Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
AKANTHOS CAPITAL MANAGEMENT LLC
  2. Issuer Name and Ticker or Trading Symbol
OSCIENT PHARMACEUTICALS CORP [OSCI]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
21700 OXNARD ST, SUITE 1520
3. Date of Earliest Transaction (Month/Day/Year)
11/25/2008
(Street)

WOODLAND HILLS, CA 91367-7584
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
12.50% Convertible Guaranteed Senior Notes Due 2011 $ 1.1 (6) 12/19/2008   J(2)(3)(7)(8)     0 (2) (3)   (5)   (5) COMMON STOCK 4,532,787 (2) (3) (7) (8) $ 0 $ 7,160,000 (2) (3) (7) (8) I See Footnotess (1) (2) (3) (4) (5) (6) (7) (8)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
AKANTHOS CAPITAL MANAGEMENT LLC
21700 OXNARD ST
SUITE 1520
WOODLAND HILLS, CA 91367-7584
    X    
AKANTHOS ARBITRAGE MASTER FUND LP
C/O APPLEBY TRUST (CAYMAN) LTD.
CLIFTON HOUSE,75 FORT ST., P.O. BOX 1350
GRAND CAYMAN KY1-1108, E9 00000
    X    
Michael Kao
21700 OXNARD STREET
SUITE 1520
WOODLAND HILLS, CA 91367-7584
    X    

Signatures

 By: /s/ Michael Kao, Manager, Akanthos Capital Management, LLC, general partner to Akanthos Arbitrage Master Fund, L.P.   12/23/2008
**Signature of Reporting Person Date

 By: /s/ Michael Kao, Manager, Akanthos Capital Management, LLC   12/23/2008
**Signature of Reporting Person Date

 By: /s/ Michael Kao, an individual   12/23/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This statement is filed by and on behalf of each of Akanthos Capital Management, LLC ("ACM"), Akanthos Arbitrage Master Fund, L.P. ("AAMF"), and Michael Kao ("Mr. Kao"). ACM acts as the investment adviser and general partner to, and manages investment and trading accounts of, other persons, including AAMF. ACM may be deemed, through investment advisory contracts or otherwise, to beneficially own securities owned by other persons, including AAMF. Mr. Kao is the Manager of ACM and may be deemed to beneficially own securities owned by ACM. On December 15, 2008, AAMF and ACM reported ownership in excess of 10% due to an exchange offer (the "Exchange") made by the issuer in which AAMF participated. (Mr. Kao was added as a reporting person through an amendment to the original Form 3, dated December 17, 2008.) All Shares (as defined below) beneficially owned by ACM and Mr. Kao are held by AAMF.
(2) On December 15, 2008, the reporting persons reported ownership of 8,299,091 shares of common stock, par value $.10 per share ("Shares"), of the issuer, consisting of: (A) 1,790,000 Shares; and (B) $7,160,000 worth of 12.50% Convertible Guaranteed Senior Notes due 2011 (the "Notes"), convertible at $1.10 per share into 6,509,091 Shares.
(3) Pursuant to an agreement by and between the issuer and AAMF effective as of December 19, 2008 (the "Blocking Agreement"), AAMF may not convert any of the Notes to the extent that AAMF would beneficially own, after any such conversion, more than 9.9% of the issuer's outstanding Shares. The Blocking Agreement had the immediate effect of restricting AAMF's use of the conversion feature of the Notes with respect to 4,532,787 Shares.
(4) Each reporting person states that neither the filing of this statement nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Act or otherwise, the beneficial owner of any securities covered by this statement. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.
(5) The Notes are immediately convertible into Shares. The Notes mature on January 15, 2011, unless earlier converted or repurchased.
(6) The initial conversion rate of the Notes is 909.0909 Shares per $1,000 principal amount of Notes (equal to a conversion price of approximately $1.10 per Share).
(7) AAMF currently owns $7,160,000 worth of Notes, which, absent the Blocking Agreement, would be convertible at $1.10 per share into 6,509,091 Shares. The Blocking Agreement prohibits conversion of the Notes to the extent that AAMF would beneficially own, after any such conversion, more than 9.9% of the issuer's outstanding Shares. As of the date hereof, the Blocking Agreement would permit conversion of the Notes into 1,976,304 Shares. Adding such 1,976,304 Shares to the 1,790,000 Shares currently held by AAMF would result in total ownership of 3,766,304 Shares.
(8) As per the information provided by the Issuer: (i) in its Prospectus dated November 24, 2008, prior to the Exchange, on November 3, 2008, the Issuer had 14,256,628 Shares outstanding; and (ii) in its Form 8-K dated November 24, 2008, 21,310,549 Shares were issued in the Exchange and 500,000 Shares were issued to Paul Royalty Fund Holdings II pursuant to that certain First Amendment to the Revenue Interests Assisgnment Agreement. Therefore, as of November 24, 2008, outstanding shares of the Issuer totaled 36,067,177 ("Current Shares Outstanding"). The number of Shares of which AAMF (and, therefore, ACM and Mr. Kao) may be deemed to be the beneficial owner constitutes approximatelly 9.9% of the total number of Shares outstanding (i.e., 3,766,304 divided by 38,043,481 total Shares outstanding which total is the sum of (A) the Current Shares Outstanding plus (B) the 1,976,304 Shares attributable to the Notes).

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