UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934.

Date of Report: March 23, 2007
(Date of earliest event reported)

ISCO International, Inc.
(Exact name of registrant as specified in its charter)
IL
(State or other jurisdiction
of incorporation) 001-22302
(Commission File Number) 36-3688459
(IRS Employer
Identification Number)
1001 Cambridge Drive, Elk Grove Village, IL
(Address of principal executive offices)   60007
(Zip Code)
847-391-9400
(Registrant's telephone number, including area code)
Not Applicable
(Former Name or Former Address, if changed since last report)


Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 5.02. Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers


On March 23, 2007 Martin Singer notified the Company of his resignation from the Company's Board of Directors effective as of April 2, 2007.

Additionally, Thomas Powers advised the Company of his intention to retire from the Company's Board of Directors at the end of his current term, consistent with the Company's Corporate Governance Guidelines' expectation of director retirement at the age of 70. Mr. Powers' term will expire at the next annual meeting of stockholders, which the Company expects to occur during June 2007.
A copy of the press release issued in connection with Mr. Singer's resignation and Mr. Powers' retirement is attached as Exhibit 99.1 to this Current Report on Form 8-K and incorporated herein by reference.

Item 8.01. Other Events

The information set forth under Item 5.02(b) of this Report with respect to Mr. Powers' retirement from the Board of Directors is hereby incorporated in Item 8.01 by reference.

Item 9.01. Financial Statements and Exhibits

(a) Financial statements:
            None
(b) Pro forma financial information:
            None
(c) Shell company transactions:
            None
(d) Exhibits
            99.1       Press Release of ISCO International, Inc. dated March 28, 2007


SIGNATURE

      Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.


Dated: March 28, 2007
ISCO INTERNATIONAL, INC.

By:  /s/ Frank Cesario                    
     Frank Cesario
     Chief Financial Officer


Exhibit Index Exhibit No. Description 99.1 Press Release of ISCO International, Inc. dated March 28, 2007