SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G


                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                                (AMENDMENT NO. )*

                          OSCIENT PHARMACEUTICALS CORP.
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                                (NAME OF ISSUER)


                    COMMON STOCK, $0.01 PAR VALUE PER SHARE 
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                         (TITLE OF CLASS OF SECURITIES)


                                    68812R105
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                                 (CUSIP NUMBER)


                                   MAY 3, 2005
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             (DATE OF EVENT WHICH REQUIRES FILING OF THIS STATEMENT)



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CHECK THE APPROPRIATE BOX TO DESIGNATE THE RULE PURSUANT TO WHICH THIS SCHEDULE
IS FILED:

[X]   RULE 13D-1(B)

[ ]   RULE 13D-1(C)

[ ]   RULE 13D-1(D)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


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CUSIP NO. 68812R105                SCHEDULE 13G                PAGE 2 OF 5 PAGES
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  1       NAME OF REPORTING PERSON:
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

          Ashford Capital Management, Inc.
--------- ----------------------------------------------------------------------
  2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a) |_|
                                                                        (b) |_|
--------- ----------------------------------------------------------------------
  3       SEC USE ONLY

--------- ----------------------------------------------------------------------
  4       CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware
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                         5    SOLE VOTING POWER

                              7,718,300 shares
                       ------ --------------------------------------------------
       NUMBER            6    SHARED VOTING POWER
      OF SHARES
    BENEFICIALLY              0 shares
      OWNED BY         ------ --------------------------------------------------
        EACH             7    SOLE DISPOSITIVE POWER
      REPORTING
     PERSON WITH              7,718,300 shares
                       ------ --------------------------------------------------
                         8    SHARED DISPOSITIVE POWER

                              0 shares
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   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   

          7,718,300 shares
--------- ----------------------------------------------------------------------
  10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* 

          |_|
--------- ----------------------------------------------------------------------
  11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          10.1%
--------- ----------------------------------------------------------------------
  12      TYPE OF REPORTING PERSON*

          IA
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CUSIP NO. 68812R105                SCHEDULE 13G                PAGE 3 OF 5 PAGES
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ITEM 1.

     (a)  Name of Issuer:

          Oscient Pharmaceuticals Corp.

     (b)  Address of Issuer's Principal Executive Offices:

          1000 Winter Street, Suite 2200, Waltham, MA 02451

ITEM 2.

     (a)  Name of Person Filing:

             Ashford Capital Management, Inc.

     (b)  Address of Principal Business Office or, if none, Residence:

             P.O. Box 4172, Wilmington, DE 19807

     (c)  Citizenship: A Delaware Corporation

     (d)  Title of Class of Securities: Common Stock, $0.01 Par Value Per Share

     (e)  CUSIP Number: 68812R105

ITEM 3.  IF THIS STATEMENT IS FILED PURSUANT TO SS.SS.240.13D-1(B) OR 
         240.13D-2(B) OR (C), CHECK WHETHER THE PERSON FILING IS A:

     (a)  |_| Broker or dealer registered under section 15 of the Act

     (b)  |_| Bank as defined in section 3(a)(6) of the Act

     (c)  |_| Insurance company as defined in section 3(a)(19) of the Act

     (d)  |_| Investment company registered under section 8 of the Investment
          Company Act of 1940

     (e)  |X| An investment adviser in accordance with ss.240.13d-1(b)(1(ii)(E)

     (f)  |_| An employee benefit plan or endowment fund in accordance with
          ss.240.13d-1(b)(1)(ii)(F)

     (g)  |_| A parent holding company or control person in accordance with
          ss.240.13d-1(b)(1)(ii)(G)

     (h)  |_| A savings association as defined in section 3(b) of the Federal
          Deposit Insurance Act

     (i)  |_| A church plan that is excluded from the definition of an
          investment company under section 3(c)(14) of the Investment Company
          Act of 1940 

     (j)  |_| Group, in accordance with ss.240.13d-1(b)-1(ii)(J)

ITEM 4.  OWNERSHIP

       Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

     (a)  Amount Beneficially Owned: 7,718,300 shares

     (b)  Percent of Class: 10.1%

          The foregoing percentage is calculated based on 76,383,155 shares of
          Common Stock reported to be outstanding as of December 31, 2004 in the
          Issuer's Quarterly Report filed on Form 10-K.

     (c)  Number of shares as to which such person has:

          (i)  Sole power to vote or to direct the vote: 7,718,300 shares

          (ii) Shared power to vote or to direct the vote: 0 shares


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CUSIP NO. 68812R105                SCHEDULE 13G                PAGE 4 OF 5 PAGES
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          (iii) Sole power to dispose or to direct the disposition of: 7,718,300
               shares

          (iv) Shared power to dispose or to direct the disposition of: 0 shares

ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following |_|. N/A

ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

     The shares reported by the Reporting Person, a registered investment
advisor, are held in separate individual client accounts, two separate limited
partnerships and nine commingled funds.

ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
         SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

         N/A

ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

         N/A

ITEM 9.  NOTICE OF DISSOLUTION OF GROUP

         N/A

ITEM 10. CERTIFICATION

     By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were acquired and are held in the ordinary
course of business and were not acquired and are not held for the purpose of or
with the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.


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CUSIP NO. 68812R105                SCHEDULE 13G                PAGE 5 OF 5 PAGES
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                                    SIGNATURE
                                    ---------

     After reasonable inquiry and to the best of its knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date: June 6, 2005


ASHFORD CAPITAL MANAGEMENT, INC.


By: /s/ Theodore H. Ashford, III                  
    ---------------------------------
    Theodore H. Ashford, III
    President