Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Czernik Marcin
   2. Issuer Name and Ticker or Trading Symbol
Karyopharm Therapeutics Inc. [KPTI] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
SIMOU MENARDOU 8,, RIA COURT 8, OFFICE 101		 3. Date of Earliest Transaction (Month/Day/Year)
09/17/2014
(Street)

6015 LARNACA, G4 		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
COMMON STOCK 09/17/2014   S   9,569 D $ 40.2623 (1) 2,925,793 I See Footnotes (2) (3) (4)
COMMON STOCK 09/18/2014   S   2,778 D $ 40.1568 (1) 2,923,015 I See Footnotes (2) (3) (4)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Czernik Marcin
SIMOU MENARDOU 8,
RIA COURT 8, OFFICE 101
6015 LARNACA, G4 		     X    
Hadjimichael Andreas
SIMOU MENARDOU 8,
RIA COURT 8, OFFICE 101
6015 LARNACA, G4 		     X    
Hadjimichael Amalia
SIMOU MENARDOU 8,
RIA COURT 8, OFFICE 101
6015 LARNACA, G4 		     X    

Signatures

 Marcin Czernik, by /s/ Simon Prisk, as attorney-in fact by power of attorney   09/19/2014
**Signature of Reporting Person Date
 /s/ Andreas Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney   09/19/2014
**Signature of Reporting Person Date
 /s/ Amalia Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney   09/19/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The prices reported in Column 4 are weighted average prices. The shares sold on September 17, 2014 were sold at prices ranging from $40.00 to $40.80, inclusive. The shares sold on September 18, 2014 were sold at prices ranging from $40.00 to $40.77, inclusive. The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth above.
(2) Shares of Common Stock are owned directly by Plio Limited ("Plio"), which holds less than 10% of the outstanding Common Stock of the issuer. Plio's directors, Marcin Czernik, Andreas Hadjimichael and Amalia Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Plio. Gregory Jankilevitsch , the sole shareholder of Plio, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Plio. The shares owned by Plio do not include the 10,223,767 shares of the issuer's Common Stock held by Chione Limited, which has the same directors as Plio.
(3) Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed, except, with respect to any person, to the extent of the pecuniary interest of such person in such securities.
(4) Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.
 
Remarks:
Exhibit Index Exhibit 24.1 - Power of Attorney, dated November 5, 2013, made by Marcin Czernik and Plio Limited in favor of Simon Prisk (previously filed) Exhibit 24.2 - Power of Attorney, dated November 5, 2013, made by Andreas Hadjimichael and Plio Limited in favor of Simon Prisk (previously filed) Exhibit 24.3 - Power of Attorney, dated November 5, 2013, made by Amalia Hadjimichael and Plio Limited in favor of Simon Prisk (previously filed) Exhibit 99.1 - Joint Filer Information (filed herewith) Exhibit 99.2 - Joint Filing Agreement (previously filed) All previously filed Exhibits were filed with the Form 3 of the reporting persons, Plio Limited and Gregory Jankilevitsch, filed on November 8, 2013.

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