SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c)
         AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b)

                               (AMENDMENT NO. 2)*

                       Oscient Pharmaceuticals Corporation
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                                (Name of Issuer)

                     Common Stock, $0.01 par value per share
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                         (Title of Class of Securities)

                                    68812R105
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                                 (CUSIP Number)

                                December 31, 2006
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             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ] Rule 13d-1(b)
[X] Rule 13d-1(c)
[ ] Rule 13d-1(d)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934, or otherwise subject to the liabilities of that section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).





--------------------------------------------------------------------------------
  1      NAMES OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         Abingworth Management Limited
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  2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
         (a) [  ]
         (b) [  ]
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  3      SEC USE ONLY

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  4      CITIZENSHIP OR PLACE OF ORGANIZATION

         England
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                        5     SOLE VOTING POWER
                              0
  NUMBER OF             ------------------------------------------------------
  SHARES                6     SHARED VOTING POWER
  BENEFICIALLY
  OWNED BY                    751,853*
  EACH                  ------------------------------------------------------
  REPORTING             7     SOLE DISPOSITIVE POWER
  PERSON WITH                 0
                        ------------------------------------------------------
                        8    SHARED DISPOSITIVE POWER

                              751,853*
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  9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         751,853*
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  10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
         (SEE INSTRUCTIONS)
         [  ]
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  11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

         5.5%
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  12     TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

          CO
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* THIS AMENDMENT DOES NOT REFLECT A SALE OR OTHER DISPOSITION BY THE REPORTING
PERSON, RATHER, IT IS BEING FILED MERELY TO CORRECT AN ERROR IN THE NUMBER OF
SHARES REPORTED AS BENEFICIALLY OWNED BY THE REPORTING PERSON IN THE SCHEDULE
13D/A FILED ON FEBRUARY 13, 2007.

Item 1(a).  NAME OF ISSUER:  Oscient Pharmaceuticals Corp. (the "Issuer")

Item 1(b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

             1000 Winter Street, Suite 2200
             Waltham, Massachusetts 02451

Item 2(a).  NAME OF PERSONS FILING:  Abingworth Management Limited
            ("Abingworth Management").

Item 2(b).  ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
            The business address for Abingworth Management,
            Princess House, 38 Jermyn Street, London, England SW1Y 6DN.

Item 2(c).  CITIZENSHIP:  Abingworth Management is a corporation organized
            under the laws of England.

Item 2(d).  TITLE OF CLASS OF SECURITIES: Common Stock, $0.01 par value
            per share

Item 2(e).  CUSIP NUMBER:  68812R105

Item 3.     IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b)
            OR (c), CHECK WHETHER THE PERSON FILING IS A:

                  Not applicable.

Item 4.     OWNERSHIP.

            (a) Amount Beneficially Owned:

                 Abingworth Management Limited is the manager of Abingworth
                 Bioequities Master Fund LTD, Abingworth Bioventures IV L.P.,
                 Abingworth   Bioventures  IV  Executives  L.P.,   Abingworth
                 Bioventures  III A L.P.,  Abingworth  Bioventures  III B LP,
                 Abingworth  Bioventures III C LP and Abingworth  Bioventures
                 III  Executives LP  (collectively,  the "Funds").

                 As of the date hereof, Abingworth  Bioequities Master Fund LTD
                 is the  record  owner of  207,292  shares of  Common  Stock;
                 Abingworth  Bioventures  IV  L.P.  is the  record  owner  of
                 186,742  shares of Common Stock;  Abingworth  Bioventures IV
                 Executives  L.P.  is the  record  owner of 1,602  shares  of
                 Common  Stock;  Abingworth  Bioventures  III A  L.P.  is the
                 record owner of 81,283  shares of Common  Stock;  Abingworth
                 Bioventures  III B L.P. is the record owner of 49,661 shares
                 of Common Stock;  Abingworth  Bioventures  III C L.P. is the
                 record  owner  of  29,677  shares  of  Common   Stock;   and
                 Abingworth  Bioventures  III  Executives  L.P. is the record
                 owner of 1,297 shares of Common Stock.

                 In  addition, Abingworth Bioequities Master Fund  LTD is the
                 record owner of warrants,  exercisable  for 56,671 shares of
                 Common Stock;  Abingworth  Bioventures IV L.P. is the record
                 owner of warrants,  exercisable  for 56,189 shares of Common
                 Stock;  Abingworth  Bioventures  IV  Executives  L.P. is the
                 record  owner of  warrants,  exercisable  for 482  shares of
                 Common  Stock;  Abingworth  Bioventures  III C  L.P.  is the



                  record owner of warrants,  exercisable  for 14,838 shares of
                  Common  Stock;  Abingworth  Bioventures  III B  L.P.  is the
                  record owner of warrants,  exercisable  for 24,830 shares of
                  Common  Stock;  Abingworth  Bioventures  III A  L.P.  is the
                  record owner of warrants,  exercisable  for 40,641 shares of
                  Common Stock; and Abingworth Bioventures III Executives L.P.
                  is the record owner of warrants,  exercisable for 648 shares
                  of Common  Stock.  All of the warrants held by the Funds are
                  immediately exercisable.

                  As the manager of each of the Funds, Abingworth Management
                  may be deemed to beneficially  own  751,853  shares of Common
                  Stock,  which  represents the shares of Common Stock and the
                  warrants  exercisable for shares of Common Stock held by the
                  Funds.

             (b)  Percent of Class:  Abingworth  Management  beneficially owns
                  5.5% of the outstanding Common Stock of the Issuer.

                  The  foregoing percentages are calculated based on the
                  13,552,125 shares of Common Stock reported to be outstanding
                  following a one-for-eight  reverse stock split as of November
                  15, 2006 in the Issuer's Form 8-K filed with the Securities
                  Exchange Commission on November 15, 2006.

             (c)  Number of shares as to which such person has:

                    (i)  sole power to vote or to direct the vote:
                         see line 5 of cover sheets.

                    (ii) shared power to vote or to direct the vote:
                         see line 6 of cover sheets.

                    (iii) sole  power to  dispose or to direct the
                          disposition: see line 7 of cover sheets.

                    (iv)  shared  power to dispose or to direct the
                          disposition: see line 8 of cover sheets.

             The Reporting Person disclaims  beneficial ownership of such
             shares  of Common  Stock  except  for the  shares,  if any,  such
             Reporting Person holds of record.

Item 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

          Not applicable.

Item 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

          Not applicable.

Item 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
          SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

          Not applicable.




Item 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

          Not applicable.

Item 9.  NOTICE OF DISSOLUTION OF GROUP.

          Not applicable.

Item 10. CERTIFICATION.

          By signing below I certify that, to the best of my knowledge
          and belief,  the  securities  referred to above were not acquired
          and are not  held  for the  purpose  of or  with  the  effect  of
          changing  or  influencing  the  control  of  the  issuer  of  the
          securities  and were not acquired and are not held in  connection
          with or as a participant in any  transaction  having that purpose
          or effect.




                                   SIGNATURE

  After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date:  March 6, 2007

ABINGWORTH MANAGEMENT LIMITED


By:   /s/ Stephen Bunting
      ----------------------------
      Name:   Stephen Bunting
      Title:  Executive Director