, liabilities, revenues and expenses. Actual results could differ from these estimates. The following is a summary of significant accounting policies consistently followed by the Fund, which are in conformity with those generally accepted in the investment company industry. INVESTMENT SECURITIES Transactions related to the investments of the Fund are recorded on the date the securities are purchased or sold. Investments traded on national securities exchanges or in the over-the-counter market that are National Market System securities are valued at the last sale price or, lacking any sales, at the mean between the last bid and asked prices. Other over-the-counter securities are valued at the most recent bid prices as obtained from one or more dealers that make markets in the securities. As indicated in Note 5, investments for which market quotations are not readily available are valued at fair value as determined in good faith by the Board of Trustees of the Fund. Temporary cash investments with maturities of 60 days or less are valued at amortized cost. Gains and losses from sales of investments are recorded using the "identified cost" method for both financial reporting and Federal income tax purposes. Investment income and expenses are recorded on the accrual basis. FEDERAL INCOME TAXES It is the Fund's policy to comply with the requirements of the Internal Revenue Code applicable to regulated investment companies and to distribute to its shareholders substantially all of its taxable income and its net realized capital gains, if any. Therefore, no Federal income tax provision is required. DISTRIBUTIONS The Fund records all distributions to shareholders from net investment income and realized gains on the ex-dividend date. Such distributions are determined in conformity with income tax regulations. Due to permanent book/tax differences in accounting for certain transactions, certain distributions may be treated as distributions from capital as opposed to distributions of net investment income or realized capital gains. DISTRIBUTION POLICY The current distribution policy is to declare distributions in stock. Stock distributions will automatically be paid in newly issued shares of the Fund unless otherwise instructed by the shareholder. The shares will be valued at the lower of net asset value or market price on the pricing date. The Fund has implemented a fixed distribution policy that permits the Fund to make quarterly distributions at a rate of 2% of the Fund's net assets to shareholders of record. The Fund intends to use net realized capital gains when making quarterly distributions. This 14 H&Q HEALTHCARE INVESTORS ------------------------ NOTES TO FINANCIAL STATEMENTS March 31, 2001 (continued) could result in a return of capital to shareholders if the amount of the distribution exceeds the Fund's net investment income and realized capital gains. It is anticipated that net realized capital gains in excess of the total distributed under this policy would be included in the December distribution. If a distribution were to be declared in cash, it would then be subject to the Dividend Reinvestment Plan. Under the Dividend Reinvestment Plan, distributions will automatically be paid in additional shares of the Fund, unless State Street Bank is otherwise instructed. Shareholders may request to be paid in cash instead of shares by responding to the bank, brokerage or nominee who holds the shares if the shares are in "street name" or by filling out a form received from State Street Bank if the shares are in registered form. (2) PURCHASES AND SALES OF INVESTMENT SECURITIES The aggregate cost of purchases and proceeds from sales of investment securities (other than temporary cash investments) for the period from October 1, 2000 through March 31, 2001 totaled $27,684,259 and $60,508,953, respectively. (3) TAX BASIS OF SECURITIES At March 31, 2001, the total cost of securities for Federal income tax purposes was $156,666,722. The aggregate gross unrealized gain on securities in which there was an excess of market value over cost was $132,416,394. The aggregate gross unrealized loss on securities in which there was an excess of cost over market value was $28,895,378. The net unrealized gain on securities held by the Fund was $103,521,016. (4) ADVISORY AGREEMENT The Fund has entered into an Investment Advisory Agreement (the Advisory Agreement) with Hambrecht & Quist Capital Management Incorporated (the Adviser). Pursuant to the terms of the Advisory Agreement, the Fund pays the Adviser a monthly fee at the rate when annualized of (i) 2.5% of the average net assets for the month of its venture capital and other restricted securities up to 25% of net assets and (ii) for the month, for all other assets, 1.0% of the average net assets up to $250 million, 0.9% of the average net assets for the next $250 million, 0.8% of the average net assets for the next $500 million and 0.7% of the average net assets thereafter. The aggregate fee may not exceed a rate when annualized of 1.375%. Certain officers and Trustees of the Fund are also officers of the Adviser. The Adviser is an indirect wholly owned subsidiary of J.P. Morgan Chase & Co. (5) VENTURE CAPITAL AND OTHER RESTRICTED SECURITIES The Fund may invest in venture capital and other restricted securities if these securities would currently comprise 40% or less of net assets. The value of these securities represents 23.1% of the Fund's net assets at March 31, 2001. The value of the venture capital and other restricted securities is determined in good faith by the Board of Trustees. However, because of the inherent uncertainty of valuations, these estimated values may differ significantly from the values that would have been used had a ready market for the securities existed, and the differences could be material. The following table details the acquisition date, cost, carrying value per unit, and value of the Fund's venture capital and other restricted securities at March 31, 2001, as determined by the Board of Trustees of the Fund. 15 H&Q HEALTHCARE INVESTORS ------------------------ NOTES TO FINANCIAL STATEMENTS March 31, 2001 (continued) Acquisition Carrying Value Security Date Cost per Unit Value ---------------------------------------- ----------- ---------- --------------- --------- AbTox Series F Cvt. Pfd. 3/7/97 $1,401,341 $0.010 $6,364 12% Promissory Note due 2001 2/26/98 65,929 3/11/98 60,000 3/26/98 60,000 ---------- 185,929 1.000 180,000 ACADIA Pharmaceuticals Series E Cvt. Pfd. 5/2/00 3,000,273 7.500 3,000,000 Advanced Medicine Series C Cvt. Pfd. 2/5/99 1,800,123 9.000 1,905,885 Series D-1 Cvt. Pfd. 8/28/00 1,800,000 9.000 1,800,000 Biofield # Common 12/15/00 300,000 0.296 177,600 Biopure ^ Common Warrants 5/13/99 0 1.181 9,844 BioTransplant * Common Warrants 8/12/94 0 0.787 2,174 Common Warrants 10/31/94 0 0.787 4,961 Common Warrants 8/18/95 0 3.163 3,638 Ceres Series C Cvt. Pfd. 12/23/98 1,500,875 6.000 2,250,000 Series D Cvt. Pfd. 3/14/01 1,667,802 6.000 1,667,802 7% Promissory Note due 2001 1/4/01 108,000 1.000 108,000 Codman Group Common 1/26/96 1,652,603 8/24/97 900,155 ---------- 2,552,758 0.100 436,692 Cubist Pharmaceuticals ## Common Warrants 9/23/98 235 18.913 3,782,519 CuraGen 6% Cvt. Debenture due 2007 1/28/00 2,974,500 3/30/00 1,694,007 6/27/00 464,800 6/28/00 975,950 ---------- 6,109,257 68.500 4,658,000 CytoLogix Series A Cvt. Pfd. 1/13/98 1,070,898 11/10/98 900,281 7/21/99 360,160 ---------- 2,331,339 5.050 2,448,386 Series B Cvt. Pfd. 1/11/01 1,147,005 5.050 1,147,005 Endocardial Solutions # Common 3/21/01 3,000,000 3.000 3,375,000 EPR Series A Cvt. Pfd. 3/9/94 1,000,409 1.500 333,333 FitForAll.com 10% Promissory Note due 2003 2/22/00 450,000 4/3/00 69,821 4/20/00 301,852 5/15/00 457,821 7/27/00 159,666 9/18/00 150,000 ---------- 1,589,160 0.000 158 16 H&Q HEALTHCARE INVESTORS ------------------------ NOTES TO FINANCIAL STATEMENTS March 31, 2001 (continued) Acquisition Carrying Value Security Date Cost per Unit Value ---------------------------------------- ----------- ---------- --------------- --------- Galileo Laboratories Series F Cvt. Pfd. 8/18/00 3,000,000 2.145 3,000,000 InterVentional Technologies Series E Cvt. Pfd. 4/2/91 500,667 0.500 200,000 Series F Cvt. Pfd. 8/21/92 700,399 2.500 218,750 Series G Cvt. Pfd. 3/8/95 150,431 2.500 37,500 KVM Technologies Series B Cvt. Pfd. 2/19/98 1,501,320 4.425 1,500,000 Adj. Cvt. Promissory Note due 2001 6/21/99 150,625 10/19/99 120,000 12/15/99 30,000 1/20/00 45,000 3/16/00 60,000 4/13/00 90,000 5/24/00 60,000 7/10/00 60,000 7/31/00 90,000 10/11/00 60,000 11/13/00 150,000 1/30/01 135,000 ---------- 1,050,625 1.000 1,050,000 LocalMed Series D Cvt. Pfd. 2/9/96 1,376,970 0.010 3,438 MASIMO Series D Cvt. Pfd. 8/14/96 1,120,000 11.000 1,760,000 Masimo Labs Common 8/14/96 1,600 0.010 1,600 Novacept Series D Cvt. Pfd. 3/27/01 3,000,005 4.750 3,000,005 Novatrix Series D Cvt. Pfd. 5/25/00 2,400,691 0.010 10,667 Orthovita ^ Common 3/16/01 4,080,000 4.000 6,024,426 Physician WebLink Common 2/5/97 1,200,325 3.920 1,200,473 Common Warrants 10/15/98 0 0.100 18,810 Raven biotechnologies Series B Cvt. Pfd. 12/12/00 3,000,000 1.650 3,000,000 Songbird Hearing Series D Cvt. Pfd. 12/14/00 3,000,001 4.690 3,000,001 Sontra Medical Series A Cvt. Pfd. 9/9/98 1,200,420 0.270 465,517 8% Promissory Note due 2002 3/26/01 180,000 1.000 180,000 Therion Biologics Common 7/12/90 7,582 6/30/93 502,648 8/20/96 818 10/16/96 3,623 ---------- 514,671 3.750 850,350 Sinking Fund Cvt. Pfd. 10/17/94 251,260 4/19/95 97,116 7/12/95 97,063 10/17/95 97,000 1/25/96 89,176 4/3/96 90,200 ---------- 721,815 3.750 135,345 17 H&Q HEALTHCARE INVESTORS ------------------------ FINANCIAL HIGHLIGHTS March 31, 2001 (continued) Acquisition Carrying Value Security Date Cost per Unit Value ---------------------------------------- ----------- ---------- --------------- --------- Therion Biologics (cont.) Series A Cvt. Pfd. 8/20/96 80,982 10/16/96 358,631 ---------- 439,613 3.750 177,776 Units 2/24/99 68,989 6/3/99 68,989 6/22/99 762,022 ---------- 900,000 3.750 900,000 TherOx Series H Cvt. Pfd. 9/11/00 2,999,996 4.600 2,999,996 Triad Therapeutics Series A Cvt. Pfd. 6/8/99 1,750,860 2.000 3,500,000 Series B Cvt. Pfd. 12/20/00 1,650,000 2.000 1,650,000 Versicor ** Common 6/28/99 427,365 10/29/99 414,733 ---------- 842,098 6.047 1,077,346 Zyomyx Series B Cvt. Pfd. 2/19/99 1,200,550 4.000 3,692,308 Series C Cvt. Pfd. 3/2/00 1,200,690 4.000 2,400,000 ---------- ----------- $68,998,253 $69,351,671 ========== =========== * Represents 60% of equivalent current market value. ** Represents 75% of equivalent current market value. # Represents 80% of equivalent current market value. ## Represents 85% of equivalent current market value. ^ Represents 90% of equivalent current market value. These accompanying notes are an integral part of these financial statements. 18 H&Q HEALTHCARE INVESTORS 30 Rowes Wharf, 4th Floor Boston, Massachusetts 02110-3328 (617) 310-0567 OFFICERS Alan G. Carr, President Kimberley L. Carroll, Treasurer Kerri A. Bisner, Secretary TRUSTEES Alan G. Carr Lawrence S. Lewin Robert P. Mack, M.D. Eric Oddleifson Oleg M. Pohotsky Uwe E. Reinhardt, Ph.D. Henri A. Termeer INVESTMENT ADVISER Hambrecht & Quist Capital Management Incorporated CUSTODIAN AND TRANSFER AGENT State Street Bank and Trust Company LEGAL COUNSEL Dechert Price & Rhoads ------------------------------------ Shareholders with questions regarding share transfers may call 1-800-426-5523 Interim daily net asset value may be obtained by calling 1-800-451-2597 For copies of the Fund's DIVIDEND REINVESTMENT PLAN, please contact the Plan Agent, State Street Bank & Trust Co. P.O. Box 8200, Boston, MA 02266-8200 Telephone: 1-800-426-5523 H&Q HEALTHCARE INVESTORS ------------------------ New York Stock Exchange Symbol: HQH www.hqcm.com --------- Out of concern for the environment and in an effort to reduce Fund expenses, this report is printed on recycled paper. HQHCM-SAR-01