SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

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                                    FORM 8-K


                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


                  Date of earliest event reported: May 14, 2002


                                   HYSEQ, INC.
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               (Exact Name of Registrant as Specified in Charter)




                  Nevada                                           000-22873                                36-3855489
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(State or Other Jurisdiction of Incorporation)             (Commission File Number)           (I.R.S. Employer Identification No.)



                 670 Almanor Avenue, Sunnyvale, California 94085
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               (Address of Principal Executive Offices) (Zip Code)

                                 (408) 524-8100
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              (Registrant's telephone number, including area code)


                                       N/A
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          (Former Name or Former Address, if Changed Since Last Report)






ITEM 5. OTHER EVENTS.

                On May 14, 2002, Hyseq, Inc., d/b/a/ Hyseq Pharmaceuticals,
        Inc., issued a press release that announced two developments. First,
        Hyseq and BASF Plant Science have agreed to accelerate the completion
        of their collaboration to discover and develop agriculturally based
        genes. Second, Hyseq has completed an internal restructuring in order
        to align its workforce with the company's focus on developing
        biopharmaceuticals.

                On May 14, 2002, the Company and BASF agreed to amend the
        collaboration agreement between the two parties. Under this amendment,
        both Hyseq's agricultural gene discovery activities and BASF Plant
        Science's payment schedule will accelerate with early completion
        scheduled for January 2003, resulting in a cost savings to both parties.
        The royalties due to the Company from BASF will also be reduced. The
        collaboration retains its original termination date of June 2003 but
        will not be renewable for any additional terms.

                In May 2002, the Company also began an internal restructuring
        that includes a realignment of research groups and a reduction of 79
        employees, primarily in the area of agricultural gene discovery. The
        reduction is being implemented over the next eight months, and the
        Company expects to have reduced the Company's workforce to approximately
        125 employees by the end of 2002.

                A copy of the press release is attached as an exhibit to this
        Form 8-K and is incorporated by reference herein in its entirety

                This document contains forward-looking statements concerning
        Hyseq Pharmaceuticals. Statements included herein which are not
        historical in nature, are intended to be, and are hereby identified as
        "forward-looking statements" for purposes of the safe harbor provided by
        the Private Securities Litigation Reform Act of 1995. Forward looking
        statements may be identified by words such as "believe," "expect,"
        "anticipate," "should," "may," "estimated" and "potential," among
        others. Hyseq cautions readers that forward-looking statements,
        including without limitation, those relating to Hyseq's future business
        prospects are subject to certain risks and uncertainties that could
        cause actual results to differ materially from those indicated in the
        forward-looking statements. For a discussion of factors that may cause
        results to differ, see Hyseq's reports filed with the SEC, including its
        Annual Report on Form 10-K for the year ended December 31, 2001. Hyseq
        disclaims any intent or obligation to update these forward-looking
        statements.

ITEM 7. EXHIBITS.




Exhibit Number     Description of Document
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99.1               Press Release, dated May 14, 2002, entitled "Hyseq
                   Pharmaceuticals Takes Steps to Further Strengthen its
                   Biopharmaceutical Focus and Financial Position"




                                   SIGNATURES

        Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.



                                          HYSEQ, INC.
                                          (Registrant)


                                          By: /s/ Peter S. Garcia
                                              ---------------------------------
                                              Peter S. Garcia
                                              Senior Vice President and
                                              Chief Financial Officer


Dated: May 16, 2002




                                  EXHIBIT INDEX


Exhibit Number     Description of Document
--------------     -----------------------
99.1               Press Release, dated May 14, 2002, entitled "Hyseq
                   Pharmaceuticals Takes Steps to Further Strengthen its
                   Biopharmaceutical Focus and Financial Position"