2.5 Weeks to Deliver Desired Humanized Antibody in ProBio

By: Get News

October 22, 2024 at 17:12 PM EDT

500+ Antibody Humanization Projects

Guarantee no loss of affinity

The most advanced project is marketed

Antibody humanization & antibody characterization can reduce the immunogenicity of monoclonal antibodies derived from xenogeneic sources and improve their activation of the human immune system by replacing non-human antibody frameworks with human ones. It is a very important step in the therapeutic antibody discovery process. ProBio is the world’s No.1 fast antibody humanization service provider, providing 2 packages for antibody humanization services.

20-year experience in antibody discovery
Delivered over 500 projects
The most advanced project is marketed
Guarantee no loss of affinity
Humanization rate >95%
Provide developability prediction reports including PTM, aggregation and immunogenicity.
Various detection systems: SPR, ELISA, FACS
Suitable for mAb, scFv and sdAb

Service Introduction

Express Service: As Fast as 2.5 weeks to Get Your Antibody Humanized

Through CDR grafting and back mutation technologies, the express package can be used to produce humanized antibodies with high expression levels, good thermal stability, and comparable affinity with the parental antibodies as fast as 2.5 weeks.

Deluxe Service: Get Humanized Antibody with No Affinity Loss

Deluxe package can be used to obtain the humanized antibodies without affinity loss through CDR grafting, back mutation, and FASEBA high-throughput screening technology as fast as 8 weeks.

Learn more about patented FASEBA screening platform

FASEBA is a patented E.Coli based system that selects good affinity, expression level and thermostable candidates. It is used to select the best protein binders from a large number of protein candidates in a high throughput fashion, without actually purifying these proteins.

Each saturation mutation library is transformed into FASEBA E.coli based expression system.

How to Avoid Developability Risk in the Early Stage of Discovery？

ProBio offers 3 developability assessment packages for antibody drug candidates at different discovery stages to identify the potential risks of manufacture and clinical failure.

Service Package

Deluxe Humanization --- Back mutaiton library screening with FASEBA

The turnaround time listed here is the time required for the service itself. For international shipping, please refer to the time provided by PM during project discussion.

Express plus humanization --- CDR grafting with back mutation

The turnaround time listed here is the time required for the service itself. For international shipping, please refer to the time provided by PM during project discussion.